“Amelioration of pathologic {alpha}-synuclein-induced Parkinson’s disease by irisin,” by Tae-In Kam, Hyejin Park, Shih-Ching Chou, Jonathan G. Van Vranken, Melanie J. Mittenbühler, Hyeonwoo Kim, Mu A, Yu Ree Choi, Devanik Biswas, Justin Wang, Yu Shin, Alexis Loder, Senthilkumar S. Karuppagounder, Christiane D. Wrann, Valina L. Dawson, Bruce M. Spiegelman bruce_spiegelman@dfci.harvard.edu, and Ted M. Dawson (Vol. 119, No. 36, September 6, 2022, e2204835119).
September 7, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 7, 2022
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August 22, 2022
CAAR – Nature Article Abstracts – August 22, 2022
A. “GPNMB confers risk for Parkinson’s disease through interaction with {alpha}-synuclein,” by Maria E. Diaz-Ortiz, Yunji Seo, Marijan Posavimarc Carceles Cordon, Elisia Clark, Nimansha Jainrakshita Charan, Michael D. Gallagher, Travis L. Unger, Noor Amarir, Tyler Skrinak, Roseanne Davila-Rivera, Eliza M. Brody, Noah Han, Rebecca Zack, Vivianna M. Van Deerlin, Thomas F. Tropea, Kelvin C. Luk, Edward B. Lee, Daniel Weintrauband, and Alice S. Chen-Plotkin (Vol. 377, No. 6608, August 19, 2022).
www.science.org/doi/abs/10.1126/science.abk0637
B. “Functional regulatory variants implicate distinct transcriptional networks in dementia,” by Yonatan A. Cooper, Noam Teyssier, Nina M. Dräger, Qiuyu Guo, Jessica E. Davis, Sydney M. Sattler, Zhongan Yang, Abdulsamie Patel, Sarah Wu, Sriram Kosuri, Giovanni Coppola, Martin Kampmann, and Daniel H. Geschwind (Vol. 377, No. 6608, August 19, 2022).
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August 1, 2022
CAAR – Public Library of Science (PLoS) Articles – August 1, 2022
A. “Knowledge, attitudes, and behavioral intentions of elderly individuals regarding advance care planning: Questionnaire development and testing,” by Hui-Chuan Cheng, Li-Shan Ke, Su-Yu Chang, Hsiu-Ying Huang, Yu-Chen Ku, and Ming-Ju Lee ( PLoS ONE 17(7): e0272351. doi.org/10.1371/journal.pone.0272351, XML, HTML, and .pdf format, 14p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0272351
B. “NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-{alpha}-synuclein mouse model of Parkinson’s disease,” by Min Kyung Song, Levi Adams, Joo Hee Lee, and Yoon-Seong Kim (PLoS ONE 17(7): e0272085. doi.org/10.1371/journal.pone.0272085, XML, HTML, and .pdf format, 15p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0272085
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July 21, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstracts: – July 21, 2022
A. “Aging-associated and CD4 T-cell–dependent ectopic CXCL13 activation predisposes to anti–PD-1 therapy-induced adverse events,” by Hirotake Tsukamoto, Yoshihiro Komohara, Yusuke Tomita, Yuji Miura, Takanobu Motoshima, Kosuke Imamura, Toshiki Kimura, Tokunori Ikeda, Yukio Fujiwara, Hiromu Yano, Tomomi Kamba, Takuro Sakagami and Hiroyuki Oshiumi (Vol. 119, No. 29, July 19, 2022, e2205378119).
www.pnas.org/doi/abs/10.1073/pnas.2205378119
B. “Therapeutic functions of astrocytes to treat {alpha}-synuclein pathology in Parkinson’s disease,” by Yunseon Yang, Jae-Jin Song, Yu Ree Choi, Seong-hoon Kim, Min-Jong Seok, Noviana Wulansari, Wahyu Handoko Wibowo Darsono, Oh-Chan Kwon, Mi-Yoon Chang, Sang Myun Park and Sang-Hun Lee (Vol. 119, No. 29, July 19, 2022, e2110746119).
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July 20, 2022
CAAR – Public Library of Science (PLoS) Article – July 20, 2022
“The impact of cognitive impairment of individuals with Parkinson’s disease on their caregivers’ mental health: A systematic review protocol,” by Paulina Beata Golińska, Łucja Bieleninik, Michał Harciarek, and Mariola Bidzan (PLoS ONE 17(7): e0271480. doi.org/10.1371/journal.pone.0271480, XML, HTML, and .pdf format, 10p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0271480
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May 17, 2022
CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 17, 2022
“Deep brain stimulation in the subthalamic nucleus for Parkinson’s disease can restore dynamics of striatal networks,” by Elie M. Adam, Emery N. Brown, Nancy Kopell, and Michelle M. McCarthy (Vol. 119, No. 19, May 17, 2022, e2120808119).
