CDHA CAAR

June 28, 2018

CAAR – Science Report Abstracts – June 28, 2018

Filed under: Reports and Articles — Tags: , , , — admin @ 4:58 pm

A. “The plateau of human mortality: Demography of longevity pioneers,” by Elisabetta Barbi, Francesco Lagona, Marco Marsili, James W. Vaupel, and Kenneth W. Wachter (Vol. 360, No. 6396, June 29, 2018, p. 1459-1461).

science.sciencemag.org/content/360/6396/1459

B. “Predictive modeling of U.S. health care spending in late life,” by Liran Einav, Amy Finkelstein, Sendhil Mullainathan, and Ziad Obermeyer (Vol. 360, No. 6396, June 29, 2018, p. 1462-1465).

science.sciencemag.org/content/360/6396/1462

March 15, 2018

CAAR – Science Report Abstract – March 15, 2018

Filed under: Reports and Articles — Tags: , — admin @ 5:09 pm

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging,” by By Dena S. Leeman, Katja Hebestreit, Tyson Ruetz, Ashley E. Webb, Andrew McKay, Elizabeth A. Pollina, Ben W. Dulken, Xiaoai Zhao, Robin W. Yeo, Theodore T. Ho, Salah Mahmoudi, Keerthana Devarajan, Emmanuelle Passegué, Thomas A. Rando, Judith Frydman, and Anne Brunet (Vol. 359, no. 6381, March 16, 2018, p. 1277-1283).

science.sciencemag.org/content/359/6381/1277

February 5, 2018

CAAR – Science Report Abstract – February 5, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 3:55 pm

Aging and neurodegeneration are associated with increased mutations in single human neurons,” by Michael A. Lodato, Rachel E. Rodin, Craig L. Bohrson, Michael E. Coulter, Alison R. Barton, Minseok Kwon, Maxwell A. Sherman, Carl M. Vitzthum, Lovelace J. Luquette, Chandri N. Yandava, Pengwei Yang, Thomas W. Chittenden, Nicole E. Hatem, Steven C. Ryu, Mollie B. Woodworth, Peter J. Park, and Christopher A. Walsh (Vol. 359, No. 6375, February 2, 2018, p. 555-559).

science.sciencemag.org/content/359/6375/555

December 14, 2017

CAAR – Science Report Abstract – December 14, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 4:49 pm

Structural basis of membrane disruption and cellular toxicity by {alpha}-synuclein oligomers,” by Giuliana Fusco, Serene W. Chen, Philip T. F. Williamson, Roberta Cascella, Michele Perni, James A. Jarvis, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti, Nunilo Cremades5, Liming Ying, Christopher M. Dobson, and Alfonso De Simone (Vol. 358, No. 6369, December 15, 2017, p. 1440-1443).

science.sciencemag.org/content/358/6369/1440

April 2, 2017

CAAR – Science Report Abstract – April 2, 2017

Filed under: Reports and Articles — Tags: , — admin @ 2:26 pm

Aging increases cell-to-cell transcriptional variability upon immune stimulation,” by Celia Pilar Martinez-Jimenez, Nils Eling, Hung-Chang Chen, Catalina A. Vallejos, Aleksandra A. Kolodziejczyk, Frances Connor, Lovorka Stojic, Timothy F. Rayner, Michael J. T. Stubbington, Sarah A. Teichmann, Maike de la Roche, John C. Marioni, and Duncan T. Odom (Vol. 355, No. 6332, March 31, 2017, p. 1433-1436).

science.sciencemag.org/content/355/6332/1433

November 18, 2016

CAAR – Science Letter Abstract – November 18, 2016

Filed under: Reports and Articles — Tags: , , , — admin @ 4:51 pm

Site-specific phosphorylation of tau inhibits amyloid-{beta} toxicity in Alzheimer’s mice,” by Arne Ittner, Sook Wern Chua, Josefine Bertz, Alexander Volkerling, Julia Van Der Hoven, Amadeus Gladbach, Magdalena Przybyla, Mian Bi, Annika Van Hummel, Claire H. Stevens, Stefania Ippati, Lisa S. Suh, Alexander Macmillan, Greg Sutherland, Jillian J. Kril, Ana P. G. Silva, Joel Mackay, Anne Poljak, Fabien Delerue, Yazi D. Ke, and Lars M. Ittner (Vol. 354, No. 6314, November 18, 2016, p. 904-908).

science.sciencemag.org/content/354/6314/904.abstract

September 29, 2016

CAAR – Science Article Abstract – September 29, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:50 pm

Pathological {alpha}-synuclein transmission initiated by binding lymphocyte-activation gene 3,” by Xiaobo Mao, Michael Tianhao Ou, Senthilkumar S. Karuppagounder, Tae-In Kam, Xiling Yin, Yulan Xiong, Preston Ge, George Essien Umanah, Saurav Brahmachari, Joo-Ho Shin, Ho Chul Kang, Jianmin Zhang, Jinchong Xu, Rong Chen, Hyejin Park, Shaida A. Andrabi, Sung Ung Kang, Rafaella Araújo Gonçalves, Yu Liang, Shu Zhang, Chen Qi, Sharon Lam, James A. Keiler, Joel Tyson, Donghoon Kim, Nikhil Panicker, Seung Pil Yun, Creg J. Workman, Dario A. A. Vignali, Valina L. Dawson, Han Seok Ko, and Ted M. Dawson (Vol. 353, No. 6037, September 30, 2016).

