“Motor planning error in Parkinson’s disease and its clinical correlates,” by Tsubasa Kawasaki, Kyohei Mikami, Tsutomu Kamo, Ryoma Aoki, Rumiko Ishiguro, Hiroshi Nakamura, Ryosuke Tozawa, Nao Asada, Yukinobu Hiiragi, Yoichi Yamada, Masahiro Hirano, and Kazuko Katsuki (PLoS ONE 13(8): e0202228. doi.org/10.1371/journal.pone.0202228, HTML, XML, and .pdf format, 10p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0202228
A. “Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid {alpha}-synuclein fibrils,” by Francesco Simone Ruggeri, Fabrizio Benedetti, Tuomas P. J. Knowles, Hilal A. Lashuel, Sergey Sekatskii, and Giovanni Dietler (Vol. 115 No. 28, July 10, 2018, p. 7230-7235).
www.pnas.org/content/115/28/7230
B. “Declining mental health among disadvantaged Americans,” by Noreen Goldman, Dana A. Glei, and Maxine Weinstein (Vol. 115 No. 28, July 10, 2018, p. 7290-7295).
www.pnas.org/content/115/28/7290
C. “Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH,” by Hari Prasad and Rajini Rao (Vol. 115 No. 28, July 10, 2018, p. E6640-E6649).
“Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease,” by Seung Pil Yun, Tae-In Kam, Nikhil Panicker, SangMin Kim, Yumin Oh, Jong-Sung Park, Seung-Hwan Kwon, Yong Joo Park, Senthilkumar S. Karuppagounder, Hyejin Park, Sangjune Kim, Nayeon Oh, Nayoung Alice Kim, Saebom Lee, Saurav Brahmachari, Xiaobo Mao, Jun Hee Lee, Manoj Kumar, Daniel An, Sung-Ung Kang, Yunjong Lee, Kang Choon Lee, Dong Hee Na, Donghoon Kim, Sang Hun Lee, Viktor V. Roschke, Shane A. Liddelow, Zoltan Mari, Ben A. Barres, Valina L. Dawson, Seulki Lee, Ted M. Dawson & Han Seok Ko (Vol. 24, No. 7, July 2018, p. 931-938).
“Emotional cues from expressive behavior of women and men with Parkinson’s disease,” by Shu-Mei Wang and Linda Tickle-Degnen (PLoS ONE 13(7): e0199886. doi.org/10.1371/journal.pone.0199886, XML, HTML, and .pdf format, 20p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0199886
“Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease,” by Qian Ren, Min Ma, Jun Yang, Risa Nonaka, Akihiro Yamaguchi, Kei-ichi Ishikawa, Kenta Kobayashi, Shigeo Murayama, Sung Hee Hwang, Shinji Saiki, Wado Akamatsu, Nobutaka Hattori, Bruce D. Hammock, and Kenji Hashimoto (Vol. 115, No. 25, June 19, 2018, p. E5815-E5823).
A. “Socioeconomic status moderates age-related differences in the brain’s functional network organization and anatomy across the adult lifespan,” by Micaela Y. Chan, Jinkyung Na, Phillip F. Agres, Neil K. Savalia, Denise C. Park, and Gagan S. Wig (Vol. 115, No. 22, May 29, 2018, p. E5144-E5153).
www.pnas.org/content/115/22/E5144
B. “Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s disease,” by Kwang Soo Kim, Paul C. Marcogliese, Jungwoo Yang, Steve M. Callaghan, Virginia Resende, Elizabeth Abdel-Messih, Connie Marras, Naomi P. Visanji, Jana Huang, Michael G. Schlossmacher, Laura Trinkle-Mulcahy, Ruth S. Slack, Anthony E. Lang, Canadian Lrrk2 in Inflammation Team (CLINT), and David S. Park (Vol. 115, No. 22, May 29, 2018, p. E5164-E5173).
“Cellular milieu imparts distinct pathological {alpha}-synuclein strains in {alpha}-synucleinopathies,” by Chao Peng, Ronald J. Gathagan, Dustin J. Covell, Coraima Medellin, Anna Stieber, John L. Robinson, Bin Zhang, Rose M. Pitkin, Modupe F. Olufemi, Kelvin C. Luk, John Q. Trojanowski & Virginia M.-Y. Lee (Vol. 557, No. 7706, May 24, 2018, p. 558-563).
“LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson’s disease,” by Maria Nguyen and Dimitri Krainc (Vol. 115, No. 21, May 22, 2018, p. 5576-5581).
www.pnas.org/content/115/21/5576?etoc=
“Parkinson’s disease-related non-motor features as risk factors for post-operative delirium in spinal surgery,” by Ki Hoon Kim, Suk Yun Kang, Dong Ah Shin, Seong Yi, Yoon Ha, Keung Nyun Kim, Young Ho Sohn, and Phil Hyu Lee (PLoS ONE 13(4): e0195749. doi.org/10.1371/journal.pone.0195749, XML, HTML, and .pdf format, 12p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0195749
“Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality,” by Jatish Kumar, Hasier Erana, Elena López-Martínez, Nathalie Claes, Víctor F. Martín, Diego M. Solís, Sara Bals, Aitziber L. Cortajarena, Joaquín Castilla, and Luis M. Liz-Marzan (Vol. 115, No. 13, March 27, 2018, p. 3225-3230).
“Identification of a highly neurotoxic {alpha}-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease,” by Diego Grassi, Shannon Howard, Minghai Zhou, Natalia Diaz-Perez, Nicolai T. Urban, Debbie Guerrero-Given, Naomi Kamasawa, Laura A. Volpicelli-Daley, Philip LoGrasso, and Corinne Ida Lasmezas (Vol. 115, No. 11, March 13, 2018, p. E2634-E2643).
“Effects of physical exercise programs on cognitive function in Parkinson’s disease patients: A systematic review of randomized controlled trials of the last 10 years,” by Franciele Cascaes da Silva, Rodrigo da Rosa Iop, Laiana Cândido de Oliveira, Alice Mathea Boll, José Gustavo Souza de Alvarenga, Paulo José Barbosa Gutierres Filho, Lídia Mara Aguiar Bezerra de Melo, André Junqueira Xavier, and Rudney da Silva (PLoS ONE 13(2): e0193113. doi.org/10.1371/journal.pone.0193113, XML, HTML, and .pdf format, 19p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0193113
A. “Social capital and Internet use in an age-comparative perspective with a focus on later life,” by Barbara Barbosa Neves, Jaime R. S. Fonseca, Fausto Amaro, and Adriano Pasqualotti (PLoS ONE 13(2): e0192119. doi.org/10.1371/journal.pone.0192119, XML, HTML, and .pdf format, 27p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0192119
B. “Analysis of age-related changes in psychosine metabolism in the human brain,” by Michael S. Marshall, Benas Jakubauskas, Wil Bogue, Monika Stoskute, Zane Hauck, Emily Rue, Matthew Nichols, Lisa L. DiAntonio, Richard B. van Breemen, Jeffrey H. Kordower, Carlos A. Saavedra-Matiz, and Ernesto R. Bongarzone (PLoS ONE 13(2): e0193438. doi.org/10.1371/journal.pone.0193438, XML, HTML, and .pdf format, 20p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0193438
“Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice,” by Yulan Xiong, Stewart Neifert, Senthilkumar S. Karuppagounder, Qinfang Liu, Jeannette N. Stankowski, Byoung Dae Lee, Han Seok Ko, Yunjong Lee, Jonathan C. Grima, Xiaobo Mao, Haisong Jiang, Sung-Ung Kang, Deborah A. Swing, Lorraine Iacovitti, Lino Tessarollo, Ted M. Dawson, and Valina L. Dawson (Vol. 115, No. 7, February 13, 2018, p. 1635-1640).
A. “Structural heterogeneity and intersubject variability of A{beta} in familial and sporadic Alzheimer’s disease,” by Carlo Condello, Thomas Lemmin, Jan Stöhr, Mimi Nick, Yibing Wu, Alison M. Maxwell, Joel C. Watts, Christoffer D. Caro, Abby Oehler, C. Dirk Keene, Thomas D. Bird, Sjoerd G. van Duinen, Lars Lannfelt, Martin Ingelsson, Caroline Graff, Kurt Giles, William F. DeGrado, and Stanley B. Prusiner (Vol. 115, No. 4, January 23, 2018, .pdf and HTML format, p. E782-E791). Note: PNAS is providing open access to the full-text of this article.
www.pnas.org/content/115/4/E782.abstract
B. “GBA1 deficiency negatively affects physiological {alpha}-synuclein tetramers and related multimers,” by Sangjune Kim, Seung Pil Yun, Saebom Lee, George Essien Umanah, Veera Venkata Ratnam Bandaru, Xiling Yin, Peter Rhee, Senthilkumar S. Karuppagounder, Seung-Hwan Kwon, Hojae Lee, Xiaobo Mao, Donghoon Kim, Akhilesh Pandey, Gabsang Lee, Valina L. Dawson, Ted M. Dawson, and Han Seok Ko (Vol. 115, No. 4, January 23, 2018, p. 798-803).
