“A smartphone intervention that enhances real-world memory and promotes differentiation of hippocampal activity in older adults,” by Chris B. Martin, Bryan Hong, Rachel N. Newsome, Katarina Savel, Melissa E. Meade, Andrew Xia, Christopher J. Honey, and Morgan D. Barense (Vol. 119, No. 51, December 20, 2022, e2214285119).
December 21, 2022
CAAR – Proceedings of the National Academy of Science Article Abstract – December 21, 2022
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December 7, 2022
CAAR – Proceedings of the National Academy of Science Article Abstracts – December 7, 2022
A. “Early diagnosis and treatment of Alzheimer’s disease by targeting toxic soluble A[beta] oligomers,” by Maram Habashi, Suresh Vutla, Kuldeep Tripathi, Sudipta Senapati, Pradeep S. Chauhan, Anat Haviv-Chesner, Michal Richman, Samia-Ait Mohand, Véronique Dumulon-Perreault, Ramakotaiah Mulamreddy, Eitan Okun, Jordan H. Chill, Brigitte Guérin, William D. Lubell, and Shai Rahimipour (Vol. 119, No. 49, December 6, 2022, e2210766119).
www.pnas.org/doi/abs/10.1073/pnas.2210766119
B. “Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer’s disease,” by Sarah Mustaly-Kalimi, Wacey Gallegos, Robert A. Marr, Alice Gilman-Sachs, Daniel A. Peterson, Israel Sekler, and Grace E. Stutzmann (Vol. 119, No. 49, December 6, 2022, e2211999119).
www.pnas.org/doi/abs/10.1073/pnas.2211999119
C. “Age-related brain atrophy is not a homogenous process: Different functional brain networks associate differentially with aging and blood factors,” by Nikola T. Markov, Cutter A. Lindbergh, Adam M. Staffaroni, Kevin Perez, Michael Stevens, Khiem Nguyen, Natalia F. Murad, Corrina Fonseca, Judith Campisi, Joel Kramer, and David Furman (Vol. 119, No. 49, December 6, 2022, e2207181119).
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November 17, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 17, 2022
A. “In utero exposure to the Great Depression is reflected in late-life epigenetic aging signatures,” by Lauren L. Schmitz and Valentina Duque (Vol. 119, No. 46, November 15, 2022, e2212205119).
www.pnas.org/doi/abs/10.1073/pnas.2208530119
B. “Trends in inequalities in the prevalence of dementia in the United States,” by Péter Hudomiet, Michael D. Hurd, and Susann Rohwedder (Vol. 119, No. 46, November 15, 2022, e2212205119).
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November 3, 2022
CAAR – Proceedings of the National Academy of Science Article Abstract – November 3, 2022
“A robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults,” by William C. Stanford, Peter J. Mucha, and Eran Dayan (Vol. 119, No. 44, November 1, 2022, e2203682119).
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October 25, 2022
CAAR – Proceedings of the National Academy of Science Article Abstracts – October 25, 2022
A. Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer’s disease,” by Abbas Dehghan, Rui Climaco Pinto, Ibrahim Karaman, Jian Huang, Brenan R. Durainayagam, Mohsen Ghanbari, Areesha Nazeer, Qi Zhong, Sonia Liggi, Luke Whiley, Rima Mustafa, Miia Kivipelto, Alina Solomon, Tiia Ngandu, Takahisa Kanekiyo, Tomonori Aikawa, Carola I. Radulescu, Samuel J. Barnes, Gonçalo Graça, Elena Chekmeneva, Stephane Camuzeaux, Matthew R. Lewis, Manuja R. Kaluarachchi, M. Arfan Ikram, Elaine Holmes, Ioanna Tzoulaki, Paul M. Matthews, Julian L. Griffin, and Paul Elliott (Vol. 119, No. 43, October 25, 2022, e2206083119).
www.pnas.org/doi/abs/10.1073/pnas.2206083119
B. “Socioeconomic inequalities in molecular risk for chronic diseases observed in young adulthood,” by Michael J. Shanahan, Steven W. Cole, Sudharshan Ravi, Justin Chumbley, Wenjia Xu, Cecilia Potente, Brandt Levitt, Julien Bodelet, Allison Aiello, Lauren Gaydosh, and Kathleen Mullan Harris (Vol. 119, No. 43, October 25, 2022, e2103088119).
