“NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models,” by Gahee Bahn, Jong-Sung Park, Ui Jeong Yun, Yoon Jee Lee, Yuri Choi, Jin Su Park, Seung Hyun Baek, Bo Youn Choi, Yoon Suk Cho, Hark Kyun Kim, Jihoon Han, Jae Hoon Sul, Sang-Ha Baik, Jinhwan Lim, Nobunao Wakabayashi, Soo Han Bae, Jeung-Whan Han, Thiruma V. Arumugam, Mark P. Mattson, and Dong-Gyu Jo (Vol. 116, No. 25, June 18, 2019, p. 12516-12523).
June 20, 2019
CAAR – Proceedings of the National Academy of Science Article Abstract – June 20, 2019
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May 14, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 14, 2019
“Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy,” by Takayuki Inoue, Satoshi Saito, Masashi Tanaka, Hajime Yamakage, Toru Kusakabe, Akira Shimatsu, Masafumi Ihara, and Noriko Satoh-Asahara (Vol. 116, No. 20, May 14, 2019, p. 10031-10038).
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May 7, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 7, 2019
“Toward personalized cognitive diagnostics of at-genetic-risk Alzheimer’s disease,” by Gillian Coughlan, Antoine Coutrot, Mizanur Khondoker, Anne-Marie Minihane, Hugo Spiers, and Michael Hornberger (Vol. 116, No. 19, May 7, 2019, p. 9285-9292).
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April 30, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – April 30, 2019
A. “{alpha}-Sheet secondary structure in amyloid {beta}-peptide drives aggregation and toxicity in Alzheimer’s disease,” by Dylan Shea, Cheng-Chieh Hsu, Timothy M. Bi, Natasha Paranjapye, Matthew Carter Childers, Joshua Cochran, Colson P. Tomberlin, Libo Wang, Daniel Paris, Jeffrey Zonderman, Gabriele Varani, Christopher D. Link, Mike Mullan, and Valerie Daggett (Vol. 116, No. 18, April 30, 2019, p. 8895-8900).
www.pnas.org/content/116/18/8895
B. “Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies,” by Jie Xiang, Zhi-Hao Wang, Eun Hee Ahn, Xia Liu, Shan-Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Gong Ju, Shengxi Wu, and Keqiang Ye (Vol. 116, No. 18, April 30, 2019, p. 9094-9102).
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April 5, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 5, 2019
“Age-related inflammation triggers skeletal stem/progenitor cell dysfunction,” by Anne Marie Josephson, Vivian Bradaschia-Correa, Sooyeon Lee, Kevin Leclerc, Karan S. Patel, Emma Muinos Lopez, Hannah P. Litwa, Shane S. Neibart, Manasa Kadiyala, Madeleine Z. Wong, Matthew M. Mizrahi, Nury L. Yim, Austin J. Ramme, Kenneth A. Egol, and Philipp Leucht (Vol. 116, No. 14, April 2, 2019, p. 6995-7004).
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March 19, 2019
CAAR – Proceedings of the National Academies of Sciences Article Abstracts – March 19, 2019
A. “Advantaged socioeconomic conditions in childhood are associated with higher cognitive functioning but stronger cognitive decline in older age,” by Marja J. Aartsen, Boris Cheval, Stefan Sieber, Bernadette W. Van der Linden, Rainer Gabriel, Delphine S. Courvoisier, Idris Guessous, Claudine Burton-Jeangros, David Blane, Andreas Ihle, Matthias Kliegel, and Stephane Cullati (Vol. 116, No. 12, March 19, 2019, p. 5478-5486).
www.pnas.org/content/116/12/5478
B. “Parkinson’s disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration,” by Xi Chen, Jennifer K. Kordich, Erin T. Williams, Nathan Levine, Allyson Cole-Strauss, Lee Marshall, Viviane Labrie, Jiyan Ma, Jack W. Lipton, and Darren J. Moore (Vol. 116, No. 12, March 19, 2019, p. 5765-5774). Note: PNAS is providng open access to the full-text of this article.
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February 25, 2019
CAAR – Proceedings of the National Academies of Sciences Article Abstract – February 25, 2019
“Hippocampal atrophy and intrinsic brain network dysfunction relate to alterations in mind wandering in neurodegeneration,” by Claire O’Callaghan, James M. Shine, John R. Hodges, Jessica R. Andrews-Hanna, and Muireann Irish (Vol. 116, No. 8, February 19, 2019, p. 3316-3321).
