“Educational attainment does not influence brain aging,” by Lars Nyberg, Fredrik Magnussen, Anders Lundquist, William Baaré, David Bartrés-Faz, Lars Bertram, C. J. Boraxbekk, Andreas M. Brandmaier, Christian A. Drevon, Klaus Ebmeier, Paolo Ghisletta, Richard N. Henson, Carme Junqué, Rogier Kievit, Maike Kleemeyer, Ethan Knights, Simone Kühn, Ulman Lindenberger, Brenda W. J. H. Penninx, Sara Pudas, Øystein Sørensen, Lídia Vaqué-Alcázar, Kristine B. Walhovd, and Anders M. Fjell (Vol. 118, No. 18, May 4, 2021, e2101644118).
May 6, 2021
CAAR – Proceedings of the National Academy of Science Article Abstract – May 6, 2021
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April 22, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 22, 2021
“Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer’s disease,” by Jodie Lord, Bradley Jermy, Rebecca Green, Andrew Wong, Jin Xu, Cristina Legido-Quigley, Richard Dobson, Marcus Richards, and Petroula Proitsi (Vol. 118, No. 16, April 20, 2021, e2009808118).
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April 15, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 15, 2021
“Soluble {alpha}-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia,” by Dorit Trudler, Kristopher L. Nazor, Yvonne S. Eisele, Titas Grabauskas, Nima Dolatabadi, James Parker, Abdullah Sultan, Zhenyu Zhong, Marshall S. Goodwin, Yona Levites, Todd E. Golde, Jeffery W. Kelly, Michael R. Sierks, Nicholas J. Schork, Michael Karin, Rajesh Ambasudhan, and Stuart A. Lipton (Vol. 118, No. 15, April 13, 2021, e2025847118).
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March 24, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 24, 2021
“Rapid initiation of cell cycle reentry processes protects neurons from amyloid-{beta} toxicity,” by Stefania Ippati, Yuanyuan Deng, Julia van der Hoven, Celine Heu, Annika van Hummel, Sook Wern Chua, Esmeralda Paric, Gabriella Chan, Astrid Feiten, Thomas Fath, Yazi D. Ke, Nikolas K. Haass, and Lars M. Ittner (Vol. 118, No. 12, March 23, 2021, e2011876118).
www.pnas.org/content/118/12/e2011876118.abstract?etoc
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March 18, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 18, 2021
A. “Life expectancy in adulthood is falling for those without a BA degree, but as educational gaps have widened, racial gaps have narrowed,” by Anne Case and Angus Deaton (Vol. 118, No. 11, March 16, 2021, e2024777118).
www.pnas.org/content/118/11/e2024777118.abstract?etoc
B. “Unique molecular characteristics and microglial origin of Kv1.3 channel–positive brain myeloid cells in Alzheimer’s disease,” by Supriya Ramesha, Sruti Rayaprolu, Christine A. Bowen, Cynthia R. Giver, Sara Bitarafan, Hai M. Nguyen, Tianwen Gao, Michael J. Chen, Ngozi Nwabueze, Eric B. Dammer, Amanda K. Engstrom, Hailian Xiao, Andrea Pennati, Nicholas T. Seyfried, David J. Katz, Jacques Galipeau, Heike Wulff, Edmund K. Waller, Levi B. Wood, Allan I. Levey, and Srikant Rangaraju (Vol. 118, No. 11, March 16, 2021, e2013545118).
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March 11, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 11, 2021
“Structural insights into {alpha}-synuclein monomer–fibril interactions,” by Pratibha Kumari, Dhiman Ghosh, Agathe Vanas, Yanick Fleischmann, Thomas Wiegand, Gunnar Jeschke,Roland Riek, and Cédric Eichmann (Vol. 118, No. 10, March 9, 2021, e2012171118).
www.pnas.org/content/118/10/e2012171118.abstract?etoc
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March 3, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 3, 2021
“TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau,” by Peter E. A. Ash, Shuwen Lei, Jenifer Shattuck, Samantha Boudeau, Yari Carlomagno, Maria Medalla, Bryce L. Mashimo, Guillermo Socorro, Louloua F. A. Al-Mohanna, Lulu Jiang, Muhammet M. Öztürk, Mark Knobel, Pavel Ivanov, Leonard Petrucelli, Susanne Wegmann, Nicholas M. Kanaan, and Benjamin Wolozin (Vol. 118, No. 9, March 2, 2021, e2014188118).