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October 19, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 19, 2022
“Aging is associated with maladaptive episodic memory-guided social decision-making,” by Karolina M. Lempert, Michael S. Cohen, Kameron A. MacNear, Frances M. Reckers, Laura Zaneski, David A. Wolk, and Joseph W. Kable (Vol. 119, No. 42, October 18, 2022, e2208681119).
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October 12, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 12, 2022
“Early death in a mouse model of Alzheimer’s disease exacerbated by microglial loss of TAM receptor signaling,” by Youtong Huang and Greg Lemke (Vol. 119, No. 41, October 11, 2022, e2204306119).
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September 15, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – September 15, 2022
A. “Aging, generational shifts, and energy consumption in urban China,” by Xiao Han, Chu Wei, and Gui-Ying Cao (Vol. 119, No. 37, September 13, 2022, e2210853119).
www.pnas.org/doi/abs/10.1073/pnas.2210853119
B. “Truncated Tau caused by intron retention is enriched in Alzheimer’s disease cortex and exhibits altered biochemical properties,” by Zhen-Kai Ngian, Yow-Yong Tan, Ching-Thong Choo, Wei-Qi Lin, Chao-Yong Leow, Shan-Jie Mah, Mitchell Kim-Peng Lai, Christopher Li-Hsian Chen, and Chin-Tong Ong (Vol. 119, No. 37, September 13, 2022, e2204179119).
www.pnas.org/doi/abs/10.1073/pnas.2204179119
C. “A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer’s disease mouse model,” by Natalia Ortí-Casañ, Inge S. Zuhorn, Petrus J. W. Naudé, Peter P. De Deyn, Pauline E. M. van Schaik, Harald Wajant, and Ulrich L. M. Eisel (Vol. 119, No. 37, September 13, 2022, e2201137119).
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September 7, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 7, 2022
“Amelioration of pathologic {alpha}-synuclein-induced Parkinson’s disease by irisin,” by Tae-In Kam, Hyejin Park, Shih-Ching Chou, Jonathan G. Van Vranken, Melanie J. Mittenbühler, Hyeonwoo Kim, Mu A, Yu Ree Choi, Devanik Biswas, Justin Wang, Yu Shin, Alexis Loder, Senthilkumar S. Karuppagounder, Christiane D. Wrann, Valina L. Dawson, Bruce M. Spiegelman bruce_spiegelman@dfci.harvard.edu, and Ted M. Dawson (Vol. 119, No. 36, September 6, 2022, e2204835119).
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August 30, 2022
CAAR – Proceedings of the Academy of Sciences Article Abstracts – August 30, 2022
A. “Leisure-time sedentary behaviors are differentially associated with all-cause dementia regardless of engagement in physical activity,” by David A. Raichlen, Yann C. Klimentidis, M. Katherine Sayre, Pradyumna K. Bharadwaj, Mark H. C. Lai, Rand R. Wilcox, and Gene E. Alexander (Vol. 119, No. 35, August 30, 2022, e2206931119).
www.pnas.org/doi/10.1073/pnas.2206931119
B. “Significant impacts of the COVID-19 pandemic on race/ethnic differences in US mortality,” by José Manuel Aburto, Andrea M. Tilstra, Ginevra Floridi, and Jennifer Beam Dowd (Vol. 119, No. 35, August 30, 2022, e2205813119).
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August 24, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 24, 2022
“Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation,” by Sivaprakasam R. Saroja, Kirill Gorbachev, TCW Julia, Alison M. Goate, and Ana C. Pereira (Vol. 119, No. 34, August 23, 2022, e2108870119).
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August 2, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 2, 2022
“Adsorption free energy predicts amyloid protein nucleation rates,” by Zenon Toprakcioglu, Ayaka Kamada, Thomas C. T. Michaels, Mengqi Xie, Johannes Krausser, Jiapeng Wei, Andela Saric, Michele Vendruscolo, and Tuomas P. J. Knowles (Vol. 119, No. 31, August 2, 2022, e2109718119).