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February 8, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 8, 2019
“Influence of young adult cognitive ability and additional education on later-life cognition,” by William S. Kremen, Asad Beck, Jeremy A. Elman, Daniel E. Gustavson, Chandra A. Reynolds, Xin M. Tu, Mark E. Sanderson-Cimino, Matthew S. Panizzon, Eero Vuoksimaa, Rosemary Toomey, Christine Fennema-Notestine, Donald J. Hagler Jr., Bin Fang, Anders M. Dale, Michael J. Lyons, and Carol E. Franz (Vol. 116, No. 6, February 5, 2019, p. 2021-2026).
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January 23, 2019
January 15, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 15, 2019
“Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo,” by Neeraj K. Aryal, Vinod Pant, Amanda R. Wasylishen, Jan Parker-Thornburg, Laura Baseler, Adel K. El-Naggar, Bin Liu, Awdhesh Kalia, Guillermina Lozano, and Swathi Arur (Vol. 116, No. 3, January 15, 2019, p. 960-969).
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January 2, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 2, 2019
A. “Bax inhibitor 1 is a {gamman}-secretase–independent presenilin-binding protein,” by Shenjie Wu, Wenqi Song, Catherine C. L. Wong, and Yigong Shi (Vol. 116, No. 1, January 2, 2019, p. 141-147).
www.pnas.org/content/116/1/141
B. “TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling,” by Bochra Zidi, Christelle Vincent-Fabert, Laurent Pouyet, Marion Seillier, Amelle Vandevelde, Prudence N’guessan, Mathilde Poplineau, Geoffrey Guittard, Stéphane J. C. Mancini, Estelle Duprez, and Alice Carrier (Vol. 116, No. 1, January 2, 2019, p. 211-216).
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December 28, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – December 28, 2018
A. “Cofactors are essential constituents of stable and seeding-active tau fibrils,” by Yann Fichou, Yanxian Lin, Jennifer N. Rauch, Michael Vigers, Zhikai Zeng, Madhur Srivastava, Timothy J. Keller, Jack H. Freed, Kenneth S. Kosik, and Songi Han (Vol. 115, No. 52, December 26, 2018, p. 13234-13239).
www.pnas.org/content/115/52/13234
B. “Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice,” by Noga Ron-Harel, Giulia Notarangelo, Jonathan M. Ghergurovich, Joao A. Paulo, Peter T. Sage, Daniel Santos, F. Kyle Satterstrom, Steven P. Gygi, Joshua D. Rabinowitz, Arlene H. Sharpe, and Marcia C. Haigis (Vol. 115, No. 52, December 26, 2018, p. 13347-13352).
www.pnas.org/content/115/52/13347
C. “Spatiotemporal activation of the C/EBP{beta}/{delta}-secretase axis regulates the pathogenesis of Alzheimer’s disease,” by Hualong Wang, Xia Liu, Shengdi Chen, and Keqiang Ye (Vol. 115, No. 52, December 26, 2018, p. E12427-E12434).
www.pnas.org/content/115/52/E12427
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December 18, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 18, 2018
“Probing the mechanism of inhibition of amyloid-{beta}(1–42)–induced neurotoxicity by the chaperonin GroEL,” by Marielle A. Walti, Joseph Steiner, Fanjie Meng, Hoi Sung Chung, John M. Louis, Rodolfo Ghirlando, Vitali Tugarinov, Avindra Nath, and G. Marius Clore (Vol. 115, No. 51, December 18, 2018, p. E11924-E11932).
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December 4, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 4,, 2018
“Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain,” by Regina F. Fernandez, Sora Q. Kim, Yingwei Zhao, Rachel M. Foguth, Marcus M. Weera, Jessica L. Counihan, Daniel K. Nomura, Julia A. Chester, Jason R. Cannon, and Jessica M. Ellis (Vol. 115, No. 49, December 4, 2018, p. 12525-12530).
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November 29, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 29, 2018
“Double dissociation of single-interval and rhythmic temporal prediction in cerebellar degeneration and Parkinson’s disease,” by Assaf Breska and Richard B. Ivry (Vol. 115, No. 48, November 27, 2018, p. 12283-12288).
