“Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence,” by Yao Li, Damir Kračun, Christopher M. Dustin, Mohamed El Massry, Shuai Yuan, Christian J. Goossen, Evan R. DeVallance, Sanghamitra Sahoo, Cynthia St. Hilaire, Aditi U. Gurkar, Toren Finkel, Adam C. Straub, Eugenia Cifuentes-Pagano, and Patrick J. Pagano (Vol. 118, No. 42, October 19, 2021, e2015666118).
October 19, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 19, 2021
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October 12, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 12, 2021
“Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration,” by Meenakshi Ambati, Ivana Apicella, Shao-bin Wang, Siddharth Narendran, Hannah Leung, Felipe Pereira, Yosuke Nagasaka, Peirong Huang, Akhil Varshney, Kirstie L. Baker, Kenneth M. Marion, Mehrdad Shadmehr, Cliff I. Stains, Brian C. Werner, Srinivas R. Sadda, Ethan W. Taylor, S. Scott Sutton, Joseph Magagnoli, and Bradley D. Gelfand (Vol. 118, No. 41, October 12, 2021, e2102975118).
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October 5, 2021
CAAR – Proceedings of the National Academy of Science Article Abstracts – October 5, 2021
A. “Inequality in mortality between Black and White Americans by age, place, and cause and in comparison to Europe, 1990 to 2018,” by Hannes Schwandt, Janet Currie, Marlies Bär, James Banks, Paola Bertoli, Aline Bütikofer, Sarah Cattan, Beatrice Zong-Ying Chao, Claudia Costa, Libertad González, Veronica Grembi, Kristiina Huttunen, René Karadakic, Lucy Kraftman, Sonya Krutikova, Stefano Lombardi, Peter Redler, Carlos Riumallo-Herl, Ana Rodríguez-González, Kjell G. Salvanes, Paula Santana, Josselin Thuilliez, Eddy van Doorslaer, Tom Van Ourti, Joachim K. Winter, Bram Wouterse, and Amelie Wuppermann (Vol. 118, No. 40, October 5, 2021, e2104684118).
www.pnas.org/content/118/40/e2104684118.abstract?etoc
B. “Metabolism modulates network synchrony in the aging brain,” by Corey Weistuch, Lilianne R. Mujica-Parodi, Rostam M. Razban, Botond Antal, Helena van Nieuwenhuizen, Anar Amgalan, and Ken A. Dill (Vol. 118, No. 40, October 5, 2021, e2025727118).
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September 29, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 29, 2021
“Amyloid-{beta} peptide dimers undergo a random coil to {beta}-sheet transition in the aqueous phase but not at the neuronal membrane,” by Hebah Fatafta, Mohammed Khaled, Michael C. Owen, Abdallah Sayyed-Ahmad, and Birgit Strodel (Vol. 118, No. 39, September 28, 2021, e2106210118).
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September 22, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 22, 2021
“Frustrated peptide chains at the fibril tip control the kinetics of growth of amyloid-{beta} fibrils,” by Yuechuan Xu, Kaitlin Knapp, Kyle N. Le, Nicholas P. Schafer, Mohammad S. Safari, Aram Davtyan, Peter G. Wolynes, and Peter G. Vekilov (Vol. 118, No. 38, September 21, 2021, e2110995118).
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September 15, 2021
CAAR – Proceedings of the National Academy of Science Article Abstracts – September 15, 2021
A. “Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites,” by Takayuki Teruya, Yung-Ju Chen, Hiroshi Kondoh, Yasuhide Fukuji, and Mitsuhiro Yanagida (Vol. 118, No. 37, September 14, 2021, e2022857118).
www.pnas.org/content/118/37/e2022857118.abstract
B. “FGF-2–dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis,” by Sebastian Mathes, Alexandra Fahrner, Umesh Ghoshdastider, Hannes A. Rüdiger, Michael Leunig, Christian Wolfrum, and Jan Krützfeldt (Vol. 118, No. 37, September 14, 2021, e2021013118).
www.pnas.org/content/118/37/e2021013118.abstract
C. “NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING,” by Yujun Hou, Yong Wei, Sofie Lautrup, Beimeng Yang, Yue Wang, Stephanie Cordonnier, Mark P. Mattson, Deborah L. Croteau, and Vilhelm A. Bohr (Vol. 118, No. 37, September 14, 2021, e2011226118).