www.pnas.org/content/115/4/798.abstract
C. “CFH and ARMS2 genetic risk determines progression to neovascular age-related macular degeneration after antioxidant and zinc supplementation,” by Demetrios G. Vavvas, Kent W. Small, Carl C. Awh, Brent W. Zanke, Robert J. Tibshirani, and Rafal Kustra (Vol. 115, No. 4, January 23, 2018, .pdf and HTML format, p. E696-E704). Note: PNAS is providing open access to the full-text of this article.
A. “Accelerated long-term forgetting in presymptomatic autosomal dominant Alzheimer’s disease: a cross-sectional study,” by Philip S. J. Weston, Jennifer M. Nicholas, Susie M. D. Henley, Yuying Liang, Kirsty Macpherson, Elizabeth Donnachie, Jonathan M. Schott, Martin N. Rossor, Sebastian J. Crutch, Christopher R. Butler, Adam Z. Zeman, and Nick C. Fox (Vol. 17, No. 2, February 2018, p. 123-132).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30434-9/abstract
B. “Effectiveness and costs of specialised physiotherapy given via ParkinsonNet: a retrospective analysis of medical claims data,” by Jan H. L. Ypinga, Nienke M. de Vries, Lieke H. H. M. Boonen, Xander Koolman, Marten Munneke, Aeilko H. Zwinderman, and Bastiaan R. Bloem (Vol. 17, No. 2, February 2018, p. 153-161).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30406-4/abstract
“Familial Parkinson’s point mutation abolishes multiple system atrophy prion replication,” by Amanda L. Woerman, Sabeen A. Kazmi, Smita Patel, Atsushi Aoyagi, Abby Oehler, Kartika Widjaja, Daniel A. Mordes, Steven H. Olson, and Stanley B. Prusiner (Vol. 115, No. 2, January 9, 2018, p. 409-414).
A. “Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice,” by Noah R. Johnson, Carlo Condello, Shenheng Guan, Abby Oehler, Julia Becker, Marta Gavidia, George A. Carlson, Kurt Giles, and Stanley B. Prusiner (Vol. 114, No. 51, December 19, 2017, p. E11029-E11036).
www.pnas.org/content/114/51/E11029.abstract
B. “Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1,” by D. Cristopher Bragg, Kotchaphorn Mangkalaphiban, Christine A. Vaine, Nichita J. Kulkarni, David Shin, Rachita Yadav, Jyotsna Dhakal, Mai-Linh Ton, Anne Cheng, Christopher T. Russo, Mark Ang, Patrick Acuña, Criscely Go, Taylor N. Franceour, Trisha Multhaupt-Buell, Naoto Ito, Ulrich Müller, William T. Hendriks, Xandra O. Breakefield, Nutan Sharma, and Laurie J. Ozelius (Vol. 114, No. 51, December 19, 2017, p. E11020-E11028). Note: _PNAS_ is providing open access to the full-text of this article.
A. “Cognitive failures in late adulthood: The role of age, social context and depressive symptoms,” by Paul Kenneth Hitchcott, Maria Chiara Fastame, Dalila Langiu, and Maria Pietronilla Penna (PLoS ONE 12(12): e0189683. doi.org/10.1371/journal.pone.0189683, XML, HTML, and .pdf format, 14p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0189683
B. “Towards the identification of Idiopathic Parkinson’s Disease from the speech. New articulatory kinetic biomarkers,” by J. I. Godino-Llorente, S. Shattuck-Hufnagel, J. Y. Choi, L. Moro-Velazquez, and J. A. Gómez-García (PLoS ONE 12(12): e0189583. doi.org/10.1371/journal.pone.0189583, XML, HTML, and .pdf format, 35p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0189583
C. “Sleep-wake functions and quality of life in patients with subthalamic deep brain stimulation for Parkinson’s disease,” by Panagiotis Bargiotas, Lukas Eugster, Michael Oberholzer, Ines Debove, M. Lenard Lachenmayer, Johannes Mathis, Claudio Pollo, W. M. Michael Schüpbach, and Claudio L. Bassetti (PLoS ONE 12(12): e0190027. doi.org/10.1371/journal.pone.0190027, XML, HTML, and .pdf format, 15p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0190027
“Structural basis of membrane disruption and cellular toxicity by {alpha}-synuclein oligomers,” by Giuliana Fusco, Serene W. Chen, Philip T. F. Williamson, Roberta Cascella, Michele Perni, James A. Jarvis, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti, Nunilo Cremades5, Liming Ying, Christopher M. Dobson, and Alfonso De Simone (Vol. 358, No. 6369, December 15, 2017, p. 1440-1443).
