CDHA CAAR

November 4, 2020

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 4, 2020

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A. “Life cycle patterns of cognitive performance over the long run,” by Anthony Strittmatter, Uwe Sunde, and Dainis Zegners (Vol. 117, No. 44, November 3, 2020, p. 27255-27261).

www.pnas.org/content/117/44/27255.abstract.html?etoc

B. “Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance,” by Oeystein Roed Brekk, Jonathan R. Honey, Seungil Lee, Penelope J. Hallett, and Ole Isacson (Vol. 117, No. 44, November 3, 2020, p. 27646-27654).

www.pnas.org/content/117/44/27646.abstract.html?etoc

October 20, 2020

CAAR – Proceedings of the National Academy of Science Article Abstract – October 20, 2020

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“Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria,” by Danielle E. Mor, Salman Sohrabi, Rachel Kaletsky, William Keyes, Alp Tartici, Vrinda Kalia, Gary W. Miller, and Coleen T. Murphy (Vol. 117, No. 42, October 20, 2020, p. 26438-26447).

www.pnas.org/content/117/42/26438.abstract?etoc

October 14, 2020

CAAR – Proceedings of the National Academy of Sciences Article Abstract -October 14, 2020

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“Single-nuceus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease,” by Shun-Fat Lau, Han Cao, Amy K. Y. Fu, and Nancy Y. Ip (Vol. 117, No. 41, October 13, 2020, p. 25272-25283).

www.pnas.org/content/117/41/25272.abstract?etoc

October 9, 2020

CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 9, 2020

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“Decoding the mystery of American pain reveals a warning for the future,” by Anne Case, Angus Deaton, and Arthur A. Stone (Vol. 117, No. 40, October 6, 2020, p. 24785-24789).

www.pnas.org/content/117/40/24785.abstract?etoc

July 28, 2020

CAAR – Proceedings of the National Academy of Science Article – July 28, 2020

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Note: Check with your organization’s library for availability. “Quantifying and explaining variation in life expectancy at census tract, county, and state levels in the United States,” by Antonio Fernando Boing, Alexandra Crispim Boing, Jack Cordes, Rockli Kim, and S. V. Subramanian (Vol. 117, No. 30, July 28, 2020, p. 17688-17694).

www.pnas.org/content/117/30/17688

July 22, 2020

CAAR – Proceedings of the National Academies of Science Article Abstracts – July 22, 2020

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A. “Dopaminergic neurodegeneration induced by Parkinson’s disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity,” by An Phu Tran Nguyen, Elpida Tsika, Kaela Kelly, Nathan Levine, Xi Chen, Andrew B. West, Sylviane Boularand, Pascal Barneoud, and Darren J. Moore (Vol. 117, No. 29, July 21, 2020, p. 17296-17307).

www.pnas.org/content/117/29/17296

B. “Basal ganglia beta oscillations during sleep underlie Parkinsonian insomnia,” by Aviv D. Mizrahi-Kliger, Alexander Kaplan, Zvi Israel, Marc Deffains, and Hagai Bergman (Vol. 117, No. 29, July 21, 2020, p. 17359-17368).

www.pnas.org/content/117/29/17359

July 14, 2020

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 14, 2020

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A. “The transition to family caregiving and its effect on biomarkers of inflammation,” by David L. Roth, William E. Haley, Orla C. Sheehan, Jin Huang, J. David Rhodes, Peter Durda, Virginia J. Howard, Jeremy D. Walston, and Mary Cushman (Vol. 117, No. 28, July 14, 2020, p. 16258-16263).

www.pnas.org/content/117/28/16258

B. “Predicting mortality from 57 economic, behavioral, social, and psychological factors,” by Eli Puterman, Jordan Weiss, Benjamin A. Hives, Alison Gemmill, Deborah Karasek, Wendy Berry Mendes, and David H. Rehkopf (Vol. 117, No. 28, July 14, 2020, p. 16273-16282).

www.pnas.org/content/117/28/16273

July 1, 2020

CAAR – Proceedings of the National Academy of Sciences Article – July 1, 2020

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Note: Check with your organization’s library for availability. “Impact of alpha-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized alpha-synuclein rat model of PD,” by Deirdre B. Hoban, Shelby Shrigley, Bengt Mattsson, Ludivine S. Breger, Ulla Jarl, Tiago Cardoso, Jenny Nelander Wahlestedt, Kelvin C. Luk, Anders Björklund, and Malin Parmar (Vol. 117, No. 26, June 30, 2020, p. 15209-15220).

