“Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality,” by Soichi Sanokeita, Horitani, Hayato Ogawajonatan Halvardson, Bicholas W. Chavkin, Ying Wang, Miho Sano, Jonas Mattisson, Atsushi Hata, Marcus Danielsson, Emiri Miura-Yura, Ammar Zaghlool, Megan A. Evans, Tove Fall, Henry N. De Hoyos, Johan Sundström, Yoshimitsu Yura, Anupreet Kour, Yohei Arai, Mark C. Thel, Yuka Arai, Josyf C. Mychaleckyj, Karen K. Hirschi, Lars A. Forsberg, and Kenneth Walsh (Vol. 377, No. 6603, July 14, 2022, p. 292-297).
July 14, 2022
CAAR – Science Article Abstract – July 14, 2022
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June 23, 2022
CAAR – Science Article Abstract – June 23, 2022
“Diverse aging rates in ectothermic tetrapods provide insights for the evolution of aging and longevity,” by Beth A. Reinke, Hugo Cayuelafredric J. Janzen, Jean-François Lemaître, Jean-Michel Gaillarda. Michelle Lawing, John B. Iversonditte G. Christiansen, Iñigo Martínez-Solano, and David A. W. Miller et. al. (Vol. 376, No. 6600, June 23, 2022, p. 1459-1466).
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January 18, 2022
CAAR – Science Article Abstract – January 18, 2022
“Cryo-EM structures of amyloid-{beta} 42 filaments from human brains,” by Yang Yang, Diana Arseni, Wenjuan Zhang, Melissa Huang, Sofia Lövestam, Manuel Schweighauser, Abhay Kotecha, Alexey G. Murzin, Sew, Y. Peak-Chew, Jennifer Macdonald, Isabelle Lavenir, Holly J. Garringer, Ellen Gelpi, Kathy L. Newell, Gabor G. Kovacs, Ruben Vidal, Bernardino Ghetti, Benjamin Ryskeldi-Falcon, Sjors H. W. Scheres, and Michel Goedert (Vol. 375, No. 6577, January 13, 2022, p. 161-172).
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July 9, 2020
CAAR – Science Article Abstract – July 9, 2020
“Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain,” by By Alana M. Horowitz, Xuelai Fan, Gregor Bieri, Lucas K. Smith, Cesar I. Sanchez-Diaz, Adam B. Schroer, Geraldine Gontier, Kaitlin B. Casaletto, Joel H. Kramer, Katherine E. Williams, and Saul A. Villeda (Vol. 369, No. 6500, July 10, 2020, p. 167-173).
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January 24, 2020
CAAR – Science Report – January 24, 2020
Note: Check with your organization’s library for availability. “Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans,” by Ashley E. Frakes, Melissa G. Metcalf, Sarah U. Tronnes, Raz Bar-Ziv, Jenni Durieux, Holly K. Gildea, Nazineen Kandahari, Samira Monshietehadi, and Andrew Dillin (Vol. 367, No. 6476, January 24, 2020, p. 436-440).
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October 31, 2019
CAAR – Science Policy Forum Summary – October 31, 2019
“To help aging populations, classify organismal senescence,” by Stuart R. G. Calimport, Barry L. Bentley, Claire E. Stewart, Graham Pawelec, Angelo Scuteri, Manlio Vinciguerra, Cathy Slack, Danica Chen, Lorna W. Harries, Gary Marchant, G. Alexander Fleming, Michael Conboy, Adam Antebi, Gary W. Small, Jesus Gil, Edward G. Lakatta, Arlan Richardson, Clifford Rosen, Karoly Nikolich, Tony Wyss-Coray, Lawrence Steinman, Thomas Montine, Joao Pedro de Magalhães, Judith Campisi, and George Church (Vol. 366, No. 6465, November 1, 2019, p. 576-578).
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August 9, 2019
CAAR – Science Article Abstract – August 9, 2019
“A vicious cycle of {beta} amyloid–dependent neuronal hyperactivation,” by By Benedikt Zott, Manuel M. Simon, Wei Hong, Felix Unger, Hsing-Jung Chen-Engerer, Matthew P. Frosch, Bert Sakmann, Dominic M. Walsh, and Arthur Konnerth (Vol. 365, No. 6453, August 9, 2019, p. 559-565).
