CDHA CAAR

May 22, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 22, 2018

LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson’s disease,” by Maria Nguyen and Dimitri Krainc (Vol. 115, No. 21, May 22, 2018, p. 5576-5581).

www.pnas.org/content/115/21/5576?etoc=

 

April 9, 2018

CAAR – Public Library of Science (PLoS) Article – April 9, 2018

Filed under: Reports and Articles — Tags: , — admin @ 4:59 pm

Parkinson’s disease-related non-motor features as risk factors for post-operative delirium in spinal surgery,” by Ki Hoon Kim, Suk Yun Kang, Dong Ah Shin, Seong Yi, Yoon Ha, Keung Nyun Kim, Young Ho Sohn, and Phil Hyu Lee (PLoS ONE 13(4): e0195749. doi.org/10.1371/journal.pone.0195749, XML, HTML, and .pdf format, 12p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0195749

March 27, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 27, 2018

Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality,” by Jatish Kumar, Hasier Erana, Elena López-Martínez, Nathalie Claes, Víctor F. Martín, Diego M. Solís, Sara Bals, Aitziber L. Cortajarena, Joaquín Castilla, and Luis M. Liz-Marzan (Vol. 115, No. 13, March 27, 2018, p. 3225-3230).

www.pnas.org/content/115/13/3225

March 14, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 14, 2018

Identification of a highly neurotoxic {alpha}-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease,” by Diego Grassi, Shannon Howard, Minghai Zhou, Natalia Diaz-Perez, Nicolai T. Urban, Debbie Guerrero-Given, Naomi Kamasawa, Laura A. Volpicelli-Daley, Philip LoGrasso, and Corinne Ida Lasmezas (Vol. 115, No. 11, March 13, 2018, p. E2634-E2643).

www.pnas.org/content/115/11/E2634?etoc=

February 27, 2018

CAAR – Public Library of Science (PLoS) Article – February 27, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 4:54 pm

Effects of physical exercise programs on cognitive function in Parkinson’s disease patients: A systematic review of randomized controlled trials of the last 10 years,” by Franciele Cascaes da Silva, Rodrigo da Rosa Iop, Laiana Cândido de Oliveira, Alice Mathea Boll, José Gustavo Souza de Alvarenga, Paulo José Barbosa Gutierres Filho, Lídia Mara Aguiar Bezerra de Melo, André Junqueira Xavier, and Rudney da Silva (PLoS ONE 13(2): e0193113. doi.org/10.1371/journal.pone.0193113, XML, HTML, and .pdf format, 19p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0193113

February 26, 2018

CAAR – Public Library of Science (PLoS) Articles – February 26, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 4:42 pm

A. “Social capital and Internet use in an age-comparative perspective with a focus on later life,” by Barbara Barbosa Neves, Jaime R. S. Fonseca, Fausto Amaro, and Adriano Pasqualotti (PLoS ONE 13(2): e0192119. doi.org/10.1371/journal.pone.0192119, XML, HTML, and .pdf format, 27p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0192119

B. “Analysis of age-related changes in psychosine metabolism in the human brain,” by Michael S. Marshall, Benas Jakubauskas, Wil Bogue, Monika Stoskute, Zane Hauck, Emily Rue, Matthew Nichols, Lisa L. DiAntonio, Richard B. van Breemen, Jeffrey H. Kordower, Carlos A. Saavedra-Matiz, and Ernesto R. Bongarzone (PLoS ONE 13(2): e0193438. doi.org/10.1371/journal.pone.0193438, XML, HTML, and .pdf format, 20p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0193438

February 13, 2018

CAAR – Proceedings of the National Academies of Science Article Abstract – February 13, 2018

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice,” by Yulan Xiong, Stewart Neifert, Senthilkumar S. Karuppagounder, Qinfang Liu, Jeannette N. Stankowski, Byoung Dae Lee, Han Seok Ko, Yunjong Lee, Jonathan C. Grima, Xiaobo Mao, Haisong Jiang, Sung-Ung Kang, Deborah A. Swing, Lorraine Iacovitti, Lino Tessarollo, Ted M. Dawson, and Valina L. Dawson (Vol. 115, No. 7, February 13, 2018, p. 1635-1640).