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November 20, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 20, 2018
A. “Role of income mobility for the measurement of inequality in life expectancy,” by Claus Thustrup Kreiner, Torben Heien Nielsen, and Benjamin Ly Serena (Vol. 115, No. 46, November 13, 2018, p. 11754-11759).
www.pnas.org/content/115/46/11754
B. “Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy,” by Jonathan S. Wall, Angela D. Williams, James S. Foster, Tina Richey, Alan Stuckey, Sallie Macy, Craig Wooliver, Shawn R. Campagna, Eric D. Tague, Abigail T. Farmer, Ronald H. Lands, Emily B. Martin, R. Eric Heidel, and Stephen J. Kennel (Vol. 115, No. 46, November 13, 2018, p. E10839-E10848).
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November 13, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 13, 2018
A. “Role of income mobility for the measurement of inequality in life expectancy,” by Claus Thustrup Kreiner, Torben Heien Nielsen, and Benjamin Ly Serena (Vol. 115, No. 46, November 13, 2018, p. 11754-11759).
www.pnas.org/content/115/46/11754
B. “Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy,” by Jonathan S. Wall, Angela D. Williams, James S. Foster, Tina Richey, Alan Stuckey, Sallie Macy, Craig Wooliver, Shawn R. Campagna, Eric D. Tague, Abigail T. Farmer, Ronald H. Lands, Emily B. Martin, R. Eric Heidel, and Stephen J. Kennel (Vol. 115, No. 46, November 13, 2018, p. E10839-E10848).
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November 6, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 6, 2018
“Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology,” by María Díaz-Moreno, Tomás Armenteros, Simona Gradari, Rafael Hortigüela, Laura García-Corzo, Ángela Fontán-Lozano, José Luis Trejo, and Helena Mira (Vol. 115, No. 45, November 6, 2018, p. 11625-11630).
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October 31, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 31, 2018
“Advancing front of old-age human survival,” by Wenyun Zuo, Sha Jiang, Zhen Guo, Marcus W. Feldman, and Shripad Tuljapurkar (Vol. 115, No. 44, October 30, 2018, p. 11209-11214).
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October 10, 2018
CAAR – Proceedings of the National Academy of Science Article Abstracts – October 10, 2018
A. “Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease,” by Sarah K. Baker, Zu-Lin Chen, Erin H. Norris, Alexey S. Revenko, A. Robert MacLeod, and Sidney Strickland (Vol. 115, No. 41, October 9, 2018, p. E9687-E9696).
www.pnas.org/content/115/41/E9687
B. “Small molecule inhibits a-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons,” by Jordi Pujols, Samuel Peña-Díaz, Diana F. Lázaro, Francesca Peccati, Francisca Pinheiro, Danilo González, Anita Carija, Susanna Navarro, María Conde-Giménez, Jesús García, Salvador Guardiola, Ernest Giralt, Xavier Salvatella, Javier Sancho, Mariona Sodupe, Tiago Fleming Outeiro, Esther Dalfó, and Salvador Ventura (Vol. 115, No. 41, October 9, 2018, p. 10481-10486).
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October 4, 2018
CAAR – Proceedings of the National Academy of Science Article Abstracts – October 4, 2018
A. “Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging,” by Anna Rieckmann, Keith A. Johnson, Reisa A. Sperling, Randy L. Buckner, and Trey Hedden (Vol. 115, No. 40, October 2, 2018, p. 10160-10165).
www.pnas.org/content/115/40/10160
B. “Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy,” by Faten A. Sayed, Maria Telpoukhovskaia, Lay Kodama, Yaqiao Li, Yungui Zhou, David Le, Axel Hauduc, Connor Ludwig, Fuying Gao, Claire Clelland, Lihong Zhan, Yonatan A. Cooper, Dimitrios Davalos, Katerina Akassoglou, Giovanni Coppola, and Li Gan (Vol. 115, No. 40, October 2, 2018, p. 10172-10177).
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September 5, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – September 5, 2018
A. “Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice,” by Te-Chen Tzeng, Yuto Hasegawa, Risa Iguchi, Amy Cheung, Daniel R. Caffrey, Elizabeth Jeanne Thatcher, Wenjie Mao, Gail Germain, Nelsy DePaula Tamburro, Shigeo Okabe, Michael T. Heneka, Eicke Latz, Kensuke Futai, and Douglas T. Golenbock (Vol. 115, No. 36, September 4, 2018, p. 9002-9007).
www.pnas.org/content/115/36/9002
B. “Local field potentials of subthalamic nucleus contain electrophysiological footprints of motor subtypes of Parkinson’s disease,” by Ilknur Telkes, Ashwin Viswanathan, Joohi Jimenez-Shahed, Aviva Abosch, Musa Ozturk, Akshay Gupte, Joseph Jankovic, and Nuri F. Ince (Vol. 115, No. 36, September 4, 2018, p. E8567-E8576).
