CDHA CAAR

February 20, 2018

CAAR – Proceedings of the National Academies of Sciences Article Abstracts – February 20, 2018

A. “Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence,” by Yang Zhao, Alexander Tyshkovskiy, Daniel Muñoz-Espín, Xiao Tian, Manuel Serrano, Joao Pedro de Magalhaes, Eviatar Nevo, Vadim N. Gladyshev, Andrei Seluanov and Vera Gorbunova (Vol. 115, No. 8, February 20, 2018, p. 1801-1806).

www.pnas.org/content/115/8/1801

B. “NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency,” by Yujun Hou, Sofie Lautrup, Stephanie Cordonnier, Yue Wang, Deborah L. Croteau, Eduardo Zavala, Yongqing Zhang, Kanako Moritoh, Jennifer F. O’Connell, Beverly A. Baptiste, Tinna V. Stevnsner, Mark P. Mattson and Vilhelm A. Bohr (Vol. 115, No. 8, February 20, 2018, p. E1876-E1885).

www.pnas.org/content/115/8/E1876

C. “Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis,” by Xiaopu Zhou, Yu Chen, Kin Y. Mok, Qianhua Zhao, Keliang Chen, Yuewen Chen, John Hardy, Yun Li, Amy K. Y. Fu, Qihao Guo, Nancy Y. Ip and for the Alzheimer’s Disease Neuroimaging Initiative (Vol. 115, No. 8, February 20, 2018, p. 1697-1706)

www.pnas.org/content/115/8/1697

February 13, 2018

CAAR – Proceedings of the National Academies of Science Article Abstract – February 13, 2018

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice,” by Yulan Xiong, Stewart Neifert, Senthilkumar S. Karuppagounder, Qinfang Liu, Jeannette N. Stankowski, Byoung Dae Lee, Han Seok Ko, Yunjong Lee, Jonathan C. Grima, Xiaobo Mao, Haisong Jiang, Sung-Ung Kang, Deborah A. Swing, Lorraine Iacovitti, Lino Tessarollo, Ted M. Dawson, and Valina L. Dawson (Vol. 115, No. 7, February 13, 2018, p. 1635-1640).

www.pnas.org/content/115/7/1635

January 31, 2018

CAAR – Proceedings of the National Academies of Science Article Abstract – January 31, 2018

The role of obesity in exceptionally slow US mortality improvement,” by Samuel H. Preston, Yana C. Vierboom and Andrew Stokes (Vol. 115, No. 5, January 30, 2018, p. 957-961).

www.pnas.org/content/115/5/957

January 23, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 23, 2018

A. “Structural heterogeneity and intersubject variability of A{beta} in familial and sporadic Alzheimer’s disease,” by Carlo Condello, Thomas Lemmin, Jan Stöhr, Mimi Nick, Yibing Wu, Alison M. Maxwell, Joel C. Watts, Christoffer D. Caro, Abby Oehler, C. Dirk Keene, Thomas D. Bird, Sjoerd G. van Duinen, Lars Lannfelt, Martin Ingelsson, Caroline Graff, Kurt Giles, William F. DeGrado, and Stanley B. Prusiner (Vol. 115, No. 4, January 23, 2018, .pdf and HTML format, p. E782-E791). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/115/4/E782.abstract

B. “GBA1 deficiency negatively affects physiological {alpha}-synuclein tetramers and related multimers,” by Sangjune Kim, Seung Pil Yun, Saebom Lee, George Essien Umanah, Veera Venkata Ratnam Bandaru, Xiling Yin, Peter Rhee, Senthilkumar S. Karuppagounder, Seung-Hwan Kwon, Hojae Lee, Xiaobo Mao, Donghoon Kim, Akhilesh Pandey, Gabsang Lee, Valina L. Dawson, Ted M. Dawson, and Han Seok Ko (Vol. 115, No. 4, January 23, 2018, p. 798-803).

www.pnas.org/content/115/4/798.abstract

C. “CFH and ARMS2 genetic risk determines progression to neovascular age-related macular degeneration after antioxidant and zinc supplementation,” by Demetrios G. Vavvas, Kent W. Small, Carl C. Awh, Brent W. Zanke, Robert J. Tibshirani, and Rafal Kustra (Vol. 115, No. 4, January 23, 2018, .pdf and HTML format, p. E696-E704). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/115/4/E696.abstract

January 18, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 18, 2018

A. “The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease,” by Chun Chen, Zhihao Wang, Zhentao Zhang, Xia Liu, Seong Su Kang, Ying Zhang, and Keqiang Ye (Vol. 115, No. 3, January 16, 2018, p. 578-583).

www.pnas.org/content/115/3/578.abstract

B. “Migration-based selections of antibodies that convert bone marrow into trafficking microglia-like cells that reduce brain amyloid {beta},” by Kyung Ho Han, Britni M. Arlian, Matthew S. Macauley, James C. Paulson, and Richard A. Lerner (Vol. 115, No. 3, January 16, 2018, p. E372-E381). Note: PNAS is providing open-access to the full-text of this article.

