“Developmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration,” by Dávid Nagy, Katelin A. Ennis, Ru Wei, Susan C. Su, Christopher A. Hinckley, Rong-Fang Gu, Benbo Gao, Ramiro H. Massol, Chris Ehrenfels, Luke Jandreski, Ankur M. Thomas, Ashley Nelson, Stefka Gyoneva, Mihály Hajós, and Linda C. Burkly (Vol. 118, No. 6, February 9, 2021, e2001679118).
www.pnas.org/content/118/6/e2001679118.abstract?etoc
“Reductions in 2020 US life expectancy due to COVID-9 and the disproportionate impact on the Black and Latino populations,” by Theresa Andrasfay and Noreen Goldman (Vol. 118, No. 5, February 2, 2021, e20147461180).
A. “Prediction of Alzheimer’s disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening,” by Sung-Hyun Kim, Sumin Yang, Key-Hwan Lim, Euiseng Ko, Hyun-Jun Jang, Mingon Kang, Pann-Ghill Suh, and Jae-Yeol Joo (Vol. 118, No. 3, January 19, 2021, e2011250118).
www.pnas.org/content/118/3/e2011250118.abstract?etoc
B. “Childhood self-control forecasts the pace of midlife aging and preparedness for old age,” by Leah S. Richmond-Rakerd, Avshalom Caspi, Antony Ambler, Tracy d’Arbeloff, Marieke de Bruine, Maxwell Elliott, HonaLee Harrington, Sean Hogan, Renate M. Houts, David Ireland, Ross Keenan, Annchen R. Knodt, Tracy R. Melzer, Sena Park, Richie Poulton, Sandhya Ramrakha, Line Jee Hartmann Rasmussen, Elizabeth Sack, Adam T. Schmidt, Maria L. Sison, Jasmin Wertz, Ahmad R. Hariri, and Terrie E. Moffitt (Vol. 118, No. 3, January 19, 2021, e2010211118).
A. “Nursing home staff networks and COVID-19,” by M. Keith Chen, Judith A. Chevalier, and Elisa F. Long (Vol. 118, No. 1, January 5, 2021, e2015455118).
www.pnas.org/content/118/1/e2015455118.abstract?etoc
B. “The Parkinson’s disease-associated gene ITPKB protects against {alpha}-synuclein aggregation by regulating ER-to-mitochondria calcium release,” by Daniel J. Apicco, Evgeny Shlevkov, Catherine L. Nezich, David T. Tran, Edward Guilmette, Justin W. Nicholatos, Collin M. Bantle, Yi Chen, Kelly E. Glajch, Neeta A. Abraham, Lan T. Dang, G. Campbell Kaynor, Ellen A. Tsai, Khanh-Dung H. Nguyen, Joost Groot, YuTing Liu, Andreas Weihofen, Jessica A. Hurt, Heiko Runz, and Warren D. Hirst (Vol. 118, No. 1, January 5, 2021, e2006476118).
“Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model,” by Kelly M. Lohr, Bess Frost, Clemens Scherzer, and Mel B. Feany (Vol. 117, No. 52, December 29, 2020, p. 33608-33618).
“Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer’s disease,” by Sonam Dubey, Stefan Heinen, Slavica Krantic, JoAnne McLaurin, Donald R. Branch, Kullervo Hynynen, and Isabelle Aubert (Vol. 117, No. 51, December 23, 2020, p. 32691-32700).
“Design of a multivalent bifunctional chelator for diagnostic 64Cu PET imaging in Alzheimer’s disease,” by Hong-Jun Cho, Truc T. Huynh, Buck E. Rogers, and Liviu M. Mirica (Vol. 117, No. 49, December 8, 2020, p. 30928-30933).
“Global associations between macronutrient supply and age-specific mortality,” by Alistair M. Senior, Shinichi Nakagawa, David Raubenheimer, and Stephen J. Simpson (Vol. 117, No. 48, December 1, 2020, p. 30824-30835).