A. “[alpha]-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B,” by Diana G Ferreira, Mariana Temido-Ferreira, Hugo Vicente Miranda, Vania L. Batalha, Joana E. Coelho, Eva M. Szego, Ines Marques-Morgado, Sandra H. Vaz, Jeong Seop Rhee, Matthias Schmitz, Inga Zerr, Luísa V. Lopes & Tiago F. Outeiro (Vol. 20, No. 11, November 2017, p. 1569-1579).
www.nature.com/neuro/journal/v20/n11/abs/nn.4648.html
B. “Dopamine induces soluble {alpha}-synuclein oligomers and nigrostriatal degeneration,” by Danielle E. Mor, Elpida Tsika, Joseph R. Mazzulli, Neal S. Gould, Hanna Kim, Malcolm J. Daniels, Shachee Doshi, Preetika Gupta, Jennifer L. Grossman, Victor X. Tan, Robert G. Kalb, Kim A Caldwell, Guy A. Caldwell, John H. Wolfe & Harry Ischiropoulos (Vol. 20, No. 11, November 2017, p. 1560-1568).
A. “Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer’s disease: a longitudinal retrospective study,” by Keith A. Josephs, Dennis W. Dickson, Nirubol Tosakulwong, Stephen D. Weigand, Melissa E. Murray, Leonard Petrucelli, Amanda M. Liesinger, Matthew L Senjem, Anthony J. Spychalla, David S. Knopman, Joseph E. Parisi, Ronald C Petersen, Clifford R. Jack Jr, and Jennifer L. Whitwell (Vol. 16, No. 11, November 2017, p. 917-924).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30284-3/abstract
B. “Large-scale identification of clinical and genetic predictors of motor progression in patients with newly diagnosed Parkinson’s disease: a longitudinal cohort study and validation,” by Jeanne C. Latourelle, Michael T. Beste, Tiffany C. Hadzi, Robert E. Miller, Jacob N. Oppenheim, Matthew P. Valko, Diane M. Wuest, Bruce W. Church, Iya G. Khalil, Boris Hayete, and Charles S. Venuto (Vol. 16, No. 11, November 2017, p. 908-916).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30328-9/abstract
A. “Exenatide once weekly versus placebo in Parkinson’s disease: a randomised, double-blind, placebo-controlled trial,” by Dilan Athauda, Kate Maclagan, Simon S Skene, Martha Bajwa-Joseph, Dawn Letchford, Kashfia Chowdhury, Steve Hibbert, Natalia Budnik, Luca Zampedri, John Dickson, Yazhou Li, Iciar Aviles-Olmos, Thomas T. Warner, Patricia Limousin, Andrew J. Lees, Nigel H. Greig, Susan Tebbs, and Thomas Foltynie (Vol. 390, No. 10103, October 7, 2017, p. 1664-1675).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31585-4/abstract
B. “Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS),” by Andrew Kingston, Pia Wohland, Raphael Wittenberg, Louise Robinson, Carol Brayne, Fiona E. Matthews, and Carol Jagger on behalf of the Cognitive Function and Ageing Studies collaboration (Vol. 390, No. 10103, October 7, 2017, p. 1676-1684).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31575-1/abstract
“Modeling Parkinson’s disease pathology by combination of fibril seeds and {alpha}-synuclein overexpression in the rat brain,” by Poonam Thakur, Ludivine S. Breger, Martin Lundblad, Oi Wan Wan, Bengt Mattsson, Kelvin C. Luk, Virginia M. Y. Lee, John Q. Trojanowski, and Anders Bjorklund (Vol. 114, No. 39, September 26, 2017, p. E8284–E8293).
“{beta}2-Adrenoreceptor is a regulator of the {alpha}-synuclein gene driving risk of Parkinson’s disease,” by Shuchi Mittal, Kjetil Bjornevik, Doo Soon Im, Adrian Flierl, Xianjun Dong, Joseph J. Locascio, Kristine M. Abo, Elizabeth Long, Ming Jin, Bing Xu, Yang K. Xiang, Jean-Christophe Rochet, Anders Engeland, Patrizia Rizzu, Peter Heutink, Tim Bartels, Dennis J. Selkoe, Barbara J. Caldarone, Marcie A. Glicksman, Vikram Khurana, Birgitt Schule, David S. Park, Trond Riise, and Clemens R. Scherzer (Vol. 357, No. 6354, September 1, 2017, p. 891-898).
“Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model,” by Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita, Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar & Jun Takahashi (Vol. 548, No. 7669, August 31, 2017, p. 592-596).Nature Letter Abstract: “Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model,” by Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita, Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar & Jun Takahashi (Vol. 548, No. 7669, August 31, 2017, p. 592-596).
www.nature.com/nature/journal/v548/n7669/abs/nature23664.html
A. “Differential diagnosis between Parkinson’s disease and essential tremor using the smartphone’s accelerometer,” by Sergi Barrantes, Antonio J. Sanchez Egea, Hernán A. González Rojas, Maria J. Martí, Yaroslau Compta, Francesc Valldeoriola, Ester Simo Mezquita, Eduard Tolosa, and Josep Valls-Sole (PLoS ONE 12(8): e0183843. doi.org/10.1371/journal.pone.0183843, XML, HTML, and .pdf format, 12p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0183843
B. “Aging effects on airflow dynamics and lung function in human bronchioles,” by JongWon Kim, Rebecca L. Heise, Angela M. Reynolds, and Ramana M. Pidaparti (PLoS ONE 12(8): e0183654. doi.org/10.1371/journal.pone.0183654, XML, HTML, and .pdf format, 20p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0183654
A. “Mortality from Amyotrophic Lateral Sclerosis and Parkinson’s Disease Among Different Occupation Groups — United States, 1985–2011,” by John D. Beard, Andrea L. Steege, Jun Ju, John Lu,Sara E. Luckhaupt, and Mary K. Schubauer-Berigan (Morbidity and Mortality Weekly Report, Vol. 66, No. 27, July 14, 2017, .pdf and HTML format, p. 718-722).
www.cdc.gov/mmwr/volumes/66/wr/mm6627a2.htm
B. “Pneumococcal Vaccination Among Medicare Beneficiaries Occurring After the Advisory Committee on Immunization Practices Recommendation for Routine Use Of 13-Valent Pneumococcal Conjugate Vaccine and 23-Valent Pneumococcal Polysaccharide Vaccine for Adults Aged {gt}=65 Years,” by Carla L. Black, Walter W. Williams, Rob Warnock Tamara Pilishvili, David Kim, and Jeffrey A. Kelman (Morbidity and Mortality Weekly Report, Vol. 66, No. 27, July 14, 2017, .pdf and HTML format, p. 728-733).
“Prediction of cognition in Parkinson’s disease with a clinical–genetic score: a longitudinal analysis of nine cohorts,” by Ganqiang Liu, Joseph J. Locascio, Jean-Christophe Corvol, Brendon Boot, Zhixiang Liao, Kara Page, Daly Franco, Kyle Burke, Iris E. Jansen, Ana Trisini-Lipsanopoulos, Sophie Winder-Rhodes, Caroline M. Tanner, Anthony E. Lang, Shirley Eberly, Alexis Elbaz, Alexis Brice, Graziella Mangone, Bernard Ravina, Ira Shoulson, Florence Cormier-Dequaire, Peter Heutink, Jacobus J. van Hilten, Roger A. Barker, Caroline H. Williams-Gray, Johan Marinus, and Clemens R. Scherzer (Vol. 16, No. 8, August 2017, p. 620-629).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30122-9/abstract
“T cells from patients with Parkinson’s disease recognize {alpha}-synuclein peptides,” by David Sulzer, Roy N. Alcalay, Francesca Garretti, Lucien Cote, Ellen Kanter, Julian Agin-Liebes, Christopher Liong, Curtis McMurtrey, William H. Hildebrand, Xiaobo Mao, Valina L. Dawson, Ted M. Dawson, Carla Oseroff, John Pham, John Sidney, Myles B. Dillon, Chelsea Carpenter, Daniela Weiskopf, Elizabeth Phillips, Simon Mallal, Bjoern Peters, April Frazier, Cecilia S. Lindestam Arlehamn & Alessandro Sette (Vol. 546, No. 7660, June 29, 2017, p. 656-661).
www.nature.com/nature/journal/v546/n7660/abs/nature22815.html
“Treatment with diphenyl–pyrazole compound anle138b/c reveals that {alpha}-synuclein protects melanoma cells from autophagic cell death,” by Elisa Turriani, Diana F. Lazaro, Sergey Ryazanov, Andrei Leonov, Armin Giese, Margarete Schon, Michael P. Schon, Christian Griesinger, Tiago F. Outeiro, Donna J. Arndt-Jovin, and Dorothea Becker (Vol. 114, No. 25, June 21, 2017, p. E4971–E4977).
“Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson’s disease,” by Georgia Kouroupi, Era Taoufik, Ioannis S. Vlachos, Konstantinos Tsioras, Nasia Antoniou, Florentia Papastefanaki, Dafni Chroni-Tzartou, Wolfgang Wrasidlo, Delphine Bohl, Dimitris Stellas, Panagiotis K. Politis, Kostas Vekrellis, Dimitra Papadimitriou, Leonidas Stefanis, Piotr Bregestovski, Artemis G. Hatzigeorgiou, Eliezer Masliah, and Rebecca Matsas (Vol. 114, No. 18, May 2, 2017, p. E3679–E3688).
“{alpha}-Synuclein promotes dilation of the exocytotic fusion pore,” by Todd Logan, Jacob Bendor, Chantal Toupin, Kurt Thorn & Robert H. Edwards (Vol. 20, No. 5, May 2017, p. 681-689).
“Parkinson’s disease-associated genetic variation is linked to quantitative expression of inflammatory genes,” by Steven Pierce and Gerhard A. Coetzee (PLoS ONE 12(4): e0175882. doi.org/10.1371/journal.pone.0175882, XML, HTML, and .pdf format, 11p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0175882
A. “Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies,” by Dr. Daryl J. Wile, Pankaj A. Agarwal, Prof. Michael Schulzer, Edwin Mak, Katherine Dinelle, Elham Shahinfard, Nasim Vafai, Kazuko Hasegawa, Prof. Jing Zhang, Jessamyn McKenzie, Nicole Neilson, Audrey Strongosky, Prof. Ryan J. Uitti, Mark Guttman, Cyrus P. Zabetian, Prof. Yu-Shin Ding, Mike Adam, Prof. Jan Aasly, Prof. Zbigniew K. Wszolek, Prof. Matthew Farrer, Prof. Vesna Sossi, and Prof. A. Jon Stoessl (Vol. 16, No. 5, May 2017, p. 351–359).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30056-X/abstract
B. “Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial,” by Sandrine Andrieu, Sophie Guyonnet, Nicola Coley, Christelle Cantet, Marc Bonnefoy, Serge Bordes, Lawrence Bories, Marie-Noelle Cufi, Thierry Dantoine, Jean-François Dartigues, Françoise Desclaux, Audrey Gabelle, Yannick Gasnier, Alain Pesce, Kristel Sudres, Jacques Touchon, Philippe Robert, Olivier Rouaud, Philippe Legrand, Pierre Payoux, Jean-Paul Caubere, Michael Weiner, Isabelle Carrié, Pierre-Jean Ousset, and Bruno Vellas for the MAPT Study Group (Vol. 16, No. 5, May 2017, p. 377–389).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30040-6/abstract
“Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson’s disease,” by Ismael Huertas, Silvia Jesus, Francisco Javier García-Gomez, Jose Antonio Lojo, Inmaculada Bernal-Bernal, Marta Bonilla-Toribio, Juan Francisco Martín-Rodriguez, David García-Solís, Pilar Gómez-Garre, and Pablo Mir (PLoS ONE 12(4): e0175560. doi.org/10.1371/journal.pone.0175560, XML, HTML, and .pdf format, 11p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0175560
“Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease,” by Amy R. Dunn, Kristen A. Stout, Minagi Ozawa, Kelly M. Lohr, Carlie A. Hoffman, Alison I. Bernstein, Yingjie Li, Minzheng Wang, Carmelo Sgobio, Namratha Sastry, Huaibin Cai, W. Michael Caudle, and Gary W. Miller (Vol. 114, No. 11, March 14, 2017, p. E2253–E2262).
A. “Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models,” by S. Pablo Sardi, Catherine Viel, Jennifer Clarke, Christopher M. Treleaven, Amy M. Richards, Hyejung Park, Maureen A. Olszewski, James C. Dodge, John Marshall, Elina Makino, Bing Wang, Richard L. Sidman, Seng H. Cheng, and Lamya S. Shihabuddin (Vol. 114, No. 10, March 7, 2017, p. 2699–2704).
www.pnas.org/content/114/10/2699.abstract.html?etoc
B. “Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson’s disease,” by Holly Green, Xiaoqun Zhang, Katarina Tiklova, Nikolaos Volakakis, Lovisa Brodin, Louise Berg, Paul Greengard, Thomas Perlmann, and Per Svenningsson (Vol. 114, No. 10, March 7, 2017, p. 2735–2740).
