CDHA CAAR

May 17, 2022

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 17, 2022

Deep brain stimulation in the subthalamic nucleus for Parkinson’s disease can restore dynamics of striatal networks,” by Elie M. Adam, Emery N. Brown, Nancy Kopell, and Michelle M. McCarthy (Vol. 119, No. 19, May 17, 2022, e2120808119).

www.pnas.org/doi/10.1073/pnas.2120808119

May 4, 2022

CAAR – Proceedings of the National Academy of Science Article Abstract – May 4, 2022

Early age–related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging,” by Sandip Ashok Sonar, Jennifer L. Uhrlaub, Christopher P. Coplen, Gregory D. Sempowski, Jarrod A. Dudakov, Marcel R. M. van den Brink, Bonnie J. LaFleur, Mladen Jergović, and Janko Nikolich-Žugich (Vol. 119, No. 17, May 3, 2022, e2121028119).

www.pnas.org/doi/10.1073/pnas.2121028119

April 27, 2022

CAAR – Proceedings of the National Academy of Science Article Abstract – April 27, 2022

Early age–related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging,” by Sandip Ashok Sonar, Jennifer L. Uhrlaub, Christopher P. Coplen, Gregory D. Sempowski, Jarrod A. Dudakov, Marcel R. M. van den Brink, Bonnie J. LaFleur, Mladen Jergović, and Janko Nikolich-Žugich (Vol. 119, No. 17, April 26, 2022, e2121028119).

www.pnas.org/doi/10.1073/pnas.2121028119

March 22, 2022

CAAR – Proceedings of the National Academy of Science Article Abstract – March 22, 2022

Modulation of amyloid precursor protein cleavage by {gamma}-secretase activating protein through phase separation,” by Chen Jin, Jiaoni Wang, Yumeng Wang, Bojun Jia, Xuefei Guo, Guanghui Yang, Peng Xu, Paul Greengard, Rui Zhou, and Yigong Shi (Vol. 119, No. 12, March 22, 2022, e2122292119).

www.pnas.org/doi/10.1073/pnas.2122292119#abstract

March 8, 2022

CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 8, 2022

Social disadvantage, economic inequality, and life expectancy in nine Indian states,” by Sangita Vyas, Payal Hathi, and Aashish Gupta (Vol. 119, No. 10, March 8, 2022, e2109226119).

www.pnas.org/doi/10.1073/pnas.2109226119

February 8, 2022

CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 8, 2022

Different {alpha}-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophym” by Jacob I. Ayers, Joanne Lee, Octovia Monteiro, Amanda L. Woerman, Ann A. Lazar, Carlo Condello, Nick A. Paras, and Stanley B. Prusiner (Vol. 119, No. 6, February 8, 2022, e2113489119).

www.pnas.org/content/119/6/e2113489119.abstract?etoc

February 1, 2022

CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 1, 2022

Soluble TREM2 inhibits secondary nucleation of A{beta} fibrillization and enhances cellular uptake of fibrillar A{beta},” by Ketaki D. Belsare, Haifan Wu, Dibyendu Mondal, Annalise Bond, Erika Castillo, Jia Jin, Hyunil Jo, Addison E. Roush, Kala Bharath Pilla, Andrej Sali, Carlo Condello, and William F. DeGrado (Vol. 119, No. 5, February 1, 2022, e2114486119).

www.pnas.org/content/119/5/e2114486119.abstract?etoc

January 19, 2022

CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 19, 2022

Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer’s disease mice,” by Min Hee Park, Kang Ho Park, Byung Jo Choi, Wan Hui Han, Hee Ji Yoon, Hye Yoon Jung, Jihoon Lee, Im-Sook Song, Dong Yu Lim, Min-Koo Choi, Yang-Ha Lee, Cheol-Min Park, Ming Wang, Jihoon Jo, Hee-Jin Kim, Seung Hyun Kim, Edward H. Schuchman, Hee Kyung Jin, and Jae-sung Bae (Vol. 119, No. 3, January 18, 2022, e2115082119).