“Aging and the encoding of changes in events: The role of neural activity pattern reinstatement,” by David Stawarczyk, Christopher N. Wahlheim, Joset A. Etzel, Abraham Z. Snyder, and Jeffrey M. Zacks (Vol. 117, No. 47, November 24, 2020, p. 29346-29353).
A. “Life cycle patterns of cognitive performance over the long run,” by Anthony Strittmatter, Uwe Sunde, and Dainis Zegners (Vol. 117, No. 44, November 3, 2020, p. 27255-27261).
www.pnas.org/content/117/44/27255.abstract.html?etoc
B. “Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance,” by Oeystein Roed Brekk, Jonathan R. Honey, Seungil Lee, Penelope J. Hallett, and Ole Isacson (Vol. 117, No. 44, November 3, 2020, p. 27646-27654).
“Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria,” by Danielle E. Mor, Salman Sohrabi, Rachel Kaletsky, William Keyes, Alp Tartici, Vrinda Kalia, Gary W. Miller, and Coleen T. Murphy (Vol. 117, No. 42, October 20, 2020, p. 26438-26447).
“Single-nuceus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease,” by Shun-Fat Lau, Han Cao, Amy K. Y. Fu, and Nancy Y. Ip (Vol. 117, No. 41, October 13, 2020, p. 25272-25283).
“Decoding the mystery of American pain reveals a warning for the future,” by Anne Case, Angus Deaton, and Arthur A. Stone (Vol. 117, No. 40, October 6, 2020, p. 24785-24789).
Note: Check with your organization’s library for availability. “Quantifying and explaining variation in life expectancy at census tract, county, and state levels in the United States,” by Antonio Fernando Boing, Alexandra Crispim Boing, Jack Cordes, Rockli Kim, and S. V. Subramanian (Vol. 117, No. 30, July 28, 2020, p. 17688-17694).
A. “Dopaminergic neurodegeneration induced by Parkinson’s disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity,” by An Phu Tran Nguyen, Elpida Tsika, Kaela Kelly, Nathan Levine, Xi Chen, Andrew B. West, Sylviane Boularand, Pascal Barneoud, and Darren J. Moore (Vol. 117, No. 29, July 21, 2020, p. 17296-17307).
www.pnas.org/content/117/29/17296
B. “Basal ganglia beta oscillations during sleep underlie Parkinsonian insomnia,” by Aviv D. Mizrahi-Kliger, Alexander Kaplan, Zvi Israel, Marc Deffains, and Hagai Bergman (Vol. 117, No. 29, July 21, 2020, p. 17359-17368).
Note: Check with your organization’s library for availability.
A. “The transition to family caregiving and its effect on biomarkers of inflammation,” by David L. Roth, William E. Haley, Orla C. Sheehan, Jin Huang, J. David Rhodes, Peter Durda, Virginia J. Howard, Jeremy D. Walston, and Mary Cushman (Vol. 117, No. 28, July 14, 2020, p. 16258-16263).
www.pnas.org/content/117/28/16258
B. “Predicting mortality from 57 economic, behavioral, social, and psychological factors,” by Eli Puterman, Jordan Weiss, Benjamin A. Hives, Alison Gemmill, Deborah Karasek, Wendy Berry Mendes, and David H. Rehkopf (Vol. 117, No. 28, July 14, 2020, p. 16273-16282).
Note: Check with your organization’s library for availability. “Impact of alpha-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized alpha-synuclein rat model of PD,” by Deirdre B. Hoban, Shelby Shrigley, Bengt Mattsson, Ludivine S. Breger, Ulla Jarl, Tiago Cardoso, Jenny Nelander Wahlestedt, Kelvin C. Luk, Anders Björklund, and Malin Parmar (Vol. 117, No. 26, June 30, 2020, p. 15209-15220).
Note: Check with your organization’s library for availability. “Cerebral amyloid angiopathy-linked {beta}-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen,” by Steven A. Cajamarca, Erin H. Norris, Louise van der Weerd, Sidney Strickland, and Hyung Jin Ahn (Vol. 117, No. 25, June 23, 2020, p. 14482-14492).