“TMEM175 deficiency impairs lysosomal and mitochondrial function and increases {alpha}-synuclein aggregation,” by Sarah Jinn, Robert E. Drolet, Paige E. Cramer, Andus Hon-Kit Wong, Dawn M. Toolan, Cheryl A. Gretzula, Bhavya Voleti, Galya Vassileva, Jyoti Disa, Marija Tadin-Strapps, and David J. Stone (Vol. 114, No. 9, February 28, 2017, .pdf and HTML format, p. 2389-2394). Note: PNAS is providing open access to the full-text of this article.
“Living near major roads and the incidence of dementia, Parkinson’s disease, and multiple sclerosis: a population-based cohort study,” by Hong Chen, Jeffrey C Kwong, Ray Copes, Karen Tu, Paul J. Villeneuve, Aaron van Donkelaar, Perry Hystad, Randall V. Martin, Brian J. Murray, Barry Jessiman, Andrew S. Wilton, Alexander Kopp, and Richard T. Burnett (Vol. 389, No. 10070, February 18, 2017, p. 718-726).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)32399-6/abstract
A. “Gleevec shifts APP processing from a {beta}-cleavage to a nonamyloidogenic cleavage,” by William J. Netzer, Karima Bettayeb, Subhash C. Sinha, Marc Flajolet, Paul Greengard, and Victor Bustos (Vol. 114, No. 6, February 7, 2017, p. 1389-1394).
www.pnas.org/content/114/6/1389.abstract
B. “A natural product inhibits the initiation of {alpha}-synuclein aggregation and suppresses its toxicity,” by Michele Perni, Céline Galvagnion, Alexander Maltsev, Georg Meisl, Martin B. D. Müller, Pavan K. Challa, Julius B. Kirkegaard, Patrick Flagmeier, Samuel I. A. Cohen, Roberta Cascella, Serene W. Chen, Ryan Limboker, Pietro Sormanni, Gabriella T. Heller, Francesco A. Aprile, Nunilo Cremades, Cristina Cecchi, Fabrizio Chiti, Ellen A. A. Nollen, Tuomas P. J. Knowles, Michele Vendruscolo, Adriaan Bax, Michael Zasloff, and Christopher M. Dobson (Vol. 114, No. 6, February 7, 2017, p. E1009-E1017). Note: PNAS is providing open access to the full-text of this article.
A. “Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry,” by Palaniappan S. Chetty, Leland Mayne, Sissel Lund-Katz, S. Walter Englander, and Michael C. Phillips (Vol. 114, No. 5, January 31, 2017, p. 968-973).
www.pnas.org/content/114/5/968.abstract.html?etoc
B. “Nrf2 mitigates LRRK2- and {alpha}-synuclein–induced neurodegeneration by modulating proteostasis,” by Gaia Skibinski, Vicky Hwang, Dale Michael Ando, Aaron Daub, Alicia K. Lee, Abinaya Ravisankar, Sara Modan, Mariel M. Finucane, Benjamin A. Shaby, and Steven Finkbeiner (Vol. 114, No. 5, January 31, 2017, p. 1165–1170).
www.pnas.org/content/114/5/1165.abstract.html?etoc
C. “{alpha}-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation,” by Seong Su Kang, Zhentao Zhang, Xia Liu, Fredric P. Manfredsson, Li He, P. Michael Iuvone, Xuebing Cao, Yi E. Sun, Lingjing Jin, and Keqiang Ye (Vol. 114, No. 5, January 31, 2017, p. 1183–1185).
“Clinical variables and biomarkers in prediction of cognitive impairment in patients with newly diagnosed Parkinson’s disease: a cohort study,” by Anette Schrag, Uzma Faisal Siddiqui, Zacharias Anastasiou, Daniel Weintraub, and Jonathan M. Schott (Vol. 17, No. 1, January 2017, p. 66-75).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(16)30328-3/abstract
“Parkinson Patients’ Initial Trust in Avatars: Theory and Evidence,” by Andrija Javor, Gerhard Ransmayr, Walter Struhal, and Rene Riedl (PLoS ONE 11(11): e0165998. doi:10.1371/journal.pone.0165998, XML, HTML, and .pdf format, 21p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0165998
“Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson’s disease,” by Istvan Horvath and Pernilla Wittung-Stafshede (Vol. 113, No. 44, November 1, 2016, p. 12473–12477).