www.pnas.org/content/119/3/e2115082119.abstract?etoc

January 11, 2022

CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 11, 2022

Association of improved air quality with lower dementia risk in older women,” by Xinhui Wang, Diana Younan, Joshua Millstein, Andrew J. Petkus, Erika Garcia, Daniel P. Beavers, Mark A. Espeland, Helena C. Chui, Susan M. Resnick, Margaret Gatz, Joel D. Kaufman, Gregory A. Wellenius, Eric A. Whitsel, JoAnn E. Manson, Stephen R. Rapp, and Jiu-Chiuan Chen (Vol. 119, No. 2, January 11, 2022, e2107833119).

www.pnas.org/content/119/2/e2107833119.abstract?etoc

December 14, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 14, 2021

Pathological {alpha}-syn aggregation is mediated by glycosphingolipid chain length and the physiological state of {alpha}-syn in vivo,” by Kristina Fredriksen, Stefanos Aivazidis, Karan Sharma, Kevin J. Burbidge, Caleb Pitcairn, Friederike Zunke, Eilrayna Gelyana, and Joseph R. Mazzulli (Vol. 118, No. 50, December 14, 2021, e2108489118).

www.pnas.org/content/118/50/e2108489118.abstract?etoc

November 30, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 30, 2021

Amyloid {beta} 42 fibril structure based on small-angle scattering,” by Veronica Lattanzi, Ingemar André, Urs Gasser, Marija Dubackic, Ulf Olsson, and Sara Linse (Vol. 118, No. 48, November 30, 2021, e2112783118).

www.pnas.org/content/118/48/e2112783118.abstract?etoc

October 19, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 19, 2021

Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence,” by Yao Li, Damir Kračun, Christopher M. Dustin, Mohamed El Massry, Shuai Yuan, Christian J. Goossen, Evan R. DeVallance, Sanghamitra Sahoo, Cynthia St. Hilaire, Aditi U. Gurkar, Toren Finkel, Adam C. Straub, Eugenia Cifuentes-Pagano, and Patrick J. Pagano (Vol. 118, No. 42, October 19, 2021, e2015666118).

www.pnas.org/content/118/42/e2015666118.abstract?etoc

October 12, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 12, 2021

Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration,” by Meenakshi Ambati, Ivana Apicella, Shao-bin Wang, Siddharth Narendran, Hannah Leung, Felipe Pereira, Yosuke Nagasaka, Peirong Huang, Akhil Varshney, Kirstie L. Baker, Kenneth M. Marion, Mehrdad Shadmehr, Cliff I. Stains, Brian C. Werner, Srinivas R. Sadda, Ethan W. Taylor, S. Scott Sutton, Joseph Magagnoli, and Bradley D. Gelfand (Vol. 118, No. 41, October 12, 2021, e2102975118).

www.pnas.org/content/118/41/e2102975118.abstract?etoc

October 5, 2021

CAAR – Proceedings of the National Academy of Science Article Abstracts – October 5, 2021

A. “Inequality in mortality between Black and White Americans by age, place, and cause and in comparison to Europe, 1990 to 2018,” by Hannes Schwandt, Janet Currie, Marlies Bär, James Banks, Paola Bertoli, Aline Bütikofer, Sarah Cattan, Beatrice Zong-Ying Chao, Claudia Costa, Libertad González, Veronica Grembi, Kristiina Huttunen, René Karadakic, Lucy Kraftman, Sonya Krutikova, Stefano Lombardi, Peter Redler, Carlos Riumallo-Herl, Ana Rodríguez-González, Kjell G. Salvanes, Paula Santana, Josselin Thuilliez, Eddy van Doorslaer, Tom Van Ourti, Joachim K. Winter, Bram Wouterse, and Amelie Wuppermann (Vol. 118, No. 40, October 5, 2021, e2104684118).

www.pnas.org/content/118/40/e2104684118.abstract?etoc

B. “Metabolism modulates network synchrony in the aging brain,” by Corey Weistuch, Lilianne R. Mujica-Parodi, Rostam M. Razban, Botond Antal, Helena van Nieuwenhuizen, Anar Amgalan, and Ken A. Dill (Vol. 118, No. 40, October 5, 2021, e2025727118).