Note: Check with your organization’s library for availability. “Ultrastructural evidence for self-replication of Alzheimer-associated A{beta}42 amyloid along the sides of fibrils,” by Mattias Törnquist, Risto Cukalevski, Ulrich Weininger, Georg Meisl, Tuomas P. J. Knowles, Thom Leiding, Anders Malmendal, Mikael Akke, and Sara Linse (Vol. 117, No. 21, May 26, 2020, p. 11265-11273).
Note: Check with your organization’s library for availability.
A. “Noninvasive hippocampal blood-brain barrier opening in Alzheimer’s disease with focused ultrasound,” by Ali R. Rezai, Manish Ranjan, Pierre-François D’Haese, Marc W. Haut, Jeffrey Carpenter, Umer Najib, Rashi I. Mehta, J. Levi Chazen, Zion Zibly, Jennifer R. Yates, Sally L. Hodder, and Michael Kaplitt (Vol. 117, No. 17, April 28, 2020, p. 9180-9182).
www.pnas.org/content/117/17/9180
B. “Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility,” by Masahiro Kameda, Takayuki Teruya, Mitsuhiro Yanagida, and Hiroshi Kondoh (Vol. 117, No. 17, April 28, 2020, p. 9483-9489).
Note: Check with your organization’s library for availability. “Population aging, migration, and productivity in Europe,” by Guillaume Marois, Alain Bélanger, and Wolfgang Lutz (Vol. 117, No. 14, April 7, 2020, p. 7690-7695).
Note: Check with your organization’s library for availability. “US life expectancy stalls due to cardiovascular disease, not drug deaths,” by Neil K. Mehta, Leah R. Abrams, and Mikko Myrskyla (Vol. 117, No. 13, March 31, 2020, p. 6998-7000).
Note: Check with your organization’s library for availability. “Diet modulates brain network stability, a biomarker for brain aging, in young adults,” by Lilianne R. Mujica-Parodi, Anar Amgalan, Syed Fahad Sultan, Botond Antal, Xiaofei Sun, Steven Skiena, Andrew Lithen, Noor Adra, Eva-Maria Ratai, Corey Weistuch, Sindhuja Tirumalai Govindarajan, Helmut H. Strey, Ken A. Dill, Steven M. Stufflebeam, Richard L. Veech, and Kieran Clarke (Vol. 117, No. 11, March 17, 2020, p. 6170-6177).
Note: Check with your organization’s library for availability.
A. “Mechanistic approaches for chemically modifying the coordination sphere of copper–amyloid-{beta} complexes,” by Jiyeon Han, Hyuck Jin Lee, Kyu Yeon Kim, Geewoo Nam, Junghyun Chae, and Mi Hee Lim (Vol. 117, No. 10, March 10, 2020, p. 5160-5167).
www.pnas.org/content/117/10/5160
B. “Dynamics of life expectancy and life span equality,” by José Manuel Aburto, Francisco Villavicencio, Ugofilippo Basellini, Søren Kjærgaard, and James W. Vaupel (Vol. 117, No. 10, March 10, 2020, p. 5250-5259).
Note: Check with your organization’s library for availability.
A. “Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination,” by Su Jin Ham, Daewon Lee, Heesuk Yoo, Kyoungho Jun, Heejin Shin, and Jongkyeong Chung (Vol. 117, No. 8, February 25, 2020, p. 4281-4291).
www.pnas.org/content/117/8/4281
B. “Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging,” by Xin Li, Jiaqiang Wang, Leyun Wang, Guihai Feng, Gen Li, Meixin Yu, Yufei Li, Chao Liu, Xuewei Yuan, Guangxi Zang, Zhihuan Li, Ling Zhao, Hong Ouyang, Qingli Quan, Guangyu Wang, Charlotte Zhang, Oulan Li, Junkai Xiang, Jian-Kang Zhu, Wei Li, Qi Zhou, and Kang Zhang (Vol. 117, No. 8, February 25, 2020, p. 4328-4336).
www.pnas.org/content/117/8/4328
C. “Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3{beta} in Alzheimer’s disease,” by Tanusree Sen, Pampa Saha, Tong Jiang, and Nilkantha Sen (Vol. 117, No. 8, February 25, 2020, p. 4418-4427).
