CDHA CAAR

September 5, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – September 5, 2018

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A. “Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice,” by Te-Chen Tzeng, Yuto Hasegawa, Risa Iguchi, Amy Cheung, Daniel R. Caffrey, Elizabeth Jeanne Thatcher, Wenjie Mao, Gail Germain, Nelsy DePaula Tamburro, Shigeo Okabe, Michael T. Heneka, Eicke Latz, Kensuke Futai, and Douglas T. Golenbock (Vol. 115, No. 36, September 4, 2018, p. 9002-9007).

www.pnas.org/content/115/36/9002

B. “Local field potentials of subthalamic nucleus contain electrophysiological footprints of motor subtypes of Parkinson’s disease,” by Ilknur Telkes, Ashwin Viswanathan, Joohi Jimenez-Shahed, Aviva Abosch, Musa Ozturk, Akshay Gupte, Joseph Jankovic, and Nuri F. Ince (Vol. 115, No. 36, September 4, 2018, p. E8567-E8576).

www.pnas.org/content/115/36/E8567

August 1, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 1, 2018

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“Aspirin binds to PPAR{alpha} to stimulate hippocampal plasticity and protect memory,” by Dhruv Patel, Avik Roy, Madhuchhanda Kundu, Malabendu Jana, Chi-Hao Luan, Frank J. Gonzalez, and Kalipada Pahan (Vol. 115, No. 31, July 31, 2018, p. E7408-E7417).

www.pnas.org/content/115/31/E7408?etoc=

 

July 26, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – July 26, 2018

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“{alpha}-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies,” by Iryna Prots, Janina Grosch, Razvan-Marius Brazdis, Katrin Simmnacher, Vanesa Veber, Steven Havlicek, Christian Hannappel, Florian Krach, Mandy Krumbiegel, Oliver Schutz, Andre Reis, Wolfgang Wrasidlo, Douglas R. Galasko, Teja W. Groemer, Eliezer Masliah, Ursula Schlotzer-Schrehardt, Wei Xiang, Jürgen Winkler, and Beate Winner (Vol. 115, No. 30, July 24, 2018, p. 7813-7818).

www.pnas.org/content/115/30/7813

July 12, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 12, 2018

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A. “Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid {alpha}-synuclein fibrils,” by Francesco Simone Ruggeri, Fabrizio Benedetti, Tuomas P. J. Knowles, Hilal A. Lashuel, Sergey Sekatskii, and Giovanni Dietler (Vol. 115 No. 28, July 10, 2018, p. 7230-7235).

www.pnas.org/content/115/28/7230

B. “Declining mental health among disadvantaged Americans,” by Noreen Goldman, Dana A. Glei, and Maxine Weinstein (Vol. 115 No. 28, July 10, 2018, p. 7290-7295).

www.pnas.org/content/115/28/7290

C. “Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH,” by Hari Prasad and Rajini Rao (Vol. 115 No. 28, July 10, 2018, p. E6640-E6649).

www.pnas.org/content/115/28/E6640

June 19, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 19, 2018

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“Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease,” by Qian Ren, Min Ma, Jun Yang, Risa Nonaka, Akihiro Yamaguchi, Kei-ichi Ishikawa, Kenta Kobayashi, Shigeo Murayama, Sung Hee Hwang, Shinji Saiki, Wado Akamatsu, Nobutaka Hattori, Bruce D. Hammock, and Kenji Hashimoto (Vol. 115, No. 25, June 19, 2018, p. E5815-E5823).

www.pnas.org/content/115/25/E5815

June 1, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – June 1, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 4:14 pm

A. “Socioeconomic status moderates age-related differences in the brain’s functional network organization and anatomy across the adult lifespan,” by Micaela Y. Chan, Jinkyung Na, Phillip F. Agres, Neil K. Savalia, Denise C. Park, and Gagan S. Wig (Vol. 115, No. 22, May 29, 2018, p. E5144-E5153).

www.pnas.org/content/115/22/E5144

B. “Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s disease,” by Kwang Soo Kim, Paul C. Marcogliese, Jungwoo Yang, Steve M. Callaghan, Virginia Resende, Elizabeth Abdel-Messih, Connie Marras, Naomi P. Visanji, Jana Huang, Michael G. Schlossmacher, Laura Trinkle-Mulcahy, Ruth S. Slack, Anthony E. Lang, Canadian Lrrk2 in Inflammation Team (CLINT), and David S. Park (Vol. 115, No. 22, May 29, 2018, p. E5164-E5173).

www.pnas.org/content/115/22/E5164

May 22, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 22, 2018

Filed under: Reports and Articles — Tags: , — admin @ 5:14 pm

“LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson’s disease,” by Maria Nguyen and Dimitri Krainc (Vol. 115, No. 21, May 22, 2018, p. 5576-5581).

www.pnas.org/content/115/21/5576?etoc=

 