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February 9, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 9, 2021
“Developmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration,” by Dávid Nagy, Katelin A. Ennis, Ru Wei, Susan C. Su, Christopher A. Hinckley, Rong-Fang Gu, Benbo Gao, Ramiro H. Massol, Chris Ehrenfels, Luke Jandreski, Ankur M. Thomas, Ashley Nelson, Stefka Gyoneva, Mihály Hajós, and Linda C. Burkly (Vol. 118, No. 6, February 9, 2021, e2001679118).
www.pnas.org/content/118/6/e2001679118.abstract?etoc
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February 4, 2021
CAAR – Proceedings of the National Academy of Science Article Abstract – February 4, 2021
“Reductions in 2020 US life expectancy due to COVID-9 and the disproportionate impact on the Black and Latino populations,” by Theresa Andrasfay and Noreen Goldman (Vol. 118, No. 5, February 2, 2021, e20147461180).
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January 19, 2021
CAAR – Proceedings of the National Academy of Science Article Abstracts – January 19, 2021
A. “Prediction of Alzheimer’s disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening,” by Sung-Hyun Kim, Sumin Yang, Key-Hwan Lim, Euiseng Ko, Hyun-Jun Jang, Mingon Kang, Pann-Ghill Suh, and Jae-Yeol Joo (Vol. 118, No. 3, January 19, 2021, e2011250118).
www.pnas.org/content/118/3/e2011250118.abstract?etoc
B. “Childhood self-control forecasts the pace of midlife aging and preparedness for old age,” by Leah S. Richmond-Rakerd, Avshalom Caspi, Antony Ambler, Tracy d’Arbeloff, Marieke de Bruine, Maxwell Elliott, HonaLee Harrington, Sean Hogan, Renate M. Houts, David Ireland, Ross Keenan, Annchen R. Knodt, Tracy R. Melzer, Sena Park, Richie Poulton, Sandhya Ramrakha, Line Jee Hartmann Rasmussen, Elizabeth Sack, Adam T. Schmidt, Maria L. Sison, Jasmin Wertz, Ahmad R. Hariri, and Terrie E. Moffitt (Vol. 118, No. 3, January 19, 2021, e2010211118).
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January 6, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 6, 2021
A. “Nursing home staff networks and COVID-19,” by M. Keith Chen, Judith A. Chevalier, and Elisa F. Long (Vol. 118, No. 1, January 5, 2021, e2015455118).
www.pnas.org/content/118/1/e2015455118.abstract?etoc
B. “The Parkinson’s disease-associated gene ITPKB protects against {alpha}-synuclein aggregation by regulating ER-to-mitochondria calcium release,” by Daniel J. Apicco, Evgeny Shlevkov, Catherine L. Nezich, David T. Tran, Edward Guilmette, Justin W. Nicholatos, Collin M. Bantle, Yi Chen, Kelly E. Glajch, Neeta A. Abraham, Lan T. Dang, G. Campbell Kaynor, Ellen A. Tsai, Khanh-Dung H. Nguyen, Joost Groot, YuTing Liu, Andreas Weihofen, Jessica A. Hurt, Heiko Runz, and Warren D. Hirst (Vol. 118, No. 1, January 5, 2021, e2006476118).
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December 29, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 29, 2020
“Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model,” by Kelly M. Lohr, Bess Frost, Clemens Scherzer, and Mel B. Feany (Vol. 117, No. 52, December 29, 2020, p. 33608-33618).