science.sciencemag.org/content/353/6307/aah3374.abstract

October 22, 2015

CAAR – Science Letter Abstract – October 22, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:42 pm

Reduced grid-cell–like representations in adults at genetic risk for Alzheimer’s disease,” by Lukas Kunz, Tobias Navarro Schroder, Hweeling Lee, Christian Montag, Bernd Lachmann, Rayna Sariyska, Martin Reuter, Rudiger Stirnberg, Tony Stocker, Paul Christian Messing-Floeter, Juergen Fell, Christian F. Doeller, and Nikolai Axmacher (Vol. 350, No. 6259, October 23, 2015, p. 430-433).

www.sciencemag.org/content/350/6259/430.abstract

September 18, 2015

CAAR – Science Report Abstract – September 18, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 4:29 pm

A mechanism for the segregation of age in mammalian neural stem cells,” by D. L. Moore, G. A. Pilz1, M. J. Araúzo-Bravo, Y. Barral, and S. Jessberger (Vol. 349, No. 6254, September 19, 2015, p. 1334-1338).

www.sciencemag.org/content/349/6254/1334.abstract

March 26, 2015

CAAR – Nature Neuroscience Article Abstract – March 26, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:28 pm

GLUT1 reductions exacerbate Alzheimer’s disease vasculo-neuronal dysfunction and degeneration,” by Ethan A. Winkler, Yoichiro Nishida, Abhay P. Sagare, Sanket V. Rege, Robert D. Bell, David Perlmutter, Jesse D. Sengillo, Sara Hillman, Pan Kong, Amy R. Nelson, John S. Sullivan, Zhen Zhao, Herbert J. Meiselman, Rosalinda B. Wenby, Jamie Soto, E Dale Abel, Jacob Makshanoff, Edward Zuniga, Darryl C. De Vivo & Berislav V. Zlokovic (Vol. 18, No. 4, April 2015, p. 521-530).

www.nature.com/neuro/journal/v18/n4/abs/nn.3966.html

March 19, 2015

CAAR – Science Report Abstract – March 19, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:36 pm

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging,” by Mary Mohrin, Jiyung Shin, Yufei Liu, Katharine Brown, Hanzhi Luo, Yannan Xi, Cole M. Haynes, Danica Chen (Vol. 346, No. 6228, March 19, 2015, p. 1374-1377).

www.sciencemag.org/content/347/6228/1374.abstract

October 16, 2014

CAAR – Science Report Abstract – October 16, 2014

Filed under: Reports and Articles — Tags: , , — admin @ 4:38 pm

HSF-1–mediated cytoskeletal integrity determines thermotolerance and life span,” by Nathan A. Baird, Peter M. Douglas, Milos S. Simic, Ana R. Grant, James J. Moresco, Suzanne C. Wolff, John R. Yates III, Gerard Manning, and Andrew Dillin (Vol. 346, No. 6207, October 17, 2014, p. 360-363).

www.sciencemag.org/content/346/6207/360.abstract

October 3, 2014

CAAR – Science Report Abstract – October 3, 2014

Filed under: Reports and Articles — Tags: , , — admin @ 4:59 pm

Aging-induced type I interferon response at the choroid plexus negatively affects brain function,” by Kuti Baruch, Aleksandra Deczkowska, Eyal David, Joseph M. Castellano, Omer Miller, Alexander Kertser, Tamara Berkutzki, Zohar Barnett-Itzhaki, Dana Bezalel, Tony Wyss-Coray, Ido Amit, and Michal Schwartz (Vol. 346, No. 6205, October 3, 2014, p. 89-93).

www.sciencemag.org/content/346/6205/89.abstract

September 20, 2013

CAAR – Science Report Abstract – September 20, 2013

Filed under: Reports and Articles — Tags: , — admin @ 12:14 pm

Human LilrB2 Is a {beta}-Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer’s Model,” by Taeho Kim, George S. Vidal, Maja Djurisic, Christopher M. William, Michael E. Birnbaum, K. Christopher Garcia, Bradley T. Hyman, and Carla J. Shatz (Vol. 341, No. 6152, September 20, 2013, p. 1399-1404).

www.sciencemag.org/content/341/6152/1399.abstract

Related NIH Press Release:

www.nih.gov/news/health/sep2013/nei-19.htm

June 1, 2012

CAAR – Science Letter Abstract – June 1, 2012

Filed under: Reports and Articles — Tags: , — admin @ 4:37 pm

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol,” by Paul J. Barrett, Yuanli Song, Wade D. Van Horn, Eric J. Hustedt, Johanna M. Schafer, Arina Hadziselimovic, Andrew J. Beel, and Charles R. Sanders (Vol. 336, No. 6085, June 1, 2012, p. 1168-1171).

www.sciencemag.org/content/336/6085/1168.short

May 3, 2012

CAAR – Science Article Abstract – May 3, 2012

Filed under: Reports and Articles — Tags: , — admin @ 3:50 pm

Don’t Look Back in Anger! Responsiveness to Missed Chances in Successful and Nonsuccessful Aging,” by Stefanie Brassen, Matthias Gamer, Jan Peters, Sebastian Gluth, and Christian Büchel (Vol. 336, No. 6081, May 3, 2012, p. 612-614).

www.sciencemag.org/content/336/6081/612.abstract

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