www.pnas.org/content/115/3/E372.abstract

January 9, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 9, 2018

Familial Parkinson’s point mutation abolishes multiple system atrophy prion replication,” by Amanda L. Woerman, Sabeen A. Kazmi, Smita Patel, Atsushi Aoyagi, Abby Oehler, Kartika Widjaja, Daniel A. Mordes, Steven H. Olson, and Stanley B. Prusiner (Vol. 115, No. 2, January 9, 2018, p. 409-414).

www.pnas.org/content/115/2/409.abstract

December 22, 2017

CAAR – Proceedings of the National Academies of Science Article Abstracts – December 22, 2017

A. “Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice,” by Noah R. Johnson, Carlo Condello, Shenheng Guan, Abby Oehler, Julia Becker, Marta Gavidia, George A. Carlson, Kurt Giles, and Stanley B. Prusiner (Vol. 114, No. 51, December 19, 2017, p. E11029-E11036).

www.pnas.org/content/114/51/E11029.abstract

B. “Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1,” by D. Cristopher Bragg, Kotchaphorn Mangkalaphiban, Christine A. Vaine, Nichita J. Kulkarni, David Shin, Rachita Yadav, Jyotsna Dhakal, Mai-Linh Ton, Anne Cheng, Christopher T. Russo, Mark Ang, Patrick Acuña, Criscely Go, Taylor N. Franceour, Trisha Multhaupt-Buell, Naoto Ito, Ulrich Müller, William T. Hendriks, Xandra O. Breakefield, Nutan Sharma, and Laurie J. Ozelius (Vol. 114, No. 51, December 19, 2017, p. E11020-E11028). Note: _PNAS_ is providing open access to the full-text of this article.

www.pnas.org/content/114/51/E11020.abstract

December 12, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 12, 2017

Loss of APOBEC1 RNA-editing function in microglia exacerbates age-related CNS pathophysiology,” Daniel C. Cole, Youngcheul Chung, Khatuna Gagnidze, Kaitlyn H. Hajdarovic, Violeta Rayon-Estrada, Dewi Harjanto, Benedetta Bigio, Judit Gal-Toth, Teresa A. Milner, Bruce S. McEwen, F. Nina Papavasiliou, and Karen Bulloch (Vol. 114, No. 50, December 12, 2017, p. 13272-13277).

www.pnas.org/content/114/50/13272.abstract

December 7, 2017

CAAR – Proceedings of the National Academies of Science Article Abstracts – December 7, 2017

A. “Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease,” by Jay Rasmussen, Jasmin Mahler, Natalie Beschorner, Stephan A. Kaeser, Lisa M. Häsler, Frank Baumann, Sofie Nyström, Erik Portelius, Kaj Blennow, Tammaryn Lashley, Nick C. Fox, Diego Sepulveda-Falla, Markus Glatzel, Adrian L. Oblak, Bernardino Ghetti, K. Peter R. Nilsson, Per Hammarström, Matthias Staufenbiel, Lary C. Walker, and Mathias Jucker (Vol. 114, No. 49, December 5, 2017, p. 13018-13023).

B. “Intercellular competition and the inevitability of multicellular aging,” by Paul Nelson and Joanna Masel (Vol. 114, No. 49, December 5, 2017, p. 12982–12987).

www.pnas.org/content/114/49/12982.abstract

November 21, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 21, 2017

Oxalate-curcumin–based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease,” by Jian Yang, Xueli Zhang, Peng Yuan, Jing Yang, Yungen Xu, Jaime Grutzendler, Yihan Shao, Anna Moore, and Chongzhao Ran (Vol. 114, No. 47, November 21, 2017, p. 12384-12389).

www.pnas.org/content/114/47/12384.abstract

November 7, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 7, 2017

A. “Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease,” by Tatsuo Mano, Kenichi Nagata, Takashi Nonaka, Airi Tarutani, Tomohiro Imamura, Tadafumi Hashimoto, Taro Bannai, Kagari Koshi-Mano, Takeyuki Tsuchida, Ryo Ohtomo, Junko Takahashi-Fujigasaki, Satoshi Yamashita, Yasumasa Ohyagi, Ryo Yamasaki, Shoji Tsuji, Akira Tamaoka, Takeshi Ikeuchi, Takaomi C. Saido, Takeshi Iwatsubo, Toshikazu Ushijima, Shigeo Murayama, Masato Hasegawa, and Atsushi Iwata (Vol. 114, No. 45, November 7, 2017, .pdf and HTML format, p. E9645–E9654). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/45/E9645.abstract

B. “Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease,” by Robert J. Andrew, Celia G. Fernandez, Molly Stanley, Hong Jiang, Phuong Nguyen, Richard C. Rice, Virginie Buggia-Prévot, Pierre De Rossi, Kulandaivelu S. Vetrivel, Raza Lamb, Arnau Argemi, Emilie S. Allaert, Elle M. Rathbun, Sofia V. Krause, Steven L. Wagner, Angèle T. Parent, David M. Holtzman, and Gopal Thinakaran (Vol. 114, No. 45, November 7, 2017, p. E9665-E9674).