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August 31, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 31, 2021
“The N terminus of {alpha}-synuclein dictates fibril formation,” by Ryan P. McGlinchey, Xiaodan Ni, Jared A. Shadish, Jiansen Jiang, and Jennifer C. Lee (Vol. 118, No. 35, August 31, 2021, e2023487118).
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April 1, 2021
CAAR – Nature Neuroscience Article – April 1, 2021
Note: Check with your organization’s library for availability. “Divergent pallidal pathways underlying distinct Parkinsonian behavioral deficits,” by Varoth Lilascharoen, Eric Hou-Jen Wang, Nam Do, Stefan Carl Pate, Amanda Ngoc Tran, Christopher Dabin Yoon, Jun-Hyeok Choi, Xiao-Yun Wang, Horia Pribiag, Young-Gyun Park, Kwanghun Chung & Byung Kook Lim (Vol. 24, No. 4, April 2021, p. 504-515).
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March 11, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 11, 2021
“Structural insights into {alpha}-synuclein monomer–fibril interactions,” by Pratibha Kumari, Dhiman Ghosh, Agathe Vanas, Yanick Fleischmann, Thomas Wiegand, Gunnar Jeschke,Roland Riek, and Cédric Eichmann (Vol. 118, No. 10, March 9, 2021, e2012171118).
www.pnas.org/content/118/10/e2012171118.abstract?etoc
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January 6, 2021
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 6, 2021
A. “Nursing home staff networks and COVID-19,” by M. Keith Chen, Judith A. Chevalier, and Elisa F. Long (Vol. 118, No. 1, January 5, 2021, e2015455118).
www.pnas.org/content/118/1/e2015455118.abstract?etoc
B. “The Parkinson’s disease-associated gene ITPKB protects against {alpha}-synuclein aggregation by regulating ER-to-mitochondria calcium release,” by Daniel J. Apicco, Evgeny Shlevkov, Catherine L. Nezich, David T. Tran, Edward Guilmette, Justin W. Nicholatos, Collin M. Bantle, Yi Chen, Kelly E. Glajch, Neeta A. Abraham, Lan T. Dang, G. Campbell Kaynor, Ellen A. Tsai, Khanh-Dung H. Nguyen, Joost Groot, YuTing Liu, Andreas Weihofen, Jessica A. Hurt, Heiko Runz, and Warren D. Hirst (Vol. 118, No. 1, January 5, 2021, e2006476118).
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November 4, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 4, 2020
A. “Life cycle patterns of cognitive performance over the long run,” by Anthony Strittmatter, Uwe Sunde, and Dainis Zegners (Vol. 117, No. 44, November 3, 2020, p. 27255-27261).
www.pnas.org/content/117/44/27255.abstract.html?etoc
B. “Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance,” by Oeystein Roed Brekk, Jonathan R. Honey, Seungil Lee, Penelope J. Hallett, and Ole Isacson (Vol. 117, No. 44, November 3, 2020, p. 27646-27654).
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October 20, 2020
CAAR – Proceedings of the National Academy of Science Article Abstract – October 20, 2020
“Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria,” by Danielle E. Mor, Salman Sohrabi, Rachel Kaletsky, William Keyes, Alp Tartici, Vrinda Kalia, Gary W. Miller, and Coleen T. Murphy (Vol. 117, No. 42, October 20, 2020, p. 26438-26447).
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October 9, 2020
CAAR – Nature Neuroscience Article – October 9, 2020
Note: Check with your organization’s library for availability. “Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective,” by Lee L. Marshall, Bryan A. Killinger, Elizabeth Ensink, Peipei Li, Katie X. Li, Wei Cui, Noah Lubben, Matthew Weiland, Xinhe Wang, Juozas Gordevicius, Gerhard A. Coetzee, Jiyan Ma, Stefan Jovinge & Viviane Labrie (Vol. 23, No. 10, October 2020, p. 1203-1214).
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September 29, 2020
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – September 29, 2020
A. “Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors,” by Thomas C. T. Michaels, Andela Saric, Georg Meisl, Gabriella T. Heller, Samo Curk, Paolo Arosio, Sara Linse, Christopher M. Dobson, Michele Vendruscolo, and Tuomas P. J. Knowles (Vol. 117, No. 39, September 29, 2020, p. 24251-24257).
www.pnas.org/content/117/39/24251.abstract.html?etoc
B. “Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson’s disease,” by Eun Hee Ahn, Seong Su Kang, Qi Qi, Xia Liu, and Keqiang Ye (Vol. 117, No. 39, September 29, 2020, p. 24503-24513).
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August 19, 2020
CAAR – Proceedings of the National Academy of Sciences Articles – August 19, 2020
Note: Check with your organization’s library for availability.