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December 28, 2020
CAAR – Proceedings of the National Academy of Science Article Abstract – December 28, 2020
“Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer’s disease,” by Sonam Dubey, Stefan Heinen, Slavica Krantic, JoAnne McLaurin, Donald R. Branch, Kullervo Hynynen, and Isabelle Aubert (Vol. 117, No. 51, December 23, 2020, p. 32691-32700).
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December 9, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 9, 2020
“Design of a multivalent bifunctional chelator for diagnostic 64Cu PET imaging in Alzheimer’s disease,” by Hong-Jun Cho, Truc T. Huynh, Buck E. Rogers, and Liviu M. Mirica (Vol. 117, No. 49, December 8, 2020, p. 30928-30933).
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December 1, 2020
CAAR – Proceedings of the National Academy of Science Article Abstract – December 1, 2020
“Global associations between macronutrient supply and age-specific mortality,” by Alistair M. Senior, Shinichi Nakagawa, David Raubenheimer, and Stephen J. Simpson (Vol. 117, No. 48, December 1, 2020, p. 30824-30835).
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November 25, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 25, 2020
“Aging and the encoding of changes in events: The role of neural activity pattern reinstatement,” by David Stawarczyk, Christopher N. Wahlheim, Joset A. Etzel, Abraham Z. Snyder, and Jeffrey M. Zacks (Vol. 117, No. 47, November 24, 2020, p. 29346-29353).
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November 4, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 4, 2020
A. “Life cycle patterns of cognitive performance over the long run,” by Anthony Strittmatter, Uwe Sunde, and Dainis Zegners (Vol. 117, No. 44, November 3, 2020, p. 27255-27261).
www.pnas.org/content/117/44/27255.abstract.html?etoc
B. “Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance,” by Oeystein Roed Brekk, Jonathan R. Honey, Seungil Lee, Penelope J. Hallett, and Ole Isacson (Vol. 117, No. 44, November 3, 2020, p. 27646-27654).
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October 20, 2020
CAAR – Proceedings of the National Academy of Science Article Abstract – October 20, 2020
“Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria,” by Danielle E. Mor, Salman Sohrabi, Rachel Kaletsky, William Keyes, Alp Tartici, Vrinda Kalia, Gary W. Miller, and Coleen T. Murphy (Vol. 117, No. 42, October 20, 2020, p. 26438-26447).
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October 14, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstract -October 14, 2020
“Single-nuceus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease,” by Shun-Fat Lau, Han Cao, Amy K. Y. Fu, and Nancy Y. Ip (Vol. 117, No. 41, October 13, 2020, p. 25272-25283).
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October 9, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 9, 2020
“Decoding the mystery of American pain reveals a warning for the future,” by Anne Case, Angus Deaton, and Arthur A. Stone (Vol. 117, No. 40, October 6, 2020, p. 24785-24789).
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July 28, 2020
CAAR – Proceedings of the National Academy of Science Article – July 28, 2020
Note: Check with your organization’s library for availability. “Quantifying and explaining variation in life expectancy at census tract, county, and state levels in the United States,” by Antonio Fernando Boing, Alexandra Crispim Boing, Jack Cordes, Rockli Kim, and S. V. Subramanian (Vol. 117, No. 30, July 28, 2020, p. 17688-17694).
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July 22, 2020
CAAR – Proceedings of the National Academies of Science Article Abstracts – July 22, 2020
A. “Dopaminergic neurodegeneration induced by Parkinson’s disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity,” by An Phu Tran Nguyen, Elpida Tsika, Kaela Kelly, Nathan Levine, Xi Chen, Andrew B. West, Sylviane Boularand, Pascal Barneoud, and Darren J. Moore (Vol. 117, No. 29, July 21, 2020, p. 17296-17307).
www.pnas.org/content/117/29/17296
B. “Basal ganglia beta oscillations during sleep underlie Parkinsonian insomnia,” by Aviv D. Mizrahi-Kliger, Alexander Kaplan, Zvi Israel, Marc Deffains, and Hagai Bergman (Vol. 117, No. 29, July 21, 2020, p. 17359-17368).