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July 21, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstracts: – July 21, 2022
A. “Aging-associated and CD4 T-cell–dependent ectopic CXCL13 activation predisposes to anti–PD-1 therapy-induced adverse events,” by Hirotake Tsukamoto, Yoshihiro Komohara, Yusuke Tomita, Yuji Miura, Takanobu Motoshima, Kosuke Imamura, Toshiki Kimura, Tokunori Ikeda, Yukio Fujiwara, Hiromu Yano, Tomomi Kamba, Takuro Sakagami and Hiroyuki Oshiumi (Vol. 119, No. 29, July 19, 2022, e2205378119).
www.pnas.org/doi/abs/10.1073/pnas.2205378119
B. “Therapeutic functions of astrocytes to treat {alpha}-synuclein pathology in Parkinson’s disease,” by Yunseon Yang, Jae-Jin Song, Yu Ree Choi, Seong-hoon Kim, Min-Jong Seok, Noviana Wulansari, Wahyu Handoko Wibowo Darsono, Oh-Chan Kwon, Mi-Yoon Chang, Sang Myun Park and Sang-Hun Lee (Vol. 119, No. 29, July 19, 2022, e2110746119).
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July 11, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstract – July 11, 2022
“Mental health, financial, and social outcomes among older adults with probable COVID-19 infection: A longitudinal cohort study,” by Eleonora Iob, Andrew Steptoe and Paola Zaninotto (Vol. 119, No. 27, July 5, 2022, e2200816119).
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June 22, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 22, 2022
“Social stressors associated with age-related T lymphocyte percentages in older US adults: Evidence from the US Health and Retirement Study,” by Eric T. Klopack, Eileen M. Crimmins, Steve W. Cole, Teresa E. Seeman and Judith E. Carroll (Vol. 119, No. 25, June 21, 2022, e2202780119).
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May 31, 2022
CAAR – Proceedings of the National Academy of Science Article Abstract – May 31, 2022
“Diffusion MRI–guided theta burst stimulation enhances memory and functional connectivity along the inferior longitudinal fasciculus in mild cognitive impairment,” by Yu-Chin Chen, Viet Ton That, Chidi Ugonna, Yilin Liu, Lynn Nadel and Ying-hui Chou (Vol. 119, No. 21, May 31, 2022, e2113778119).
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May 17, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 17, 2022
“Deep brain stimulation in the subthalamic nucleus for Parkinson’s disease can restore dynamics of striatal networks,” by Elie M. Adam, Emery N. Brown, Nancy Kopell, and Michelle M. McCarthy (Vol. 119, No. 19, May 17, 2022, e2120808119).
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May 4, 2022
CAAR – Proceedings of the National Academy of Science Article Abstract – May 4, 2022
“Early age–related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging,” by Sandip Ashok Sonar, Jennifer L. Uhrlaub, Christopher P. Coplen, Gregory D. Sempowski, Jarrod A. Dudakov, Marcel R. M. van den Brink, Bonnie J. LaFleur, Mladen Jergović, and Janko Nikolich-Žugich (Vol. 119, No. 17, May 3, 2022, e2121028119).
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April 27, 2022
CAAR – Proceedings of the National Academy of Science Article Abstract – April 27, 2022
“Early age–related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging,” by Sandip Ashok Sonar, Jennifer L. Uhrlaub, Christopher P. Coplen, Gregory D. Sempowski, Jarrod A. Dudakov, Marcel R. M. van den Brink, Bonnie J. LaFleur, Mladen Jergović, and Janko Nikolich-Žugich (Vol. 119, No. 17, April 26, 2022, e2121028119).
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March 22, 2022
CAAR – Proceedings of the National Academy of Science Article Abstract – March 22, 2022
“Modulation of amyloid precursor protein cleavage by {gamma}-secretase activating protein through phase separation,” by Chen Jin, Jiaoni Wang, Yumeng Wang, Bojun Jia, Xuefei Guo, Guanghui Yang, Peng Xu, Paul Greengard, Rui Zhou, and Yigong Shi (Vol. 119, No. 12, March 22, 2022, e2122292119).