www.pnas.org/content/118/40/e2025727118.abstract?etoc

September 29, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 29, 2021

Amyloid-{beta} peptide dimers undergo a random coil to {beta}-sheet transition in the aqueous phase but not at the neuronal membrane,” by Hebah Fatafta, Mohammed Khaled, Michael C. Owen, Abdallah Sayyed-Ahmad, and Birgit Strodel (Vol. 118, No. 39, September 28, 2021, e2106210118).

www.pnas.org/content/118/39/e2106210118.abstract?etoc

September 22, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 22, 2021

Frustrated peptide chains at the fibril tip control the kinetics of growth of amyloid-{beta} fibrils,” by Yuechuan Xu, Kaitlin Knapp, Kyle N. Le, Nicholas P. Schafer, Mohammad S. Safari, Aram Davtyan, Peter G. Wolynes, and Peter G. Vekilov (Vol. 118, No. 38, September 21, 2021, e2110995118).

www.pnas.org/content/118/38/e2110995118.abstract?etoc

September 15, 2021

CAAR – Proceedings of the National Academy of Science Article Abstracts – September 15, 2021

A. “Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites,” by Takayuki Teruya, Yung-Ju Chen, Hiroshi Kondoh, Yasuhide Fukuji, and Mitsuhiro Yanagida (Vol. 118, No. 37, September 14, 2021, e2022857118).

www.pnas.org/content/118/37/e2022857118.abstract

B. “FGF-2–dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis,” by Sebastian Mathes, Alexandra Fahrner, Umesh Ghoshdastider, Hannes A. Rüdiger, Michael Leunig, Christian Wolfrum, and Jan Krützfeldt (Vol. 118, No. 37, September 14, 2021, e2021013118).

www.pnas.org/content/118/37/e2021013118.abstract

C. “NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING,” by Yujun Hou, Yong Wei, Sofie Lautrup, Beimeng Yang, Yue Wang, Stephanie Cordonnier, Mark P. Mattson, Deborah L. Croteau, and Vilhelm A. Bohr (Vol. 118, No. 37, September 14, 2021, e2011226118).

www.pnas.org/content/118/37/e2011226118.abstract

September 7, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 7, 2021

All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of {alpha}-synuclein toxic species,” by Aitor Franco, Pablo Gracia, Adai Colom, José D. Camino, José Ángel Fernández-Higuero, Natalia Orozco, Alexander Dulebo, Leonor Saiz, Nunilo Cremades, Jose M.G. Vilar, Adelina Prado, and Arturo Muga (Vol. 118, No. 36, September 7, 2021, e2105548118).

www.pnas.org/content/118/36/e2105548118.abstract?etoc

August 31, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 31, 2021

The N terminus of {alpha}-synuclein dictates fibril formation,” by Ryan P. McGlinchey, Xiaodan Ni, Jared A. Shadish, Jiansen Jiang, and Jennifer C. Lee (Vol. 118, No. 35, August 31, 2021, e2023487118).

www.pnas.org/content/118/35/e2023487118.abstract?etoc

August 25, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 25, 2021

Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration,” by Chenyin Wang, Chun Yin Lau, Fuqiang Ma, and Chaogu Zheng (Vol. 118, No. 34, August 24, 2021, e2106504118).

www.pnas.org/content/118/34/e2106504118.abstract?etoc

August 18, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – August 18, 2021

A. “Effects of sex and aging on the immune cell landscape as assessed by single-cell transcriptomic analysis,” by Zhaohao Huang, Binyao Chen, Xiuxing Liu, He Li, Lihui Xie, Yuehan Gao, Runping Duan, Zhaohuai Li, Jian Zhang, Yingfeng Zheng, and Wenru Su (Vol. 118, No. 33, August 17, 2021, e2023216118).

www.pnas.org/content/118/33/e2023216118.abstract?etoc

B. “Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol,” by Hao Wang, Joshua A. Kulas, Chao Wang, David M. Holtzman, Heather A. Ferris, and Scott B. Hansen (Vol. 118, No. 33, August 17, 2021, e2102191118).

www.pnas.org/content/118/33/e2102191118.abstract?etoc

August 11, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 11, 2021

Psychological resilience predicting cardiometabolic conditions in adulthood in the Midlife in the United States Study,” by Kristen M. Nishimi, Karestan C. Koenen, Brent A. Coull, Ruijia Chen, and Laura D. Kubzansky (Vol. 118, No. 32, August 10, 2021, e2102619118).