www.pnas.org/content/117/26/15209

June 23, 2020

CAAR – Proceedings of the National Academy of Sciences Article – June 23, 2020

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Note: Check with your organization’s library for availability. “Cerebral amyloid angiopathy-linked {beta}-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen,” by Steven A. Cajamarca, Erin H. Norris, Louise van der Weerd, Sidney Strickland, and Hyung Jin Ahn (Vol. 117, No. 25, June 23, 2020, p. 14482-14492).

www.pnas.org/content/117/25/14482

May 27, 2020

CAAR – Proceedings of the National Academy of Science Article – May 27, 2020

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Note: Check with your organization’s library for availability. “Ultrastructural evidence for self-replication of Alzheimer-associated A{beta}42 amyloid along the sides of fibrils,” by Mattias Törnquist, Risto Cukalevski, Ulrich Weininger, Georg Meisl, Tuomas P. J. Knowles, Thom Leiding, Anders Malmendal, Mikael Akke, and Sara Linse (Vol. 117, No. 21, May 26, 2020, p. 11265-11273).

www.pnas.org/content/117/21/11265

April 29, 2020

CAAR – Proceedings of the National Academies of Science Articles – April 29, 2020

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A. “Noninvasive hippocampal blood-brain barrier opening in Alzheimer’s disease with focused ultrasound,” by Ali R. Rezai, Manish Ranjan, Pierre-François D’Haese, Marc W. Haut, Jeffrey Carpenter, Umer Najib, Rashi I. Mehta, J. Levi Chazen, Zion Zibly, Jennifer R. Yates, Sally L. Hodder, and Michael Kaplitt (Vol. 117, No. 17, April 28, 2020, p. 9180-9182).

www.pnas.org/content/117/17/9180

B. “Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility,” by Masahiro Kameda, Takayuki Teruya, Mitsuhiro Yanagida, and Hiroshi Kondoh (Vol. 117, No. 17, April 28, 2020, p. 9483-9489).

www.pnas.org/content/117/17/9483

April 7, 2020

CAAR – Proceedings of the National Academy of Sciences Article – April 7, 2020

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Note: Check with your organization’s library for availability. “Population aging, migration, and productivity in Europe,” by Guillaume Marois, Alain Bélanger, and Wolfgang Lutz (Vol. 117, No. 14, April 7, 2020, p. 7690-7695).

www.pnas.org/content/117/14/7690

March 31, 2020

CAAR – Proceedings of the National Academy of Sciences Article – March 31, 2020

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Note: Check with your organization’s library for availability. “US life expectancy stalls due to cardiovascular disease, not drug deaths,” by Neil K. Mehta, Leah R. Abrams, and Mikko Myrskyla (Vol. 117, No. 13, March 31, 2020, p. 6998-7000).

www.pnas.org/content/117/13/6998

March 17, 2020

CAAR – Proceedings of the National Academies of Science Article – March 17, 2020

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Note: Check with your organization’s library for availability. “Diet modulates brain network stability, a biomarker for brain aging, in young adults,” by Lilianne R. Mujica-Parodi, Anar Amgalan, Syed Fahad Sultan, Botond Antal, Xiaofei Sun, Steven Skiena, Andrew Lithen, Noor Adra, Eva-Maria Ratai, Corey Weistuch, Sindhuja Tirumalai Govindarajan, Helmut H. Strey, Ken A. Dill, Steven M. Stufflebeam, Richard L. Veech, and Kieran Clarke (Vol. 117, No. 11, March 17, 2020, p. 6170-6177).

www.pnas.org/content/117/11/6170

March 11, 2020

CAAR – Proceedings of the National Academy of Sciences Articles

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Note: Check with your organization’s library for availability.