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March 8, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 8, 2022
“Social disadvantage, economic inequality, and life expectancy in nine Indian states,” by Sangita Vyas, Payal Hathi, and Aashish Gupta (Vol. 119, No. 10, March 8, 2022, e2109226119).
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February 8, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 8, 2022
“Different {alpha}-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophym” by Jacob I. Ayers, Joanne Lee, Octovia Monteiro, Amanda L. Woerman, Ann A. Lazar, Carlo Condello, Nick A. Paras, and Stanley B. Prusiner (Vol. 119, No. 6, February 8, 2022, e2113489119).
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February 1, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 1, 2022
“Soluble TREM2 inhibits secondary nucleation of A{beta} fibrillization and enhances cellular uptake of fibrillar A{beta},” by Ketaki D. Belsare, Haifan Wu, Dibyendu Mondal, Annalise Bond, Erika Castillo, Jia Jin, Hyunil Jo, Addison E. Roush, Kala Bharath Pilla, Andrej Sali, Carlo Condello, and William F. DeGrado (Vol. 119, No. 5, February 1, 2022, e2114486119).
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January 19, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 19, 2022
“Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer’s disease mice,” by Min Hee Park, Kang Ho Park, Byung Jo Choi, Wan Hui Han, Hee Ji Yoon, Hye Yoon Jung, Jihoon Lee, Im-Sook Song, Dong Yu Lim, Min-Koo Choi, Yang-Ha Lee, Cheol-Min Park, Ming Wang, Jihoon Jo, Hee-Jin Kim, Seung Hyun Kim, Edward H. Schuchman, Hee Kyung Jin, and Jae-sung Bae (Vol. 119, No. 3, January 18, 2022, e2115082119).
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January 11, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 11, 2022
“Association of improved air quality with lower dementia risk in older women,” by Xinhui Wang, Diana Younan, Joshua Millstein, Andrew J. Petkus, Erika Garcia, Daniel P. Beavers, Mark A. Espeland, Helena C. Chui, Susan M. Resnick, Margaret Gatz, Joel D. Kaufman, Gregory A. Wellenius, Eric A. Whitsel, JoAnn E. Manson, Stephen R. Rapp, and Jiu-Chiuan Chen (Vol. 119, No. 2, January 11, 2022, e2107833119).
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December 14, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 14, 2021
“Pathological {alpha}-syn aggregation is mediated by glycosphingolipid chain length and the physiological state of {alpha}-syn in vivo,” by Kristina Fredriksen, Stefanos Aivazidis, Karan Sharma, Kevin J. Burbidge, Caleb Pitcairn, Friederike Zunke, Eilrayna Gelyana, and Joseph R. Mazzulli (Vol. 118, No. 50, December 14, 2021, e2108489118).
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November 30, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 30, 2021
“Amyloid {beta} 42 fibril structure based on small-angle scattering,” by Veronica Lattanzi, Ingemar André, Urs Gasser, Marija Dubackic, Ulf Olsson, and Sara Linse (Vol. 118, No. 48, November 30, 2021, e2112783118).
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October 19, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 19, 2021
“Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence,” by Yao Li, Damir Kračun, Christopher M. Dustin, Mohamed El Massry, Shuai Yuan, Christian J. Goossen, Evan R. DeVallance, Sanghamitra Sahoo, Cynthia St. Hilaire, Aditi U. Gurkar, Toren Finkel, Adam C. Straub, Eugenia Cifuentes-Pagano, and Patrick J. Pagano (Vol. 118, No. 42, October 19, 2021, e2015666118).