A. “Differences in the free energies between the excited states of A{beta}40 and A{beta}42 monomers encode their aggregation propensities,” by Debayan Chakraborty, John E. Straub, and D. Thirumalai (Vol. 117, No. 33, August 18, 2020, p. 19926-19937).
www.pnas.org/content/117/33/19926
B. “Parkinson’s disease-related phosphorylation at Tyr39 rearranges {alpha}-synuclein amyloid fibril structure revealed by cryo-EM,” by Kun Zhao, Yeh-Jun Lim, Zhenying Liu, Houfang Long, Yunpeng Sun, Jin-Jian Hu, Chunyu Zhao, Youqi Tao, Xing Zhang, Dan Li, Yan-Mei Li, and Cong Liu (Vol. 117, No. 33, August 18, 2020, p. 20305-20315).
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July 22, 2020
CAAR – Proceedings of the National Academies of Science Article Abstracts – July 22, 2020
A. “Dopaminergic neurodegeneration induced by Parkinson’s disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity,” by An Phu Tran Nguyen, Elpida Tsika, Kaela Kelly, Nathan Levine, Xi Chen, Andrew B. West, Sylviane Boularand, Pascal Barneoud, and Darren J. Moore (Vol. 117, No. 29, July 21, 2020, p. 17296-17307).
www.pnas.org/content/117/29/17296
B. “Basal ganglia beta oscillations during sleep underlie Parkinsonian insomnia,” by Aviv D. Mizrahi-Kliger, Alexander Kaplan, Zvi Israel, Marc Deffains, and Hagai Bergman (Vol. 117, No. 29, July 21, 2020, p. 17359-17368).
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July 1, 2020
CAAR – Proceedings of the National Academy of Sciences Article – July 1, 2020
Note: Check with your organization’s library for availability. “Impact of alpha-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized alpha-synuclein rat model of PD,” by Deirdre B. Hoban, Shelby Shrigley, Bengt Mattsson, Ludivine S. Breger, Ulla Jarl, Tiago Cardoso, Jenny Nelander Wahlestedt, Kelvin C. Luk, Anders Björklund, and Malin Parmar (Vol. 117, No. 26, June 30, 2020, p. 15209-15220).
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June 25, 2020
CAAR – Nature Article – June 25, 2020
Note: Check with your organization’s library for availability. “Reversing a model of Parkinson’s disease with in situ converted nigral neurons,” by Hao Qian, Xinjiang Kang, Jing Hu, Dongyang Zhang, Zhengyu Liang, Fan Meng, Xuan Zhang, Yuanchao Xue, Roy Maimon, Steven F. Dowdy, Neal K. Devaraj, Zhuan Zhou, William C. Mobley, Don W. Cleveland & Xiang-Dong Fu (Vol. 582, No. 7813, June 25, 2020, p. 550-556).
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June 18, 2020
CAAR – Lancet Neurology Articles – June 18, 2020
Note: Check with our organization’s library for availability.
A. “Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial,” by Tali Cukierman-Yaffe, Hertzel C. Gerstein, Helen M. Colhoun, Rafael Diaz, Luis-Emilio García-Pérez, Mark Lakshmanan, Angelyn Bethel, Denis Xavier, Jeffrey Probstfield, Matthew C. Riddle, Lars Rydén, Charles Messan Atisso, Stephanie Hall, Purnima Rao-Melacini, Jan Basile, William C. Cushman, Edward Franek, Matyas Keltai, Fernando Lanas, Lawrence A. Leiter, Patricio Lopez-Jaramillo, Valdis Pirags, Nana Pogosova, Peter J. Raubenheimer, Jonathan E. Shaw, Wayne H-H Sheu, and Theodora Temelkova-Kurktschiev (Vol. 19, No. 7, July 2020, p. 582-590).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30173-3/fulltext
B. “Safety and immunogenicity of the{alpha}α-synuclein active immunotherapeutic PD01A in patients with Parkinson’s disease: a randomised, single-blinded, phase 1 trial,” by Dieter Volc, Werner Poewe, Alexandra Kutzelnigg, Petra Lührs, Caroline Thun-Hohenstein, Achim Schneeberger, Gergana Galabova, Nour Majbour, Nishant Vaikath, Omar El-Agnaf, Dorian Winter, Eva Mihailovska, Andreas Mairhofer, Carsten Schwenke, Günther Staffler, and Rossella Medori (Vol. 19, No. 7, July 2020, p. 591-600).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30136-8/fulltext
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May 28, 2020
CAAR – Lancet Neurology Articles – May 28, 2020