A. “Mechanistic approaches for chemically modifying the coordination sphere of copper–amyloid-{beta} complexes,” by Jiyeon Han, Hyuck Jin Lee, Kyu Yeon Kim, Geewoo Nam, Junghyun Chae, and Mi Hee Lim (Vol. 117, No. 10, March 10, 2020, p. 5160-5167).

www.pnas.org/content/117/10/5160

B. “Dynamics of life expectancy and life span equality,” by José Manuel Aburto, Francisco Villavicencio, Ugofilippo Basellini, Søren Kjærgaard, and James W. Vaupel (Vol. 117, No. 10, March 10, 2020, p. 5250-5259).

www.pnas.org/content/117/10/5250

February 25, 2020

CAAR – Proceedings of the National Academy of Sciences Articles – February 25, 2020

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Note: Check with your organization’s library for availability.

A. “Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination,” by Su Jin Ham, Daewon Lee, Heesuk Yoo, Kyoungho Jun, Heejin Shin, and Jongkyeong Chung (Vol. 117, No. 8, February 25, 2020, p. 4281-4291).

www.pnas.org/content/117/8/4281

B. “Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging,” by Xin Li, Jiaqiang Wang, Leyun Wang, Guihai Feng, Gen Li, Meixin Yu, Yufei Li, Chao Liu, Xuewei Yuan, Guangxi Zang, Zhihuan Li, Ling Zhao, Hong Ouyang, Qingli Quan, Guangyu Wang, Charlotte Zhang, Oulan Li, Junkai Xiang, Jian-Kang Zhu, Wei Li, Qi Zhou, and Kang Zhang (Vol. 117, No. 8, February 25, 2020, p. 4328-4336).

www.pnas.org/content/117/8/4328

C. “Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3{beta} in Alzheimer’s disease,” by Tanusree Sen, Pampa Saha, Tong Jiang, and Nilkantha Sen (Vol. 117, No. 8, February 25, 2020, p. 4418-4427).

www.pnas.org/content/117/8/4418

February 19, 2020

CAAR – Proceedings of the National Academy of Science Article – February 19, 2020

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Note: Check with your organization’s library for availability. “The {alpha}-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure,” by David R. Boyer, Binsen Li, Chuanqi Sun, Weijia Fan, Kang Zhou, Michael P. Hughes, Michael R. Sawaya, Lin Jiang, and David S. Eisenberg (Vol. 117, No. 7, February 18, 2020, p. 3592-3602).

www.pnas.org/content/117/7/3592

February 12, 2020

CAAR – Proceedings of the National Academy of Sciences Articles – February 12, 2020

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A. “Release of a disordered domain enhances HspB1 chaperone activity toward tau,” by Hannah E. R. Baughman, Thanh-Hau T. Pham, Chloe S. Adams, Abhinav Nath, and Rachel E. Klevit (Vol. 117, No. 6, February 11, 2020, p. 2923-2929).

www.pnas.org/content/117/6/2923

B. “FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis,” by Kwang Il Lee, Sungwook Choi, Tokio Matsuzaki, Oscar Alvarez-Garcia, Merissa Olmer, Shawn P. Grogan, Darryl D. D’Lima, and Martin K. Lotz (Vol. 117, No. 6, February 11, 2020, p. 3135-3143).

www.pnas.org/content/117/6/3135

January 21, 2020

CAAR – Proceedings of the National Academy of Sciences Article – January 21, 2020

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Note: Check with your organization’s library for availability. “NK cells clear {alpha}-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of {alpha}-synucleinopathy,” by Rachael H. Earls, Kelly B. Menees, Jaegwon Chung, Claire-Anne Gutekunst, Hyun Joon Lee, Manuel G. Hazim, Balázs Rada, Levi B. Wood, and Jae-Kyung Lee (Vol. 117, No. 3, January 21, 2020, p. 1762-1771).

www.pnas.org/content/117/3/1762

December 27, 2019

CAAR – Proceedings of the National Academies of Science Article Abstracts – December 27, 2019

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A. “Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease,” by Amy F. T. Arnsten, Dibyadeep Datta, Shannon Leslie, Sheng-Tao Yang, Min Wang, and Angus C. Nairn (Vol. 116, No. 52, December 26, 2019, p. 26230-26238).

www.pnas.org/content/116/52/26230

B. “Oligomeric A{beta} in the monkey brain impacts synaptic integrity and induces accelerated cortical aging,” by Danielle Beckman, Sean Ott, Kristine Donis-Cox, William G. Janssen, Eliza Bliss-Moreau, Peter H. Rudebeck, Mark G. Baxter, and John H. Morrison (Vol. 116, No. 52, December 26, 2019, p. 26239-26246).