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October 12, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 12, 2021
“Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration,” by Meenakshi Ambati, Ivana Apicella, Shao-bin Wang, Siddharth Narendran, Hannah Leung, Felipe Pereira, Yosuke Nagasaka, Peirong Huang, Akhil Varshney, Kirstie L. Baker, Kenneth M. Marion, Mehrdad Shadmehr, Cliff I. Stains, Brian C. Werner, Srinivas R. Sadda, Ethan W. Taylor, S. Scott Sutton, Joseph Magagnoli, and Bradley D. Gelfand (Vol. 118, No. 41, October 12, 2021, e2102975118).
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October 5, 2021
CAAR – Proceedings of the National Academy of Science Article Abstracts – October 5, 2021
A. “Inequality in mortality between Black and White Americans by age, place, and cause and in comparison to Europe, 1990 to 2018,” by Hannes Schwandt, Janet Currie, Marlies Bär, James Banks, Paola Bertoli, Aline Bütikofer, Sarah Cattan, Beatrice Zong-Ying Chao, Claudia Costa, Libertad González, Veronica Grembi, Kristiina Huttunen, René Karadakic, Lucy Kraftman, Sonya Krutikova, Stefano Lombardi, Peter Redler, Carlos Riumallo-Herl, Ana Rodríguez-González, Kjell G. Salvanes, Paula Santana, Josselin Thuilliez, Eddy van Doorslaer, Tom Van Ourti, Joachim K. Winter, Bram Wouterse, and Amelie Wuppermann (Vol. 118, No. 40, October 5, 2021, e2104684118).
www.pnas.org/content/118/40/e2104684118.abstract?etoc
B. “Metabolism modulates network synchrony in the aging brain,” by Corey Weistuch, Lilianne R. Mujica-Parodi, Rostam M. Razban, Botond Antal, Helena van Nieuwenhuizen, Anar Amgalan, and Ken A. Dill (Vol. 118, No. 40, October 5, 2021, e2025727118).
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September 29, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 29, 2021
“Amyloid-{beta} peptide dimers undergo a random coil to {beta}-sheet transition in the aqueous phase but not at the neuronal membrane,” by Hebah Fatafta, Mohammed Khaled, Michael C. Owen, Abdallah Sayyed-Ahmad, and Birgit Strodel (Vol. 118, No. 39, September 28, 2021, e2106210118).
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September 22, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 22, 2021
“Frustrated peptide chains at the fibril tip control the kinetics of growth of amyloid-{beta} fibrils,” by Yuechuan Xu, Kaitlin Knapp, Kyle N. Le, Nicholas P. Schafer, Mohammad S. Safari, Aram Davtyan, Peter G. Wolynes, and Peter G. Vekilov (Vol. 118, No. 38, September 21, 2021, e2110995118).
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September 15, 2021
CAAR – Proceedings of the National Academy of Science Article Abstracts – September 15, 2021
A. “Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites,” by Takayuki Teruya, Yung-Ju Chen, Hiroshi Kondoh, Yasuhide Fukuji, and Mitsuhiro Yanagida (Vol. 118, No. 37, September 14, 2021, e2022857118).
www.pnas.org/content/118/37/e2022857118.abstract
B. “FGF-2–dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis,” by Sebastian Mathes, Alexandra Fahrner, Umesh Ghoshdastider, Hannes A. Rüdiger, Michael Leunig, Christian Wolfrum, and Jan Krützfeldt (Vol. 118, No. 37, September 14, 2021, e2021013118).
www.pnas.org/content/118/37/e2021013118.abstract
C. “NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING,” by Yujun Hou, Yong Wei, Sofie Lautrup, Beimeng Yang, Yue Wang, Stephanie Cordonnier, Mark P. Mattson, Deborah L. Croteau, and Vilhelm A. Bohr (Vol. 118, No. 37, September 14, 2021, e2011226118).
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September 7, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 7, 2021
“All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of {alpha}-synuclein toxic species,” by Aitor Franco, Pablo Gracia, Adai Colom, José D. Camino, José Ángel Fernández-Higuero, Natalia Orozco, Alexander Dulebo, Leonor Saiz, Nunilo Cremades, Jose M.G. Vilar, Adelina Prado, and Arturo Muga (Vol. 118, No. 36, September 7, 2021, e2105548118).