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A. “Plasma neurofilament light chain in the presenilin 1 E280A autosomal dominant Alzheimer’s disease kindred: a cross-sectional and longitudinal cohort study,” by Yakeel T Quiroz, Prof. Henrik Zetterberg, Prof. Eric M Reiman, Yinghua Chen, Yi Su, Joshua T. Fox-Fuller, Gloria Garcia, Andres Villegas, Diego Sepulveda-Falla, Marina Villada, Joseph F. Arboleda-Velasquez, Edmarie Guzmán-Vélez, Clara Vila-Castelar, Brian A. Gordon, Stephanie A. Schultz, Hillary D. Protas, Valentina Ghisays, Margarita Giraldo, Victoria Tirado, Ana Baena, Claudia Munoz, Silvia Rios-Romenets, Prof. Pierre N. Tariot, Prof. Kaj Blennow, and Prof. Francisco Lopera (Vol. 19, No. 6, June 2020, p. 513-521).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30137-X/fulltext
B. “Subthalamic nucleus deep brain stimulation with a multiple independent constant current-controlled device in Parkinson’s disease (INTREPID): a multicentre, double-blind, randomised, sham-controlled study, ” by Jerrold L. Vitek, Roshini Jain, Lilly Chen, Alexander I. Tröster, Lauren E. Schrock, Paul A. House, Monique L. Giroux, Adam O. Hebb, Sierra M. Farris, Donald M. Whiting, Timothy A. Leichliter, Jill L. Ostrem, Marta San Luciano, Nicholas Galifianakis, Leo Verhagen Metman, Sepehr Sani, Jessica A. Karl, Mustafa S. Siddiqui, Stephen B, Tatter, Ihtsham ul Haq, Andre G. Machado, Michal Gostkowski, Michele Tagliati, Adam N. Mamelak, Michael S. Okun, Kelly D. Foote, Guillermo Moguel-Cobos, Francisco A. Ponce,Rajesh Pahwa, Jules M. Nazzaro, Cathrin M. Buetefisch, Robert E. Gross, Corneliu C. Luca, Jonathan R. Jagid, Gonzalo J. Revuelta, Istvan Takacs, Michael H. Pourfar, Alon Y. Mogilner, Andrew P. Duker, George T. Mandybur, Joshua M. Rosenow, Scott E. Cooper, Michael C. Park, Suketu M. Khandhar, Mark Sedrak, Fenna T. Phibbs, Julie G. Pilitsis, Ryan J. Uitti, and Philip A. Starr (Vol. 19, No. 6, June 2020, p. 491-501).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30108-3/fulltext
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April 29, 2020
CAAR – Public Library of Science (PLoS) Article – April 29, 2020
“Total daily physical activity, brain pathologies, and parkinsonism in older adults,” by Shahram Oveisgharan, Robert J. Dawe, Sue E. Leurgans, Lei Yu, Julie A. Schneider, David A. Bennett, and Aron S. Buchman (PLoS ONE 15(4): e0232404. doi.org/10.1371/journal.pone.0232404, XML, HTML, and .pdf format, 16p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0232404
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March 26, 2020
CAAR – Proceedings of the National Academy of Science Articles – March 26, 2020
Note: Check with your organization’s library for availability.
A. “Disruption of cellular proteostasis by H1N1 influenza A virus causes alpha-synuclein aggregation,” by Rita Marreiros, Andreas Müller-Schiffmann, Svenja V. Trossbach, Ingrid Prikulis, Sebastian Hänsch, Stefanie Weidtkamp-Peters, Ana Raquel Moreira, Shriya Sahu, Irina Soloviev, Suganya Selvarajah, Vishwanath R. Lingappa, and Carsten Korth (Vol. 117, No. 12, March 24, 2020, p. 6741-6751).
www.pnas.org/content/117/12/6741.abstract?etoc
B. “Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM,” by Urszula Cendrowska, Paulo Jacob Silva, Nadine Ait-Bouziad, Marie Müller, Zekiye Pelin Guven, Sophie Vieweg, Anass Chiki, Lynn Radamaker, Senthil T. Kumar, Marcus Fändrich, Francesco Tavanti, Maria Cristina Menziani, Alfredo Alexander-Katz,
Francesco Stellacci, and Hilal A. Lashuel (Vol. 117, No. 12, March 24, 2020, p. 6866-6874).
www.pnas.org/content/117/12/6866.abstract?etoc
C. “Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain,” by Lindsay A. Welikovitch, Sonia Do Carmo, Zsófia Maglóczky, Janice C. Malcolm, János Loke, William L. Klein, Tamás Freund, and A. Claudio Cuello (Vol. 117, No. 12, March 24, 2020, p. 6844-6854).
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March 3, 2020
CAAR – Proceedings of the National Academy of Sciences Article – March 3, 2020
Note: Check with your organization’s library for availability. “The process of Lewy body formation, rather than simply {alpha}-synuclein fibrillization, is one of the major drivers of neurodegeneration,” by Anne-Laure Mahul-Mellier, Johannes Burtscher, Niran Maharjan, Laura Weerens, Marie Croisier, Fabien Kuttler, Marion Leleu, Graham W. Knott, and Hilal A. Lashuel (Vol. 117, No. 9, March 3, 2020, p. 4971-4982).
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February 25, 2020
CAAR – Proceedings of the National Academy of Sciences Articles – February 25, 2020
Note: Check with your organization’s library for availability.