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July 14, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 14, 2020
Note: Check with your organization’s library for availability.
A. “The transition to family caregiving and its effect on biomarkers of inflammation,” by David L. Roth, William E. Haley, Orla C. Sheehan, Jin Huang, J. David Rhodes, Peter Durda, Virginia J. Howard, Jeremy D. Walston, and Mary Cushman (Vol. 117, No. 28, July 14, 2020, p. 16258-16263).
www.pnas.org/content/117/28/16258
B. “Predicting mortality from 57 economic, behavioral, social, and psychological factors,” by Eli Puterman, Jordan Weiss, Benjamin A. Hives, Alison Gemmill, Deborah Karasek, Wendy Berry Mendes, and David H. Rehkopf (Vol. 117, No. 28, July 14, 2020, p. 16273-16282).
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July 1, 2020
CAAR – Proceedings of the National Academy of Sciences Article – July 1, 2020
Note: Check with your organization’s library for availability. “Impact of alpha-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized alpha-synuclein rat model of PD,” by Deirdre B. Hoban, Shelby Shrigley, Bengt Mattsson, Ludivine S. Breger, Ulla Jarl, Tiago Cardoso, Jenny Nelander Wahlestedt, Kelvin C. Luk, Anders Björklund, and Malin Parmar (Vol. 117, No. 26, June 30, 2020, p. 15209-15220).
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June 23, 2020
CAAR – Proceedings of the National Academy of Sciences Article – June 23, 2020
Note: Check with your organization’s library for availability. “Cerebral amyloid angiopathy-linked {beta}-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen,” by Steven A. Cajamarca, Erin H. Norris, Louise van der Weerd, Sidney Strickland, and Hyung Jin Ahn (Vol. 117, No. 25, June 23, 2020, p. 14482-14492).
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May 27, 2020
CAAR – Proceedings of the National Academy of Science Article – May 27, 2020
Note: Check with your organization’s library for availability. “Ultrastructural evidence for self-replication of Alzheimer-associated A{beta}42 amyloid along the sides of fibrils,” by Mattias Törnquist, Risto Cukalevski, Ulrich Weininger, Georg Meisl, Tuomas P. J. Knowles, Thom Leiding, Anders Malmendal, Mikael Akke, and Sara Linse (Vol. 117, No. 21, May 26, 2020, p. 11265-11273).
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April 29, 2020
CAAR – Proceedings of the National Academies of Science Articles – April 29, 2020
Note: Check with your organization’s library for availability.
A. “Noninvasive hippocampal blood-brain barrier opening in Alzheimer’s disease with focused ultrasound,” by Ali R. Rezai, Manish Ranjan, Pierre-François D’Haese, Marc W. Haut, Jeffrey Carpenter, Umer Najib, Rashi I. Mehta, J. Levi Chazen, Zion Zibly, Jennifer R. Yates, Sally L. Hodder, and Michael Kaplitt (Vol. 117, No. 17, April 28, 2020, p. 9180-9182).
www.pnas.org/content/117/17/9180
B. “Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility,” by Masahiro Kameda, Takayuki Teruya, Mitsuhiro Yanagida, and Hiroshi Kondoh (Vol. 117, No. 17, April 28, 2020, p. 9483-9489).
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April 7, 2020
CAAR – Proceedings of the National Academy of Sciences Article – April 7, 2020
Note: Check with your organization’s library for availability. “Population aging, migration, and productivity in Europe,” by Guillaume Marois, Alain Bélanger, and Wolfgang Lutz (Vol. 117, No. 14, April 7, 2020, p. 7690-7695).
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March 31, 2020
CAAR – Proceedings of the National Academy of Sciences Article – March 31, 2020
Note: Check with your organization’s library for availability. “US life expectancy stalls due to cardiovascular disease, not drug deaths,” by Neil K. Mehta, Leah R. Abrams, and Mikko Myrskyla (Vol. 117, No. 13, March 31, 2020, p. 6998-7000).