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August 31, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 31, 2021
“The N terminus of {alpha}-synuclein dictates fibril formation,” by Ryan P. McGlinchey, Xiaodan Ni, Jared A. Shadish, Jiansen Jiang, and Jennifer C. Lee (Vol. 118, No. 35, August 31, 2021, e2023487118).
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August 25, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 25, 2021
“Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration,” by Chenyin Wang, Chun Yin Lau, Fuqiang Ma, and Chaogu Zheng (Vol. 118, No. 34, August 24, 2021, e2106504118).
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August 18, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – August 18, 2021
A. “Effects of sex and aging on the immune cell landscape as assessed by single-cell transcriptomic analysis,” by Zhaohao Huang, Binyao Chen, Xiuxing Liu, He Li, Lihui Xie, Yuehan Gao, Runping Duan, Zhaohuai Li, Jian Zhang, Yingfeng Zheng, and Wenru Su (Vol. 118, No. 33, August 17, 2021, e2023216118).
www.pnas.org/content/118/33/e2023216118.abstract?etoc
B. “Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol,” by Hao Wang, Joshua A. Kulas, Chao Wang, David M. Holtzman, Heather A. Ferris, and Scott B. Hansen (Vol. 118, No. 33, August 17, 2021, e2102191118).
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August 11, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 11, 2021
“Psychological resilience predicting cardiometabolic conditions in adulthood in the Midlife in the United States Study,” by Kristen M. Nishimi, Karestan C. Koenen, Brent A. Coull, Ruijia Chen, and Laura D. Kubzansky (Vol. 118, No. 32, August 10, 2021, e2102619118).
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July 6, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 6, 2021
A. “Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading,” by Yin Xu, Nicholas E. Propson, Shuqi Du, Wen Xiong, and Hui Zheng (Vol. 118, No. 27, July 6, 2021, e2023418118).
www.pnas.org/content/118/27/e2023418118.abstract?etoc
B. “Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice,” by Kathleen M. Schoch, Lubov A. Ezerskiy, Michaela M. Morhaus, Riley N. Bannon, Andrew D. Sauerbeck, Mark Shabsovich, Paymaan Jafar-nejad, Frank Rigo, and Timothy M. Miller (Vol. 118, No. 27, July 6, 2021, e2100356118).
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June 17, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 17, 2021
“The balance of giving versus receiving social support and all-cause mortality in a US national sample,” by Edith Chen, Phoebe H. Lam, Eric D. Finegood, Nicholas A. Turiano, Daniel K. Mroczek, and Gregory E. Miller (Vol. 118, No. 24, June 15, 2021, e2024770118).
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June 1, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 1, 2021
“Aging as a consequence of selection to reduce the environmental risk of dying,” by Stig W. Omholt and Thomas B. L. Kirkwood (Vol. 118, No. 22, June 1, 2021, e2102088118).
www.pnas.org/content/118/22/e2102088118.abstract?etoc
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May 18, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 18, 2021
“Death rates at specific life stages mold the sex gap in life expectancy,” by Virginia Zarulli, Ilya Kashnitsky, and James W. Vaupel (Vol. 118, No. 20, May 18, 2021, e2010588118).
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May 6, 2021
CAAR – Proceedings of the National Academy of Science Article Abstract – May 6, 2021
“Educational attainment does not influence brain aging,” by Lars Nyberg, Fredrik Magnussen, Anders Lundquist, William Baaré, David Bartrés-Faz, Lars Bertram, C. J. Boraxbekk, Andreas M. Brandmaier, Christian A. Drevon, Klaus Ebmeier, Paolo Ghisletta, Richard N. Henson, Carme Junqué, Rogier Kievit, Maike Kleemeyer, Ethan Knights, Simone Kühn, Ulman Lindenberger, Brenda W. J. H. Penninx, Sara Pudas, Øystein Sørensen, Lídia Vaqué-Alcázar, Kristine B. Walhovd, and Anders M. Fjell (Vol. 118, No. 18, May 4, 2021, e2101644118).