www.pnas.org/content/114/45/E9665.abstract

C. “Individual differences in associative memory among older adults explained by hippocampal subfield structure and function,” by Valerie A. Carr, Jeffrey D. Bernstein, Serra E. Favila, Brian K. Rutt, Geoffrey A. Kerchner, and Anthony D. Wagner (Vol. 114, No. 45, November 7, 2017, p. 12075-12080).

www.pnas.org/content/114/45/12075.abstract

October 24, 2017

CAAR – Proceedings of the National Academies of Sciences Article Abstracts – October 24, 2017

A. “M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer’s disease genes and improving memory,” by Claude-Henry Volmar, Hasib Salah-Uddin, Karolina J. Janczura, Paul Halley, Guerline Lambert, Andrew Wodrich, Sivan Manoah, Nidhi H. Patel, Gregory C. Sartor, Neil Mehta, Nancy T. H. Miles, Sachi Desse, David Dorcius, Michael D. Cameron, Shaun P. Brothers, and Claes Wahlestedt (Vol. 114, No. 43, October 24, 2017, .pdf and HTML format, p. E9135–E9144). Note: PNAS is providing open access to the full text of this article.

www.pnas.org/content/114/43/E9135.abstract

B. “TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy,” by Cheryl E. G. Leyns, Jason D. Ulrich, Mary B. Finn, Floy R. Stewart, Lauren J. Koscal, Javier Remolina Serrano, Grace O. Robinson, Elise Anderson, Marco Colonna, and David M. Holtzman  (Vol. 114, No. 43, October 24, 2017, .pdf and HTML format, p. 11524-11529). Note: PNAS is providing open access to the full text of this article.

www.pnas.org/content/114/43/11524.abstract

October 19, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – October 19, 2017

A. “Projections of white and black older adults without living kin in the United States, 2015 to 2060,” by Ashton M. Verdery and Rachel Margolis (Vol. 114, No. 42, October 17, 2017, p. 11109-11114).

www.pnas.org/content/114/42/11109.abstract.html?etoc

B. “Multigenerational silencing dynamics control cell aging,” by Yang Li, Meng Jin, Richard O’Laughlin Philip Bittihn, Lev S. Tsimring, Lorraine Pillus, Jeff Hasty, and Nan Hao (Vol. 114, No. 42, October 17, 2017, p. 11253-11258).

www.pnas.org/content/114/42/11253.abstract.html?etoc

September 26, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 26, 2017

Modeling Parkinson’s disease pathology by combination of fibril seeds and {alpha}-synuclein overexpression in the rat brain,” by Poonam Thakur, Ludivine S. Breger, Martin Lundblad, Oi Wan Wan, Bengt Mattsson, Kelvin C. Luk, Virginia M. Y. Lee, John Q. Trojanowski, and Anders Bjorklund (Vol. 114, No. 39, September 26, 2017, p. E8284–E8293).

www.pnas.org/content/114/39/E8284.abstract.html?etoc

September 19, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – September 19, 2017

A. “Differential diagnosis of Alzheimer’s disease using spectrochemical analysis of blood,” by Maria Paraskevaidi, Camilo L. M. Morais, Kassio M. G. Lima, Julie S. Snowden, Jennifer A. Saxon, Anna M. T. Richardson, Matthew Jones, David M. A. Mann, David Allsop, Pierre L. Martin-Hirsch, and Francis L. Martin (Vol. 114, No. 38, September 19, 2017, p. E7929–E7938).

www.pnas.org/content/114/38/E7929.abstract.html?etoc

B. “Temporal binding function of dorsal CA1 is critical for declarative memory formation,” by Azza Sellami, Alice Shaam Al Abed, Laurent Brayda-Bruno, Nicole Etchamendy, Stephane Valerio, Marie Oule, Laura Pantaleon, Valerie Lamothe, Mylene Potier, Katy Bernard, Maritza Jabourian, Cyril Herry, Nicole Mons, Pier-Vincenzo Piazza, Howard Eichenbaum, and Aline Marighetto (Vol. 114, No. 38, September 19, 2017, p. 10262–10267).

www.pnas.org/content/114/38/10262.abstract.html?etoc

C. “Dorsolateral prefrontal cortex GABA deficit in older adults with sleep-disordered breathing,” by Ana C. Pereira, Xiangling Mao, Caroline S. Jiang, Guoxin Kang, Sara Milrad, Bruce S. McEwen, Ana C. Krieger, and Dikoma C. Shungu (Vol. 114, No. 38, September 19, 2017, p. 10250–10255).

www.pnas.org/content/114/38/10250.abstract.html?etoc

September 12, 2017

CAAR – Proceedings of the National Academy Sciences Article Abstract – September 12, 2017

Distribution of lifetime nursing home use and of out-of-pocket spending,” by Michael D. Hurd, Pierre-Carl Michaud, and Susann Rohwedder (Vol. 114, No. 37, September 12, 2017, p. 9838–9842).

www.pnas.org/content/114/37/9838.abstract.html?etoc

August 29, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 29, 2017

Knee osteoarthritis has doubled in prevalence since the mid-20th century,” by Ian J. Wallace, Steven Worthington, David T. Felson, Robert D. Jurmain, Kimberly T. Wren, Heli Maijanen, Robert J. Woods, and Daniel E. Lieberman (Vol. 114, No. 35, August 29, 2017, p. 9332–9336).