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March 17, 2020
CAAR – Proceedings of the National Academies of Science Article – March 17, 2020
Note: Check with your organization’s library for availability. “Diet modulates brain network stability, a biomarker for brain aging, in young adults,” by Lilianne R. Mujica-Parodi, Anar Amgalan, Syed Fahad Sultan, Botond Antal, Xiaofei Sun, Steven Skiena, Andrew Lithen, Noor Adra, Eva-Maria Ratai, Corey Weistuch, Sindhuja Tirumalai Govindarajan, Helmut H. Strey, Ken A. Dill, Steven M. Stufflebeam, Richard L. Veech, and Kieran Clarke (Vol. 117, No. 11, March 17, 2020, p. 6170-6177).
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March 11, 2020
CAAR – Proceedings of the National Academy of Sciences Articles
Note: Check with your organization’s library for availability.
A. “Mechanistic approaches for chemically modifying the coordination sphere of copper–amyloid-{beta} complexes,” by Jiyeon Han, Hyuck Jin Lee, Kyu Yeon Kim, Geewoo Nam, Junghyun Chae, and Mi Hee Lim (Vol. 117, No. 10, March 10, 2020, p. 5160-5167).
www.pnas.org/content/117/10/5160
B. “Dynamics of life expectancy and life span equality,” by José Manuel Aburto, Francisco Villavicencio, Ugofilippo Basellini, Søren Kjærgaard, and James W. Vaupel (Vol. 117, No. 10, March 10, 2020, p. 5250-5259).
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February 25, 2020
CAAR – Proceedings of the National Academy of Sciences Articles – February 25, 2020
Note: Check with your organization’s library for availability.
A. “Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination,” by Su Jin Ham, Daewon Lee, Heesuk Yoo, Kyoungho Jun, Heejin Shin, and Jongkyeong Chung (Vol. 117, No. 8, February 25, 2020, p. 4281-4291).
www.pnas.org/content/117/8/4281
B. “Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging,” by Xin Li, Jiaqiang Wang, Leyun Wang, Guihai Feng, Gen Li, Meixin Yu, Yufei Li, Chao Liu, Xuewei Yuan, Guangxi Zang, Zhihuan Li, Ling Zhao, Hong Ouyang, Qingli Quan, Guangyu Wang, Charlotte Zhang, Oulan Li, Junkai Xiang, Jian-Kang Zhu, Wei Li, Qi Zhou, and Kang Zhang (Vol. 117, No. 8, February 25, 2020, p. 4328-4336).
www.pnas.org/content/117/8/4328
C. “Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3{beta} in Alzheimer’s disease,” by Tanusree Sen, Pampa Saha, Tong Jiang, and Nilkantha Sen (Vol. 117, No. 8, February 25, 2020, p. 4418-4427).
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February 19, 2020
CAAR – Proceedings of the National Academy of Science Article – February 19, 2020
Note: Check with your organization’s library for availability. “The {alpha}-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure,” by David R. Boyer, Binsen Li, Chuanqi Sun, Weijia Fan, Kang Zhou, Michael P. Hughes, Michael R. Sawaya, Lin Jiang, and David S. Eisenberg (Vol. 117, No. 7, February 18, 2020, p. 3592-3602).
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February 12, 2020
CAAR – Proceedings of the National Academy of Sciences Articles – February 12, 2020
Note: Check with your organization’s library for availability.
A. “Release of a disordered domain enhances HspB1 chaperone activity toward tau,” by Hannah E. R. Baughman, Thanh-Hau T. Pham, Chloe S. Adams, Abhinav Nath, and Rachel E. Klevit (Vol. 117, No. 6, February 11, 2020, p. 2923-2929).
www.pnas.org/content/117/6/2923
B. “FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis,” by Kwang Il Lee, Sungwook Choi, Tokio Matsuzaki, Oscar Alvarez-Garcia, Merissa Olmer, Shawn P. Grogan, Darryl D. D’Lima, and Martin K. Lotz (Vol. 117, No. 6, February 11, 2020, p. 3135-3143).