April 25, 2018

CAAR – Proceedings of the National Academies of Science Article Abstract – April 25, 2018

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“[beta}-Amyloid accumulation in the human brain after one night of sleep deprivation,” by Ehsan Shokri-Kojori, Gene-Jack Wang, Corinde E. Wiers, Sukru B. Demiral, Min Guo, Sung Won Kim, Elsa Lindgren, Veronica Ramirez, Amna Zehra, Clara Freeman, Gregg Miller, Peter Manza, Tansha Srivastava, Susan De Santi, Dardo Tomasi, Helene Benveniste and Nora D. Volkow (Vol. 115, No. 17, April 24, 2018, p. 4483-4488).

doi.org/10.1073/pnas.1721694115

April 17, 2018

CAAR – Proceedings of the National Academies of Sciences Article Abstract – April 17, 2018

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“Characterizing the human hippocampus in aging and Alzheimer’s disease using a computational atlas derived from ex vivo MRI and histology,” by Daniel H. Adler, Laura E. M. Wisse, Ranjit Ittyerah, John B. Pluta, Song-Lin Ding, Long Xie, Jiancong Wang, Salmon Kadivar, John L. Robinson, Theresa Schuck, John Q. Trojanowski, Murray Grossman, John A. Detre, Mark A. Elliott, Jon B. Toledo, Weixia Liu, Stephen Pickup, Michael I. Miller, Sandhitsu R. Das, David A. Wolk, and Paul A. Yushkevich (Vol. 115, No. 16, April 17, 2018, p. 4252-4257).

www.pnas.org/content/115/16/4252

April 10, 2018

CAAR – Proceedings of the National Academies of Science Article Abstract – April 10, 2018

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“BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s disease,” by Jian Bao, Min Qin, Yacoubou Abdoul Razak Mahaman, Bin Zhang, Fang Huang, Kuan Zeng, Yiyuan Xia, Dan Ke, Qun Wang, Rong Liu, Jian-Zhi Wang, Keqiang Ye, and Xiaochuan Wang (Vol. 115, No. 15, April 10, 2018, p. 3954-3959).

www.pnas.org/content/115/15/3954?etoc=

March 27, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 27, 2018

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“Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality,” by Jatish Kumar, Hasier Erana, Elena López-Martínez, Nathalie Claes, Víctor F. Martín, Diego M. Solís, Sara Bals, Aitziber L. Cortajarena, Joaquín Castilla, and Luis M. Liz-Marzan (Vol. 115, No. 13, March 27, 2018, p. 3225-3230).

www.pnas.org/content/115/13/3225

March 14, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 14, 2018

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“Identification of a highly neurotoxic {alpha}-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease,” by Diego Grassi, Shannon Howard, Minghai Zhou, Natalia Diaz-Perez, Nicolai T. Urban, Debbie Guerrero-Given, Naomi Kamasawa, Laura A. Volpicelli-Daley, Philip LoGrasso, and Corinne Ida Lasmezas (Vol. 115, No. 11, March 13, 2018, p. E2634-E2643).

www.pnas.org/content/115/11/E2634?etoc=

March 6, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 6, 2018

Filed under: Reports and Articles — Tags: , , , — admin @ 3:53 pm

A. “Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice,” by Kan Xie, Devon P. Ryan, Brandon L. Pearson, Kristin S. Henzel, Frauke Neff, Ramon O. Vidal, Magali Hennion, Isabelle Lehmann, Melvin Schleif, Susanne Schröder, Thure Adler, Birgit Rathkolb, Jan Rozman, Anna-Lena Schütz, Cornelia Prehn, Michel E. Mickael, Marco Weiergräber, Jerzy Adamski, Dirk H. Busch, Gerhard Ehninger, Anna Matynia, Walker S. Jackson, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Stefan Bonn, Martin Hrabe de Angelis and Dan Ehninger (Vol. 115, No. 10, March 6, 2018, p. E2348-E2357).

doi.org/10.1073/pnas.1707337115

B. “Environmental enrichment and exercise are better than social enrichment to reduce memory deficits in amyloid beta neurotoxicity,” by Mariza G. Prado Lima, Helen L. Schimidt, Alexandre Garcia, Letícia R. Daré, Felipe P. Carpes, Ivan Izquierdo and Pâmela B. Mello-Carpes (Vol. 115, No. 10, March 6, 2018, p. E2403-E2408).

doi.org/10.1073/pnas.1718435115

February 27, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 27, 2018

Filed under: Reports and Articles — Tags: , — admin @ 4:55 pm

Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events,” by Dorothea Hammerer, Martina F. Callaghan, Alexandra Hopkins, Julian Kosciessa, Matthew Betts, Arturo Cardenas-Blanco, Martin Kanowski, Nikolaus Weiskopf, Peter Dayan, Raymond J. Dolan and Emrah Düzel (Vol. 115, No. 9, February 27, 2018, p. 2228-2233).