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September 7, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 7, 2021
“All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of {alpha}-synuclein toxic species,” by Aitor Franco, Pablo Gracia, Adai Colom, José D. Camino, José Ángel Fernández-Higuero, Natalia Orozco, Alexander Dulebo, Leonor Saiz, Nunilo Cremades, Jose M.G. Vilar, Adelina Prado, and Arturo Muga (Vol. 118, No. 36, September 7, 2021, e2105548118).
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August 31, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 31, 2021
“The N terminus of {alpha}-synuclein dictates fibril formation,” by Ryan P. McGlinchey, Xiaodan Ni, Jared A. Shadish, Jiansen Jiang, and Jennifer C. Lee (Vol. 118, No. 35, August 31, 2021, e2023487118).
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August 25, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 25, 2021
“Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration,” by Chenyin Wang, Chun Yin Lau, Fuqiang Ma, and Chaogu Zheng (Vol. 118, No. 34, August 24, 2021, e2106504118).
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August 18, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – August 18, 2021
A. “Effects of sex and aging on the immune cell landscape as assessed by single-cell transcriptomic analysis,” by Zhaohao Huang, Binyao Chen, Xiuxing Liu, He Li, Lihui Xie, Yuehan Gao, Runping Duan, Zhaohuai Li, Jian Zhang, Yingfeng Zheng, and Wenru Su (Vol. 118, No. 33, August 17, 2021, e2023216118).
www.pnas.org/content/118/33/e2023216118.abstract?etoc
B. “Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol,” by Hao Wang, Joshua A. Kulas, Chao Wang, David M. Holtzman, Heather A. Ferris, and Scott B. Hansen (Vol. 118, No. 33, August 17, 2021, e2102191118).
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August 11, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 11, 2021
“Psychological resilience predicting cardiometabolic conditions in adulthood in the Midlife in the United States Study,” by Kristen M. Nishimi, Karestan C. Koenen, Brent A. Coull, Ruijia Chen, and Laura D. Kubzansky (Vol. 118, No. 32, August 10, 2021, e2102619118).
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July 6, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 6, 2021
A. “Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading,” by Yin Xu, Nicholas E. Propson, Shuqi Du, Wen Xiong, and Hui Zheng (Vol. 118, No. 27, July 6, 2021, e2023418118).
www.pnas.org/content/118/27/e2023418118.abstract?etoc
B. “Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice,” by Kathleen M. Schoch, Lubov A. Ezerskiy, Michaela M. Morhaus, Riley N. Bannon, Andrew D. Sauerbeck, Mark Shabsovich, Paymaan Jafar-nejad, Frank Rigo, and Timothy M. Miller (Vol. 118, No. 27, July 6, 2021, e2100356118).
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June 17, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 17, 2021
“The balance of giving versus receiving social support and all-cause mortality in a US national sample,” by Edith Chen, Phoebe H. Lam, Eric D. Finegood, Nicholas A. Turiano, Daniel K. Mroczek, and Gregory E. Miller (Vol. 118, No. 24, June 15, 2021, e2024770118).
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June 1, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 1, 2021
“Aging as a consequence of selection to reduce the environmental risk of dying,” by Stig W. Omholt and Thomas B. L. Kirkwood (Vol. 118, No. 22, June 1, 2021, e2102088118).
www.pnas.org/content/118/22/e2102088118.abstract?etoc
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May 18, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 18, 2021
“Death rates at specific life stages mold the sex gap in life expectancy,” by Virginia Zarulli, Ilya Kashnitsky, and James W. Vaupel (Vol. 118, No. 20, May 18, 2021, e2010588118).