www.pnas.org/content/116/52/26239

C. “Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function,” by Daniel T. Gray and Carol A. Barnes (Vol. 116, No. 52, December 26, 2019, p. 26247-26254).

www.pnas.org/content/116/52/26247

December 17, 2019

CAAR – Proceedings of the National Academy of Sciences Article – December 17, 2019

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Note: For full text availability check your organization’s library. “Endogenous retroviruses are associated with hippocampus-based memory impairment,” by Roman Sankowski, Joshua J. Strohl, Tomás S. Huerta, Elham Nasiri, Andrea N. Mazzarello, Cristina D’Abramo, Kai Fan Cheng, Ori Staszewski, Marco Prinz, Patricio T. Huerta, and Yousef Al-Abed (Vol. 116, No. 51, December 17, 2019, p. 25982-25990).

www.pnas.org/content/116/51/25982.abstract?etoc

December 3, 2019

CAAR – Proceedings of the National Academy of Sciences Article – December 3, 2019

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Note: For full text availability check your organization’s library. “A locomotor assay reveals deficits in heterozygous Parkinson’s disease model and proprioceptive mutants in adult Drosophila,” by Aman Aggarwal, Heinrich Reichert, and K. VijayRaghavan (Vol. 116, No. 49, December 3, 2019, p. 24830-24839).

www.pnas.org/content/116/49/24830

November 26, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 26, 2019

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A. “Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration,” by Andrew P. Voigt, Kelly Mulfaul, Nathaniel K. Mullin, Miles J. Flamme-Wiese, Joseph C. Giacalone, Edwin M. Stone, Budd A. Tucker, Todd E. Scheetz, and Robert F. Mullins (Vol. 116, No. 48, November 26, 2019, p. 24100-24107).

www.pnas.org/content/116/48/24100

B. “Elovanoids counteract oligomeric {beta}-amyloid-induced gene expression and protect photoreceptors,” by Khanh V. Do, Marie-Audrey I. Kautzmann, Bokkyoo Jun, William C. Gordon, Robert Nshimiyimana, Rong Yang, Nicos A. Petasis, and Nicolas G. Bazan (Vol. 116, No. 48, November 26, 2019, p. 24317-24325).

www.pnas.org/content/116/48/24317

November 19, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 19, 2019

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A. “N,N′-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice,” by Min Hee Park, Misun Lee, Geewoo Nam, Mingeun Kim, Juhye Kang, Byung Jo Choi, Min Seock Jeong, Kang Ho Park, Wan Hui Han, Eunyoung Tak, Min Sun Kim, Juri Lee, Yuxi Lin, Young-Ho Lee, Im-Sook Song, Min-Koo Choi, Joo-Yong Lee, Hee Kyung Jin, Jae-sung Bae, and Mi Hee Lim (Vol. 116, No. 47, November 19, 2019, p. 23426-23436).

www.pnas.org/content/116/47/23426

B. “Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina,” by Shoji Notomi, Kenji Ishihara, Nikolaos E. Efstathiou, Jong-Jer Lee, Toshio Hisatomi, Takashi Tachibana, Eleni K. Konstantinou, Takashi Ueta, Yusuke Murakami, Daniel E. Maidana, Yasuhiro Ikeda, Shinji Kume, Hiroto Terasaki, Shozo Sonoda, Judith Blanz, Lucy Young, Taiji Sakamoto, Koh-Hei Sonoda, Paul Saftig, Tatsuro Ishibashi, Joan W. Miller, Guido Kroemer, and Demetrios G. Vavvas (Vol. 116, No. 47, November 19, 2019, p. 23724-23734).

www.pnas.org/content/116/47/23724

C. “Swim exercise in Caenorhabditis elegans extends neuromuscular and gut healthspan, enhances learning ability, and protects against neurodegeneration,” by Ricardo Laranjeiro, Girish Harinath, Jennifer E. Hewitt, Jessica H. Hartman, Mary Anne Royal, Joel N. Meyer, Siva A. Vanapalli, and Monica Driscoll (Vol. 116, No. 47, November 19, 2019, p. 23829-23839).

www.pnas.org/content/116/47/23829

November 14, 2019

CAAR – Proceedings of the National Academy of Science Brief Report, Article – November 14, 2019