www.pnas.org/content/115/9/2228

February 20, 2018

CAAR – Proceedings of the National Academies of Sciences Article Abstracts – February 20, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 3:07 pm

A. “Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence,” by Yang Zhao, Alexander Tyshkovskiy, Daniel Muñoz-Espín, Xiao Tian, Manuel Serrano, Joao Pedro de Magalhaes, Eviatar Nevo, Vadim N. Gladyshev, Andrei Seluanov and Vera Gorbunova (Vol. 115, No. 8, February 20, 2018, p. 1801-1806).

www.pnas.org/content/115/8/1801

B. “NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency,” by Yujun Hou, Sofie Lautrup, Stephanie Cordonnier, Yue Wang, Deborah L. Croteau, Eduardo Zavala, Yongqing Zhang, Kanako Moritoh, Jennifer F. O’Connell, Beverly A. Baptiste, Tinna V. Stevnsner, Mark P. Mattson and Vilhelm A. Bohr (Vol. 115, No. 8, February 20, 2018, p. E1876-E1885).

www.pnas.org/content/115/8/E1876

C. “Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis,” by Xiaopu Zhou, Yu Chen, Kin Y. Mok, Qianhua Zhao, Keliang Chen, Yuewen Chen, John Hardy, Yun Li, Amy K. Y. Fu, Qihao Guo, Nancy Y. Ip and for the Alzheimer’s Disease Neuroimaging Initiative (Vol. 115, No. 8, February 20, 2018, p. 1697-1706)

www.pnas.org/content/115/8/1697

February 13, 2018

CAAR – Proceedings of the National Academies of Science Article Abstract – February 13, 2018

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“Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice,” by Yulan Xiong, Stewart Neifert, Senthilkumar S. Karuppagounder, Qinfang Liu, Jeannette N. Stankowski, Byoung Dae Lee, Han Seok Ko, Yunjong Lee, Jonathan C. Grima, Xiaobo Mao, Haisong Jiang, Sung-Ung Kang, Deborah A. Swing, Lorraine Iacovitti, Lino Tessarollo, Ted M. Dawson, and Valina L. Dawson (Vol. 115, No. 7, February 13, 2018, p. 1635-1640).

www.pnas.org/content/115/7/1635

January 31, 2018

CAAR – Proceedings of the National Academies of Science Article Abstract – January 31, 2018

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“The role of obesity in exceptionally slow US mortality improvement,” by Samuel H. Preston, Yana C. Vierboom and Andrew Stokes (Vol. 115, No. 5, January 30, 2018, p. 957-961).

www.pnas.org/content/115/5/957

January 23, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 23, 2018

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A. “Structural heterogeneity and intersubject variability of A{beta} in familial and sporadic Alzheimer’s disease,” by Carlo Condello, Thomas Lemmin, Jan Stöhr, Mimi Nick, Yibing Wu, Alison M. Maxwell, Joel C. Watts, Christoffer D. Caro, Abby Oehler, C. Dirk Keene, Thomas D. Bird, Sjoerd G. van Duinen, Lars Lannfelt, Martin Ingelsson, Caroline Graff, Kurt Giles, William F. DeGrado, and Stanley B. Prusiner (Vol. 115, No. 4, January 23, 2018, .pdf and HTML format, p. E782-E791). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/115/4/E782.abstract

B. “GBA1 deficiency negatively affects physiological {alpha}-synuclein tetramers and related multimers,” by Sangjune Kim, Seung Pil Yun, Saebom Lee, George Essien Umanah, Veera Venkata Ratnam Bandaru, Xiling Yin, Peter Rhee, Senthilkumar S. Karuppagounder, Seung-Hwan Kwon, Hojae Lee, Xiaobo Mao, Donghoon Kim, Akhilesh Pandey, Gabsang Lee, Valina L. Dawson, Ted M. Dawson, and Han Seok Ko (Vol. 115, No. 4, January 23, 2018, p. 798-803).

www.pnas.org/content/115/4/798.abstract

C. “CFH and ARMS2 genetic risk determines progression to neovascular age-related macular degeneration after antioxidant and zinc supplementation,” by Demetrios G. Vavvas, Kent W. Small, Carl C. Awh, Brent W. Zanke, Robert J. Tibshirani, and Rafal Kustra (Vol. 115, No. 4, January 23, 2018, .pdf and HTML format, p. E696-E704). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/115/4/E696.abstract

January 18, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 18, 2018

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A. “The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease,” by Chun Chen, Zhihao Wang, Zhentao Zhang, Xia Liu, Seong Su Kang, Ying Zhang, and Keqiang Ye (Vol. 115, No. 3, January 16, 2018, p. 578-583).

www.pnas.org/content/115/3/578.abstract

B. “Migration-based selections of antibodies that convert bone marrow into trafficking microglia-like cells that reduce brain amyloid {beta},” by Kyung Ho Han, Britni M. Arlian, Matthew S. Macauley, James C. Paulson, and Richard A. Lerner (Vol. 115, No. 3, January 16, 2018, p. E372-E381). Note: PNAS is providing open-access to the full-text of this article.