www.pnas.org/content/114/35/9332.abstract.html?etoc

August 22, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – August 22, 2017

A. “Identification of the Tau phosphorylation pattern that drives its aggregation,” by Clement Despres, Cillian Byrne, Haoling Qi, Francois-Xavier Cantrelle, Isabelle Huvent, Beatrice Chambraud, Etienne-Emile Baulieu, Yves Jacquot, Isabelle Landrieu, Guy Lippens, and Caroline Smet-Nocca (Vol. 114, No. 34, August 22, 2017, p. 9080-9085).

www.pnas.org/content/114/34/9080.abstract.html?etoc

B. “MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life,” by Quan Lin, Ravikumar Ponnusamy, Jocelyn Widagdo, Jung A. Choi, Weihong Ge, Christine Probst, Tyler Buckley, Mimi Lou, Timothy W. Bredy, Michael S. Fanselow, Keqiang Ye, and Yi E. Sun (Vol. 114, No. 34, August 22, 2017, p. 9188–9193).

www.pnas.org/content/114/34/9188.abstract.html?etoc

August 16, 2017

CAAR – Proceedings of the National Academies of Sciences Article Abstract – August 16, 2017

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways,” by Aleksandra M. Wojtas, Silvia S. Kang, Benjamin M. Olley, Maureen Gatherer, Mitsuru Shinohara, Patricia A. Lozano, Chia-Chen Liu, Aishe Kurti, Kelsey E. Baker, Dennis W. Dickson, Mei Yue, Leonard Petrucelli, Guojun Bu, Roxana O. Carare, and John D. Fryer (Vol. 114, No. 33, August 15, 2017, p. E6962-E6971). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/33/E6962.abstract

July 11, 2017

CAAR – Proceedings of the National Academies of Sciences Article Abstracts – July 11, 2017

A. “Poor caregiver mental health predicts mortality of patients with neurodegenerative disease,” by Sandy J. Lwi, Brett Q. Ford, James J. Casey, Bruce L. Miller, and Robert W. Levenson (Vol. 118, No. 28, July 11, 2017, p. 7319-7324).

www.pnas.org/content/114/28/7319.abstract

B. “Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease,” by Rishika Kundra, Prajwal Ciryam, Richard I. Morimoto, Christopher M. Dobson, and Michele Vendruscolo (Vol. 118, No. 28, July 11, 2017, p. E5703-E5711).

www.pnas.org/content/114/28/E5703.abstract

July 7, 2017

CAAR – Proceedings of the National Academies of Sciences Article Abstracts – July 7, 2017

A. “Childhood social class and cognitive aging in the Swedish Adoption/Twin Study of Aging,” by Malin Ericsson, Cecilia Lundholm, Stefan Fors, Anna K. Dahl Aslan, Catalina Zavala, Chandra A. Reynolds, and Nancy L. Pedersen (Vol. 114, No. 27, July 3, 2017, HTML and .pdf format, p. 7001-7006). Note: PNAS is providing open access to the full-text of this message.

www.pnas.org/content/114/27/7001.abstract

B. “Bidirectional regulation of A{beta} levels by Presenilin 1,” by Victor Bustos, Maria V. Pulina, Yildiz Kelahmetoglu, Subhash C. Sinha, Fred S. Gorelick, Marc Flajolet, and Paul Greengard Vol. 114, No. 27, July 3, 2017, HTML and .pdf format, p. 7142–7147). Note: PNAS is providing open access to the full-text of this message.

www.pnas.org/content/114/27/7142.abstract

June 20, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 20, 2017

Treatment with diphenyl–pyrazole compound anle138b/c reveals that {alpha}-synuclein protects melanoma cells from autophagic cell death,” by Elisa Turriani, Diana F. Lazaro, Sergey Ryazanov, Andrei Leonov, Armin Giese, Margarete Schon, Michael P. Schon, Christian Griesinger, Tiago F. Outeiro, Donna J. Arndt-Jovin, and Dorothea Becker (Vol. 114, No. 25, June 21, 2017, p. E4971–E4977).

www.pnas.org/content/114/25/E4971.abstract.html?etoc

June 15, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 15, 2017

Positive impacts of early auditory training on cortical processing at an older age,” by Yuan Cheng, Guoqiang Jia, Yifan Zhang, Huanhuan Hao, Ye Shan, Liping Yu, Xinde Sun, Qingyin Zheng, Nina Kraus, Michael M. Merzenich, and Xiaoming Zhou (Vol. 114, No. 24, June 13, 2017, p. 6364–6369).

www.pnas.org/content/114/24/6364.abstract

June 6, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 6, 2017

Selective lowering of synapsins induced by oligomeric {alpha}-synuclein exacerbates memory deficits,” by Megan E. Larson, Susan J. Greimel, Fatou Amar, Michael LaCroix, Gabriel Boyle, Mathew A. Sherman, Hallie Schley, Camille Miel, Julie A. Schneider, Rakez Kayed, Fabio Benfenati, Michael K. Lee, David A. Bennett, and Sylvain E. Lesne (Vol. 114, No. 23, June 7, 2017, p. E4648-E4657).