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A. “An antibody against HK blocks Alzheimer’s disease peptide {beta}-amyloid-induced bradykinin release in human plasma,” by Zu-Lin Chen, Pradeep Singh, Jyen Wong, Katharina Horn, Sidney Strickland, and Erin H. Norris (Vol. 116, No. 46, November 12, 2019, p. 22921-22923).

www.pnas.org/content/116/46/22921

B. “SERF engages in a fuzzy complex that accelerates primary nucleation of amyloid proteins,” by Ben A. Meinen, Varun V. Gadkari, Frederick Stull, Brandon T. Ruotolo, and James C. A. Bardwell (Vol. 116, No. 46, November 12, 2019, p. 23040-23049). Note: Check with you organization’s library for availability.

www.pnas.org/content/116/46/23040

October 22, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 22, 2019

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“Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer’s molecular signatures,” by Abhijeet Sharma, Syed Faraz Kazim, Chloe S. Larson, Aarthi Ramakrishnan, Jason D. Gray, Bruce S. McEwen, Paul A. Rosenberg, Li Shen, and Ana C. Pereira (Vol. 116, No. 43, October 25, 2019, p. 21800-21811).

www.pnas.org/content/116/43/21800

October 15, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – October 15, 2019

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A. “Amyloid-beta impairs TOM1-mediated IL-1R1 signaling,” by Alessandra Cadete Martini, Angela Gomez-Arboledas, Stefania Forner, Carlos J. Rodriguez-Ortiz, Amanda McQuade, Emma Danhash, Jimmy Phan, Dominic Javonillo, Jordan-Vu Ha, Melanie Tram, Laura Trujillo-Estrada, Celia da Cunha, Rahasson R. Ager, Jose C. Davila, Masashi Kitazawa, Mathew Blurton-Jones, Antonia Gutierrez, David Baglietto-Vargas, Rodrigo Medeiros, and Frank M. LaFerla (Vol. 116, No. 42, October 15, 2019, p. 21198-21206).

www.pnas.org/content/116/42/21198

B. “Gray Matter Age Prediction as a Biomarker for Risk of Dementia,” by Johnny Wang, Maria J. Knol, Aleksei Tiulpin, Florian Dubost, Marleen de Bruijne, Meike W. Vernooij, Hieab H. H. Adams, M. Arfan Ikram, Wiro J. Niessen, and Gennady V. Roshchupkin (Vol. 116, No. 42, October 15, 2019, p. 21213-21218).

www.pnas.org/content/116/42/21213

October 8, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – October 8, 2019

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A. “Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence,” by Cristian Tomasetti, Justin Poling, Nicholas J. Roberts, Nyall R. London Jr., Meredith E. Pittman, Michael C. Haffner, Anthony Rizzo, Alex Baras, Baktiar Karim, Antonio Kim, Christopher M. Heaphy, Alan K. Meeker, Ralph H. Hruban, Christine A. Iacobuzio-Donahue, and Bert Vogelstein (Vol. 116, No. 41, October 8, 2019, p. 20482-20488).

www.pnas.org/content/116/41/20482

B. “Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and {alpha}-synuclein stability through membrane remodeling,” by Akio Mori, Taku Hatano, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Takahiro Koinuma, Hongrui Meng, Shin-ichiro Kubo, Spencer Spratt, Changxu Cui, Chikara Yamashita, Yoshimi Miki, Kei Yamamoto, Tetsuya Hirabayashi, Makoto Murakami, Yoshikazu Takahashi, Hideo Shindou, Takashi Nonaka, Masato Hasegawa, Ayami Okuzumi, Yuzuru Imai, and Nobutaka Hattori (Vol. 116, No. 41, October 8, 2019, p. 20689-20699).

www.pnas.org/content/116/41/20689

September 10, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – September 10, 2019

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A. “Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women,” by Lewina O. Lee, Peter James, Emily S. Zevon, Eric S. Kim, Claudia Trudel-Fitzgerald, Avron Spiro III, Francine Grodstein, and Laura D. Kubzansky (Vol. 116, No. 37, September 10, 2019, p. 18357-18362).

www.pnas.org/content/116/37/18357

B. “The joint influence of intelligence and practice on skill development throughout the life span,” by Nemanja Vaci, Peter Edelsbrunner, Elsbeth Stern, Aljoscha Neubauer, Merim Bilalić, and Roland H. Grabner (Vol. 116, No. 37, September 10, 2019, p. 18363-18369).