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August 1, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 1, 2018
“Aspirin binds to PPAR{alpha} to stimulate hippocampal plasticity and protect memory,” by Dhruv Patel, Avik Roy, Madhuchhanda Kundu, Malabendu Jana, Chi-Hao Luan, Frank J. Gonzalez, and Kalipada Pahan (Vol. 115, No. 31, July 31, 2018, p. E7408-E7417).
www.pnas.org/content/115/31/E7408?etoc=
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July 26, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstract – July 26, 2018
“{alpha}-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies,” by Iryna Prots, Janina Grosch, Razvan-Marius Brazdis, Katrin Simmnacher, Vanesa Veber, Steven Havlicek, Christian Hannappel, Florian Krach, Mandy Krumbiegel, Oliver Schutz, Andre Reis, Wolfgang Wrasidlo, Douglas R. Galasko, Teja W. Groemer, Eliezer Masliah, Ursula Schlotzer-Schrehardt, Wei Xiang, Jürgen Winkler, and Beate Winner (Vol. 115, No. 30, July 24, 2018, p. 7813-7818).
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July 12, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 12, 2018
A. “Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid {alpha}-synuclein fibrils,” by Francesco Simone Ruggeri, Fabrizio Benedetti, Tuomas P. J. Knowles, Hilal A. Lashuel, Sergey Sekatskii, and Giovanni Dietler (Vol. 115 No. 28, July 10, 2018, p. 7230-7235).
www.pnas.org/content/115/28/7230
B. “Declining mental health among disadvantaged Americans,” by Noreen Goldman, Dana A. Glei, and Maxine Weinstein (Vol. 115 No. 28, July 10, 2018, p. 7290-7295).
www.pnas.org/content/115/28/7290
C. “Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH,” by Hari Prasad and Rajini Rao (Vol. 115 No. 28, July 10, 2018, p. E6640-E6649).
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June 19, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 19, 2018
“Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease,” by Qian Ren, Min Ma, Jun Yang, Risa Nonaka, Akihiro Yamaguchi, Kei-ichi Ishikawa, Kenta Kobayashi, Shigeo Murayama, Sung Hee Hwang, Shinji Saiki, Wado Akamatsu, Nobutaka Hattori, Bruce D. Hammock, and Kenji Hashimoto (Vol. 115, No. 25, June 19, 2018, p. E5815-E5823).
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June 1, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – June 1, 2018
A. “Socioeconomic status moderates age-related differences in the brain’s functional network organization and anatomy across the adult lifespan,” by Micaela Y. Chan, Jinkyung Na, Phillip F. Agres, Neil K. Savalia, Denise C. Park, and Gagan S. Wig (Vol. 115, No. 22, May 29, 2018, p. E5144-E5153).
www.pnas.org/content/115/22/E5144
B. “Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s disease,” by Kwang Soo Kim, Paul C. Marcogliese, Jungwoo Yang, Steve M. Callaghan, Virginia Resende, Elizabeth Abdel-Messih, Connie Marras, Naomi P. Visanji, Jana Huang, Michael G. Schlossmacher, Laura Trinkle-Mulcahy, Ruth S. Slack, Anthony E. Lang, Canadian Lrrk2 in Inflammation Team (CLINT), and David S. Park (Vol. 115, No. 22, May 29, 2018, p. E5164-E5173).
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May 22, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 22, 2018
“LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson’s disease,” by Maria Nguyen and Dimitri Krainc (Vol. 115, No. 21, May 22, 2018, p. 5576-5581).
www.pnas.org/content/115/21/5576?etoc=
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April 25, 2018
CAAR – Proceedings of the National Academies of Science Article Abstract – April 25, 2018
“[beta}-Amyloid accumulation in the human brain after one night of sleep deprivation,” by Ehsan Shokri-Kojori, Gene-Jack Wang, Corinde E. Wiers, Sukru B. Demiral, Min Guo, Sung Won Kim, Elsa Lindgren, Veronica Ramirez, Amna Zehra, Clara Freeman, Gregg Miller, Peter Manza, Tansha Srivastava, Susan De Santi, Dardo Tomasi, Helene Benveniste and Nora D. Volkow (Vol. 115, No. 17, April 24, 2018, p. 4483-4488).