“Pathological {alpha}-synuclein transmission initiated by binding lymphocyte-activation gene 3,” by Xiaobo Mao, Michael Tianhao Ou, Senthilkumar S. Karuppagounder, Tae-In Kam, Xiling Yin, Yulan Xiong, Preston Ge, George Essien Umanah, Saurav Brahmachari, Joo-Ho Shin, Ho Chul Kang, Jianmin Zhang, Jinchong Xu, Rong Chen, Hyejin Park, Shaida A. Andrabi, Sung Ung Kang, Rafaella Araújo Gonçalves, Yu Liang, Shu Zhang, Chen Qi, Sharon Lam, James A. Keiler, Joel Tyson, Donghoon Kim, Nikhil Panicker, Seung Pil Yun, Creg J. Workman, Dario A. A. Vignali, Valina L. Dawson, Han Seok Ko, and Ted M. Dawson (Vol. 353, No. 6037, September 30, 2016).
“Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of {alpha}-synuclein aggregation,” by Patrick Flagmeier, Georg Meisl, Michele Vendruscolo, Tuomas P. J. Knowles, Christopher M. Dobson, Alexander K. Buell, and Celine Galvagnion (Vol. 113, No. 37, September 13, 2016, p. 10328–10333).
“Alpha–Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant,” by Claire Hoenen, Audrey Gustin, Cindy Birck, Melanie Kirchmeyer, Nicolas Beaume, Paul Felten, Luc Grandbarbe, Paul Heuschling, and Tony Heurtaux (PLoS ONE 11(9): e0162717. doi:10.1371/journal.pone.0162717, XML, HTML, and .pdf format, 24p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162717
A. “Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes,” by Jianjia Fan, Shahab Zareyan, Wenchen Zhao, Yoko Shimizu, Tom A. Pfeifer, Jun-Hyung Tak, Murray B. Isman, Bernard Van den Hoven, Mark E. Duggan, Michael W. Wood, Cheryl L. Wellington, and Iva Kulic (PLoS ONE 11(9): e0162384. doi:10.1371/journal.pone.0162384, XML, HTML, and .pdf format, 27p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162384
B. “Quantitative Susceptibility Mapping in Parkinson’s Disease,” by Christian Langkammer, Lukas Pirpamer, Stephan Seiler, Andreas Deistung, Ferdinand Schweser, Sebastian Franthal, Nina Homayoon, Petra Katschnig-Winter, Mariella Koegl-Wallner, Tamara Pendl, Eva Maria Stoegerer, Karoline Wenzel, Franz Fazekas, Stefan Ropele, Jurgen Rainer Reichenbach, Reinhold Schmidt, and Petra Schwingenschuh (PLoS ONE 11(9): e0162460. doi:10.1371/journal.pone.0162460, XML, HTML, and .pdf format, 13p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162460
C. “Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis,” by Yoshihisa Okuchi, Masamichi Imajo, Rei Mizuno, Yuji Kamioka, Hiroyuki Miyoshi, Makoto Mark Taketo, Satoshi Nagayama, Yoshiharu Sakai, and Michiyuki Matsuda ( PLoS ONE 11(9): e0162300. doi:10.1371/journal.pone.0162300, XML, HTML, and .pdf format, 22p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162300
D. “Development of Clinical Vignettes to Describe Alzheimer’s Disease Health States: A Qualitative Study,” by Mark Oremus, Feng Xie, and Kathryn Gaebel (PLoS ONE 11(9): e0162422. doi:10.1371/journal.pone.0162422, XML, HTML, and .pdf format, 15p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162422
A. “Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein {alpha}-synuclein,” by Wei Wang, Linh T. T. Nguyen, Christopher Burlak, Fariba Chegini, Feng Guo, Tim Chataway, Shulin Ju, Oriana S. Fisher, David W. Miller, Debajyoti Datta, Fang Wu, Chun-Xiang Wu, Anuradha Landeru, James A. Wells, Mark R. Cookson, Matthew B. Boxer, Craig J. Thomas, Wei Ping Gai, Dagmar Ringe, Gregory A. Petsko, and Quyen Q. Hoang (Vol. 113, No. 34, August 23, 2016, p. 9587–9592).
www.pnas.org/content/113/34/9587.abstract.html?etoc
B. “Human striatal recordings reveal abnormal discharge of projection neurons in Parkinson’s disease,” by Arun Singh, Klaus Mewes, Robert E. Gross, Mahlon R. DeLong, José A. Obeso, and Stella M. Papa (Vol. 113, No. 34, August 23, 2016, p. 9629–9634).
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