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July 18, 2019
CAAR – Science Article Abstract – July 18, 2019
“Amyloid {beta} oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes,” by Ross Nortley, Nils Korte, Pablo Izquierdo, Chanawee Hirunpattarasilp, Anusha Mishra, Zane Jaunmuktane, Vasiliki Kyrargyri, Thomas Pfeiffer, Lila Khennouf, Christian Madry, Hui Gong, Angela Richard-Loendt, Wenhui Huang, Takashi Saito, Takaomi C. Saido, Sebastian Brandner, Huma Sethi, and David Attwel (Vol. 365, No. 6450, July 19, 2019).
science.sciencemag.org/content/365/6450/eaav9518.editor-summary
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June 17, 2019
CAAR – Science Article Abstract – June 17, 2019
“Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism,” by Vayu Maini Rekdal, Elizabeth N. Bess, Jordan E. Bisanz, Peter J. Turnbaugh, and Emily P. Balskus (Vol. 364, No. 6445, June 14, 2019).
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February 25, 2019
CAAR – Science Report Abstract – February 25, 2019
“The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans,” by Jerrah K. Holth, Sarah K. Fritschi, Chanung Wang, Nigel P. Pedersen, John R. Cirrito, Thomas E. Mahan, Mary Beth Finn, Melissa Manis, Joel C. Geerling, Patrick M. Fuller, Brendan P. Lucey, and David M. Holtzman (Vol. 363, No. 6429, February 22, 2019, p. 880-884).
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February 18, 2019
CAAR – Science Article Abstract – February 18, 2019
“Recognition of the amyloid precursor protein by human {gamma}-secretase,” by Rui Zhou, Guanghui Yang, Xuefei Guo, Qiang Zhou, Jianlin Lei, and Yigong Shi (Vol. 363, No. 6428, February 15, 2019).
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November 5, 2018
CAAR – Science Article Abstract – November 5, 2018
“Poly(ADP-ribose) drives pathologic {alpha}-synuclein neurodegeneration in Parkinson’s disease,” by Tae-In Kam, Xiaobo Mao, Hyejin Park, Shih-Ching Chou, Senthilkumar S. Karuppagounder, George Essien Umanah, Seung Pil Yun, Saurav Brahmachari, Nikhil Panicker, Rong Chen, Shaida A. Andrabi, Chen Qi, Guy G. Poirier, Olga Pletnikova, Juan C. Troncoso, Lynn M. Bekris, James B. Leverenz, Alexander Pantelyat, Han Seok Ko, Liana S. Rosenthal, Ted M. Dawson, Valina L. Dawson (Vol. 362, No. 6414, November 2, 2018).
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September 6, 2018
CAAR – Science Article Abstract – September 6, 2018
“Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model,” by By Se Hoon Choi, Enjana Bylykbashi, Zena K. Chatila, Star W. Lee, Benjamin Pulli, Gregory D. Clemenson, Eunhee Kim, Alexander Rompala, Mary K. Oram, Caroline Asselin, Jenna Aronson, Can Zhang, Sean J. Miller, Andrea Lesinski, John W. Chen, Doo Yeon Kim, Henriette van Praag, Bruce M. Spiegelman, Fred H. Gage, Rudolph E. Tanzi (Vol. 361, No. 6406, September 7, 2018).
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June 28, 2018
CAAR – Science Report Abstracts – June 28, 2018
A. “The plateau of human mortality: Demography of longevity pioneers,” by Elisabetta Barbi, Francesco Lagona, Marco Marsili, James W. Vaupel, and Kenneth W. Wachter (Vol. 360, No. 6396, June 29, 2018, p. 1459-1461).
science.sciencemag.org/content/360/6396/1459
B. “Predictive modeling of U.S. health care spending in late life,” by Liran Einav, Amy Finkelstein, Sendhil Mullainathan, and Ziad Obermeyer (Vol. 360, No. 6396, June 29, 2018, p. 1462-1465).