www.pnas.org/content/114/23/E4648.abstract

May 1, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 1, 2017

Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson’s disease,” by Georgia Kouroupi, Era Taoufik, Ioannis S. Vlachos, Konstantinos Tsioras, Nasia Antoniou, Florentia Papastefanaki, Dafni Chroni-Tzartou, Wolfgang Wrasidlo, Delphine Bohl, Dimitris Stellas, Panagiotis K. Politis, Kostas Vekrellis, Dimitra Papadimitriou, Leonidas Stefanis, Piotr Bregestovski, Artemis G. Hatzigeorgiou, Eliezer Masliah, and Rebecca Matsas (Vol. 114, No. 18, May 2, 2017, p. E3679–E3688).

www.pnas.org/content/114/18/E3679.abstract.html?etoc

April 26, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 26, 2017

APC/CCdh1-Rock2 pathway controls dendritic integrity and memory,” by Veronica Bobo-Jimenez, María Delgado-Esteban, Julie Angibaud, Irene Sanchez-Moran, Antonio de la Fuente, Javier Yajeya, U. Valentin Nagerl, Jose Castillo, Juan P. Bolaños, and Angeles Almeida (Vol. 114, No. 17, April 26, 2017, p. 4513–4518).

www.pnas.org/content/114/17/4513.abstract.html?etoc

April 19, 2017

CAAR – Proceedings of the National Academy of Science Article Abstract – April 19, 2017

Prenatal loss of father during World War One is predictive of a reduced lifespan in adulthood,” by Nicolas Todd, Alain-Jacques Valleron, and Pierre Bougnères (Vol. 114, No. 16, April 18, 2017, p. 4201–4206).

www.pnas.org/content/114/16/4201.abstract

April 11, 2017

CAAR – Proceedings of the National Academy of Science Article Abstracts – April 11, 2017

A. “Why the US science and engineering workforce is aging rapidly,” by David M. Blau and Bruce A. Weinberg (Vol. 114, No. 15, April 11, 2017, p. 3879–3884).

www.pnas.org/content/114/15/3879.abstract.html?etoc

B. “ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer’s disease,” by Bo-Jeng Wang, Guor Mour Her, Ming-Kuan Hu, Yun-Wen Chen, Ying-Tsen Tung, Pei-Yi Wu, Wen-Ming Hsu, Hsinyu Lee, Lee-Way Jin, Sheng-Ping L. Hwang, Rita P.-Y. Chen, Chang-Jen Huang, and Yung-Feng Liao
(Vol. 114, No. 15, April 11, 2017, p. E3129–E3138).

www.pnas.org/content/114/15/E3129.abstract.html?etoc

April 5, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – April 5, 2017

A. “Prion protein dynamics before aggregation,” by Kinshuk Raj Srivastava and Lisa J. Lapidus (Vol. 114, No. 14, April 4, 2017, p. 3572-3577).

www.pnas.org/content/114/14/3572.abstract

B. “Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer’s pathology,” by Zui Zhang, Yoshiko Takeda-Uchimura, Tahmina Foyez, Shiori Ohtake-Niimi, Narentuya, Hiroyasu Akatsu, Kazuchika Nishitsuji, Makoto Michikawa, Tony Wyss-Coray, Kenji Kadomatsu, and Kenji Uchimura (Vol. 114, No. 14, April 4, 2017, p. E2947-E2954).

www.pnas.org/content/114/14/E2947.abstract

March 14, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 14, 2017

Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease,” by Amy R. Dunn, Kristen A. Stout, Minagi Ozawa, Kelly M. Lohr, Carlie A. Hoffman, Alison I. Bernstein, Yingjie Li, Minzheng Wang, Carmelo Sgobio, Namratha Sastry, Huaibin Cai, W. Michael Caudle, and Gary W. Miller (Vol. 114, No. 11, March 14, 2017, p. E2253–E2262).

www.pnas.org/content/114/11/E2253.abstract.html?etoc

March 7, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 7, 2017

A. “Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models,” by S. Pablo Sardi, Catherine Viel, Jennifer Clarke, Christopher M. Treleaven, Amy M. Richards, Hyejung Park, Maureen A. Olszewski, James C. Dodge, John Marshall, Elina Makino, Bing Wang, Richard L. Sidman, Seng H. Cheng, and Lamya S. Shihabuddin (Vol. 114, No. 10, March 7, 2017, p. 2699–2704).

www.pnas.org/content/114/10/2699.abstract.html?etoc

B. “Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson’s disease,” by Holly Green, Xiaoqun Zhang, Katarina Tiklova, Nikolaos Volakakis, Lovisa Brodin, Louise Berg, Paul Greengard, Thomas Perlmann, and Per Svenningsson (Vol. 114, No. 10, March 7, 2017, p. 2735–2740).

www.pnas.org/content/114/10/2735.abstract.html?etoc

February 28, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 28, 2017

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases {alpha}-synuclein aggregation,” by Sarah Jinn, Robert E. Drolet, Paige E. Cramer, Andus Hon-Kit Wong, Dawn M. Toolan, Cheryl A. Gretzula, Bhavya Voleti, Galya Vassileva, Jyoti Disa, Marija Tadin-Strapps, and David J. Stone (Vol. 114, No. 9, February 28, 2017, .pdf and HTML format, p. 2389-2394). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/9/2389.abstract