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April 22, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 22, 2021
“Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer’s disease,” by Jodie Lord, Bradley Jermy, Rebecca Green, Andrew Wong, Jin Xu, Cristina Legido-Quigley, Richard Dobson, Marcus Richards, and Petroula Proitsi (Vol. 118, No. 16, April 20, 2021, e2009808118).
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April 15, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 15, 2021
“Soluble {alpha}-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia,” by Dorit Trudler, Kristopher L. Nazor, Yvonne S. Eisele, Titas Grabauskas, Nima Dolatabadi, James Parker, Abdullah Sultan, Zhenyu Zhong, Marshall S. Goodwin, Yona Levites, Todd E. Golde, Jeffery W. Kelly, Michael R. Sierks, Nicholas J. Schork, Michael Karin, Rajesh Ambasudhan, and Stuart A. Lipton (Vol. 118, No. 15, April 13, 2021, e2025847118).
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March 24, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 24, 2021
“Rapid initiation of cell cycle reentry processes protects neurons from amyloid-{beta} toxicity,” by Stefania Ippati, Yuanyuan Deng, Julia van der Hoven, Celine Heu, Annika van Hummel, Sook Wern Chua, Esmeralda Paric, Gabriella Chan, Astrid Feiten, Thomas Fath, Yazi D. Ke, Nikolas K. Haass, and Lars M. Ittner (Vol. 118, No. 12, March 23, 2021, e2011876118).
www.pnas.org/content/118/12/e2011876118.abstract?etoc
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March 18, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 18, 2021
A. “Life expectancy in adulthood is falling for those without a BA degree, but as educational gaps have widened, racial gaps have narrowed,” by Anne Case and Angus Deaton (Vol. 118, No. 11, March 16, 2021, e2024777118).
www.pnas.org/content/118/11/e2024777118.abstract?etoc
B. “Unique molecular characteristics and microglial origin of Kv1.3 channel–positive brain myeloid cells in Alzheimer’s disease,” by Supriya Ramesha, Sruti Rayaprolu, Christine A. Bowen, Cynthia R. Giver, Sara Bitarafan, Hai M. Nguyen, Tianwen Gao, Michael J. Chen, Ngozi Nwabueze, Eric B. Dammer, Amanda K. Engstrom, Hailian Xiao, Andrea Pennati, Nicholas T. Seyfried, David J. Katz, Jacques Galipeau, Heike Wulff, Edmund K. Waller, Levi B. Wood, Allan I. Levey, and Srikant Rangaraju (Vol. 118, No. 11, March 16, 2021, e2013545118).
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March 11, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 11, 2021
“Structural insights into {alpha}-synuclein monomer–fibril interactions,” by Pratibha Kumari, Dhiman Ghosh, Agathe Vanas, Yanick Fleischmann, Thomas Wiegand, Gunnar Jeschke,Roland Riek, and Cédric Eichmann (Vol. 118, No. 10, March 9, 2021, e2012171118).
www.pnas.org/content/118/10/e2012171118.abstract?etoc
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March 3, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 3, 2021
“TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau,” by Peter E. A. Ash, Shuwen Lei, Jenifer Shattuck, Samantha Boudeau, Yari Carlomagno, Maria Medalla, Bryce L. Mashimo, Guillermo Socorro, Louloua F. A. Al-Mohanna, Lulu Jiang, Muhammet M. Öztürk, Mark Knobel, Pavel Ivanov, Leonard Petrucelli, Susanne Wegmann, Nicholas M. Kanaan, and Benjamin Wolozin (Vol. 118, No. 9, March 2, 2021, e2014188118).
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February 9, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 9, 2021
“Developmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration,” by Dávid Nagy, Katelin A. Ennis, Ru Wei, Susan C. Su, Christopher A. Hinckley, Rong-Fang Gu, Benbo Gao, Ramiro H. Massol, Chris Ehrenfels, Luke Jandreski, Ankur M. Thomas, Ashley Nelson, Stefka Gyoneva, Mihály Hajós, and Linda C. Burkly (Vol. 118, No. 6, February 9, 2021, e2001679118).
www.pnas.org/content/118/6/e2001679118.abstract?etoc
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