Note: Check with your organization’s library for availability. “The {alpha}-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure,” by David R. Boyer, Binsen Li, Chuanqi Sun, Weijia Fan, Kang Zhou, Michael P. Hughes, Michael R. Sawaya, Lin Jiang, and David S. Eisenberg (Vol. 117, No. 7, February 18, 2020, p. 3592-3602).
Note: Check with your organization’s library for availability.
A. “Release of a disordered domain enhances HspB1 chaperone activity toward tau,” by Hannah E. R. Baughman, Thanh-Hau T. Pham, Chloe S. Adams, Abhinav Nath, and Rachel E. Klevit (Vol. 117, No. 6, February 11, 2020, p. 2923-2929).
www.pnas.org/content/117/6/2923
B. “FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis,” by Kwang Il Lee, Sungwook Choi, Tokio Matsuzaki, Oscar Alvarez-Garcia, Merissa Olmer, Shawn P. Grogan, Darryl D. D’Lima, and Martin K. Lotz (Vol. 117, No. 6, February 11, 2020, p. 3135-3143).
Note: Check with your organization’s library for availability. “NK cells clear {alpha}-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of {alpha}-synucleinopathy,” by Rachael H. Earls, Kelly B. Menees, Jaegwon Chung, Claire-Anne Gutekunst, Hyun Joon Lee, Manuel G. Hazim, Balázs Rada, Levi B. Wood, and Jae-Kyung Lee (Vol. 117, No. 3, January 21, 2020, p. 1762-1771).
Note: Check your organization’s library for availability.
A. “Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease,” by Amy F. T. Arnsten, Dibyadeep Datta, Shannon Leslie, Sheng-Tao Yang, Min Wang, and Angus C. Nairn (Vol. 116, No. 52, December 26, 2019, p. 26230-26238).
www.pnas.org/content/116/52/26230
B. “Oligomeric A{beta} in the monkey brain impacts synaptic integrity and induces accelerated cortical aging,” by Danielle Beckman, Sean Ott, Kristine Donis-Cox, William G. Janssen, Eliza Bliss-Moreau, Peter H. Rudebeck, Mark G. Baxter, and John H. Morrison (Vol. 116, No. 52, December 26, 2019, p. 26239-26246).
www.pnas.org/content/116/52/26239
C. “Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function,” by Daniel T. Gray and Carol A. Barnes (Vol. 116, No. 52, December 26, 2019, p. 26247-26254).
Note: For full text availability check your organization’s library. “Endogenous retroviruses are associated with hippocampus-based memory impairment,” by Roman Sankowski, Joshua J. Strohl, Tomás S. Huerta, Elham Nasiri, Andrea N. Mazzarello, Cristina D’Abramo, Kai Fan Cheng, Ori Staszewski, Marco Prinz, Patricio T. Huerta, and Yousef Al-Abed (Vol. 116, No. 51, December 17, 2019, p. 25982-25990).
Note: For full text availability check your organization’s library. “A locomotor assay reveals deficits in heterozygous Parkinson’s disease model and proprioceptive mutants in adult Drosophila,” by Aman Aggarwal, Heinrich Reichert, and K. VijayRaghavan (Vol. 116, No. 49, December 3, 2019, p. 24830-24839).
Note: For full text availability check your organization’s library.
