CDHA CAAR

A. “Bax inhibitor 1 is a {gamman}-secretase–independent presenilin-binding protein,” by Shenjie Wu, Wenqi Song, Catherine C. L. Wong, and Yigong Shi (Vol. 116, No. 1, January 2, 2019, p. 141-147).

www.pnas.org/content/116/1/141

B. “TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling,” by Bochra Zidi, Christelle Vincent-Fabert, Laurent Pouyet, Marion Seillier, Amelle Vandevelde, Prudence N’guessan, Mathilde Poplineau, Geoffrey Guittard, Stéphane J. C. Mancini, Estelle Duprez, and Alice Carrier (Vol. 116, No. 1, January 2, 2019, p. 211-216).

www.pnas.org/content/116/1/211

“Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology,” by María Díaz-Moreno, Tomás Armenteros, Simona Gradari, Rafael Hortigüela, Laura García-Corzo, Ángela Fontán-Lozano, José Luis Trejo, and Helena Mira (Vol. 115, No. 45, November 6, 2018, p. 11625-11630).

www.pnas.org/content/115/45/11625

“Characterizing the human hippocampus in aging and Alzheimer’s disease using a computational atlas derived from ex vivo MRI and histology,” by Daniel H. Adler, Laura E. M. Wisse, Ranjit Ittyerah, John B. Pluta, Song-Lin Ding, Long Xie, Jiancong Wang, Salmon Kadivar, John L. Robinson, Theresa Schuck, John Q. Trojanowski, Murray Grossman, John A. Detre, Mark A. Elliott, Jon B. Toledo, Weixia Liu, Stephen Pickup, Michael I. Miller, Sandhitsu R. Das, David A. Wolk, and Paul A. Yushkevich (Vol. 115, No. 16, April 17, 2018, p. 4252-4257).

www.pnas.org/content/115/16/4252

A. “Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence,” by Yang Zhao, Alexander Tyshkovskiy, Daniel Muñoz-Espín, Xiao Tian, Manuel Serrano, Joao Pedro de Magalhaes, Eviatar Nevo, Vadim N. Gladyshev, Andrei Seluanov and Vera Gorbunova (Vol. 115, No. 8, February 20, 2018, p. 1801-1806).

www.pnas.org/content/115/8/1801

B. “NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency,” by Yujun Hou, Sofie Lautrup, Stephanie Cordonnier, Yue Wang, Deborah L. Croteau, Eduardo Zavala, Yongqing Zhang, Kanako Moritoh, Jennifer F. O’Connell, Beverly A. Baptiste, Tinna V. Stevnsner, Mark P. Mattson and Vilhelm A. Bohr (Vol. 115, No. 8, February 20, 2018, p. E1876-E1885).

www.pnas.org/content/115/8/E1876

C. “Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis,” by Xiaopu Zhou, Yu Chen, Kin Y. Mok, Qianhua Zhao, Keliang Chen, Yuewen Chen, John Hardy, Yun Li, Amy K. Y. Fu, Qihao Guo, Nancy Y. Ip and for the Alzheimer’s Disease Neuroimaging Initiative (Vol. 115, No. 8, February 20, 2018, p. 1697-1706)

www.pnas.org/content/115/8/1697