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May 6, 2021
CAAR – Proceedings of the National Academy of Science Article Abstract – May 6, 2021
“Educational attainment does not influence brain aging,” by Lars Nyberg, Fredrik Magnussen, Anders Lundquist, William Baaré, David Bartrés-Faz, Lars Bertram, C. J. Boraxbekk, Andreas M. Brandmaier, Christian A. Drevon, Klaus Ebmeier, Paolo Ghisletta, Richard N. Henson, Carme Junqué, Rogier Kievit, Maike Kleemeyer, Ethan Knights, Simone Kühn, Ulman Lindenberger, Brenda W. J. H. Penninx, Sara Pudas, Øystein Sørensen, Lídia Vaqué-Alcázar, Kristine B. Walhovd, and Anders M. Fjell (Vol. 118, No. 18, May 4, 2021, e2101644118).
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April 22, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 22, 2021
“Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer’s disease,” by Jodie Lord, Bradley Jermy, Rebecca Green, Andrew Wong, Jin Xu, Cristina Legido-Quigley, Richard Dobson, Marcus Richards, and Petroula Proitsi (Vol. 118, No. 16, April 20, 2021, e2009808118).
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April 15, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 15, 2021
“Soluble {alpha}-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia,” by Dorit Trudler, Kristopher L. Nazor, Yvonne S. Eisele, Titas Grabauskas, Nima Dolatabadi, James Parker, Abdullah Sultan, Zhenyu Zhong, Marshall S. Goodwin, Yona Levites, Todd E. Golde, Jeffery W. Kelly, Michael R. Sierks, Nicholas J. Schork, Michael Karin, Rajesh Ambasudhan, and Stuart A. Lipton (Vol. 118, No. 15, April 13, 2021, e2025847118).
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March 24, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 24, 2021
“Rapid initiation of cell cycle reentry processes protects neurons from amyloid-{beta} toxicity,” by Stefania Ippati, Yuanyuan Deng, Julia van der Hoven, Celine Heu, Annika van Hummel, Sook Wern Chua, Esmeralda Paric, Gabriella Chan, Astrid Feiten, Thomas Fath, Yazi D. Ke, Nikolas K. Haass, and Lars M. Ittner (Vol. 118, No. 12, March 23, 2021, e2011876118).
www.pnas.org/content/118/12/e2011876118.abstract?etoc
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March 18, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 18, 2021
A. “Life expectancy in adulthood is falling for those without a BA degree, but as educational gaps have widened, racial gaps have narrowed,” by Anne Case and Angus Deaton (Vol. 118, No. 11, March 16, 2021, e2024777118).
www.pnas.org/content/118/11/e2024777118.abstract?etoc
B. “Unique molecular characteristics and microglial origin of Kv1.3 channel–positive brain myeloid cells in Alzheimer’s disease,” by Supriya Ramesha, Sruti Rayaprolu, Christine A. Bowen, Cynthia R. Giver, Sara Bitarafan, Hai M. Nguyen, Tianwen Gao, Michael J. Chen, Ngozi Nwabueze, Eric B. Dammer, Amanda K. Engstrom, Hailian Xiao, Andrea Pennati, Nicholas T. Seyfried, David J. Katz, Jacques Galipeau, Heike Wulff, Edmund K. Waller, Levi B. Wood, Allan I. Levey, and Srikant Rangaraju (Vol. 118, No. 11, March 16, 2021, e2013545118).
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March 11, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 11, 2021
“Structural insights into {alpha}-synuclein monomer–fibril interactions,” by Pratibha Kumari, Dhiman Ghosh, Agathe Vanas, Yanick Fleischmann, Thomas Wiegand, Gunnar Jeschke,Roland Riek, and Cédric Eichmann (Vol. 118, No. 10, March 9, 2021, e2012171118).
www.pnas.org/content/118/10/e2012171118.abstract?etoc
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March 3, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 3, 2021
“TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau,” by Peter E. A. Ash, Shuwen Lei, Jenifer Shattuck, Samantha Boudeau, Yari Carlomagno, Maria Medalla, Bryce L. Mashimo, Guillermo Socorro, Louloua F. A. Al-Mohanna, Lulu Jiang, Muhammet M. Öztürk, Mark Knobel, Pavel Ivanov, Leonard Petrucelli, Susanne Wegmann, Nicholas M. Kanaan, and Benjamin Wolozin (Vol. 118, No. 9, March 2, 2021, e2014188118).