A. “Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination,” by Su Jin Ham, Daewon Lee, Heesuk Yoo, Kyoungho Jun, Heejin Shin, and Jongkyeong Chung (Vol. 117, No. 8, February 25, 2020, p. 4281-4291).
www.pnas.org/content/117/8/4281
B. “Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging,” by Xin Li, Jiaqiang Wang, Leyun Wang, Guihai Feng, Gen Li, Meixin Yu, Yufei Li, Chao Liu, Xuewei Yuan, Guangxi Zang, Zhihuan Li, Ling Zhao, Hong Ouyang, Qingli Quan, Guangyu Wang, Charlotte Zhang, Oulan Li, Junkai Xiang, Jian-Kang Zhu, Wei Li, Qi Zhou, and Kang Zhang (Vol. 117, No. 8, February 25, 2020, p. 4328-4336).
www.pnas.org/content/117/8/4328
C. “Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3{beta} in Alzheimer’s disease,” by Tanusree Sen, Pampa Saha, Tong Jiang, and Nilkantha Sen (Vol. 117, No. 8, February 25, 2020, p. 4418-4427).
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February 19, 2020
CAAR – Proceedings of the National Academy of Science Article – February 19, 2020
Note: Check with your organization’s library for availability. “The {alpha}-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure,” by David R. Boyer, Binsen Li, Chuanqi Sun, Weijia Fan, Kang Zhou, Michael P. Hughes, Michael R. Sawaya, Lin Jiang, and David S. Eisenberg (Vol. 117, No. 7, February 18, 2020, p. 3592-3602).
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December 3, 2019
CAAR – Proceedings of the National Academy of Sciences Article – December 3, 2019
Note: For full text availability check your organization’s library. “A locomotor assay reveals deficits in heterozygous Parkinson’s disease model and proprioceptive mutants in adult Drosophila,” by Aman Aggarwal, Heinrich Reichert, and K. VijayRaghavan (Vol. 116, No. 49, December 3, 2019, p. 24830-24839).
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October 11, 2019
CAAR – Lancet Neurology Article Abstracts – October 11, 2019
A. “Effectiveness of home-based and remotely supervised aerobic exercise in Parkinson’s disease: a double-blind, randomised controlled trial,” by Nicolien M. van der Kolk, Nienke M. de Vries, Roy P. C. Kessels, Hilde Joosten, Aeilko H. Zwinderman, Bart Post, and Prof. Bastiaan R. Bloem (Vol. 18, No. 11, November 2019, p. 998-1008).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(19)30285-6/fulltext
B. “Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study,” by Ingrid S. van Maurik, Stephanie J. Vos, Isabelle Bos, Femke H. Bouwman, Charlotte E. Teunissen, Philip Scheltens, Frederik Barkhof, Lutz Frolich, Johannes Kornhuber, Jens Wiltfang, Wolfgang Maier, Oliver Peters, Eckart Rüther, Flavio Nobili, Giovanni B. Frisoni, Luiza Spiru, Yvonne Freund-Levi, Asa K. Wallin, Harald Hampel, Hilkka Soininen, Magda Tsolaki, Frans Verhey, Iwona Kłoszewska, Patrizia Mecocci, Bruno Vellas, Simon Lovestone, Samantha Galluzzi, Sanna-Kaisa Herukka, Isabel Santana, Ines Baldeiras, Alexandre de Mendonça,Dina Silva, Gael Chetelat, Stephanie Egret, Sebastian Palmqvist, Oskar Hansson, Pieter Jelle Visser, Johannes Berkhof, and Wiesje M. van der Flier for the Alzheimer’s Disease Neuroimaging Initiative (Vol. 18, No. 11, November 2019, p. 1034-1044).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(19)30283-2/fulltext
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October 8, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – October 8, 2019
A. “Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence,” by Cristian Tomasetti, Justin Poling, Nicholas J. Roberts, Nyall R. London Jr., Meredith E. Pittman, Michael C. Haffner, Anthony Rizzo, Alex Baras, Baktiar Karim, Antonio Kim, Christopher M. Heaphy, Alan K. Meeker, Ralph H. Hruban, Christine A. Iacobuzio-Donahue, and Bert Vogelstein (Vol. 116, No. 41, October 8, 2019, p. 20482-20488).
www.pnas.org/content/116/41/20482
B. “Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and {alpha}-synuclein stability through membrane remodeling,” by Akio Mori, Taku Hatano, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Takahiro Koinuma, Hongrui Meng, Shin-ichiro Kubo, Spencer Spratt, Changxu Cui, Chikara Yamashita, Yoshimi Miki, Kei Yamamoto, Tetsuya Hirabayashi, Makoto Murakami, Yoshikazu Takahashi, Hideo Shindou, Takashi Nonaka, Masato Hasegawa, Ayami Okuzumi, Yuzuru Imai, and Nobutaka Hattori (Vol. 116, No. 41, October 8, 2019, p. 20689-20699).