www.pnas.org/content/116/37/18363

August 29, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 29, 2019

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“Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis,” by Latika Matai, Gautam Chandra Sarkar, Manish Chamoli, Yasir Malik, Shashi Shekhar Kumar, Umanshi Rautela, Nihar Ranjan Jana, Kausik Chakraborty, and Arnab Mukhopadhyay (Vol. 116, No. 35, August 27, 2019, p. 17383-17392).

www.pnas.org/content/116/35/17383

 

August 13, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 13, 2019

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“Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson’s disease,” by Joohyung Lee, Paulo Pinares-Garcia, Hannah Loke, Seungmin Ham, Eric Vilain, and Vincent R. Harley (Vol. 116, No. 33, August 13, 2019, p. 16577-16582).

www.pnas.org/content/116/33/16577

August 6, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 6, 2019

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“Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network,” by Hayriye Cagnan, Nicolas Mallet, Christian K. E. Moll, Alessandro Gulberti, Abbey B. Holt, Manfred Westphal, Christian Gerloff, Andreas K. Engel, Wolfgang Hamel, Peter J. Magill, Peter Brown, and Andrew Sharott (Vol. 116, No. 32, August 6, 2019, p. 16095-16104).

www.pnas.org/content/116/32/16095

June 20, 2019

CAAR – Proceedings of the National Academy of Science Article Abstract – June 20, 2019

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“NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models,” by Gahee Bahn, Jong-Sung Park, Ui Jeong Yun, Yoon Jee Lee, Yuri Choi, Jin Su Park, Seung Hyun Baek, Bo Youn Choi, Yoon Suk Cho, Hark Kyun Kim, Jihoon Han, Jae Hoon Sul, Sang-Ha Baik, Jinhwan Lim, Nobunao Wakabayashi, Soo Han Bae, Jeung-Whan Han, Thiruma V. Arumugam, Mark P. Mattson, and Dong-Gyu Jo (Vol. 116, No. 25, June 18, 2019, p. 12516-12523).

www.pnas.org/content/116/25/12516

May 14, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 14, 2019

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“Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy,” by Takayuki Inoue, Satoshi Saito, Masashi Tanaka, Hajime Yamakage, Toru Kusakabe, Akira Shimatsu, Masafumi Ihara, and Noriko Satoh-Asahara (Vol. 116, No. 20, May 14, 2019, p. 10031-10038).

www.pnas.org/content/116/20/10031

May 7, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 7, 2019

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“Toward personalized cognitive diagnostics of at-genetic-risk Alzheimer’s disease,” by Gillian Coughlan, Antoine Coutrot, Mizanur Khondoker, Anne-Marie Minihane, Hugo Spiers, and Michael Hornberger (Vol. 116, No. 19, May 7, 2019, p. 9285-9292).

www.pnas.org/content/116/19/9285

April 30, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – April 30, 2019

Filed under: Reports and Articles — Tags: , — admin @ 5:21 pm

A. “{alpha}-Sheet secondary structure in amyloid {beta}-peptide drives aggregation and toxicity in Alzheimer’s disease,” by Dylan Shea, Cheng-Chieh Hsu, Timothy M. Bi, Natasha Paranjapye, Matthew Carter Childers, Joshua Cochran, Colson P. Tomberlin, Libo Wang, Daniel Paris, Jeffrey Zonderman, Gabriele Varani, Christopher D. Link, Mike Mullan, and Valerie Daggett (Vol. 116, No. 18, April 30, 2019, p. 8895-8900).

www.pnas.org/content/116/18/8895

B. “Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies,” by Jie Xiang, Zhi-Hao Wang, Eun Hee Ahn, Xia Liu, Shan-Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Gong Ju, Shengxi Wu, and Keqiang Ye (Vol. 116, No. 18, April 30, 2019, p. 9094-9102).

www.pnas.org/content/116/18/9094

April 5, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 5, 2019

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“Age-related inflammation triggers skeletal stem/progenitor cell dysfunction,” by Anne Marie Josephson, Vivian Bradaschia-Correa, Sooyeon Lee, Kevin Leclerc, Karan S. Patel, Emma Muinos Lopez, Hannah P. Litwa, Shane S. Neibart, Manasa Kadiyala, Madeleine Z. Wong, Matthew M. Mizrahi, Nury L. Yim, Austin J. Ramme, Kenneth A. Egol, and Philipp Leucht (Vol. 116, No. 14, April 2, 2019, p. 6995-7004).