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April 17, 2018
CAAR – Proceedings of the National Academies of Sciences Article Abstract – April 17, 2018
“Characterizing the human hippocampus in aging and Alzheimer’s disease using a computational atlas derived from ex vivo MRI and histology,” by Daniel H. Adler, Laura E. M. Wisse, Ranjit Ittyerah, John B. Pluta, Song-Lin Ding, Long Xie, Jiancong Wang, Salmon Kadivar, John L. Robinson, Theresa Schuck, John Q. Trojanowski, Murray Grossman, John A. Detre, Mark A. Elliott, Jon B. Toledo, Weixia Liu, Stephen Pickup, Michael I. Miller, Sandhitsu R. Das, David A. Wolk, and Paul A. Yushkevich (Vol. 115, No. 16, April 17, 2018, p. 4252-4257).
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April 10, 2018
CAAR – Proceedings of the National Academies of Science Article Abstract – April 10, 2018
“BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s disease,” by Jian Bao, Min Qin, Yacoubou Abdoul Razak Mahaman, Bin Zhang, Fang Huang, Kuan Zeng, Yiyuan Xia, Dan Ke, Qun Wang, Rong Liu, Jian-Zhi Wang, Keqiang Ye, and Xiaochuan Wang (Vol. 115, No. 15, April 10, 2018, p. 3954-3959).
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March 27, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 27, 2018
“Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality,” by Jatish Kumar, Hasier Erana, Elena López-Martínez, Nathalie Claes, Víctor F. Martín, Diego M. Solís, Sara Bals, Aitziber L. Cortajarena, Joaquín Castilla, and Luis M. Liz-Marzan (Vol. 115, No. 13, March 27, 2018, p. 3225-3230).
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March 14, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 14, 2018
“Identification of a highly neurotoxic {alpha}-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease,” by Diego Grassi, Shannon Howard, Minghai Zhou, Natalia Diaz-Perez, Nicolai T. Urban, Debbie Guerrero-Given, Naomi Kamasawa, Laura A. Volpicelli-Daley, Philip LoGrasso, and Corinne Ida Lasmezas (Vol. 115, No. 11, March 13, 2018, p. E2634-E2643).
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March 6, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 6, 2018
A. “Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice,” by Kan Xie, Devon P. Ryan, Brandon L. Pearson, Kristin S. Henzel, Frauke Neff, Ramon O. Vidal, Magali Hennion, Isabelle Lehmann, Melvin Schleif, Susanne Schröder, Thure Adler, Birgit Rathkolb, Jan Rozman, Anna-Lena Schütz, Cornelia Prehn, Michel E. Mickael, Marco Weiergräber, Jerzy Adamski, Dirk H. Busch, Gerhard Ehninger, Anna Matynia, Walker S. Jackson, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Stefan Bonn, Martin Hrabe de Angelis and Dan Ehninger (Vol. 115, No. 10, March 6, 2018, p. E2348-E2357).
doi.org/10.1073/pnas.1707337115
B. “Environmental enrichment and exercise are better than social enrichment to reduce memory deficits in amyloid beta neurotoxicity,” by Mariza G. Prado Lima, Helen L. Schimidt, Alexandre Garcia, Letícia R. Daré, Felipe P. Carpes, Ivan Izquierdo and Pâmela B. Mello-Carpes (Vol. 115, No. 10, March 6, 2018, p. E2403-E2408).
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February 27, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 27, 2018
Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events,” by Dorothea Hammerer, Martina F. Callaghan, Alexandra Hopkins, Julian Kosciessa, Matthew Betts, Arturo Cardenas-Blanco, Martin Kanowski, Nikolaus Weiskopf, Peter Dayan, Raymond J. Dolan and Emrah Düzel (Vol. 115, No. 9, February 27, 2018, p. 2228-2233).
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February 20, 2018
CAAR – Proceedings of the National Academies of Sciences Article Abstracts – February 20, 2018
A. “Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence,” by Yang Zhao, Alexander Tyshkovskiy, Daniel Muñoz-Espín, Xiao Tian, Manuel Serrano, Joao Pedro de Magalhaes, Eviatar Nevo, Vadim N. Gladyshev, Andrei Seluanov and Vera Gorbunova (Vol. 115, No. 8, February 20, 2018, p. 1801-1806).
www.pnas.org/content/115/8/1801
B. “NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency,” by Yujun Hou, Sofie Lautrup, Stephanie Cordonnier, Yue Wang, Deborah L. Croteau, Eduardo Zavala, Yongqing Zhang, Kanako Moritoh, Jennifer F. O’Connell, Beverly A. Baptiste, Tinna V. Stevnsner, Mark P. Mattson and Vilhelm A. Bohr (Vol. 115, No. 8, February 20, 2018, p. E1876-E1885).