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September 5, 2019
CAAR – Proceedings of the National Academies of Science Article Abstract – September 5, 2019
“Parkinson’s disease is a type of amyloidosis featuring accumulation of amyloid fibrils of {alpha}-synuclein,” by Katsuya Araki, Naoto Yagi, Koki Aoyama, Chi-Jing Choong, Hideki Hayakawa, Harutoshi Fujimura, Yoshitaka Nagai, Yuji Goto, and Hideki Mochizuki (Vol. 116, No. 36, September 3, 2019, p. 17963-17969).
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September 3, 2019
CAAR – Public Library of Science (PLoS) Articles – September 3, 2019
A. “No association between preoperative physical activity level and time to return to work in patients after total hip or knee arthroplasty: A prospective cohort study,” by Anton R. Boersma, Sandra Brouwer, Wendy Koolhaas, Reinoud W. Brouwer, Wierd P. Zijlstra, Jan van Beveren, and Martin Stevens (PLoS ONE 14(9): e0221932. doi.org/10.1371/journal.pone.0221932, HTML, XML, and .pdf format, 13p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0221932
B. “Subjective judgments of rhythmic complexity in Parkinson’s disease: Higher baseline, preserved relative ability, and modulated by tempo,” by Kjetil Vikene, Geir Olve Skeie, and Karsten Specht (PLoS ONE 14(9): e0221752. doi.org/10.1371/journal.pone.0221752, XML, HTML, and .pdf format, 21p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0221752
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August 13, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 13, 2019
“Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson’s disease,” by Joohyung Lee, Paulo Pinares-Garcia, Hannah Loke, Seungmin Ham, Eric Vilain, and Vincent R. Harley (Vol. 116, No. 33, August 13, 2019, p. 16577-16582).
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August 6, 2019
CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 6, 2019
“Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network,” by Hayriye Cagnan, Nicolas Mallet, Christian K. E. Moll, Alessandro Gulberti, Abbey B. Holt, Manfred Westphal, Christian Gerloff, Andreas K. Engel, Wolfgang Hamel, Peter J. Magill, Peter Brown, and Andrew Sharott (Vol. 116, No. 32, August 6, 2019, p. 16095-16104).
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July 30, 2019
CAAR – Nature Neuroscience Article Abstracts – July 30, 2019
A. “Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer’s disease pathogenesis,” by Pilar Esteve, Javier Rueda-Carrasco, María Inés Mateo, María Jesús Martin-Bermejo, Jonathan Draffin, Guadalupe Pereyra, África Sandonís, Inmaculada Crespo, Inmaculada Moreno, Ester Aso, Paula Garcia-Esparcia, Estrella Gomez-Tortosa, Alberto Rábano, Juan Fortea, Daniel Alcolea, Alberto Lleo, Michael T. Heneka, José M. Valpuesta, José A. Esteban, Isidro Ferrer, Mercedes Domínguez & Paola Bovolenta (Vol. 22, No. 8, August 2019, p. 1258-1268).
www.nature.com/articles/s41593-019-0432-1
B. “Spread of {alpha}-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis,” by Michael X. Henderson, Eli J. Cornblath, Adam Darwich, Bin Zhang, Hannah Brown, Ronald J. Gathagan, Raizel M. Sandler, Danielle S. Bassett, John Q. Trojanowski & Virginia M. Y. Lee (Vol. 22, No. 8, August 2019, p. 1248-1257).
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July 23, 2019
CAAR – Proceedings of the National Academies of Science Article Abstract – July 23, 2019
“{alpha}-synuclein−lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson’s disease patients,” by Wojciech Paslawski, Justyna Zareba-Paslawska, Xiaoqun Zhang, Katharina Hölzl, Henrik Wadensten, Mohammadreza Shariatgorji, Shorena Janelidze, Oskar Hansson, Lars Forsgren, Per E. Andrén, and Per Svenningsson (Vol. 116, No. 30, July 23, 2019, p. 15226-15235).
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July 11, 2019
CAAR – Lancet Neurology Article Abstract – July 11, 2019
“Serotonergic pathology and disease burden in the premotor and motor phase of A53T {alpha}-synuclein parkinsonism: a cross-sectional study,” by Heather Wilson, George Dervenoulas, Gennaro Pagano, Christos Koros, Tayyabah Yousaf, Marina Picillo, Sotirios Polychronis, Athina Simitsi, Beniamino Giordano, Zachary Chappell, Benjamin Corcoran, Maria Stamelou, Roger N. Gunn, Maria Teresa Pellecchia, Eugenii A. Rabiner, Paolo Barone, Leonidas Stefanis, and Marios Politis (Vol. 18, No. 8, August 2019, p. 748-759).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(19)30140-1/fulltext
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June 25, 2019
CAAR – Nature Neuroscience Article Abstract – June 25, 2019
“Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes,” by Sarah H. Shahmoradian, Amanda J. Lewis, Christel Genoud, Jürgen Hench, Tim E. Moors, Paula P. Navarro, Daniel Castaño-Díez, Gabriel Schweighauser, Alexandra Graff-Meyer, Kenneth N. Goldie, Rosmarie Sütterlin, Evelien Huisman, Angela Ingrassia, Yvonne de Gier, Annemieke J. M. Rozemuller, Jing Wang, Anne De Paepe, Johannes Erny, Andreas Staempfli, Joerg Hoernschemeyer, Frederik Großerüschkamp, Daniel Niedieker, Samir F. El-Mashtoly, Marialuisa Quadri, Wilfred F. J. Van IJcken, Vincenzo Bonifati, Klaus Gerwert, Bernd Bohrmann, Stephan Frank, Markus Britschgi, Henning Stahlberg, Wilma D. J. Van de Berg & Matthias E. Lauer (Vol. 22, No. 7, July 2019, p. 1099-1109).