www.pnas.org/content/115/7/1635

January 23, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 23, 2018

A. “Structural heterogeneity and intersubject variability of A{beta} in familial and sporadic Alzheimer’s disease,” by Carlo Condello, Thomas Lemmin, Jan Stöhr, Mimi Nick, Yibing Wu, Alison M. Maxwell, Joel C. Watts, Christoffer D. Caro, Abby Oehler, C. Dirk Keene, Thomas D. Bird, Sjoerd G. van Duinen, Lars Lannfelt, Martin Ingelsson, Caroline Graff, Kurt Giles, William F. DeGrado, and Stanley B. Prusiner (Vol. 115, No. 4, January 23, 2018, .pdf and HTML format, p. E782-E791). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/115/4/E782.abstract

B. “GBA1 deficiency negatively affects physiological {alpha}-synuclein tetramers and related multimers,” by Sangjune Kim, Seung Pil Yun, Saebom Lee, George Essien Umanah, Veera Venkata Ratnam Bandaru, Xiling Yin, Peter Rhee, Senthilkumar S. Karuppagounder, Seung-Hwan Kwon, Hojae Lee, Xiaobo Mao, Donghoon Kim, Akhilesh Pandey, Gabsang Lee, Valina L. Dawson, Ted M. Dawson, and Han Seok Ko (Vol. 115, No. 4, January 23, 2018, p. 798-803).

www.pnas.org/content/115/4/798.abstract

C. “CFH and ARMS2 genetic risk determines progression to neovascular age-related macular degeneration after antioxidant and zinc supplementation,” by Demetrios G. Vavvas, Kent W. Small, Carl C. Awh, Brent W. Zanke, Robert J. Tibshirani, and Rafal Kustra (Vol. 115, No. 4, January 23, 2018, .pdf and HTML format, p. E696-E704). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/115/4/E696.abstract

January 18, 2018

CAAR – Lancet Neurology Article Abstracts – January 18, 2018

Filed under: Reports and Articles — Tags: , — admin @ 4:52 pm

A. “Accelerated long-term forgetting in presymptomatic autosomal dominant Alzheimer’s disease: a cross-sectional study,” by Philip S. J. Weston, Jennifer M. Nicholas, Susie M. D. Henley, Yuying Liang, Kirsty Macpherson, Elizabeth Donnachie, Jonathan M. Schott, Martin N. Rossor, Sebastian J. Crutch, Christopher R. Butler, Adam Z. Zeman, and Nick C. Fox (Vol. 17, No. 2, February 2018, p. 123-132).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30434-9/abstract

B. “Effectiveness and costs of specialised physiotherapy given via ParkinsonNet: a retrospective analysis of medical claims data,” by Jan H. L. Ypinga, Nienke M. de Vries, Lieke H. H. M. Boonen, Xander Koolman, Marten Munneke, Aeilko H. Zwinderman, and Bastiaan R. Bloem (Vol. 17, No. 2, February 2018, p. 153-161).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30406-4/abstract

 

January 9, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 9, 2018

Familial Parkinson’s point mutation abolishes multiple system atrophy prion replication,” by Amanda L. Woerman, Sabeen A. Kazmi, Smita Patel, Atsushi Aoyagi, Abby Oehler, Kartika Widjaja, Daniel A. Mordes, Steven H. Olson, and Stanley B. Prusiner (Vol. 115, No. 2, January 9, 2018, p. 409-414).

www.pnas.org/content/115/2/409.abstract

December 22, 2017

CAAR – Proceedings of the National Academies of Science Article Abstracts – December 22, 2017

A. “Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice,” by Noah R. Johnson, Carlo Condello, Shenheng Guan, Abby Oehler, Julia Becker, Marta Gavidia, George A. Carlson, Kurt Giles, and Stanley B. Prusiner (Vol. 114, No. 51, December 19, 2017, p. E11029-E11036).

www.pnas.org/content/114/51/E11029.abstract

B. “Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1,” by D. Cristopher Bragg, Kotchaphorn Mangkalaphiban, Christine A. Vaine, Nichita J. Kulkarni, David Shin, Rachita Yadav, Jyotsna Dhakal, Mai-Linh Ton, Anne Cheng, Christopher T. Russo, Mark Ang, Patrick Acuña, Criscely Go, Taylor N. Franceour, Trisha Multhaupt-Buell, Naoto Ito, Ulrich Müller, William T. Hendriks, Xandra O. Breakefield, Nutan Sharma, and Laurie J. Ozelius (Vol. 114, No. 51, December 19, 2017, p. E11020-E11028). Note: _PNAS_ is providing open access to the full-text of this article.