www.pnas.org/content/115/3/E372.abstract

January 9, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 9, 2018

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“Familial Parkinson’s point mutation abolishes multiple system atrophy prion replication,” by Amanda L. Woerman, Sabeen A. Kazmi, Smita Patel, Atsushi Aoyagi, Abby Oehler, Kartika Widjaja, Daniel A. Mordes, Steven H. Olson, and Stanley B. Prusiner (Vol. 115, No. 2, January 9, 2018, p. 409-414).

www.pnas.org/content/115/2/409.abstract

December 22, 2017

CAAR – Proceedings of the National Academies of Science Article Abstracts – December 22, 2017

Filed under: Reports and Articles — Tags: , , , — admin @ 12:36 pm

A. “Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice,” by Noah R. Johnson, Carlo Condello, Shenheng Guan, Abby Oehler, Julia Becker, Marta Gavidia, George A. Carlson, Kurt Giles, and Stanley B. Prusiner (Vol. 114, No. 51, December 19, 2017, p. E11029-E11036).

www.pnas.org/content/114/51/E11029.abstract

B. “Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1,” by D. Cristopher Bragg, Kotchaphorn Mangkalaphiban, Christine A. Vaine, Nichita J. Kulkarni, David Shin, Rachita Yadav, Jyotsna Dhakal, Mai-Linh Ton, Anne Cheng, Christopher T. Russo, Mark Ang, Patrick Acuña, Criscely Go, Taylor N. Franceour, Trisha Multhaupt-Buell, Naoto Ito, Ulrich Müller, William T. Hendriks, Xandra O. Breakefield, Nutan Sharma, and Laurie J. Ozelius (Vol. 114, No. 51, December 19, 2017, p. E11020-E11028). Note: _PNAS_ is providing open access to the full-text of this article.

www.pnas.org/content/114/51/E11020.abstract

December 12, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 12, 2017

Filed under: Reports and Articles — Tags: , — admin @ 4:53 pm

“Loss of APOBEC1 RNA-editing function in microglia exacerbates age-related CNS pathophysiology,” Daniel C. Cole, Youngcheul Chung, Khatuna Gagnidze, Kaitlyn H. Hajdarovic, Violeta Rayon-Estrada, Dewi Harjanto, Benedetta Bigio, Judit Gal-Toth, Teresa A. Milner, Bruce S. McEwen, F. Nina Papavasiliou, and Karen Bulloch (Vol. 114, No. 50, December 12, 2017, p. 13272-13277).

www.pnas.org/content/114/50/13272.abstract

December 7, 2017

CAAR – Proceedings of the National Academies of Science Article Abstracts – December 7, 2017

Filed under: Reports and Articles — Tags: , , , — admin @ 4:39 pm

A. “Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease,” by Jay Rasmussen, Jasmin Mahler, Natalie Beschorner, Stephan A. Kaeser, Lisa M. Häsler, Frank Baumann, Sofie Nyström, Erik Portelius, Kaj Blennow, Tammaryn Lashley, Nick C. Fox, Diego Sepulveda-Falla, Markus Glatzel, Adrian L. Oblak, Bernardino Ghetti, K. Peter R. Nilsson, Per Hammarström, Matthias Staufenbiel, Lary C. Walker, and Mathias Jucker (Vol. 114, No. 49, December 5, 2017, p. 13018-13023).

B. “Intercellular competition and the inevitability of multicellular aging,” by Paul Nelson and Joanna Masel (Vol. 114, No. 49, December 5, 2017, p. 12982–12987).

www.pnas.org/content/114/49/12982.abstract

November 21, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 21, 2017

Filed under: Reports and Articles — Tags: , — admin @ 5:01 pm

“Oxalate-curcumin–based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease,” by Jian Yang, Xueli Zhang, Peng Yuan, Jing Yang, Yungen Xu, Jaime Grutzendler, Yihan Shao, Anna Moore, and Chongzhao Ran (Vol. 114, No. 47, November 21, 2017, p. 12384-12389).

www.pnas.org/content/114/47/12384.abstract

November 7, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 7, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:10 pm

A. “Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease,” by Tatsuo Mano, Kenichi Nagata, Takashi Nonaka, Airi Tarutani, Tomohiro Imamura, Tadafumi Hashimoto, Taro Bannai, Kagari Koshi-Mano, Takeyuki Tsuchida, Ryo Ohtomo, Junko Takahashi-Fujigasaki, Satoshi Yamashita, Yasumasa Ohyagi, Ryo Yamasaki, Shoji Tsuji, Akira Tamaoka, Takeshi Ikeuchi, Takaomi C. Saido, Takeshi Iwatsubo, Toshikazu Ushijima, Shigeo Murayama, Masato Hasegawa, and Atsushi Iwata (Vol. 114, No. 45, November 7, 2017, .pdf and HTML format, p. E9645–E9654). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/45/E9645.abstract