February 14, 2017

CAAR – Proceedings of the National Academy of Science Article Abstract – February 14, 2017

The impact of bilingualism on brain reserve and metabolic connectivity in Alzheimer’s dementia,” by Daniela Perani, Mohsen Farsad, Tommaso Ballarini, Francesca Lubian, Maura Malpetti, Alessandro Fracchetti, Giuseppe Magnani, Albert March, and Jubin Abutalebi (Vol. 114, No. 7, February 14, 2017, p. 1690-1695).

www.pnas.org/content/114/7/1690.abstract

February 8, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 8, 2017

A. “Gleevec shifts APP processing from a {beta}-cleavage to a nonamyloidogenic cleavage,” by William J. Netzer, Karima Bettayeb, Subhash C. Sinha, Marc Flajolet, Paul Greengard, and Victor Bustos (Vol. 114, No. 6, February 7, 2017, p. 1389-1394).

www.pnas.org/content/114/6/1389.abstract

B. “A natural product inhibits the initiation of {alpha}-synuclein aggregation and suppresses its toxicity,” by Michele Perni, Céline Galvagnion, Alexander Maltsev, Georg Meisl, Martin B. D. Müller, Pavan K. Challa, Julius B. Kirkegaard, Patrick Flagmeier, Samuel I. A. Cohen, Roberta Cascella, Serene W. Chen, Ryan Limboker, Pietro Sormanni, Gabriella T. Heller, Francesco A. Aprile, Nunilo Cremades, Cristina Cecchi, Fabrizio Chiti, Ellen A. A. Nollen, Tuomas P. J. Knowles, Michele Vendruscolo, Adriaan Bax, Michael Zasloff, and Christopher M. Dobson (Vol. 114, No. 6, February 7, 2017, p. E1009-E1017). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/6/E1009.abstract

January 24, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 24, 2017

Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of A{beta}42 and A{beta}40 peptides by {gamma}-secretase,” by Linfeng Sun, Rui Zhou, Guanghui Yang, and Yigong Shi (Vol. 114, No. 4, January 24, 2017, p. E476–E485).

www.pnas.org/content/114/4/E476.abstract.html?etoc

January 17, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 17, 2017

Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation,” by William A. McEwan, Benjamin Falcon, Marina Vaysburd, Dean Clift, Adrian L. Oblak, Bernardino Ghetti, Michel Goedert, and Leo C. James (Vol. 114, No. 3, January 17, 2017, p. 574-579).

www.pnas.org/content/114/3/574.abstract

January 10, 2017

CAAR – Proceedings of the National Academy of Science Article Abstract – January 10, 2017

Systematic development of small molecules to inhibit specific microscopic steps of A{betaaa]42 aggregation in Alzheimer’s disease,” by Johnny Habchi, Sean Chia, Ryan Limbocker, Benedetta Mannini, Minkoo Ahn, Michele Perni, Oskar Hansson, Paolo Arosio, Janet R. Kumita, Pavan Kumar Challa, Samuel I. A. Cohen, Sara Linse, Christopher M. Dobson, Tuomas P. J. Knowles, and Michele Vendruscolo (Vol. 114, No. 2, January 10, 2017, p. E200-E208). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/2/E200.abstract

November 29, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 29, 2016

A. “The emergence of longevous populations,” by Fernando Colchero, Roland Rau, Owen R. Jones, Julia A. Barthold, Dalia A. Conde, Adam Lenart, Laszlo Nemeth, Alexander Scheuerlein, Jonas Schoeley, Catalina Torres, Virginia Zarulli, Jeanne Altmann, Diane K. Brockman, Anne M. Bronikowski, Linda M. Fedigan, Anne E. Pusey, Tara S. Stoinski, Karen B. Strier, Annette Baudisch, Susan C. Alberts, and James W. Vaupel (Vol. 113, No. 48, November 30, 2016, p. E7681–E7690).

www.pnas.org/content/113/48/E7681.abstract.html?etoc

B. “VEGF preconditioning leads to stem cell remodeling and attenuates age-related decay of adult hippocampal neurogenesis,” by Tamar Licht, Gadiel Rothe, Tirzah Kreisel, Brachi Wolf, Ofra Benny, Alasdair G. Rooney, Charles ffrench-Constant, Grigori Enikolopov, and Eli Keshet (Vol. 113, No. 48, November 30, 2016, p. E7828–E7836).

www.pnas.org/content/113/48/E7828.abstract.html?etoc

November 28, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 28, 2016

Genetic variants linked to education predict longevity,” by Riccardo E. Marioni, Stuart J. Ritchie, Peter K. Joshi, Saskia P. Hagenaars, Aysu Okbay, Krista Fischer, Mark J. Adams, W. David Hill, Gail Davies, Reka Nagy, Carmen Amador, Kristi Lall, Andres Metspalu, David C. Liewald, Archie Campbell, James F. Wilson, Caroline Hayward, Tonu Esko, David J. Porteous, Catharine R. Gale and Ian J. Deary (Vol. 113, No. 47, November 22, 2016, p. 13366–13371).