www.pnas.org/content/118/32/e2102619118.abstract?etoc

July 6, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 6, 2021

A. “Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading,” by Yin Xu, Nicholas E. Propson, Shuqi Du, Wen Xiong, and Hui Zheng (Vol. 118, No. 27, July 6, 2021, e2023418118).

www.pnas.org/content/118/27/e2023418118.abstract?etoc

B. “Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice,” by Kathleen M. Schoch, Lubov A. Ezerskiy, Michaela M. Morhaus, Riley N. Bannon, Andrew D. Sauerbeck, Mark Shabsovich, Paymaan Jafar-nejad, Frank Rigo, and Timothy M. Miller (Vol. 118, No. 27, July 6, 2021, e2100356118).

www.pnas.org/content/118/27/e2100356118.abstract?etoc

June 17, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 17, 2021

The balance of giving versus receiving social support and all-cause mortality in a US national sample,” by Edith Chen, Phoebe H. Lam, Eric D. Finegood, Nicholas A. Turiano, Daniel K. Mroczek, and Gregory E. Miller (Vol. 118, No. 24, June 15, 2021, e2024770118).

www.pnas.org/content/118/24/e2024770118.abstract?etoc

June 1, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 1, 2021

Aging as a consequence of selection to reduce the environmental risk of dying,” by Stig W. Omholt and Thomas B. L. Kirkwood (Vol. 118, No. 22, June 1, 2021, e2102088118).

www.pnas.org/content/118/22/e2102088118.abstract?etoc

 

May 18, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 18, 2021

Death rates at specific life stages mold the sex gap in life expectancy,” by Virginia Zarulli, Ilya Kashnitsky, and James W. Vaupel (Vol. 118, No. 20, May 18, 2021, e2010588118).

www.pnas.org/content/118/20/e2010588118.abstract?etoc

May 6, 2021

CAAR – Proceedings of the National Academy of Science Article Abstract – May 6, 2021

Educational attainment does not influence brain aging,” by Lars Nyberg, Fredrik Magnussen, Anders Lundquist, William Baaré, David Bartrés-Faz, Lars Bertram, C. J. Boraxbekk, Andreas M. Brandmaier, Christian A. Drevon, Klaus Ebmeier, Paolo Ghisletta, Richard N. Henson, Carme Junqué, Rogier Kievit, Maike Kleemeyer, Ethan Knights, Simone Kühn, Ulman Lindenberger, Brenda W. J. H. Penninx, Sara Pudas, Øystein Sørensen, Lídia Vaqué-Alcázar, Kristine B. Walhovd, and Anders M. Fjell (Vol. 118, No. 18, May 4, 2021, e2101644118).

www.pnas.org/content/118/18/e2101644118.abstract?etoc

April 22, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 22, 2021

Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer’s disease,” by Jodie Lord, Bradley Jermy, Rebecca Green, Andrew Wong, Jin Xu, Cristina Legido-Quigley, Richard Dobson, Marcus Richards, and Petroula Proitsi (Vol. 118, No. 16, April 20, 2021, e2009808118).

www.pnas.org/content/118/16/e2009808118.abstract?etoc

April 15, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 15, 2021

Soluble {alpha}-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia,” by Dorit Trudler, Kristopher L. Nazor, Yvonne S. Eisele, Titas Grabauskas, Nima Dolatabadi, James Parker, Abdullah Sultan, Zhenyu Zhong, Marshall S. Goodwin, Yona Levites, Todd E. Golde, Jeffery W. Kelly, Michael R. Sierks, Nicholas J. Schork, Michael Karin, Rajesh Ambasudhan, and Stuart A. Lipton (Vol. 118, No. 15, April 13, 2021, e2025847118).

www.pnas.org/content/118/15/e2025847118.abstract?etoc

March 24, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 24, 2021

Rapid initiation of cell cycle reentry processes protects neurons from amyloid-{beta} toxicity,” by Stefania Ippati, Yuanyuan Deng, Julia van der Hoven, Celine Heu, Annika van Hummel, Sook Wern Chua, Esmeralda Paric, Gabriella Chan, Astrid Feiten, Thomas Fath, Yazi D. Ke, Nikolas K. Haass, and Lars M. Ittner (Vol. 118, No. 12, March 23, 2021, e2011876118).