B. “Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease,” by Robert J. Andrew, Celia G. Fernandez, Molly Stanley, Hong Jiang, Phuong Nguyen, Richard C. Rice, Virginie Buggia-Prévot, Pierre De Rossi, Kulandaivelu S. Vetrivel, Raza Lamb, Arnau Argemi, Emilie S. Allaert, Elle M. Rathbun, Sofia V. Krause, Steven L. Wagner, Angèle T. Parent, David M. Holtzman, and Gopal Thinakaran (Vol. 114, No. 45, November 7, 2017, p. E9665-E9674).

www.pnas.org/content/114/45/E9665.abstract

C. “Individual differences in associative memory among older adults explained by hippocampal subfield structure and function,” by Valerie A. Carr, Jeffrey D. Bernstein, Serra E. Favila, Brian K. Rutt, Geoffrey A. Kerchner, and Anthony D. Wagner (Vol. 114, No. 45, November 7, 2017, p. 12075-12080).

www.pnas.org/content/114/45/12075.abstract

October 24, 2017

CAAR – Proceedings of the National Academies of Sciences Article Abstracts – October 24, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:28 pm

A. “M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer’s disease genes and improving memory,” by Claude-Henry Volmar, Hasib Salah-Uddin, Karolina J. Janczura, Paul Halley, Guerline Lambert, Andrew Wodrich, Sivan Manoah, Nidhi H. Patel, Gregory C. Sartor, Neil Mehta, Nancy T. H. Miles, Sachi Desse, David Dorcius, Michael D. Cameron, Shaun P. Brothers, and Claes Wahlestedt (Vol. 114, No. 43, October 24, 2017, .pdf and HTML format, p. E9135–E9144). Note: PNAS is providing open access to the full text of this article.

www.pnas.org/content/114/43/E9135.abstract

B. “TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy,” by Cheryl E. G. Leyns, Jason D. Ulrich, Mary B. Finn, Floy R. Stewart, Lauren J. Koscal, Javier Remolina Serrano, Grace O. Robinson, Elise Anderson, Marco Colonna, and David M. Holtzman  (Vol. 114, No. 43, October 24, 2017, .pdf and HTML format, p. 11524-11529). Note: PNAS is providing open access to the full text of this article.

www.pnas.org/content/114/43/11524.abstract

October 19, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – October 19, 2017

Filed under: Reports and Articles — Tags: , — admin @ 4:49 pm

A. “Projections of white and black older adults without living kin in the United States, 2015 to 2060,” by Ashton M. Verdery and Rachel Margolis (Vol. 114, No. 42, October 17, 2017, p. 11109-11114).

www.pnas.org/content/114/42/11109.abstract.html?etoc

B. “Multigenerational silencing dynamics control cell aging,” by Yang Li, Meng Jin, Richard O’Laughlin Philip Bittihn, Lev S. Tsimring, Lorraine Pillus, Jeff Hasty, and Nan Hao (Vol. 114, No. 42, October 17, 2017, p. 11253-11258).

www.pnas.org/content/114/42/11253.abstract.html?etoc

September 26, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 26, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 4:36 pm

“Modeling Parkinson’s disease pathology by combination of fibril seeds and {alpha}-synuclein overexpression in the rat brain,” by Poonam Thakur, Ludivine S. Breger, Martin Lundblad, Oi Wan Wan, Bengt Mattsson, Kelvin C. Luk, Virginia M. Y. Lee, John Q. Trojanowski, and Anders Bjorklund (Vol. 114, No. 39, September 26, 2017, p. E8284–E8293).

www.pnas.org/content/114/39/E8284.abstract.html?etoc

September 19, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – September 19, 2017

Filed under: Reports and Articles — Tags: , , , , — admin @ 5:02 pm

A. “Differential diagnosis of Alzheimer’s disease using spectrochemical analysis of blood,” by Maria Paraskevaidi, Camilo L. M. Morais, Kassio M. G. Lima, Julie S. Snowden, Jennifer A. Saxon, Anna M. T. Richardson, Matthew Jones, David M. A. Mann, David Allsop, Pierre L. Martin-Hirsch, and Francis L. Martin (Vol. 114, No. 38, September 19, 2017, p. E7929–E7938).

www.pnas.org/content/114/38/E7929.abstract.html?etoc

B. “Temporal binding function of dorsal CA1 is critical for declarative memory formation,” by Azza Sellami, Alice Shaam Al Abed, Laurent Brayda-Bruno, Nicole Etchamendy, Stephane Valerio, Marie Oule, Laura Pantaleon, Valerie Lamothe, Mylene Potier, Katy Bernard, Maritza Jabourian, Cyril Herry, Nicole Mons, Pier-Vincenzo Piazza, Howard Eichenbaum, and Aline Marighetto (Vol. 114, No. 38, September 19, 2017, p. 10262–10267).