www.pnas.org/content/113/47/13366.abstract.html?etoc

November 15, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 15, 2016

Online social integration is associated with reduced mortality risk,” by William R. Hobbs, Moira Burke, Nicholas A. Christakis, and James H. Fowler (Vol. 113, No. 46, November 15, 2016, p. 12980–12984).

www.pnas.org/content/113/46/12980.abstract.html?etoc

November 8, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 8, 2016

A. “Increased risk of dementia in the aftermath of the 2011 Great East Japan Earthquake and Tsunami,” by Hiroyuki Hikichi, Jun Aida, Katsunori Kondo, Toru Tsuboya, Yusuke Matsuyama, S. V. Subramanian, and Ichiro Kawachi (Vol. 113, No. 45, November 8, 2016, p. E6911–E6918).

www.pnas.org/content/113/45/E6911.abstract.html?etoc

B. “Universality in human cortical folding in health and disease,” by Yujiang Wang, Joe Necus, Marcus Kaiser, and Bruno Mota (Vol. 113, No. 45, November 8, 2016, p. 12820–12825).

www.pnas.org/content/113/45/12820.abstract.html?etoc

November 1, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 1, 2016

Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson’s disease,” by Istvan Horvath and Pernilla Wittung-Stafshede (Vol. 113, No. 44, November 1, 2016, p. 12473–12477).

www.pnas.org/content/113/44/12473.abstract

October 26, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – October 26, 2016

A. “Functional connectivity with the retrosplenial cortex predicts cognitive aging in rats,” by Jessica A. Ash, Hanbing Lu, Lisa R. Taxier, Jeffrey M. Long, Yihong Yang, Elliot A. Stein, and Peter R. Rapp (Vol. 113, No. 43, October 26, 2016, p. 12286-12291).

www.pnas.org/content/113/43/12286.abstract

B. “PPAR{gamma}-coactivator-1{alpha} gene transfer reduces neuronal loss and amyloid-{beta| generation by reducing {beta}-secretase in an Alzheimer’s disease model,” by Loukia Katsouri, Yau M. Lim, Katrin Blondrath, Ioanna Eleftheriadou, Laura Lombardero, Amy M. Birch, Nazanin Mirzaei, Elaine E. Irvine, Nicholas D. Mazarakis, and Magdalena Sastre (Vol. 113, No. 43, October 26, 2016, p. 12292–12297).

www.pnas.org/content/113/43/12292.abstract.html?etoc

October 18, 2016

CAAR – Proceedings of the National Academy Sciences Article Abstracts – October 18, 2016

A. “Exploring the aggregation free energy landscape of the amyloid-{beta} protein (1–40),” by Weihua Zheng, Min-Yeh Tsai, Mingchen Chen, and Peter G. Wolynes (Vol. 113, No. 42, October 18, 2016, p. 11835–11840).

www.pnas.org/content/113/42/11835.abstract.html?etoc

B. “Lifespan adversity and later adulthood telomere length in the nationally representative US Health and Retirement Study,” by Eli Puterman, Alison Gemmill, Deborah Karasek, David Weir, Nancy E. Adler, Aric A. Prather, and Elissa S. Epel (Vol. 113, No. 42, October 18, 2016, p. E6335–E6342).

www.pnas.org/content/113/42/11835.abstract.html?etoc

C. “Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK,” by Takafumi Ogawa, Ryohei Tsubakiyama, Muneyoshi Kanai, Tetsuya Koyama, Tsutomu Fujii, Haruyuki Iefuji, Tomoyoshi Soga, Kazunori Kume, Tokichi Miyakawa, Dai Hirata, and Masaki Mizunuma (Vol. 113, No. 42, October 18, 2016, p. 11913–11918).

www.pnas.org/content/113/42/11913.abstract.html?etoc

D. “Amyloid-{beta} effects on synapses and memory require AMPA receptor subunit GluA3,” by Niels R. Reinders, Yvonne Pao, Maria C. Renner, Carla M. da Silva-Matos, Tessa R. Lodder, Roberto Malinow, and Helmut W. Kessels (Vol. 113, No. 42, October 18, 2016, p. E6526–E6534).

www.pnas.org/content/113/42/E6526.abstract.html?etoc

E. “Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer’s disease,” by Xiuming Zhang, Elizabeth C. Mormino, Nanbo Sun, Reisa A. Sperling, Mert R. Sabuncu, B. T. Thomas Yeo, and the Alzheimer’s Disease Neuroimaging Initiative (Vol. 113, No. 42, October 18, 2016, p. E6535–E6544).

www.pnas.org/content/113/42/E6535.abstract.html?etoc

September 27, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 27, 2016

A{beta}42 assembles into specific {beta}-barrel pore-forming oligomers in membrane-mimicking environments,” by Montserrat Serra-Batiste, Martí Ninot-Pedrosa, Mariam Bayoumi, Margarida Gairí, Giovanni Maglia, and Natàlia Carulla (Vol. 113, No. 39, September 28, 2016, p. 10866–10871).