www.pnas.org/content/118/12/e2011876118.abstract?etoc

 

March 18, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 18, 2021

A. “Life expectancy in adulthood is falling for those without a BA degree, but as educational gaps have widened, racial gaps have narrowed,” by Anne Case and Angus Deaton (Vol. 118, No. 11, March 16, 2021, e2024777118).

www.pnas.org/content/118/11/e2024777118.abstract?etoc

B. “Unique molecular characteristics and microglial origin of Kv1.3 channel–positive brain myeloid cells in Alzheimer’s disease,” by Supriya Ramesha, Sruti Rayaprolu, Christine A. Bowen, Cynthia R. Giver, Sara Bitarafan, Hai M. Nguyen, Tianwen Gao, Michael J. Chen, Ngozi Nwabueze, Eric B. Dammer, Amanda K. Engstrom, Hailian Xiao, Andrea Pennati, Nicholas T. Seyfried, David J. Katz, Jacques Galipeau, Heike Wulff, Edmund K. Waller, Levi B. Wood, Allan I. Levey, and Srikant Rangaraju (Vol. 118, No. 11, March 16, 2021, e2013545118).

www.pnas.org/content/118/11/e2013545118.abstract?etoc

March 11, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 11, 2021

Structural insights into {alpha}-synuclein monomer–fibril interactions,” by Pratibha Kumari, Dhiman Ghosh, Agathe Vanas, Yanick Fleischmann, Thomas Wiegand, Gunnar Jeschke,Roland Riek, and Cédric Eichmann (Vol. 118, No. 10, March 9, 2021, e2012171118).

www.pnas.org/content/118/10/e2012171118.abstract?etoc

 

March 3, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 3, 2021

Filed under: Reports and Articles — Tags: , — admin @ 9:43 pm

TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau,” by Peter E. A. Ash, Shuwen Lei, Jenifer Shattuck, Samantha Boudeau, Yari Carlomagno, Maria Medalla, Bryce L. Mashimo, Guillermo Socorro, Louloua F. A. Al-Mohanna, Lulu Jiang, Muhammet M. Öztürk, Mark Knobel, Pavel Ivanov, Leonard Petrucelli, Susanne Wegmann, Nicholas M. Kanaan, and Benjamin Wolozin (Vol. 118, No. 9, March 2, 2021, e2014188118).

www.pnas.org/content/118/9/e2014188118.abstract?etoc

February 9, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 9, 2021

Developmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration,” by Dávid Nagy, Katelin A. Ennis, Ru Wei, Susan C. Su, Christopher A. Hinckley, Rong-Fang Gu, Benbo Gao, Ramiro H. Massol, Chris Ehrenfels, Luke Jandreski, Ankur M. Thomas, Ashley Nelson, Stefka Gyoneva, Mihály Hajós, and Linda C. Burkly (Vol. 118, No. 6, February 9, 2021, e2001679118).

www.pnas.org/content/118/6/e2001679118.abstract?etoc

 

February 4, 2021

CAAR – Proceedings of the National Academy of Science Article Abstract – February 4, 2021

Reductions in 2020 US life expectancy due to COVID-9 and the disproportionate impact on the Black and Latino populations,” by Theresa Andrasfay and Noreen Goldman (Vol. 118, No. 5, February 2, 2021, e20147461180).

www.pnas.org/content/118/5/e2014746118.abstract?etoc

January 19, 2021

CAAR – Proceedings of the National Academy of Science Article Abstracts – January 19, 2021

A. “Prediction of Alzheimer’s disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening,” by Sung-Hyun Kim, Sumin Yang, Key-Hwan Lim, Euiseng Ko, Hyun-Jun Jang, Mingon Kang, Pann-Ghill Suh, and Jae-Yeol Joo (Vol. 118, No. 3, January 19, 2021, e2011250118).