www.pnas.org/content/114/38/10262.abstract.html?etoc

C. “Dorsolateral prefrontal cortex GABA deficit in older adults with sleep-disordered breathing,” by Ana C. Pereira, Xiangling Mao, Caroline S. Jiang, Guoxin Kang, Sara Milrad, Bruce S. McEwen, Ana C. Krieger, and Dikoma C. Shungu (Vol. 114, No. 38, September 19, 2017, p. 10250–10255).

www.pnas.org/content/114/38/10250.abstract.html?etoc

September 12, 2017

CAAR – Proceedings of the National Academy Sciences Article Abstract – September 12, 2017

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“Distribution of lifetime nursing home use and of out-of-pocket spending,” by Michael D. Hurd, Pierre-Carl Michaud, and Susann Rohwedder (Vol. 114, No. 37, September 12, 2017, p. 9838–9842).

www.pnas.org/content/114/37/9838.abstract.html?etoc

August 29, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 29, 2017

Filed under: Reports and Articles — Tags: , — admin @ 4:24 pm

“Knee osteoarthritis has doubled in prevalence since the mid-20th century,” by Ian J. Wallace, Steven Worthington, David T. Felson, Robert D. Jurmain, Kimberly T. Wren, Heli Maijanen, Robert J. Woods, and Daniel E. Lieberman (Vol. 114, No. 35, August 29, 2017, p. 9332–9336).

www.pnas.org/content/114/35/9332.abstract.html?etoc

August 22, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – August 22, 2017

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A. “Identification of the Tau phosphorylation pattern that drives its aggregation,” by Clement Despres, Cillian Byrne, Haoling Qi, Francois-Xavier Cantrelle, Isabelle Huvent, Beatrice Chambraud, Etienne-Emile Baulieu, Yves Jacquot, Isabelle Landrieu, Guy Lippens, and Caroline Smet-Nocca (Vol. 114, No. 34, August 22, 2017, p. 9080-9085).

www.pnas.org/content/114/34/9080.abstract.html?etoc

B. “MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life,” by Quan Lin, Ravikumar Ponnusamy, Jocelyn Widagdo, Jung A. Choi, Weihong Ge, Christine Probst, Tyler Buckley, Mimi Lou, Timothy W. Bredy, Michael S. Fanselow, Keqiang Ye, and Yi E. Sun (Vol. 114, No. 34, August 22, 2017, p. 9188–9193).

www.pnas.org/content/114/34/9188.abstract.html?etoc

August 16, 2017

CAAR – Proceedings of the National Academies of Sciences Article Abstract – August 16, 2017

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“Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways,” by Aleksandra M. Wojtas, Silvia S. Kang, Benjamin M. Olley, Maureen Gatherer, Mitsuru Shinohara, Patricia A. Lozano, Chia-Chen Liu, Aishe Kurti, Kelsey E. Baker, Dennis W. Dickson, Mei Yue, Leonard Petrucelli, Guojun Bu, Roxana O. Carare, and John D. Fryer (Vol. 114, No. 33, August 15, 2017, p. E6962-E6971). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/33/E6962.abstract

July 11, 2017

CAAR – Proceedings of the National Academies of Sciences Article Abstracts – July 11, 2017

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A. “Poor caregiver mental health predicts mortality of patients with neurodegenerative disease,” by Sandy J. Lwi, Brett Q. Ford, James J. Casey, Bruce L. Miller, and Robert W. Levenson (Vol. 118, No. 28, July 11, 2017, p. 7319-7324).

www.pnas.org/content/114/28/7319.abstract

B. “Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease,” by Rishika Kundra, Prajwal Ciryam, Richard I. Morimoto, Christopher M. Dobson, and Michele Vendruscolo (Vol. 118, No. 28, July 11, 2017, p. E5703-E5711).

www.pnas.org/content/114/28/E5703.abstract

July 7, 2017

CAAR – Proceedings of the National Academies of Sciences Article Abstracts – July 7, 2017

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A. “Childhood social class and cognitive aging in the Swedish Adoption/Twin Study of Aging,” by Malin Ericsson, Cecilia Lundholm, Stefan Fors, Anna K. Dahl Aslan, Catalina Zavala, Chandra A. Reynolds, and Nancy L. Pedersen (Vol. 114, No. 27, July 3, 2017, HTML and .pdf format, p. 7001-7006). Note: PNAS is providing open access to the full-text of this message.

www.pnas.org/content/114/27/7001.abstract

B. “Bidirectional regulation of A{beta} levels by Presenilin 1,” by Victor Bustos, Maria V. Pulina, Yildiz Kelahmetoglu, Subhash C. Sinha, Fred S. Gorelick, Marc Flajolet, and Paul Greengard Vol. 114, No. 27, July 3, 2017, HTML and .pdf format, p. 7142–7147). Note: PNAS is providing open access to the full-text of this message.