A. “Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration,” by Andrew P. Voigt, Kelly Mulfaul, Nathaniel K. Mullin, Miles J. Flamme-Wiese, Joseph C. Giacalone, Edwin M. Stone, Budd A. Tucker, Todd E. Scheetz, and Robert F. Mullins (Vol. 116, No. 48, November 26, 2019, p. 24100-24107).
www.pnas.org/content/116/48/24100
B. “Elovanoids counteract oligomeric {beta}-amyloid-induced gene expression and protect photoreceptors,” by Khanh V. Do, Marie-Audrey I. Kautzmann, Bokkyoo Jun, William C. Gordon, Robert Nshimiyimana, Rong Yang, Nicos A. Petasis, and Nicolas G. Bazan (Vol. 116, No. 48, November 26, 2019, p. 24317-24325).
Note: Check with you organization’s library for availability.
A. “N,N′-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice,” by Min Hee Park, Misun Lee, Geewoo Nam, Mingeun Kim, Juhye Kang, Byung Jo Choi, Min Seock Jeong, Kang Ho Park, Wan Hui Han, Eunyoung Tak, Min Sun Kim, Juri Lee, Yuxi Lin, Young-Ho Lee, Im-Sook Song, Min-Koo Choi, Joo-Yong Lee, Hee Kyung Jin, Jae-sung Bae, and Mi Hee Lim (Vol. 116, No. 47, November 19, 2019, p. 23426-23436).
www.pnas.org/content/116/47/23426
B. “Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina,” by Shoji Notomi, Kenji Ishihara, Nikolaos E. Efstathiou, Jong-Jer Lee, Toshio Hisatomi, Takashi Tachibana, Eleni K. Konstantinou, Takashi Ueta, Yusuke Murakami, Daniel E. Maidana, Yasuhiro Ikeda, Shinji Kume, Hiroto Terasaki, Shozo Sonoda, Judith Blanz, Lucy Young, Taiji Sakamoto, Koh-Hei Sonoda, Paul Saftig, Tatsuro Ishibashi, Joan W. Miller, Guido Kroemer, and Demetrios G. Vavvas (Vol. 116, No. 47, November 19, 2019, p. 23724-23734).
www.pnas.org/content/116/47/23724
C. “Swim exercise in Caenorhabditis elegans extends neuromuscular and gut healthspan, enhances learning ability, and protects against neurodegeneration,” by Ricardo Laranjeiro, Girish Harinath, Jennifer E. Hewitt, Jessica H. Hartman, Mary Anne Royal, Joel N. Meyer, Siva A. Vanapalli, and Monica Driscoll (Vol. 116, No. 47, November 19, 2019, p. 23829-23839).
A. “An antibody against HK blocks Alzheimer’s disease peptide {beta}-amyloid-induced bradykinin release in human plasma,” by Zu-Lin Chen, Pradeep Singh, Jyen Wong, Katharina Horn, Sidney Strickland, and Erin H. Norris (Vol. 116, No. 46, November 12, 2019, p. 22921-22923).
www.pnas.org/content/116/46/22921
B. “SERF engages in a fuzzy complex that accelerates primary nucleation of amyloid proteins,” by Ben A. Meinen, Varun V. Gadkari, Frederick Stull, Brandon T. Ruotolo, and James C. A. Bardwell (Vol. 116, No. 46, November 12, 2019, p. 23040-23049). Note: Check with you organization’s library for availability.
“Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer’s molecular signatures,” by Abhijeet Sharma, Syed Faraz Kazim, Chloe S. Larson, Aarthi Ramakrishnan, Jason D. Gray, Bruce S. McEwen, Paul A. Rosenberg, Li Shen, and Ana C. Pereira (Vol. 116, No. 43, October 25, 2019, p. 21800-21811).
A. “Amyloid-beta impairs TOM1-mediated IL-1R1 signaling,” by Alessandra Cadete Martini, Angela Gomez-Arboledas, Stefania Forner, Carlos J. Rodriguez-Ortiz, Amanda McQuade, Emma Danhash, Jimmy Phan, Dominic Javonillo, Jordan-Vu Ha, Melanie Tram, Laura Trujillo-Estrada, Celia da Cunha, Rahasson R. Ager, Jose C. Davila, Masashi Kitazawa, Mathew Blurton-Jones, Antonia Gutierrez, David Baglietto-Vargas, Rodrigo Medeiros, and Frank M. LaFerla (Vol. 116, No. 42, October 15, 2019, p. 21198-21206).
www.pnas.org/content/116/42/21198
B. “Gray Matter Age Prediction as a Biomarker for Risk of Dementia,” by Johnny Wang, Maria J. Knol, Aleksei Tiulpin, Florian Dubost, Marleen de Bruijne, Meike W. Vernooij, Hieab H. H. Adams, M. Arfan Ikram, Wiro J. Niessen, and Gennady V. Roshchupkin (Vol. 116, No. 42, October 15, 2019, p. 21213-21218).