www.pnas.org/content/118/3/e2011250118.abstract?etoc

B. “Childhood self-control forecasts the pace of midlife aging and preparedness for old age,” by Leah S. Richmond-Rakerd, Avshalom Caspi, Antony Ambler, Tracy d’Arbeloff, Marieke de Bruine, Maxwell Elliott, HonaLee Harrington, Sean Hogan, Renate M. Houts, David Ireland, Ross Keenan, Annchen R. Knodt, Tracy R. Melzer, Sena Park, Richie Poulton, Sandhya Ramrakha, Line Jee Hartmann Rasmussen, Elizabeth Sack, Adam T. Schmidt, Maria L. Sison, Jasmin Wertz, Ahmad R. Hariri, and Terrie E. Moffitt (Vol. 118, No. 3, January 19, 2021, e2010211118).

www.pnas.org/content/118/3/e2010211118.abstract?etoc

January 6, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 6, 2021

A. “Nursing home staff networks and COVID-19,” by M. Keith Chen, Judith A. Chevalier, and Elisa F. Long (Vol. 118, No. 1, January 5, 2021, e2015455118).

www.pnas.org/content/118/1/e2015455118.abstract?etoc

B. “The Parkinson’s disease-associated gene ITPKB protects against {alpha}-synuclein aggregation by regulating ER-to-mitochondria calcium release,” by Daniel J. Apicco, Evgeny Shlevkov, Catherine L. Nezich, David T. Tran, Edward Guilmette, Justin W. Nicholatos, Collin M. Bantle, Yi Chen, Kelly E. Glajch, Neeta A. Abraham, Lan T. Dang, G. Campbell Kaynor, Ellen A. Tsai, Khanh-Dung H. Nguyen, Joost Groot, YuTing Liu, Andreas Weihofen, Jessica A. Hurt, Heiko Runz, and Warren D. Hirst (Vol. 118, No. 1, January 5, 2021, e2006476118).

www.pnas.org/content/118/1/e2006476118.abstract?etoc

December 29, 2020

CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 29, 2020

Filed under: Reports and Articles — Tags: , — admin @ 5:41 pm

Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model,” by Kelly M. Lohr, Bess Frost, Clemens Scherzer, and Mel B. Feany (Vol. 117, No. 52, December 29, 2020, p. 33608-33618).

www.pnas.org/content/117/52/33608.abstract?etoc

December 28, 2020

CAAR – Proceedings of the National Academy of Science Article Abstract – December 28, 2020

Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer’s disease,” by Sonam Dubey, Stefan Heinen, Slavica Krantic, JoAnne McLaurin, Donald R. Branch, Kullervo Hynynen, and Isabelle Aubert (Vol. 117, No. 51, December 23, 2020, p. 32691-32700).

www.pnas.org/content/117/51/32691

December 9, 2020

CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 9, 2020

Design of a multivalent bifunctional chelator for diagnostic 64Cu PET imaging in Alzheimer’s disease,” by Hong-Jun Cho, Truc T. Huynh, Buck E. Rogers, and Liviu M. Mirica (Vol. 117, No. 49, December 8, 2020, p. 30928-30933).

www.pnas.org/content/117/49/30928.abstract.html?etoc

December 1, 2020

CAAR – Proceedings of the National Academy of Science Article Abstract – December 1, 2020

Global associations between macronutrient supply and age-specific mortality,” by Alistair M. Senior, Shinichi Nakagawa, David Raubenheimer, and Stephen J. Simpson (Vol. 117, No. 48, December 1, 2020, p. 30824-30835).

www.pnas.org/content/117/48/30824.abstract?etoc

November 25, 2020

CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 25, 2020

Aging and the encoding of changes in events: The role of neural activity pattern reinstatement,” by David Stawarczyk, Christopher N. Wahlheim, Joset A. Etzel, Abraham Z. Snyder, and Jeffrey M. Zacks (Vol. 117, No. 47, November 24, 2020, p. 29346-29353).

www.pnas.org/content/117/47/29346.abstract.html?etoc

November 4, 2020

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 4, 2020

A. “Life cycle patterns of cognitive performance over the long run,” by Anthony Strittmatter, Uwe Sunde, and Dainis Zegners (Vol. 117, No. 44, November 3, 2020, p. 27255-27261).