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June 17, 2019
CAAR – Science Article Abstract – June 17, 2019
“Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism,” by Vayu Maini Rekdal, Elizabeth N. Bess, Jordan E. Bisanz, Peter J. Turnbaugh, and Emily P. Balskus (Vol. 364, No. 6445, June 14, 2019).
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June 4, 2019
CAAR – Public Library of Science (PLoS) Article – June 4, 2019
“Impulse control disorders in Parkinson’s disease: A systematic review on the psychometric properties of the existing measures,” by Viola Angela Izzo, Maria Anna Donati, Silvia Ramat, and Caterina Primi (PLoS ONE 14(6): e0217700. doi.org/10.1371/journal.pone.0217700, XML, HTML, and .pdf format, 18p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0217700
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March 19, 2019
CAAR – Proceedings of the National Academies of Sciences Article Abstracts – March 19, 2019
A. “Advantaged socioeconomic conditions in childhood are associated with higher cognitive functioning but stronger cognitive decline in older age,” by Marja J. Aartsen, Boris Cheval, Stefan Sieber, Bernadette W. Van der Linden, Rainer Gabriel, Delphine S. Courvoisier, Idris Guessous, Claudine Burton-Jeangros, David Blane, Andreas Ihle, Matthias Kliegel, and Stephane Cullati (Vol. 116, No. 12, March 19, 2019, p. 5478-5486).
www.pnas.org/content/116/12/5478
B. “Parkinson’s disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration,” by Xi Chen, Jennifer K. Kordich, Erin T. Williams, Nathan Levine, Allyson Cole-Strauss, Lee Marshall, Viviane Labrie, Jiyan Ma, Jack W. Lipton, and Darren J. Moore (Vol. 116, No. 12, March 19, 2019, p. 5765-5774). Note: PNAS is providng open access to the full-text of this article.
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February 12, 2019
CAAR – Lancet Neurology Article Abstracts – February 12, 2019
A. “Safety and efficacy of CVT-301 (levodopa inhalation powder) on motor function during off periods in patients with Parkinson’s disease: a randomised, double-blind, placebo-controlled phase 3 trial,” by Peter A. LeWitt, Robert A. Hauser, Rajesh Pahwa, Stuart H. Isaacson, Hubert H. Fernandez, Mark Lew, Marie Saint-Hilaire, Emmanuelle Pourcher, Lydia Lopez-Manzanares, Cheryl Waters, Monika Rudzínska, Alexander Sedkov, Richard Batycky, and Charles Oh on behalf of the SPAN-PD Study Investigators (Vol. 18, No. 2, February 2019, p. 145-154).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(18)30405-8/fulltext
B. “Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer’s disease: a cross-sectional analysis of data from the Rush Memory and Aging Project,” by Lindsay M. K. Wallace, Olga Theou, Judith Godin, Melissa K. Andrew, David A. Bennett, and Kenneth Rockwood (Vol. 18, No. 2, February 2019, p. 177-184).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(18)30371-5/fulltext
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January 29, 2019
CAAR – Proceedings of the National Academies of Science Article Abstract – January 29, 2019
“{alpha}-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson’s disease,” by Paul M. Levine, Ana Galesic, Aaron T. Balana, Anne-Laure Mahul-Mellier, Mariana X. Navarro, Cesar A. De Leon, Hilal A. Lashuel, and Matthew R. Pratt (Vol. 116, No. 5, January 29, 2019, p. 1511-1519).
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December 13, 2018
CAAR – Public Library of Science (PLoS) Article – December 13, 2018
“Impaired cognitive modification for estimating time duration in Parkinson’s disease,” by Motoyasu Honma, Yuri Masaoka, Shinichi Koyama, Takeshi Kuroda, Akinori Futamura, Azusa Shiromaru, Yasuo Terao, Kenjiro Ono, and Mitsuru Kawamura (PLoS ONE 13(12): e0208956. doi.org/10.1371/journal.pone.0208956, HTML, XML, and .pdf format, 10p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0208956
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November 29, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 29, 2018
“Double dissociation of single-interval and rhythmic temporal prediction in cerebellar degeneration and Parkinson’s disease,” by Assaf Breska and Richard B. Ivry (Vol. 115, No. 48, November 27, 2018, p. 12283-12288).