A. “Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence,” by Cristian Tomasetti, Justin Poling, Nicholas J. Roberts, Nyall R. London Jr., Meredith E. Pittman, Michael C. Haffner, Anthony Rizzo, Alex Baras, Baktiar Karim, Antonio Kim, Christopher M. Heaphy, Alan K. Meeker, Ralph H. Hruban, Christine A. Iacobuzio-Donahue, and Bert Vogelstein (Vol. 116, No. 41, October 8, 2019, p. 20482-20488).
www.pnas.org/content/116/41/20482
B. “Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and {alpha}-synuclein stability through membrane remodeling,” by Akio Mori, Taku Hatano, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Takahiro Koinuma, Hongrui Meng, Shin-ichiro Kubo, Spencer Spratt, Changxu Cui, Chikara Yamashita, Yoshimi Miki, Kei Yamamoto, Tetsuya Hirabayashi, Makoto Murakami, Yoshikazu Takahashi, Hideo Shindou, Takashi Nonaka, Masato Hasegawa, Ayami Okuzumi, Yuzuru Imai, and Nobutaka Hattori (Vol. 116, No. 41, October 8, 2019, p. 20689-20699).
A. “Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women,” by Lewina O. Lee, Peter James, Emily S. Zevon, Eric S. Kim, Claudia Trudel-Fitzgerald, Avron Spiro III, Francine Grodstein, and Laura D. Kubzansky (Vol. 116, No. 37, September 10, 2019, p. 18357-18362).
www.pnas.org/content/116/37/18357
B. “The joint influence of intelligence and practice on skill development throughout the life span,” by Nemanja Vaci, Peter Edelsbrunner, Elsbeth Stern, Aljoscha Neubauer, Merim Bilalić, and Roland H. Grabner (Vol. 116, No. 37, September 10, 2019, p. 18363-18369).
“Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis,” by Latika Matai, Gautam Chandra Sarkar, Manish Chamoli, Yasir Malik, Shashi Shekhar Kumar, Umanshi Rautela, Nihar Ranjan Jana, Kausik Chakraborty, and Arnab Mukhopadhyay (Vol. 116, No. 35, August 27, 2019, p. 17383-17392).
www.pnas.org/content/116/35/17383
“Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson’s disease,” by Joohyung Lee, Paulo Pinares-Garcia, Hannah Loke, Seungmin Ham, Eric Vilain, and Vincent R. Harley (Vol. 116, No. 33, August 13, 2019, p. 16577-16582).
“Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network,” by Hayriye Cagnan, Nicolas Mallet, Christian K. E. Moll, Alessandro Gulberti, Abbey B. Holt, Manfred Westphal, Christian Gerloff, Andreas K. Engel, Wolfgang Hamel, Peter J. Magill, Peter Brown, and Andrew Sharott (Vol. 116, No. 32, August 6, 2019, p. 16095-16104).
“NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models,” by Gahee Bahn, Jong-Sung Park, Ui Jeong Yun, Yoon Jee Lee, Yuri Choi, Jin Su Park, Seung Hyun Baek, Bo Youn Choi, Yoon Suk Cho, Hark Kyun Kim, Jihoon Han, Jae Hoon Sul, Sang-Ha Baik, Jinhwan Lim, Nobunao Wakabayashi, Soo Han Bae, Jeung-Whan Han, Thiruma V. Arumugam, Mark P. Mattson, and Dong-Gyu Jo (Vol. 116, No. 25, June 18, 2019, p. 12516-12523).
“Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy,” by Takayuki Inoue, Satoshi Saito, Masashi Tanaka, Hajime Yamakage, Toru Kusakabe, Akira Shimatsu, Masafumi Ihara, and Noriko Satoh-Asahara (Vol. 116, No. 20, May 14, 2019, p. 10031-10038).
“Toward personalized cognitive diagnostics of at-genetic-risk Alzheimer’s disease,” by Gillian Coughlan, Antoine Coutrot, Mizanur Khondoker, Anne-Marie Minihane, Hugo Spiers, and Michael Hornberger (Vol. 116, No. 19, May 7, 2019, p. 9285-9292).
A. “{alpha}-Sheet secondary structure in amyloid {beta}-peptide drives aggregation and toxicity in Alzheimer’s disease,” by Dylan Shea, Cheng-Chieh Hsu, Timothy M. Bi, Natasha Paranjapye, Matthew Carter Childers, Joshua Cochran, Colson P. Tomberlin, Libo Wang, Daniel Paris, Jeffrey Zonderman, Gabriele Varani, Christopher D. Link, Mike Mullan, and Valerie Daggett (Vol. 116, No. 18, April 30, 2019, p. 8895-8900).
www.pnas.org/content/116/18/8895
B. “Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies,” by Jie Xiang, Zhi-Hao Wang, Eun Hee Ahn, Xia Liu, Shan-Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Gong Ju, Shengxi Wu, and Keqiang Ye (Vol. 116, No. 18, April 30, 2019, p. 9094-9102).
“Age-related inflammation triggers skeletal stem/progenitor cell dysfunction,” by Anne Marie Josephson, Vivian Bradaschia-Correa, Sooyeon Lee, Kevin Leclerc, Karan S. Patel, Emma Muinos Lopez, Hannah P. Litwa, Shane S. Neibart, Manasa Kadiyala, Madeleine Z. Wong, Matthew M. Mizrahi, Nury L. Yim, Austin J. Ramme, Kenneth A. Egol, and Philipp Leucht (Vol. 116, No. 14, April 2, 2019, p. 6995-7004).
A. “Advantaged socioeconomic conditions in childhood are associated with higher cognitive functioning but stronger cognitive decline in older age,” by Marja J. Aartsen, Boris Cheval, Stefan Sieber, Bernadette W. Van der Linden, Rainer Gabriel, Delphine S. Courvoisier, Idris Guessous, Claudine Burton-Jeangros, David Blane, Andreas Ihle, Matthias Kliegel, and Stephane Cullati (Vol. 116, No. 12, March 19, 2019, p. 5478-5486).
www.pnas.org/content/116/12/5478
B. “Parkinson’s disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration,” by Xi Chen, Jennifer K. Kordich, Erin T. Williams, Nathan Levine, Allyson Cole-Strauss, Lee Marshall, Viviane Labrie, Jiyan Ma, Jack W. Lipton, and Darren J. Moore (Vol. 116, No. 12, March 19, 2019, p. 5765-5774). Note: PNAS is providng open access to the full-text of this article.
“Hippocampal atrophy and intrinsic brain network dysfunction relate to alterations in mind wandering in neurodegeneration,” by Claire O’Callaghan, James M. Shine, John R. Hodges, Jessica R. Andrews-Hanna, and Muireann Irish (Vol. 116, No. 8, February 19, 2019, p. 3316-3321).
“Influence of young adult cognitive ability and additional education on later-life cognition,” by William S. Kremen, Asad Beck, Jeremy A. Elman, Daniel E. Gustavson, Chandra A. Reynolds, Xin M. Tu, Mark E. Sanderson-Cimino, Matthew S. Panizzon, Eero Vuoksimaa, Rosemary Toomey, Christine Fennema-Notestine, Donald J. Hagler Jr., Bin Fang, Anders M. Dale, Michael J. Lyons, and Carol E. Franz (Vol. 116, No. 6, February 5, 2019, p. 2021-2026).
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