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January 21, 2020
CAAR – Proceedings of the National Academy of Sciences Article – January 21, 2020
Note: Check with your organization’s library for availability. “NK cells clear {alpha}-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of {alpha}-synucleinopathy,” by Rachael H. Earls, Kelly B. Menees, Jaegwon Chung, Claire-Anne Gutekunst, Hyun Joon Lee, Manuel G. Hazim, Balázs Rada, Levi B. Wood, and Jae-Kyung Lee (Vol. 117, No. 3, January 21, 2020, p. 1762-1771).
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December 27, 2019
CAAR – Proceedings of the National Academies of Science Article Abstracts – December 27, 2019
Note: Check your organization’s library for availability.
A. “Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease,” by Amy F. T. Arnsten, Dibyadeep Datta, Shannon Leslie, Sheng-Tao Yang, Min Wang, and Angus C. Nairn (Vol. 116, No. 52, December 26, 2019, p. 26230-26238).
www.pnas.org/content/116/52/26230
B. “Oligomeric A{beta} in the monkey brain impacts synaptic integrity and induces accelerated cortical aging,” by Danielle Beckman, Sean Ott, Kristine Donis-Cox, William G. Janssen, Eliza Bliss-Moreau, Peter H. Rudebeck, Mark G. Baxter, and John H. Morrison (Vol. 116, No. 52, December 26, 2019, p. 26239-26246).
www.pnas.org/content/116/52/26239
C. “Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function,” by Daniel T. Gray and Carol A. Barnes (Vol. 116, No. 52, December 26, 2019, p. 26247-26254).
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December 17, 2019
CAAR – Proceedings of the National Academy of Sciences Article – December 17, 2019
Note: For full text availability check your organization’s library. “Endogenous retroviruses are associated with hippocampus-based memory impairment,” by Roman Sankowski, Joshua J. Strohl, Tomás S. Huerta, Elham Nasiri, Andrea N. Mazzarello, Cristina D’Abramo, Kai Fan Cheng, Ori Staszewski, Marco Prinz, Patricio T. Huerta, and Yousef Al-Abed (Vol. 116, No. 51, December 17, 2019, p. 25982-25990).
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December 3, 2019
CAAR – Proceedings of the National Academy of Sciences Article – December 3, 2019
Note: For full text availability check your organization’s library. “A locomotor assay reveals deficits in heterozygous Parkinson’s disease model and proprioceptive mutants in adult Drosophila,” by Aman Aggarwal, Heinrich Reichert, and K. VijayRaghavan (Vol. 116, No. 49, December 3, 2019, p. 24830-24839).
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November 26, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 26, 2019
Note: For full text availability check your organization’s library.
A. “Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration,” by Andrew P. Voigt, Kelly Mulfaul, Nathaniel K. Mullin, Miles J. Flamme-Wiese, Joseph C. Giacalone, Edwin M. Stone, Budd A. Tucker, Todd E. Scheetz, and Robert F. Mullins (Vol. 116, No. 48, November 26, 2019, p. 24100-24107).
www.pnas.org/content/116/48/24100
B. “Elovanoids counteract oligomeric {beta}-amyloid-induced gene expression and protect photoreceptors,” by Khanh V. Do, Marie-Audrey I. Kautzmann, Bokkyoo Jun, William C. Gordon, Robert Nshimiyimana, Rong Yang, Nicos A. Petasis, and Nicolas G. Bazan (Vol. 116, No. 48, November 26, 2019, p. 24317-24325).
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November 19, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 19, 2019
Note: Check with you organization’s library for availability.