www.pnas.org/content/117/44/27255.abstract.html?etoc

B. “Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance,” by Oeystein Roed Brekk, Jonathan R. Honey, Seungil Lee, Penelope J. Hallett, and Ole Isacson (Vol. 117, No. 44, November 3, 2020, p. 27646-27654).

www.pnas.org/content/117/44/27646.abstract.html?etoc

October 20, 2020

CAAR – Proceedings of the National Academy of Science Article Abstract – October 20, 2020

Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria,” by Danielle E. Mor, Salman Sohrabi, Rachel Kaletsky, William Keyes, Alp Tartici, Vrinda Kalia, Gary W. Miller, and Coleen T. Murphy (Vol. 117, No. 42, October 20, 2020, p. 26438-26447).

www.pnas.org/content/117/42/26438.abstract?etoc

October 14, 2020

CAAR – Proceedings of the National Academy of Sciences Article Abstract -October 14, 2020

Single-nuceus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease,” by Shun-Fat Lau, Han Cao, Amy K. Y. Fu, and Nancy Y. Ip (Vol. 117, No. 41, October 13, 2020, p. 25272-25283).

www.pnas.org/content/117/41/25272.abstract?etoc

October 9, 2020

CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 9, 2020

Decoding the mystery of American pain reveals a warning for the future,” by Anne Case, Angus Deaton, and Arthur A. Stone (Vol. 117, No. 40, October 6, 2020, p. 24785-24789).

www.pnas.org/content/117/40/24785.abstract?etoc

July 28, 2020

CAAR – Proceedings of the National Academy of Science Article – July 28, 2020

Note: Check with your organization’s library for availability. “Quantifying and explaining variation in life expectancy at census tract, county, and state levels in the United States,” by Antonio Fernando Boing, Alexandra Crispim Boing, Jack Cordes, Rockli Kim, and S. V. Subramanian (Vol. 117, No. 30, July 28, 2020, p. 17688-17694).

www.pnas.org/content/117/30/17688

July 22, 2020

CAAR – Proceedings of the National Academies of Science Article Abstracts – July 22, 2020

A. “Dopaminergic neurodegeneration induced by Parkinson’s disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity,” by An Phu Tran Nguyen, Elpida Tsika, Kaela Kelly, Nathan Levine, Xi Chen, Andrew B. West, Sylviane Boularand, Pascal Barneoud, and Darren J. Moore (Vol. 117, No. 29, July 21, 2020, p. 17296-17307).

www.pnas.org/content/117/29/17296

B. “Basal ganglia beta oscillations during sleep underlie Parkinsonian insomnia,” by Aviv D. Mizrahi-Kliger, Alexander Kaplan, Zvi Israel, Marc Deffains, and Hagai Bergman (Vol. 117, No. 29, July 21, 2020, p. 17359-17368).

www.pnas.org/content/117/29/17359

July 14, 2020

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 14, 2020

Note: Check with your organization’s library for availability.

A. “The transition to family caregiving and its effect on biomarkers of inflammation,” by David L. Roth, William E. Haley, Orla C. Sheehan, Jin Huang, J. David Rhodes, Peter Durda, Virginia J. Howard, Jeremy D. Walston, and Mary Cushman (Vol. 117, No. 28, July 14, 2020, p. 16258-16263).

www.pnas.org/content/117/28/16258

B. “Predicting mortality from 57 economic, behavioral, social, and psychological factors,” by Eli Puterman, Jordan Weiss, Benjamin A. Hives, Alison Gemmill, Deborah Karasek, Wendy Berry Mendes, and David H. Rehkopf (Vol. 117, No. 28, July 14, 2020, p. 16273-16282).

www.pnas.org/content/117/28/16273

July 1, 2020

CAAR – Proceedings of the National Academy of Sciences Article – July 1, 2020

Note: Check with your organization’s library for availability. “Impact of alpha-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized alpha-synuclein rat model of PD,” by Deirdre B. Hoban, Shelby Shrigley, Bengt Mattsson, Ludivine S. Breger, Ulla Jarl, Tiago Cardoso, Jenny Nelander Wahlestedt, Kelvin C. Luk, Anders Björklund, and Malin Parmar (Vol. 117, No. 26, June 30, 2020, p. 15209-15220).

www.pnas.org/content/117/26/15209

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