www.pnas.org/content/114/27/7142.abstract

June 20, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 20, 2017

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“Treatment with diphenyl–pyrazole compound anle138b/c reveals that {alpha}-synuclein protects melanoma cells from autophagic cell death,” by Elisa Turriani, Diana F. Lazaro, Sergey Ryazanov, Andrei Leonov, Armin Giese, Margarete Schon, Michael P. Schon, Christian Griesinger, Tiago F. Outeiro, Donna J. Arndt-Jovin, and Dorothea Becker (Vol. 114, No. 25, June 21, 2017, p. E4971–E4977).

www.pnas.org/content/114/25/E4971.abstract.html?etoc

June 15, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 15, 2017

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“Positive impacts of early auditory training on cortical processing at an older age,” by Yuan Cheng, Guoqiang Jia, Yifan Zhang, Huanhuan Hao, Ye Shan, Liping Yu, Xinde Sun, Qingyin Zheng, Nina Kraus, Michael M. Merzenich, and Xiaoming Zhou (Vol. 114, No. 24, June 13, 2017, p. 6364–6369).

www.pnas.org/content/114/24/6364.abstract

June 6, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 6, 2017

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“Selective lowering of synapsins induced by oligomeric {alpha}-synuclein exacerbates memory deficits,” by Megan E. Larson, Susan J. Greimel, Fatou Amar, Michael LaCroix, Gabriel Boyle, Mathew A. Sherman, Hallie Schley, Camille Miel, Julie A. Schneider, Rakez Kayed, Fabio Benfenati, Michael K. Lee, David A. Bennett, and Sylvain E. Lesne (Vol. 114, No. 23, June 7, 2017, p. E4648-E4657).

www.pnas.org/content/114/23/E4648.abstract

May 1, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 1, 2017

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“Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson’s disease,” by Georgia Kouroupi, Era Taoufik, Ioannis S. Vlachos, Konstantinos Tsioras, Nasia Antoniou, Florentia Papastefanaki, Dafni Chroni-Tzartou, Wolfgang Wrasidlo, Delphine Bohl, Dimitris Stellas, Panagiotis K. Politis, Kostas Vekrellis, Dimitra Papadimitriou, Leonidas Stefanis, Piotr Bregestovski, Artemis G. Hatzigeorgiou, Eliezer Masliah, and Rebecca Matsas (Vol. 114, No. 18, May 2, 2017, p. E3679–E3688).

www.pnas.org/content/114/18/E3679.abstract.html?etoc

April 26, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 26, 2017

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“APC/CCdh1-Rock2 pathway controls dendritic integrity and memory,” by Veronica Bobo-Jimenez, María Delgado-Esteban, Julie Angibaud, Irene Sanchez-Moran, Antonio de la Fuente, Javier Yajeya, U. Valentin Nagerl, Jose Castillo, Juan P. Bolaños, and Angeles Almeida (Vol. 114, No. 17, April 26, 2017, p. 4513–4518).

www.pnas.org/content/114/17/4513.abstract.html?etoc

April 19, 2017

CAAR – Proceedings of the National Academy of Science Article Abstract – April 19, 2017

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“Prenatal loss of father during World War One is predictive of a reduced lifespan in adulthood,” by Nicolas Todd, Alain-Jacques Valleron, and Pierre Bougnères (Vol. 114, No. 16, April 18, 2017, p. 4201–4206).

www.pnas.org/content/114/16/4201.abstract

April 11, 2017

CAAR – Proceedings of the National Academy of Science Article Abstracts – April 11, 2017

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A. “Why the US science and engineering workforce is aging rapidly,” by David M. Blau and Bruce A. Weinberg (Vol. 114, No. 15, April 11, 2017, p. 3879–3884).

www.pnas.org/content/114/15/3879.abstract.html?etoc

B. “ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer’s disease,” by Bo-Jeng Wang, Guor Mour Her, Ming-Kuan Hu, Yun-Wen Chen, Ying-Tsen Tung, Pei-Yi Wu, Wen-Ming Hsu, Hsinyu Lee, Lee-Way Jin, Sheng-Ping L. Hwang, Rita P.-Y. Chen, Chang-Jen Huang, and Yung-Feng Liao
(Vol. 114, No. 15, April 11, 2017, p. E3129–E3138).

www.pnas.org/content/114/15/E3129.abstract.html?etoc

April 5, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – April 5, 2017

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A. “Prion protein dynamics before aggregation,” by Kinshuk Raj Srivastava and Lisa J. Lapidus (Vol. 114, No. 14, April 4, 2017, p. 3572-3577).