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February 9, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 9, 2021
“Developmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration,” by Dávid Nagy, Katelin A. Ennis, Ru Wei, Susan C. Su, Christopher A. Hinckley, Rong-Fang Gu, Benbo Gao, Ramiro H. Massol, Chris Ehrenfels, Luke Jandreski, Ankur M. Thomas, Ashley Nelson, Stefka Gyoneva, Mihály Hajós, and Linda C. Burkly (Vol. 118, No. 6, February 9, 2021, e2001679118).
www.pnas.org/content/118/6/e2001679118.abstract?etoc
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February 4, 2021
CAAR – Proceedings of the National Academy of Science Article Abstract – February 4, 2021
“Reductions in 2020 US life expectancy due to COVID-9 and the disproportionate impact on the Black and Latino populations,” by Theresa Andrasfay and Noreen Goldman (Vol. 118, No. 5, February 2, 2021, e20147461180).
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January 19, 2021
CAAR – Proceedings of the National Academy of Science Article Abstracts – January 19, 2021
A. “Prediction of Alzheimer’s disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening,” by Sung-Hyun Kim, Sumin Yang, Key-Hwan Lim, Euiseng Ko, Hyun-Jun Jang, Mingon Kang, Pann-Ghill Suh, and Jae-Yeol Joo (Vol. 118, No. 3, January 19, 2021, e2011250118).
www.pnas.org/content/118/3/e2011250118.abstract?etoc
B. “Childhood self-control forecasts the pace of midlife aging and preparedness for old age,” by Leah S. Richmond-Rakerd, Avshalom Caspi, Antony Ambler, Tracy d’Arbeloff, Marieke de Bruine, Maxwell Elliott, HonaLee Harrington, Sean Hogan, Renate M. Houts, David Ireland, Ross Keenan, Annchen R. Knodt, Tracy R. Melzer, Sena Park, Richie Poulton, Sandhya Ramrakha, Line Jee Hartmann Rasmussen, Elizabeth Sack, Adam T. Schmidt, Maria L. Sison, Jasmin Wertz, Ahmad R. Hariri, and Terrie E. Moffitt (Vol. 118, No. 3, January 19, 2021, e2010211118).
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January 6, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 6, 2021
A. “Nursing home staff networks and COVID-19,” by M. Keith Chen, Judith A. Chevalier, and Elisa F. Long (Vol. 118, No. 1, January 5, 2021, e2015455118).
www.pnas.org/content/118/1/e2015455118.abstract?etoc
B. “The Parkinson’s disease-associated gene ITPKB protects against {alpha}-synuclein aggregation by regulating ER-to-mitochondria calcium release,” by Daniel J. Apicco, Evgeny Shlevkov, Catherine L. Nezich, David T. Tran, Edward Guilmette, Justin W. Nicholatos, Collin M. Bantle, Yi Chen, Kelly E. Glajch, Neeta A. Abraham, Lan T. Dang, G. Campbell Kaynor, Ellen A. Tsai, Khanh-Dung H. Nguyen, Joost Groot, YuTing Liu, Andreas Weihofen, Jessica A. Hurt, Heiko Runz, and Warren D. Hirst (Vol. 118, No. 1, January 5, 2021, e2006476118).
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December 29, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 29, 2020
“Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model,” by Kelly M. Lohr, Bess Frost, Clemens Scherzer, and Mel B. Feany (Vol. 117, No. 52, December 29, 2020, p. 33608-33618).
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December 28, 2020
CAAR – Proceedings of the National Academy of Science Article Abstract – December 28, 2020
“Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer’s disease,” by Sonam Dubey, Stefan Heinen, Slavica Krantic, JoAnne McLaurin, Donald R. Branch, Kullervo Hynynen, and Isabelle Aubert (Vol. 117, No. 51, December 23, 2020, p. 32691-32700).