www.pnas.org/content/114/51/E11020.abstract

December 18, 2017

CAAR – Public Library of Science (PLoS) Articles – December 18, 2017

Filed under: Reports and Articles — Tags: , — admin @ 4:50 pm

A. “Cognitive failures in late adulthood: The role of age, social context and depressive symptoms,” by Paul Kenneth Hitchcott, Maria Chiara Fastame, Dalila Langiu, and Maria Pietronilla Penna (PLoS ONE 12(12): e0189683. doi.org/10.1371/journal.pone.0189683, XML, HTML, and .pdf format, 14p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0189683

B. “Towards the identification of Idiopathic Parkinson’s Disease from the speech. New articulatory kinetic biomarkers,” by J. I. Godino-Llorente, S. Shattuck-Hufnagel, J. Y. Choi, L. Moro-Velazquez, and J. A. Gómez-García (PLoS ONE 12(12): e0189583. doi.org/10.1371/journal.pone.0189583, XML, HTML, and .pdf format, 35p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0189583

C. “Sleep-wake functions and quality of life in patients with subthalamic deep brain stimulation for Parkinson’s disease,” by Panagiotis Bargiotas, Lukas Eugster, Michael Oberholzer, Ines Debove, M. Lenard Lachenmayer, Johannes Mathis, Claudio Pollo, W. M. Michael Schüpbach, and Claudio L. Bassetti (PLoS ONE 12(12): e0190027. doi.org/10.1371/journal.pone.0190027, XML, HTML, and .pdf format, 15p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0190027

 

December 14, 2017

CAAR – Science Report Abstract – December 14, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 4:49 pm

Structural basis of membrane disruption and cellular toxicity by {alpha}-synuclein oligomers,” by Giuliana Fusco, Serene W. Chen, Philip T. F. Williamson, Roberta Cascella, Michele Perni, James A. Jarvis, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti, Nunilo Cremades5, Liming Ying, Christopher M. Dobson, and Alfonso De Simone (Vol. 358, No. 6369, December 15, 2017, p. 1440-1443).

science.sciencemag.org/content/358/6369/1440

October 31, 2017

CAAR – Nature Neuroscience Article Abstracts – October 31, 2017

Filed under: Reports and Articles — Tags: , , , — admin @ 4:44 pm

A. “[alpha]-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B,” by Diana G Ferreira, Mariana Temido-Ferreira, Hugo Vicente Miranda, Vania L. Batalha, Joana E. Coelho, Eva M. Szego, Ines Marques-Morgado, Sandra H. Vaz, Jeong Seop Rhee, Matthias Schmitz, Inga Zerr, Luísa V. Lopes & Tiago F. Outeiro (Vol. 20, No. 11, November 2017, p. 1569-1579).

www.nature.com/neuro/journal/v20/n11/abs/nn.4648.html

B. “Dopamine induces soluble {alpha}-synuclein oligomers and nigrostriatal degeneration,” by Danielle E. Mor, Elpida Tsika, Joseph R. Mazzulli, Neal S. Gould, Hanna Kim, Malcolm J. Daniels, Shachee Doshi, Preetika Gupta, Jennifer L. Grossman, Victor X. Tan, Robert G. Kalb, Kim A Caldwell, Guy A. Caldwell, John H. Wolfe & Harry Ischiropoulos (Vol. 20, No. 11, November 2017, p. 1560-1568).

www.nature.com/neuro/journal/v20/n11/abs/nn.4641.html

October 13, 2017

CAAR – Lancet Neurology Article Abstracts – October 13, 2017

Filed under: Reports and Articles — Tags: , — admin @ 5:03 pm

A. “Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer’s disease: a longitudinal retrospective study,” by Keith A. Josephs, Dennis W. Dickson, Nirubol Tosakulwong, Stephen D. Weigand, Melissa E. Murray, Leonard Petrucelli, Amanda M. Liesinger, Matthew L Senjem, Anthony J. Spychalla, David S. Knopman, Joseph E. Parisi, Ronald C Petersen, Clifford R. Jack Jr, and Jennifer L. Whitwell (Vol. 16, No. 11, November 2017, p. 917-924).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30284-3/abstract

B. “Large-scale identification of clinical and genetic predictors of motor progression in patients with newly diagnosed Parkinson’s disease: a longitudinal cohort study and validation,” by Jeanne C. Latourelle, Michael T. Beste, Tiffany C. Hadzi, Robert E. Miller, Jacob N. Oppenheim, Matthew P. Valko, Diane M. Wuest, Bruce W. Church, Iya G. Khalil, Boris Hayete, and Charles S. Venuto (Vol. 16, No. 11, November 2017, p. 908-916).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30328-9/abstract