A. “N,N′-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice,” by Min Hee Park, Misun Lee, Geewoo Nam, Mingeun Kim, Juhye Kang, Byung Jo Choi, Min Seock Jeong, Kang Ho Park, Wan Hui Han, Eunyoung Tak, Min Sun Kim, Juri Lee, Yuxi Lin, Young-Ho Lee, Im-Sook Song, Min-Koo Choi, Joo-Yong Lee, Hee Kyung Jin, Jae-sung Bae, and Mi Hee Lim (Vol. 116, No. 47, November 19, 2019, p. 23426-23436).
www.pnas.org/content/116/47/23426
B. “Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina,” by Shoji Notomi, Kenji Ishihara, Nikolaos E. Efstathiou, Jong-Jer Lee, Toshio Hisatomi, Takashi Tachibana, Eleni K. Konstantinou, Takashi Ueta, Yusuke Murakami, Daniel E. Maidana, Yasuhiro Ikeda, Shinji Kume, Hiroto Terasaki, Shozo Sonoda, Judith Blanz, Lucy Young, Taiji Sakamoto, Koh-Hei Sonoda, Paul Saftig, Tatsuro Ishibashi, Joan W. Miller, Guido Kroemer, and Demetrios G. Vavvas (Vol. 116, No. 47, November 19, 2019, p. 23724-23734).
www.pnas.org/content/116/47/23724
C. “Swim exercise in Caenorhabditis elegans extends neuromuscular and gut healthspan, enhances learning ability, and protects against neurodegeneration,” by Ricardo Laranjeiro, Girish Harinath, Jennifer E. Hewitt, Jessica H. Hartman, Mary Anne Royal, Joel N. Meyer, Siva A. Vanapalli, and Monica Driscoll (Vol. 116, No. 47, November 19, 2019, p. 23829-23839).
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November 14, 2019
CAAR – Proceedings of the National Academy of Science Brief Report, Article – November 14, 2019
A. “An antibody against HK blocks Alzheimer’s disease peptide {beta}-amyloid-induced bradykinin release in human plasma,” by Zu-Lin Chen, Pradeep Singh, Jyen Wong, Katharina Horn, Sidney Strickland, and Erin H. Norris (Vol. 116, No. 46, November 12, 2019, p. 22921-22923).
www.pnas.org/content/116/46/22921
B. “SERF engages in a fuzzy complex that accelerates primary nucleation of amyloid proteins,” by Ben A. Meinen, Varun V. Gadkari, Frederick Stull, Brandon T. Ruotolo, and James C. A. Bardwell (Vol. 116, No. 46, November 12, 2019, p. 23040-23049). Note: Check with you organization’s library for availability.
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October 22, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 22, 2019
“Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer’s molecular signatures,” by Abhijeet Sharma, Syed Faraz Kazim, Chloe S. Larson, Aarthi Ramakrishnan, Jason D. Gray, Bruce S. McEwen, Paul A. Rosenberg, Li Shen, and Ana C. Pereira (Vol. 116, No. 43, October 25, 2019, p. 21800-21811).
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October 15, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – October 15, 2019
A. “Amyloid-beta impairs TOM1-mediated IL-1R1 signaling,” by Alessandra Cadete Martini, Angela Gomez-Arboledas, Stefania Forner, Carlos J. Rodriguez-Ortiz, Amanda McQuade, Emma Danhash, Jimmy Phan, Dominic Javonillo, Jordan-Vu Ha, Melanie Tram, Laura Trujillo-Estrada, Celia da Cunha, Rahasson R. Ager, Jose C. Davila, Masashi Kitazawa, Mathew Blurton-Jones, Antonia Gutierrez, David Baglietto-Vargas, Rodrigo Medeiros, and Frank M. LaFerla (Vol. 116, No. 42, October 15, 2019, p. 21198-21206).
www.pnas.org/content/116/42/21198
B. “Gray Matter Age Prediction as a Biomarker for Risk of Dementia,” by Johnny Wang, Maria J. Knol, Aleksei Tiulpin, Florian Dubost, Marleen de Bruijne, Meike W. Vernooij, Hieab H. H. Adams, M. Arfan Ikram, Wiro J. Niessen, and Gennady V. Roshchupkin (Vol. 116, No. 42, October 15, 2019, p. 21213-21218).