www.pnas.org/content/115/8/E1876
C. “Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis,” by Xiaopu Zhou, Yu Chen, Kin Y. Mok, Qianhua Zhao, Keliang Chen, Yuewen Chen, John Hardy, Yun Li, Amy K. Y. Fu, Qihao Guo, Nancy Y. Ip and for the Alzheimer’s Disease Neuroimaging Initiative (Vol. 115, No. 8, February 20, 2018, p. 1697-1706)
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February 13, 2018
CAAR – Proceedings of the National Academies of Science Article Abstract – February 13, 2018
“Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice,” by Yulan Xiong, Stewart Neifert, Senthilkumar S. Karuppagounder, Qinfang Liu, Jeannette N. Stankowski, Byoung Dae Lee, Han Seok Ko, Yunjong Lee, Jonathan C. Grima, Xiaobo Mao, Haisong Jiang, Sung-Ung Kang, Deborah A. Swing, Lorraine Iacovitti, Lino Tessarollo, Ted M. Dawson, and Valina L. Dawson (Vol. 115, No. 7, February 13, 2018, p. 1635-1640).
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January 31, 2018
CAAR – Proceedings of the National Academies of Science Article Abstract – January 31, 2018
“The role of obesity in exceptionally slow US mortality improvement,” by Samuel H. Preston, Yana C. Vierboom and Andrew Stokes (Vol. 115, No. 5, January 30, 2018, p. 957-961).
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January 23, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 23, 2018
A. “Structural heterogeneity and intersubject variability of A{beta} in familial and sporadic Alzheimer’s disease,” by Carlo Condello, Thomas Lemmin, Jan Stöhr, Mimi Nick, Yibing Wu, Alison M. Maxwell, Joel C. Watts, Christoffer D. Caro, Abby Oehler, C. Dirk Keene, Thomas D. Bird, Sjoerd G. van Duinen, Lars Lannfelt, Martin Ingelsson, Caroline Graff, Kurt Giles, William F. DeGrado, and Stanley B. Prusiner (Vol. 115, No. 4, January 23, 2018, .pdf and HTML format, p. E782-E791). Note: PNAS is providing open access to the full-text of this article.
www.pnas.org/content/115/4/E782.abstract
B. “GBA1 deficiency negatively affects physiological {alpha}-synuclein tetramers and related multimers,” by Sangjune Kim, Seung Pil Yun, Saebom Lee, George Essien Umanah, Veera Venkata Ratnam Bandaru, Xiling Yin, Peter Rhee, Senthilkumar S. Karuppagounder, Seung-Hwan Kwon, Hojae Lee, Xiaobo Mao, Donghoon Kim, Akhilesh Pandey, Gabsang Lee, Valina L. Dawson, Ted M. Dawson, and Han Seok Ko (Vol. 115, No. 4, January 23, 2018, p. 798-803).
www.pnas.org/content/115/4/798.abstract
C. “CFH and ARMS2 genetic risk determines progression to neovascular age-related macular degeneration after antioxidant and zinc supplementation,” by Demetrios G. Vavvas, Kent W. Small, Carl C. Awh, Brent W. Zanke, Robert J. Tibshirani, and Rafal Kustra (Vol. 115, No. 4, January 23, 2018, .pdf and HTML format, p. E696-E704). Note: PNAS is providing open access to the full-text of this article.
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January 18, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 18, 2018
A. “The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease,” by Chun Chen, Zhihao Wang, Zhentao Zhang, Xia Liu, Seong Su Kang, Ying Zhang, and Keqiang Ye (Vol. 115, No. 3, January 16, 2018, p. 578-583).
www.pnas.org/content/115/3/578.abstract
B. “Migration-based selections of antibodies that convert bone marrow into trafficking microglia-like cells that reduce brain amyloid {beta},” by Kyung Ho Han, Britni M. Arlian, Matthew S. Macauley, James C. Paulson, and Richard A. Lerner (Vol. 115, No. 3, January 16, 2018, p. E372-E381). Note: PNAS is providing open-access to the full-text of this article.
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January 9, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 9, 2018
“Familial Parkinson’s point mutation abolishes multiple system atrophy prion replication,” by Amanda L. Woerman, Sabeen A. Kazmi, Smita Patel, Atsushi Aoyagi, Abby Oehler, Kartika Widjaja, Daniel A. Mordes, Steven H. Olson, and Stanley B. Prusiner (Vol. 115, No. 2, January 9, 2018, p. 409-414).