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December 9, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 9, 2020
“Design of a multivalent bifunctional chelator for diagnostic 64Cu PET imaging in Alzheimer’s disease,” by Hong-Jun Cho, Truc T. Huynh, Buck E. Rogers, and Liviu M. Mirica (Vol. 117, No. 49, December 8, 2020, p. 30928-30933).
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December 1, 2020
CAAR – Proceedings of the National Academy of Science Article Abstract – December 1, 2020
“Global associations between macronutrient supply and age-specific mortality,” by Alistair M. Senior, Shinichi Nakagawa, David Raubenheimer, and Stephen J. Simpson (Vol. 117, No. 48, December 1, 2020, p. 30824-30835).
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November 25, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 25, 2020
“Aging and the encoding of changes in events: The role of neural activity pattern reinstatement,” by David Stawarczyk, Christopher N. Wahlheim, Joset A. Etzel, Abraham Z. Snyder, and Jeffrey M. Zacks (Vol. 117, No. 47, November 24, 2020, p. 29346-29353).
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November 4, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 4, 2020
A. “Life cycle patterns of cognitive performance over the long run,” by Anthony Strittmatter, Uwe Sunde, and Dainis Zegners (Vol. 117, No. 44, November 3, 2020, p. 27255-27261).
www.pnas.org/content/117/44/27255.abstract.html?etoc
B. “Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance,” by Oeystein Roed Brekk, Jonathan R. Honey, Seungil Lee, Penelope J. Hallett, and Ole Isacson (Vol. 117, No. 44, November 3, 2020, p. 27646-27654).
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October 20, 2020
CAAR – Proceedings of the National Academy of Science Article Abstract – October 20, 2020
“Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria,” by Danielle E. Mor, Salman Sohrabi, Rachel Kaletsky, William Keyes, Alp Tartici, Vrinda Kalia, Gary W. Miller, and Coleen T. Murphy (Vol. 117, No. 42, October 20, 2020, p. 26438-26447).
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October 14, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstract -October 14, 2020
“Single-nuceus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease,” by Shun-Fat Lau, Han Cao, Amy K. Y. Fu, and Nancy Y. Ip (Vol. 117, No. 41, October 13, 2020, p. 25272-25283).
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October 9, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 9, 2020
“Decoding the mystery of American pain reveals a warning for the future,” by Anne Case, Angus Deaton, and Arthur A. Stone (Vol. 117, No. 40, October 6, 2020, p. 24785-24789).
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July 28, 2020
CAAR – Proceedings of the National Academy of Science Article – July 28, 2020
Note: Check with your organization’s library for availability. “Quantifying and explaining variation in life expectancy at census tract, county, and state levels in the United States,” by Antonio Fernando Boing, Alexandra Crispim Boing, Jack Cordes, Rockli Kim, and S. V. Subramanian (Vol. 117, No. 30, July 28, 2020, p. 17688-17694).
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July 22, 2020
CAAR – Proceedings of the National Academies of Science Article Abstracts – July 22, 2020
A. “Dopaminergic neurodegeneration induced by Parkinson’s disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity,” by An Phu Tran Nguyen, Elpida Tsika, Kaela Kelly, Nathan Levine, Xi Chen, Andrew B. West, Sylviane Boularand, Pascal Barneoud, and Darren J. Moore (Vol. 117, No. 29, July 21, 2020, p. 17296-17307).
www.pnas.org/content/117/29/17296
B. “Basal ganglia beta oscillations during sleep underlie Parkinsonian insomnia,” by Aviv D. Mizrahi-Kliger, Alexander Kaplan, Zvi Israel, Marc Deffains, and Hagai Bergman (Vol. 117, No. 29, July 21, 2020, p. 17359-17368).
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July 14, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 14, 2020
Note: Check with your organization’s library for availability.