www.pnas.org/content/113/39/10866.abstract.html?etoc

September 20, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 20, 2016

Circulating microRNA signature for the diagnosis of very high-risk prostate cancer,” by Ali H. Alhasan, Alexander W. Scott, Jia J. Wu, Gang Feng, Joshua J. Meeks, C. Shad Thaxton, and Chad A. Mirkin (Vol. 113, No. 38, September 20, 2016, p. 10655-10660).

www.pnas.org/content/113/38/10655.abstract

September 6, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 6, 2016

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes,” by Won-Suk Chung, Philip B. Verghese, Chandrani Chakraborty, Julia Joung, Bradley T. Hyman, Jason D. Ulrich, David M. Holtzman, and Ben A. Barres (Vol. 113, No. 36, September 6, 2016, p. 10186–10191).

www.pnas.org/content/113/36/10186.abstract.html?etoc

August 30, 2016

CAAR – Proceedings of the National Academy of Science Article Abstracts – August 30, 2016

A. “Holdase activity of secreted Hsp70 masks amyloid-{beta}42 neurotoxicity in Drosophila,” by Pedro Fernandez-Funez, Jonatan Sanchez-Garcia, Lorena de Mena, Yan Zhang, Yona Levites, Swati Khare, Todd E. Golde, and Diego E. Rincon-Limas (Vol. 113, No. 35, August 30, 2016, p. E5212–E5221).

www.pnas.org/content/113/35/E5212.abstract.html?etoc

B. “Glimpse of natural selection of long-lived T-cell clones in healthy life,” by Baojun Zhang, Qingzhu Jia, Cheryl Bock, Gang Chen, Haili Yu, Qingshan Ni, Ying Wan, Qijing Li, and Yuan Zhuang (Vol. 113, No. 35, August 30, 2016, p. 9858–9863).

www.pnas.org/content/113/35/9858.abstract.html?etoc

August 17, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – August 17, 2016

A. “Neurodevelopmental origins of lifespan changes in brain and cognition,” by Kristine B. Walhovd, Stine K. Krogsrud, Inge K. Amlien, Hauke Bartsch, Atle Bjornerud, Paulina Due-Tonnessen, Hakon Grydeland, Donald J. Hagler Jr., Asta K. Haberg, William S. Kremen, Lia Ferschmann, Lars Nyberg, Matthew S. Panizzon, Darius A. Rohani, Jon Skranes, Andreas B. Storsve, Anne Elisabeth Solsnes, Christian K. Tamnes, Wesley K. Thompson, Chase Reuter, Anders M. Dale, and Anders M. Fjell (Vol. 113, No. 33, August 16, 2016, p. 9357–9362).

www.pnas.org/content/113/33/9357.abstract.html?etoc

B. “Menopause accelerates biological aging ,” by Morgan E. Levine, Ake T. Lu, Brian H. Chen, Dena G. Hernandez, Andrew B. Singleton, Luigi Ferrucci, Stefania Bandinelli, Elias Salfati, JoAnn E. Manson, Austin Quach, Cynthia D. J. Kusters, Diana Kuh, Andrew Wong, Andrew E. Teschendorff, Martin Widschwendter, Beate R. Ritz, Devin Absher, Themistocles L. Assimes, and Steve Horvath (Vol. 113, No. 33, August 16, 2016, p. 9327–9332).

www.pnas.org/content/113/33/9327.abstract.html?etoc

August 9, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – August 9, 2016

A. “Hhip haploinsufficiency sensitizes mice to age-related emphysema,” by Taotao Lao, Zhiqiang Jiang, Jeong Yun, Weiliang Qiu, Feng Guo, Chunfang Huang, John Dominic Mancini, Kushagra Gupta, Maria E. Laucho-Contreras, Zun Zar Chi Naing, Li Zhang, Mark A. Perrella, Caroline A. Owen, Edwin K. Silverman, and Xiaobo Zhou (Vol. 113, No. 32, August 9, 2016, p. E4681-E4687).

www.pnas.org/content/113/32/E4681.abstract

B. “Deubiquitinase Usp8 regulates {alpha}-synuclein clearance and modifies its toxicity in Lewy body disease,” by Zoi Alexopoulou, Johannes Lang, Rebecca M. Perrett, Myriam Elschami, Madeleine E. D. Hurry, Hyoung Tae Kim, Dimitra Mazaraki, Aron Szabo, Benedikt M. Kessler, Alfred Lewis Goldberg, Olaf Ansorge, Tudor A. Fulga, and George K. Tofaris (Vol. 113, No. 32, August 9, 2016, p. E4688-E4697).

www.pnas.org/content/113/32/E4688.abstract

C. “The neural chaperone proSAAS blocks {alpha}-synuclein fibrillation and neurotoxicity,” by Timothy S. Jarvela, Hoa A. Lam, Michael Helwig, Nikolai Lorenzen, Daniel E. Otzen, Pamela J. McLean, Nigel T. Maidment, and Iris Lindberg (Vol. 113, No. 32, August 9, 2016, p. E4708-E4715).

www.pnas.org/content/113/32/E4708.abstract

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