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March 15, 2018
CAAR – Science Report Abstract – March 15, 2018
“Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging,” by By Dena S. Leeman, Katja Hebestreit, Tyson Ruetz, Ashley E. Webb, Andrew McKay, Elizabeth A. Pollina, Ben W. Dulken, Xiaoai Zhao, Robin W. Yeo, Theodore T. Ho, Salah Mahmoudi, Keerthana Devarajan, Emmanuelle Passegué, Thomas A. Rando, Judith Frydman, and Anne Brunet (Vol. 359, no. 6381, March 16, 2018, p. 1277-1283).
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February 5, 2018
CAAR – Science Report Abstract – February 5, 2018
“Aging and neurodegeneration are associated with increased mutations in single human neurons,” by Michael A. Lodato, Rachel E. Rodin, Craig L. Bohrson, Michael E. Coulter, Alison R. Barton, Minseok Kwon, Maxwell A. Sherman, Carl M. Vitzthum, Lovelace J. Luquette, Chandri N. Yandava, Pengwei Yang, Thomas W. Chittenden, Nicole E. Hatem, Steven C. Ryu, Mollie B. Woodworth, Peter J. Park, and Christopher A. Walsh (Vol. 359, No. 6375, February 2, 2018, p. 555-559).
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December 14, 2017
CAAR – Science Report Abstract – December 14, 2017
“Structural basis of membrane disruption and cellular toxicity by {alpha}-synuclein oligomers,” by Giuliana Fusco, Serene W. Chen, Philip T. F. Williamson, Roberta Cascella, Michele Perni, James A. Jarvis, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti, Nunilo Cremades5, Liming Ying, Christopher M. Dobson, and Alfonso De Simone (Vol. 358, No. 6369, December 15, 2017, p. 1440-1443).
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April 2, 2017
CAAR – Science Report Abstract – April 2, 2017
“Aging increases cell-to-cell transcriptional variability upon immune stimulation,” by Celia Pilar Martinez-Jimenez, Nils Eling, Hung-Chang Chen, Catalina A. Vallejos, Aleksandra A. Kolodziejczyk, Frances Connor, Lovorka Stojic, Timothy F. Rayner, Michael J. T. Stubbington, Sarah A. Teichmann, Maike de la Roche, John C. Marioni, and Duncan T. Odom (Vol. 355, No. 6332, March 31, 2017, p. 1433-1436).
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November 18, 2016
CAAR – Science Letter Abstract – November 18, 2016
“Site-specific phosphorylation of tau inhibits amyloid-{beta} toxicity in Alzheimer’s mice,” by Arne Ittner, Sook Wern Chua, Josefine Bertz, Alexander Volkerling, Julia Van Der Hoven, Amadeus Gladbach, Magdalena Przybyla, Mian Bi, Annika Van Hummel, Claire H. Stevens, Stefania Ippati, Lisa S. Suh, Alexander Macmillan, Greg Sutherland, Jillian J. Kril, Ana P. G. Silva, Joel Mackay, Anne Poljak, Fabien Delerue, Yazi D. Ke, and Lars M. Ittner (Vol. 354, No. 6314, November 18, 2016, p. 904-908).
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September 29, 2016
CAAR – Science Article Abstract – September 29, 2016
“Pathological {alpha}-synuclein transmission initiated by binding lymphocyte-activation gene 3,” by Xiaobo Mao, Michael Tianhao Ou, Senthilkumar S. Karuppagounder, Tae-In Kam, Xiling Yin, Yulan Xiong, Preston Ge, George Essien Umanah, Saurav Brahmachari, Joo-Ho Shin, Ho Chul Kang, Jianmin Zhang, Jinchong Xu, Rong Chen, Hyejin Park, Shaida A. Andrabi, Sung Ung Kang, Rafaella Araújo Gonçalves, Yu Liang, Shu Zhang, Chen Qi, Sharon Lam, James A. Keiler, Joel Tyson, Donghoon Kim, Nikhil Panicker, Seung Pil Yun, Creg J. Workman, Dario A. A. Vignali, Valina L. Dawson, Han Seok Ko, and Ted M. Dawson (Vol. 353, No. 6037, September 30, 2016).