 

October 6, 2017

CAAR – Lancet Article Abstracts – October 6, 2017

Filed under: Reports and Articles — Tags: , , , — admin @ 12:54 pm

A. “Exenatide once weekly versus placebo in Parkinson’s disease: a randomised, double-blind, placebo-controlled trial,” by Dilan Athauda, Kate Maclagan, Simon S Skene, Martha Bajwa-Joseph, Dawn Letchford, Kashfia Chowdhury, Steve Hibbert, Natalia Budnik, Luca Zampedri, John Dickson, Yazhou Li, Iciar Aviles-Olmos, Thomas T. Warner, Patricia Limousin, Andrew J. Lees, Nigel H. Greig, Susan Tebbs, and Thomas Foltynie (Vol. 390, No. 10103, October 7, 2017, p. 1664-1675).

www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31585-4/abstract

B. “Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS),” by Andrew Kingston, Pia Wohland, Raphael Wittenberg, Louise Robinson, Carol Brayne, Fiona E. Matthews, and Carol Jagger on behalf of the Cognitive Function and Ageing Studies collaboration (Vol. 390, No. 10103, October 7, 2017, p. 1676-1684).

www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31575-1/abstract

September 26, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 26, 2017

Modeling Parkinson’s disease pathology by combination of fibril seeds and {alpha}-synuclein overexpression in the rat brain,” by Poonam Thakur, Ludivine S. Breger, Martin Lundblad, Oi Wan Wan, Bengt Mattsson, Kelvin C. Luk, Virginia M. Y. Lee, John Q. Trojanowski, and Anders Bjorklund (Vol. 114, No. 39, September 26, 2017, p. E8284–E8293).

www.pnas.org/content/114/39/E8284.abstract.html?etoc

September 5, 2017

CAAR – Science Article Abstract – September 5, 2017

Filed under: Reports and Articles — Tags: , — admin @ 4:07 pm

{beta}2-Adrenoreceptor is a regulator of the {alpha}-synuclein gene driving risk of Parkinson’s disease,” by Shuchi Mittal, Kjetil Bjornevik, Doo Soon Im, Adrian Flierl, Xianjun Dong, Joseph J. Locascio, Kristine M. Abo, Elizabeth Long, Ming Jin, Bing Xu, Yang K. Xiang, Jean-Christophe Rochet, Anders Engeland, Patrizia Rizzu, Peter Heutink, Tim Bartels, Dennis J. Selkoe, Barbara J. Caldarone, Marcie A. Glicksman, Vikram Khurana, Birgitt Schule, David S. Park, Trond Riise, and Clemens R. Scherzer (Vol. 357, No. 6354, September 1, 2017, p. 891-898).

science.sciencemag.org/content/357/6354/891

August 30, 2017

CAAR – Nature Letter Abstract – August 30, 2017

Filed under: Reports and Articles — Tags: , — admin @ 4:57 pm

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model,” by Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita, Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar & Jun Takahashi (Vol. 548, No. 7669, August 31, 2017, p. 592-596).Nature Letter Abstract: “Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model,” by Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita, Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar & Jun Takahashi (Vol. 548, No. 7669, August 31, 2017, p. 592-596).

www.nature.com/nature/journal/v548/n7669/abs/nature23664.html

August 28, 2017

CAAR – Public Library of Science (PLoS) Articles – August 28, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 4:20 pm

A. “Differential diagnosis between Parkinson’s disease and essential tremor using the smartphone’s accelerometer,” by Sergi Barrantes, Antonio J. Sanchez Egea, Hernán A. González Rojas, Maria J. Martí, Yaroslau Compta, Francesc Valldeoriola, Ester Simo Mezquita, Eduard Tolosa, and Josep Valls-Sole (PLoS ONE 12(8): e0183843. doi.org/10.1371/journal.pone.0183843, XML, HTML, and .pdf format, 12p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0183843

B. “Aging effects on airflow dynamics and lung function in human bronchioles,” by JongWon Kim, Rebecca L. Heise, Angela M. Reynolds, and Ramana M. Pidaparti (PLoS ONE 12(8): e0183654. doi.org/10.1371/journal.pone.0183654, XML, HTML, and .pdf format, 20p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0183654