www.pnas.org/content/116/14/6995

March 19, 2019

CAAR – Proceedings of the National Academies of Sciences Article Abstracts – March 19, 2019

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A. “Advantaged socioeconomic conditions in childhood are associated with higher cognitive functioning but stronger cognitive decline in older age,” by Marja J. Aartsen, Boris Cheval, Stefan Sieber, Bernadette W. Van der Linden, Rainer Gabriel, Delphine S. Courvoisier, Idris Guessous, Claudine Burton-Jeangros, David Blane, Andreas Ihle, Matthias Kliegel, and Stephane Cullati (Vol. 116, No. 12, March 19, 2019, p. 5478-5486).

www.pnas.org/content/116/12/5478

B. “Parkinson’s disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration,” by Xi Chen, Jennifer K. Kordich, Erin T. Williams, Nathan Levine, Allyson Cole-Strauss, Lee Marshall, Viviane Labrie, Jiyan Ma, Jack W. Lipton, and Darren J. Moore (Vol. 116, No. 12, March 19, 2019, p. 5765-5774). Note: PNAS is providng open access to the full-text of this article.

www.pnas.org/content/116/12/5765

February 25, 2019

CAAR – Proceedings of the National Academies of Sciences Article Abstract – February 25, 2019

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“Hippocampal atrophy and intrinsic brain network dysfunction relate to alterations in mind wandering in neurodegeneration,” by Claire O’Callaghan, James M. Shine, John R. Hodges, Jessica R. Andrews-Hanna, and Muireann Irish (Vol. 116, No. 8, February 19, 2019, p. 3316-3321).

www.pnas.org/content/116/8/3316

February 8, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 8, 2019

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“Influence of young adult cognitive ability and additional education on later-life cognition,” by William S. Kremen, Asad Beck, Jeremy A. Elman, Daniel E. Gustavson, Chandra A. Reynolds, Xin M. Tu, Mark E. Sanderson-Cimino, Matthew S. Panizzon, Eero Vuoksimaa, Rosemary Toomey, Christine Fennema-Notestine, Donald J. Hagler Jr., Bin Fang, Anders M. Dale, Michael J. Lyons, and Carol E. Franz (Vol. 116, No. 6, February 5, 2019, p. 2021-2026).

www.pnas.org/content/116/6/2021

January 23, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 23, 2019

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“Leading a meaningful life at older ages and its relationship with social engagement, prosperity, health, biology, and time use,” by Andrew Steptoe and Daisy Fancourt (Vol. 116, No. 4, January 22, 2019, .pdf and HTML format, p. 1207-1212). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/116/4/1207

 

January 15, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 15, 2019

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“Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo,” by Neeraj K. Aryal, Vinod Pant, Amanda R. Wasylishen, Jan Parker-Thornburg, Laura Baseler, Adel K. El-Naggar, Bin Liu, Awdhesh Kalia, Guillermina Lozano, and Swathi Arur (Vol. 116, No. 3, January 15, 2019, p. 960-969).

www.pnas.org/content/116/3/960?etoc=

January 2, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 2, 2019

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A. “Bax inhibitor 1 is a {gamman}-secretase–independent presenilin-binding protein,” by Shenjie Wu, Wenqi Song, Catherine C. L. Wong, and Yigong Shi (Vol. 116, No. 1, January 2, 2019, p. 141-147).

www.pnas.org/content/116/1/141

B. “TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling,” by Bochra Zidi, Christelle Vincent-Fabert, Laurent Pouyet, Marion Seillier, Amelle Vandevelde, Prudence N’guessan, Mathilde Poplineau, Geoffrey Guittard, Stéphane J. C. Mancini, Estelle Duprez, and Alice Carrier (Vol. 116, No. 1, January 2, 2019, p. 211-216).

www.pnas.org/content/116/1/211

December 28, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – December 28, 2018

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A. “Cofactors are essential constituents of stable and seeding-active tau fibrils,” by Yann Fichou, Yanxian Lin, Jennifer N. Rauch, Michael Vigers, Zhikai Zeng, Madhur Srivastava, Timothy J. Keller, Jack H. Freed, Kenneth S. Kosik, and Songi Han (Vol. 115, No. 52, December 26, 2018, p. 13234-13239).