A. “The transition to family caregiving and its effect on biomarkers of inflammation,” by David L. Roth, William E. Haley, Orla C. Sheehan, Jin Huang, J. David Rhodes, Peter Durda, Virginia J. Howard, Jeremy D. Walston, and Mary Cushman (Vol. 117, No. 28, July 14, 2020, p. 16258-16263).
www.pnas.org/content/117/28/16258
B. “Predicting mortality from 57 economic, behavioral, social, and psychological factors,” by Eli Puterman, Jordan Weiss, Benjamin A. Hives, Alison Gemmill, Deborah Karasek, Wendy Berry Mendes, and David H. Rehkopf (Vol. 117, No. 28, July 14, 2020, p. 16273-16282).
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July 1, 2020
CAAR – Proceedings of the National Academy of Sciences Article – July 1, 2020
Note: Check with your organization’s library for availability. “Impact of alpha-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized alpha-synuclein rat model of PD,” by Deirdre B. Hoban, Shelby Shrigley, Bengt Mattsson, Ludivine S. Breger, Ulla Jarl, Tiago Cardoso, Jenny Nelander Wahlestedt, Kelvin C. Luk, Anders Björklund, and Malin Parmar (Vol. 117, No. 26, June 30, 2020, p. 15209-15220).
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June 23, 2020
CAAR – Proceedings of the National Academy of Sciences Article – June 23, 2020
Note: Check with your organization’s library for availability. “Cerebral amyloid angiopathy-linked {beta}-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen,” by Steven A. Cajamarca, Erin H. Norris, Louise van der Weerd, Sidney Strickland, and Hyung Jin Ahn (Vol. 117, No. 25, June 23, 2020, p. 14482-14492).
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May 27, 2020
CAAR – Proceedings of the National Academy of Science Article – May 27, 2020
Note: Check with your organization’s library for availability. “Ultrastructural evidence for self-replication of Alzheimer-associated A{beta}42 amyloid along the sides of fibrils,” by Mattias Törnquist, Risto Cukalevski, Ulrich Weininger, Georg Meisl, Tuomas P. J. Knowles, Thom Leiding, Anders Malmendal, Mikael Akke, and Sara Linse (Vol. 117, No. 21, May 26, 2020, p. 11265-11273).
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April 29, 2020
CAAR – Proceedings of the National Academies of Science Articles – April 29, 2020
Note: Check with your organization’s library for availability.
A. “Noninvasive hippocampal blood-brain barrier opening in Alzheimer’s disease with focused ultrasound,” by Ali R. Rezai, Manish Ranjan, Pierre-François D’Haese, Marc W. Haut, Jeffrey Carpenter, Umer Najib, Rashi I. Mehta, J. Levi Chazen, Zion Zibly, Jennifer R. Yates, Sally L. Hodder, and Michael Kaplitt (Vol. 117, No. 17, April 28, 2020, p. 9180-9182).
www.pnas.org/content/117/17/9180
B. “Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility,” by Masahiro Kameda, Takayuki Teruya, Mitsuhiro Yanagida, and Hiroshi Kondoh (Vol. 117, No. 17, April 28, 2020, p. 9483-9489).
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April 7, 2020
CAAR – Proceedings of the National Academy of Sciences Article – April 7, 2020
Note: Check with your organization’s library for availability. “Population aging, migration, and productivity in Europe,” by Guillaume Marois, Alain Bélanger, and Wolfgang Lutz (Vol. 117, No. 14, April 7, 2020, p. 7690-7695).
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March 31, 2020
CAAR – Proceedings of the National Academy of Sciences Article – March 31, 2020
Note: Check with your organization’s library for availability. “US life expectancy stalls due to cardiovascular disease, not drug deaths,” by Neil K. Mehta, Leah R. Abrams, and Mikko Myrskyla (Vol. 117, No. 13, March 31, 2020, p. 6998-7000).
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March 17, 2020
CAAR – Proceedings of the National Academies of Science Article – March 17, 2020
Note: Check with your organization’s library for availability. “Diet modulates brain network stability, a biomarker for brain aging, in young adults,” by Lilianne R. Mujica-Parodi, Anar Amgalan, Syed Fahad Sultan, Botond Antal, Xiaofei Sun, Steven Skiena, Andrew Lithen, Noor Adra, Eva-Maria Ratai, Corey Weistuch, Sindhuja Tirumalai Govindarajan, Helmut H. Strey, Ken A. Dill, Steven M. Stufflebeam, Richard L. Veech, and Kieran Clarke (Vol. 117, No. 11, March 17, 2020, p. 6170-6177).