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October 22, 2015
CAAR – Science Letter Abstract – October 22, 2015
“Reduced grid-cell–like representations in adults at genetic risk for Alzheimer’s disease,” by Lukas Kunz, Tobias Navarro Schroder, Hweeling Lee, Christian Montag, Bernd Lachmann, Rayna Sariyska, Martin Reuter, Rudiger Stirnberg, Tony Stocker, Paul Christian Messing-Floeter, Juergen Fell, Christian F. Doeller, and Nikolai Axmacher (Vol. 350, No. 6259, October 23, 2015, p. 430-433).
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September 18, 2015
CAAR – Science Report Abstract – September 18, 2015
“A mechanism for the segregation of age in mammalian neural stem cells,” by D. L. Moore, G. A. Pilz1, M. J. Araúzo-Bravo, Y. Barral, and S. Jessberger (Vol. 349, No. 6254, September 19, 2015, p. 1334-1338).
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March 26, 2015
CAAR – Nature Neuroscience Article Abstract – March 26, 2015
“GLUT1 reductions exacerbate Alzheimer’s disease vasculo-neuronal dysfunction and degeneration,” by Ethan A. Winkler, Yoichiro Nishida, Abhay P. Sagare, Sanket V. Rege, Robert D. Bell, David Perlmutter, Jesse D. Sengillo, Sara Hillman, Pan Kong, Amy R. Nelson, John S. Sullivan, Zhen Zhao, Herbert J. Meiselman, Rosalinda B. Wenby, Jamie Soto, E Dale Abel, Jacob Makshanoff, Edward Zuniga, Darryl C. De Vivo & Berislav V. Zlokovic (Vol. 18, No. 4, April 2015, p. 521-530).
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March 19, 2015
CAAR – Science Report Abstract – March 19, 2015
“A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging,” by Mary Mohrin, Jiyung Shin, Yufei Liu, Katharine Brown, Hanzhi Luo, Yannan Xi, Cole M. Haynes, Danica Chen (Vol. 346, No. 6228, March 19, 2015, p. 1374-1377).
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October 16, 2014
CAAR – Science Report Abstract – October 16, 2014
“HSF-1–mediated cytoskeletal integrity determines thermotolerance and life span,” by Nathan A. Baird, Peter M. Douglas, Milos S. Simic, Ana R. Grant, James J. Moresco, Suzanne C. Wolff, John R. Yates III, Gerard Manning, and Andrew Dillin (Vol. 346, No. 6207, October 17, 2014, p. 360-363).
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October 3, 2014
CAAR – Science Report Abstract – October 3, 2014
“Aging-induced type I interferon response at the choroid plexus negatively affects brain function,” by Kuti Baruch, Aleksandra Deczkowska, Eyal David, Joseph M. Castellano, Omer Miller, Alexander Kertser, Tamara Berkutzki, Zohar Barnett-Itzhaki, Dana Bezalel, Tony Wyss-Coray, Ido Amit, and Michal Schwartz (Vol. 346, No. 6205, October 3, 2014, p. 89-93).
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September 20, 2013
CAAR – Science Report Abstract – September 20, 2013
“Human LilrB2 Is a {beta}-Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer’s Model,” by Taeho Kim, George S. Vidal, Maja Djurisic, Christopher M. William, Michael E. Birnbaum, K. Christopher Garcia, Bradley T. Hyman, and Carla J. Shatz (Vol. 341, No. 6152, September 20, 2013, p. 1399-1404).
www.sciencemag.org/content/341/6152/1399.abstract
Related NIH Press Release:
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June 1, 2012
CAAR – Science Letter Abstract – June 1, 2012
“The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol,” by Paul J. Barrett, Yuanli Song, Wade D. Van Horn, Eric J. Hustedt, Johanna M. Schafer, Arina Hadziselimovic, Andrew J. Beel, and Charles R. Sanders (Vol. 336, No. 6085, June 1, 2012, p. 1168-1171).
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May 3, 2012
CAAR – Science Article Abstract – May 3, 2012
“Don’t Look Back in Anger! Responsiveness to Missed Chances in Successful and Nonsuccessful Aging,” by Stefanie Brassen, Matthias Gamer, Jan Peters, Sebastian Gluth, and Christian Büchel (Vol. 336, No. 6081, May 3, 2012, p. 612-614).
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