www.pnas.org/content/115/52/13234

B. “Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice,” by Noga Ron-Harel, Giulia Notarangelo, Jonathan M. Ghergurovich, Joao A. Paulo, Peter T. Sage, Daniel Santos, F. Kyle Satterstrom, Steven P. Gygi, Joshua D. Rabinowitz, Arlene H. Sharpe, and Marcia C. Haigis (Vol. 115, No. 52, December 26, 2018, p. 13347-13352).

www.pnas.org/content/115/52/13347

C. “Spatiotemporal activation of the C/EBP{beta}/{delta}-secretase axis regulates the pathogenesis of Alzheimer’s disease,” by Hualong Wang, Xia Liu, Shengdi Chen, and Keqiang Ye (Vol. 115, No. 52, December 26, 2018, p. E12427-E12434).

www.pnas.org/content/115/52/E12427

 

December 18, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 18, 2018

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“Probing the mechanism of inhibition of amyloid-{beta}(1–42)–induced neurotoxicity by the chaperonin GroEL,” by Marielle A. Walti, Joseph Steiner, Fanjie Meng, Hoi Sung Chung, John M. Louis, Rodolfo Ghirlando, Vitali Tugarinov, Avindra Nath, and G. Marius Clore (Vol. 115, No. 51, December 18, 2018, p. E11924-E11932).

doi.org/10.1073/pnas.1817477115

December 4, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 4,, 2018

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“Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain,” by Regina F. Fernandez, Sora Q. Kim, Yingwei Zhao, Rachel M. Foguth, Marcus M. Weera, Jessica L. Counihan, Daniel K. Nomura, Julia A. Chester, Jason R. Cannon, and Jessica M. Ellis (Vol. 115, No. 49, December 4, 2018, p. 12525-12530).

www.pnas.org/content/115/49/12525

November 29, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 29, 2018

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“Double dissociation of single-interval and rhythmic temporal prediction in cerebellar degeneration and Parkinson’s disease,” by Assaf Breska and Richard B. Ivry (Vol. 115, No. 48, November 27, 2018, p. 12283-12288).

www.pnas.org/content/115/48/12283?etoc=

November 20, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 20, 2018

Filed under: Reports and Articles — Tags: , , , — admin @ 5:42 pm

A. “Role of income mobility for the measurement of inequality in life expectancy,” by Claus Thustrup Kreiner, Torben Heien Nielsen, and Benjamin Ly Serena (Vol. 115, No. 46, November 13, 2018, p. 11754-11759).

www.pnas.org/content/115/46/11754

B. “Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy,” by Jonathan S. Wall, Angela D. Williams, James S. Foster, Tina Richey, Alan Stuckey, Sallie Macy, Craig Wooliver, Shawn R. Campagna, Eric D. Tague, Abigail T. Farmer, Ronald H. Lands, Emily B. Martin, R. Eric Heidel, and Stephen J. Kennel (Vol. 115, No. 46, November 13, 2018, p. E10839-E10848).

www.pnas.org/content/115/46/E10839

November 13, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 13, 2018

Filed under: Reports and Articles — Tags: , , , — admin @ 4:40 pm

A. “Role of income mobility for the measurement of inequality in life expectancy,” by Claus Thustrup Kreiner, Torben Heien Nielsen, and Benjamin Ly Serena (Vol. 115, No. 46, November 13, 2018, p. 11754-11759).

www.pnas.org/content/115/46/11754

B. “Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy,” by Jonathan S. Wall, Angela D. Williams, James S. Foster, Tina Richey, Alan Stuckey, Sallie Macy, Craig Wooliver, Shawn R. Campagna, Eric D. Tague, Abigail T. Farmer, Ronald H. Lands, Emily B. Martin, R. Eric Heidel, and Stephen J. Kennel (Vol. 115, No. 46, November 13, 2018, p. E10839-E10848).

www.pnas.org/content/115/46/E10839

November 6, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 6, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 5:06 pm

“Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology,” by María Díaz-Moreno, Tomás Armenteros, Simona Gradari, Rafael Hortigüela, Laura García-Corzo, Ángela Fontán-Lozano, José Luis Trejo, and Helena Mira (Vol. 115, No. 45, November 6, 2018, p. 11625-11630).

www.pnas.org/content/115/45/11625

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