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March 11, 2020
CAAR – Proceedings of the National Academy of Sciences Articles
Note: Check with your organization’s library for availability.
A. “Mechanistic approaches for chemically modifying the coordination sphere of copper–amyloid-{beta} complexes,” by Jiyeon Han, Hyuck Jin Lee, Kyu Yeon Kim, Geewoo Nam, Junghyun Chae, and Mi Hee Lim (Vol. 117, No. 10, March 10, 2020, p. 5160-5167).
www.pnas.org/content/117/10/5160
B. “Dynamics of life expectancy and life span equality,” by José Manuel Aburto, Francisco Villavicencio, Ugofilippo Basellini, Søren Kjærgaard, and James W. Vaupel (Vol. 117, No. 10, March 10, 2020, p. 5250-5259).
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February 25, 2020
CAAR – Proceedings of the National Academy of Sciences Articles – February 25, 2020
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A. “Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination,” by Su Jin Ham, Daewon Lee, Heesuk Yoo, Kyoungho Jun, Heejin Shin, and Jongkyeong Chung (Vol. 117, No. 8, February 25, 2020, p. 4281-4291).
www.pnas.org/content/117/8/4281
B. “Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging,” by Xin Li, Jiaqiang Wang, Leyun Wang, Guihai Feng, Gen Li, Meixin Yu, Yufei Li, Chao Liu, Xuewei Yuan, Guangxi Zang, Zhihuan Li, Ling Zhao, Hong Ouyang, Qingli Quan, Guangyu Wang, Charlotte Zhang, Oulan Li, Junkai Xiang, Jian-Kang Zhu, Wei Li, Qi Zhou, and Kang Zhang (Vol. 117, No. 8, February 25, 2020, p. 4328-4336).
www.pnas.org/content/117/8/4328
C. “Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3{beta} in Alzheimer’s disease,” by Tanusree Sen, Pampa Saha, Tong Jiang, and Nilkantha Sen (Vol. 117, No. 8, February 25, 2020, p. 4418-4427).
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February 19, 2020
CAAR – Proceedings of the National Academy of Science Article – February 19, 2020
Note: Check with your organization’s library for availability. “The {alpha}-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure,” by David R. Boyer, Binsen Li, Chuanqi Sun, Weijia Fan, Kang Zhou, Michael P. Hughes, Michael R. Sawaya, Lin Jiang, and David S. Eisenberg (Vol. 117, No. 7, February 18, 2020, p. 3592-3602).
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February 12, 2020
CAAR – Proceedings of the National Academy of Sciences Articles – February 12, 2020
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A. “Release of a disordered domain enhances HspB1 chaperone activity toward tau,” by Hannah E. R. Baughman, Thanh-Hau T. Pham, Chloe S. Adams, Abhinav Nath, and Rachel E. Klevit (Vol. 117, No. 6, February 11, 2020, p. 2923-2929).
www.pnas.org/content/117/6/2923
B. “FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis,” by Kwang Il Lee, Sungwook Choi, Tokio Matsuzaki, Oscar Alvarez-Garcia, Merissa Olmer, Shawn P. Grogan, Darryl D. D’Lima, and Martin K. Lotz (Vol. 117, No. 6, February 11, 2020, p. 3135-3143).
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January 21, 2020
CAAR – Proceedings of the National Academy of Sciences Article – January 21, 2020
Note: Check with your organization’s library for availability. “NK cells clear {alpha}-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of {alpha}-synucleinopathy,” by Rachael H. Earls, Kelly B. Menees, Jaegwon Chung, Claire-Anne Gutekunst, Hyun Joon Lee, Manuel G. Hazim, Balázs Rada, Levi B. Wood, and Jae-Kyung Lee (Vol. 117, No. 3, January 21, 2020, p. 1762-1771).
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