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December 22, 2017
CAAR – Proceedings of the National Academies of Science Article Abstracts – December 22, 2017
A. “Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice,” by Noah R. Johnson, Carlo Condello, Shenheng Guan, Abby Oehler, Julia Becker, Marta Gavidia, George A. Carlson, Kurt Giles, and Stanley B. Prusiner (Vol. 114, No. 51, December 19, 2017, p. E11029-E11036).
www.pnas.org/content/114/51/E11029.abstract
B. “Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1,” by D. Cristopher Bragg, Kotchaphorn Mangkalaphiban, Christine A. Vaine, Nichita J. Kulkarni, David Shin, Rachita Yadav, Jyotsna Dhakal, Mai-Linh Ton, Anne Cheng, Christopher T. Russo, Mark Ang, Patrick Acuña, Criscely Go, Taylor N. Franceour, Trisha Multhaupt-Buell, Naoto Ito, Ulrich Müller, William T. Hendriks, Xandra O. Breakefield, Nutan Sharma, and Laurie J. Ozelius (Vol. 114, No. 51, December 19, 2017, p. E11020-E11028). Note: _PNAS_ is providing open access to the full-text of this article.
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December 12, 2017
CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 12, 2017
“Loss of APOBEC1 RNA-editing function in microglia exacerbates age-related CNS pathophysiology,” Daniel C. Cole, Youngcheul Chung, Khatuna Gagnidze, Kaitlyn H. Hajdarovic, Violeta Rayon-Estrada, Dewi Harjanto, Benedetta Bigio, Judit Gal-Toth, Teresa A. Milner, Bruce S. McEwen, F. Nina Papavasiliou, and Karen Bulloch (Vol. 114, No. 50, December 12, 2017, p. 13272-13277).
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December 7, 2017
CAAR – Proceedings of the National Academies of Science Article Abstracts – December 7, 2017
A. “Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease,” by Jay Rasmussen, Jasmin Mahler, Natalie Beschorner, Stephan A. Kaeser, Lisa M. Häsler, Frank Baumann, Sofie Nyström, Erik Portelius, Kaj Blennow, Tammaryn Lashley, Nick C. Fox, Diego Sepulveda-Falla, Markus Glatzel, Adrian L. Oblak, Bernardino Ghetti, K. Peter R. Nilsson, Per Hammarström, Matthias Staufenbiel, Lary C. Walker, and Mathias Jucker (Vol. 114, No. 49, December 5, 2017, p. 13018-13023).
B. “Intercellular competition and the inevitability of multicellular aging,” by Paul Nelson and Joanna Masel (Vol. 114, No. 49, December 5, 2017, p. 12982–12987).
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November 21, 2017
CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 21, 2017
“Oxalate-curcumin–based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease,” by Jian Yang, Xueli Zhang, Peng Yuan, Jing Yang, Yungen Xu, Jaime Grutzendler, Yihan Shao, Anna Moore, and Chongzhao Ran (Vol. 114, No. 47, November 21, 2017, p. 12384-12389).
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November 7, 2017
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 7, 2017
A. “Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease,” by Tatsuo Mano, Kenichi Nagata, Takashi Nonaka, Airi Tarutani, Tomohiro Imamura, Tadafumi Hashimoto, Taro Bannai, Kagari Koshi-Mano, Takeyuki Tsuchida, Ryo Ohtomo, Junko Takahashi-Fujigasaki, Satoshi Yamashita, Yasumasa Ohyagi, Ryo Yamasaki, Shoji Tsuji, Akira Tamaoka, Takeshi Ikeuchi, Takaomi C. Saido, Takeshi Iwatsubo, Toshikazu Ushijima, Shigeo Murayama, Masato Hasegawa, and Atsushi Iwata (Vol. 114, No. 45, November 7, 2017, .pdf and HTML format, p. E9645–E9654). Note: PNAS is providing open access to the full-text of this article.
www.pnas.org/content/114/45/E9645.abstract
B. “Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease,” by Robert J. Andrew, Celia G. Fernandez, Molly Stanley, Hong Jiang, Phuong Nguyen, Richard C. Rice, Virginie Buggia-Prévot, Pierre De Rossi, Kulandaivelu S. Vetrivel, Raza Lamb, Arnau Argemi, Emilie S. Allaert, Elle M. Rathbun, Sofia V. Krause, Steven L. Wagner, Angèle T. Parent, David M. Holtzman, and Gopal Thinakaran (Vol. 114, No. 45, November 7, 2017, p. E9665-E9674).
www.pnas.org/content/114/45/E9665.abstract
C. “Individual differences in associative memory among older adults explained by hippocampal subfield structure and function,” by Valerie A. Carr, Jeffrey D. Bernstein, Serra E. Favila, Brian K. Rutt, Geoffrey A. Kerchner, and Anthony D. Wagner (Vol. 114, No. 45, November 7, 2017, p. 12075-12080).