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November 21, 2018
November 5, 2018
CAAR – Science Article Abstract – November 5, 2018
“Poly(ADP-ribose) drives pathologic {alpha}-synuclein neurodegeneration in Parkinson’s disease,” by Tae-In Kam, Xiaobo Mao, Hyejin Park, Shih-Ching Chou, Senthilkumar S. Karuppagounder, George Essien Umanah, Seung Pil Yun, Saurav Brahmachari, Nikhil Panicker, Rong Chen, Shaida A. Andrabi, Chen Qi, Guy G. Poirier, Olga Pletnikova, Juan C. Troncoso, Lynn M. Bekris, James B. Leverenz, Alexander Pantelyat, Han Seok Ko, Liana S. Rosenthal, Ted M. Dawson, Valina L. Dawson (Vol. 362, No. 6414, November 2, 2018).
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October 17, 2018
CAAR – Lancet Neurology Article Abstract – October 17, 2018
“Global, regional, and national burden of Parkinson’s disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016,” (Vol. 17, No. 11, November 2018, p. 939-953).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(18)30295-3/fulltext
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October 10, 2018
CAAR – Proceedings of the National Academy of Science Article Abstracts – October 10, 2018
A. “Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease,” by Sarah K. Baker, Zu-Lin Chen, Erin H. Norris, Alexey S. Revenko, A. Robert MacLeod, and Sidney Strickland (Vol. 115, No. 41, October 9, 2018, p. E9687-E9696).
www.pnas.org/content/115/41/E9687
B. “Small molecule inhibits a-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons,” by Jordi Pujols, Samuel Peña-Díaz, Diana F. Lázaro, Francesca Peccati, Francisca Pinheiro, Danilo González, Anita Carija, Susanna Navarro, María Conde-Giménez, Jesús García, Salvador Guardiola, Ernest Giralt, Xavier Salvatella, Javier Sancho, Mariona Sodupe, Tiago Fleming Outeiro, Esther Dalfó, and Salvador Ventura (Vol. 115, No. 41, October 9, 2018, p. 10481-10486).
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September 13, 2018
CAAR – Nature Letter Abstract – September 13, 2018
“Parkin and PINK1 mitigate STING-induced inflammation,” by Danielle A. Sliter, Jennifer Martinez, Ling Hao, Xi Chen, Nuo Sun, Tara D. Fischer, Jonathon L. Burman, Yan Li, Zhe Zhang, Derek P. Narendra, Huaibin Cai, Max Borsche, Christine Klein & Richard J. Youle (Vol. 561, No. 7722, September 13, 2018, p. 258-262).
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September 5, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – September 5, 2018
A. “Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice,” by Te-Chen Tzeng, Yuto Hasegawa, Risa Iguchi, Amy Cheung, Daniel R. Caffrey, Elizabeth Jeanne Thatcher, Wenjie Mao, Gail Germain, Nelsy DePaula Tamburro, Shigeo Okabe, Michael T. Heneka, Eicke Latz, Kensuke Futai, and Douglas T. Golenbock (Vol. 115, No. 36, September 4, 2018, p. 9002-9007).
www.pnas.org/content/115/36/9002
B. “Local field potentials of subthalamic nucleus contain electrophysiological footprints of motor subtypes of Parkinson’s disease,” by Ilknur Telkes, Ashwin Viswanathan, Joohi Jimenez-Shahed, Aviva Abosch, Musa Ozturk, Akshay Gupte, Joseph Jankovic, and Nuri F. Ince (Vol. 115, No. 36, September 4, 2018, p. E8567-E8576).
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August 15, 2018
CAAR – Lancet Neurology Article Abstracts – August 15, 2018
A. “Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE e4 haplotype status: a community-based cohort study,” by Hyun-Sik Yang, Lei Yu, Charles C. White, Lori B. Chibnik, Jasmeer P. Chhatwal, Reisa A. Sperling, David A. Bennett, Julie A. Schneider, and Philip L. De Jager (Vol. 17, No. 9, September 2018, p. 773-781).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(18)30251-5/abstract
B. “Apomorphine subcutaneous infusion in patients with Parkinson’s disease with persistent motor fluctuations (TOLEDO): a multicentre, double-blind, randomised, placebo-controlled trial,” by Regina Katzenschlager, Werner Poewe, Olivier Rascol, Claudia Trenkwalder, Gunther Deuschl, K. Ray Chaudhuri, Tove Henriksen, Teus van Laar, Kevin Spivey, Senthil Vel, Harry Staines, and Andrew Lees (Vol. 17, No. 9, September 2017, p. 749-759).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(18)30239-4/abstract
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