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October 8, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – October 8, 2019
A. “Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence,” by Cristian Tomasetti, Justin Poling, Nicholas J. Roberts, Nyall R. London Jr., Meredith E. Pittman, Michael C. Haffner, Anthony Rizzo, Alex Baras, Baktiar Karim, Antonio Kim, Christopher M. Heaphy, Alan K. Meeker, Ralph H. Hruban, Christine A. Iacobuzio-Donahue, and Bert Vogelstein (Vol. 116, No. 41, October 8, 2019, p. 20482-20488).
www.pnas.org/content/116/41/20482
B. “Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and {alpha}-synuclein stability through membrane remodeling,” by Akio Mori, Taku Hatano, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Takahiro Koinuma, Hongrui Meng, Shin-ichiro Kubo, Spencer Spratt, Changxu Cui, Chikara Yamashita, Yoshimi Miki, Kei Yamamoto, Tetsuya Hirabayashi, Makoto Murakami, Yoshikazu Takahashi, Hideo Shindou, Takashi Nonaka, Masato Hasegawa, Ayami Okuzumi, Yuzuru Imai, and Nobutaka Hattori (Vol. 116, No. 41, October 8, 2019, p. 20689-20699).
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September 10, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – September 10, 2019
A. “Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women,” by Lewina O. Lee, Peter James, Emily S. Zevon, Eric S. Kim, Claudia Trudel-Fitzgerald, Avron Spiro III, Francine Grodstein, and Laura D. Kubzansky (Vol. 116, No. 37, September 10, 2019, p. 18357-18362).
www.pnas.org/content/116/37/18357
B. “The joint influence of intelligence and practice on skill development throughout the life span,” by Nemanja Vaci, Peter Edelsbrunner, Elsbeth Stern, Aljoscha Neubauer, Merim Bilalić, and Roland H. Grabner (Vol. 116, No. 37, September 10, 2019, p. 18363-18369).
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August 29, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 29, 2019
“Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis,” by Latika Matai, Gautam Chandra Sarkar, Manish Chamoli, Yasir Malik, Shashi Shekhar Kumar, Umanshi Rautela, Nihar Ranjan Jana, Kausik Chakraborty, and Arnab Mukhopadhyay (Vol. 116, No. 35, August 27, 2019, p. 17383-17392).
www.pnas.org/content/116/35/17383
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August 13, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 13, 2019
“Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson’s disease,” by Joohyung Lee, Paulo Pinares-Garcia, Hannah Loke, Seungmin Ham, Eric Vilain, and Vincent R. Harley (Vol. 116, No. 33, August 13, 2019, p. 16577-16582).
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August 6, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 6, 2019
“Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network,” by Hayriye Cagnan, Nicolas Mallet, Christian K. E. Moll, Alessandro Gulberti, Abbey B. Holt, Manfred Westphal, Christian Gerloff, Andreas K. Engel, Wolfgang Hamel, Peter J. Magill, Peter Brown, and Andrew Sharott (Vol. 116, No. 32, August 6, 2019, p. 16095-16104).
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June 20, 2019
CAAR – Proceedings of the National Academy of Science Article Abstract – June 20, 2019
“NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models,” by Gahee Bahn, Jong-Sung Park, Ui Jeong Yun, Yoon Jee Lee, Yuri Choi, Jin Su Park, Seung Hyun Baek, Bo Youn Choi, Yoon Suk Cho, Hark Kyun Kim, Jihoon Han, Jae Hoon Sul, Sang-Ha Baik, Jinhwan Lim, Nobunao Wakabayashi, Soo Han Bae, Jeung-Whan Han, Thiruma V. Arumugam, Mark P. Mattson, and Dong-Gyu Jo (Vol. 116, No. 25, June 18, 2019, p. 12516-12523).
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May 14, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 14, 2019
“Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy,” by Takayuki Inoue, Satoshi Saito, Masashi Tanaka, Hajime Yamakage, Toru Kusakabe, Akira Shimatsu, Masafumi Ihara, and Noriko Satoh-Asahara (Vol. 116, No. 20, May 14, 2019, p. 10031-10038).
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