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October 24, 2017
CAAR – Proceedings of the National Academies of Sciences Article Abstracts – October 24, 2017
A. “M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer’s disease genes and improving memory,” by Claude-Henry Volmar, Hasib Salah-Uddin, Karolina J. Janczura, Paul Halley, Guerline Lambert, Andrew Wodrich, Sivan Manoah, Nidhi H. Patel, Gregory C. Sartor, Neil Mehta, Nancy T. H. Miles, Sachi Desse, David Dorcius, Michael D. Cameron, Shaun P. Brothers, and Claes Wahlestedt (Vol. 114, No. 43, October 24, 2017, .pdf and HTML format, p. E9135–E9144). Note: PNAS is providing open access to the full text of this article.
www.pnas.org/content/114/43/E9135.abstract
B. “TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy,” by Cheryl E. G. Leyns, Jason D. Ulrich, Mary B. Finn, Floy R. Stewart, Lauren J. Koscal, Javier Remolina Serrano, Grace O. Robinson, Elise Anderson, Marco Colonna, and David M. Holtzman (Vol. 114, No. 43, October 24, 2017, .pdf and HTML format, p. 11524-11529). Note: PNAS is providing open access to the full text of this article.
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October 19, 2017
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – October 19, 2017
A. “Projections of white and black older adults without living kin in the United States, 2015 to 2060,” by Ashton M. Verdery and Rachel Margolis (Vol. 114, No. 42, October 17, 2017, p. 11109-11114).
www.pnas.org/content/114/42/11109.abstract.html?etoc
B. “Multigenerational silencing dynamics control cell aging,” by Yang Li, Meng Jin, Richard O’Laughlin Philip Bittihn, Lev S. Tsimring, Lorraine Pillus, Jeff Hasty, and Nan Hao (Vol. 114, No. 42, October 17, 2017, p. 11253-11258).
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September 26, 2017
CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 26, 2017
“Modeling Parkinson’s disease pathology by combination of fibril seeds and {alpha}-synuclein overexpression in the rat brain,” by Poonam Thakur, Ludivine S. Breger, Martin Lundblad, Oi Wan Wan, Bengt Mattsson, Kelvin C. Luk, Virginia M. Y. Lee, John Q. Trojanowski, and Anders Bjorklund (Vol. 114, No. 39, September 26, 2017, p. E8284–E8293).
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September 19, 2017
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – September 19, 2017
A. “Differential diagnosis of Alzheimer’s disease using spectrochemical analysis of blood,” by Maria Paraskevaidi, Camilo L. M. Morais, Kassio M. G. Lima, Julie S. Snowden, Jennifer A. Saxon, Anna M. T. Richardson, Matthew Jones, David M. A. Mann, David Allsop, Pierre L. Martin-Hirsch, and Francis L. Martin (Vol. 114, No. 38, September 19, 2017, p. E7929–E7938).
www.pnas.org/content/114/38/E7929.abstract.html?etoc
B. “Temporal binding function of dorsal CA1 is critical for declarative memory formation,” by Azza Sellami, Alice Shaam Al Abed, Laurent Brayda-Bruno, Nicole Etchamendy, Stephane Valerio, Marie Oule, Laura Pantaleon, Valerie Lamothe, Mylene Potier, Katy Bernard, Maritza Jabourian, Cyril Herry, Nicole Mons, Pier-Vincenzo Piazza, Howard Eichenbaum, and Aline Marighetto (Vol. 114, No. 38, September 19, 2017, p. 10262–10267).
www.pnas.org/content/114/38/10262.abstract.html?etoc
C. “Dorsolateral prefrontal cortex GABA deficit in older adults with sleep-disordered breathing,” by Ana C. Pereira, Xiangling Mao, Caroline S. Jiang, Guoxin Kang, Sara Milrad, Bruce S. McEwen, Ana C. Krieger, and Dikoma C. Shungu (Vol. 114, No. 38, September 19, 2017, p. 10250–10255).
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