www.pnas.org/content/114/14/3572.abstract

B. “Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer’s pathology,” by Zui Zhang, Yoshiko Takeda-Uchimura, Tahmina Foyez, Shiori Ohtake-Niimi, Narentuya, Hiroyasu Akatsu, Kazuchika Nishitsuji, Makoto Michikawa, Tony Wyss-Coray, Kenji Kadomatsu, and Kenji Uchimura (Vol. 114, No. 14, April 4, 2017, p. E2947-E2954).

www.pnas.org/content/114/14/E2947.abstract

March 14, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 14, 2017

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“Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease,” by Amy R. Dunn, Kristen A. Stout, Minagi Ozawa, Kelly M. Lohr, Carlie A. Hoffman, Alison I. Bernstein, Yingjie Li, Minzheng Wang, Carmelo Sgobio, Namratha Sastry, Huaibin Cai, W. Michael Caudle, and Gary W. Miller (Vol. 114, No. 11, March 14, 2017, p. E2253–E2262).

www.pnas.org/content/114/11/E2253.abstract.html?etoc

March 7, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 7, 2017

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A. “Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models,” by S. Pablo Sardi, Catherine Viel, Jennifer Clarke, Christopher M. Treleaven, Amy M. Richards, Hyejung Park, Maureen A. Olszewski, James C. Dodge, John Marshall, Elina Makino, Bing Wang, Richard L. Sidman, Seng H. Cheng, and Lamya S. Shihabuddin (Vol. 114, No. 10, March 7, 2017, p. 2699–2704).

www.pnas.org/content/114/10/2699.abstract.html?etoc

B. “Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson’s disease,” by Holly Green, Xiaoqun Zhang, Katarina Tiklova, Nikolaos Volakakis, Lovisa Brodin, Louise Berg, Paul Greengard, Thomas Perlmann, and Per Svenningsson (Vol. 114, No. 10, March 7, 2017, p. 2735–2740).

www.pnas.org/content/114/10/2735.abstract.html?etoc

February 28, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 28, 2017

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“TMEM175 deficiency impairs lysosomal and mitochondrial function and increases {alpha}-synuclein aggregation,” by Sarah Jinn, Robert E. Drolet, Paige E. Cramer, Andus Hon-Kit Wong, Dawn M. Toolan, Cheryl A. Gretzula, Bhavya Voleti, Galya Vassileva, Jyoti Disa, Marija Tadin-Strapps, and David J. Stone (Vol. 114, No. 9, February 28, 2017, .pdf and HTML format, p. 2389-2394). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/9/2389.abstract

February 14, 2017

CAAR – Proceedings of the National Academy of Science Article Abstract – February 14, 2017

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“The impact of bilingualism on brain reserve and metabolic connectivity in Alzheimer’s dementia,” by Daniela Perani, Mohsen Farsad, Tommaso Ballarini, Francesca Lubian, Maura Malpetti, Alessandro Fracchetti, Giuseppe Magnani, Albert March, and Jubin Abutalebi (Vol. 114, No. 7, February 14, 2017, p. 1690-1695).

www.pnas.org/content/114/7/1690.abstract

February 8, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 8, 2017

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A. “Gleevec shifts APP processing from a {beta}-cleavage to a nonamyloidogenic cleavage,” by William J. Netzer, Karima Bettayeb, Subhash C. Sinha, Marc Flajolet, Paul Greengard, and Victor Bustos (Vol. 114, No. 6, February 7, 2017, p. 1389-1394).

www.pnas.org/content/114/6/1389.abstract

B. “A natural product inhibits the initiation of {alpha}-synuclein aggregation and suppresses its toxicity,” by Michele Perni, Céline Galvagnion, Alexander Maltsev, Georg Meisl, Martin B. D. Müller, Pavan K. Challa, Julius B. Kirkegaard, Patrick Flagmeier, Samuel I. A. Cohen, Roberta Cascella, Serene W. Chen, Ryan Limboker, Pietro Sormanni, Gabriella T. Heller, Francesco A. Aprile, Nunilo Cremades, Cristina Cecchi, Fabrizio Chiti, Ellen A. A. Nollen, Tuomas P. J. Knowles, Michele Vendruscolo, Adriaan Bax, Michael Zasloff, and Christopher M. Dobson (Vol. 114, No. 6, February 7, 2017, p. E1009-E1017). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/6/E1009.abstract

January 24, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 24, 2017

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“Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of A{beta}42 and A{beta}40 peptides by {gamma}-secretase,” by Linfeng Sun, Rui Zhou, Guanghui Yang, and Yigong Shi (Vol. 114, No. 4, January 24, 2017, p. E476–E485).

www.pnas.org/content/114/4/E476.abstract.html?etoc

January 17, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 17, 2017

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“Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation,” by William A. McEwan, Benjamin Falcon, Marina Vaysburd, Dean Clift, Adrian L. Oblak, Bernardino Ghetti, Michel Goedert, and Leo C. James (Vol. 114, No. 3, January 17, 2017, p. 574-579).

www.pnas.org/content/114/3/574.abstract

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