July 17, 2017

CAAR – Center for Disease Control Articles – July 17, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:04 pm

A. “Mortality from Amyotrophic Lateral Sclerosis and Parkinson’s Disease Among Different Occupation Groups — United States, 1985–2011,” by John D. Beard, Andrea L. Steege, Jun Ju, John Lu,Sara E. Luckhaupt, and Mary K. Schubauer-Berigan (Morbidity and Mortality Weekly Report, Vol. 66, No. 27, July 14, 2017, .pdf and HTML format, p. 718-722).

www.cdc.gov/mmwr/volumes/66/wr/mm6627a2.htm

B. “Pneumococcal Vaccination Among Medicare Beneficiaries Occurring After the Advisory Committee on Immunization Practices Recommendation for Routine Use Of 13-Valent Pneumococcal Conjugate Vaccine and 23-Valent Pneumococcal Polysaccharide Vaccine for Adults Aged {gt}=65 Years,” by Carla L. Black, Walter W. Williams, Rob Warnock Tamara Pilishvili, David Kim, and Jeffrey A. Kelman (Morbidity and Mortality Weekly Report, Vol. 66, No. 27, July 14, 2017, .pdf and HTML format, p. 728-733).

www.cdc.gov/mmwr/volumes/66/wr/mm6627a4.htm

July 13, 2017

CAAR – Lancet Neurology Article Abstract – July 13, 2017

Filed under: Reports and Articles — Tags: — admin @ 5:18 pm

Prediction of cognition in Parkinson’s disease with a clinical–genetic score: a longitudinal analysis of nine cohorts,” by Ganqiang Liu, Joseph J. Locascio, Jean-Christophe Corvol, Brendon Boot, Zhixiang Liao, Kara Page, Daly Franco, Kyle Burke, Iris E. Jansen, Ana Trisini-Lipsanopoulos, Sophie Winder-Rhodes, Caroline M. Tanner, Anthony E. Lang, Shirley Eberly, Alexis Elbaz, Alexis Brice, Graziella Mangone, Bernard Ravina, Ira Shoulson, Florence Cormier-Dequaire, Peter Heutink, Jacobus J. van Hilten, Roger A. Barker, Caroline H. Williams-Gray, Johan Marinus, and Clemens R. Scherzer (Vol. 16, No. 8, August 2017, p. 620-629).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30122-9/abstract

June 28, 2017

CAAR – Nature Letter Abstract – June 28, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:15 pm

T cells from patients with Parkinson’s disease recognize {alpha}-synuclein peptides,” by David Sulzer, Roy N. Alcalay, Francesca Garretti, Lucien Cote, Ellen Kanter, Julian Agin-Liebes, Christopher Liong, Curtis McMurtrey, William H. Hildebrand, Xiaobo Mao, Valina L. Dawson, Ted M. Dawson, Carla Oseroff, John Pham, John Sidney, Myles B. Dillon, Chelsea Carpenter, Daniela Weiskopf, Elizabeth Phillips, Simon Mallal, Bjoern Peters, April Frazier, Cecilia S. Lindestam Arlehamn & Alessandro Sette (Vol. 546, No. 7660, June 29, 2017, p. 656-661).

www.nature.com/nature/journal/v546/n7660/abs/nature22815.html

June 20, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 20, 2017

Treatment with diphenyl–pyrazole compound anle138b/c reveals that {alpha}-synuclein protects melanoma cells from autophagic cell death,” by Elisa Turriani, Diana F. Lazaro, Sergey Ryazanov, Andrei Leonov, Armin Giese, Margarete Schon, Michael P. Schon, Christian Griesinger, Tiago F. Outeiro, Donna J. Arndt-Jovin, and Dorothea Becker (Vol. 114, No. 25, June 21, 2017, p. E4971–E4977).

www.pnas.org/content/114/25/E4971.abstract.html?etoc

May 1, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 1, 2017

Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson’s disease,” by Georgia Kouroupi, Era Taoufik, Ioannis S. Vlachos, Konstantinos Tsioras, Nasia Antoniou, Florentia Papastefanaki, Dafni Chroni-Tzartou, Wolfgang Wrasidlo, Delphine Bohl, Dimitris Stellas, Panagiotis K. Politis, Kostas Vekrellis, Dimitra Papadimitriou, Leonidas Stefanis, Piotr Bregestovski, Artemis G. Hatzigeorgiou, Eliezer Masliah, and Rebecca Matsas (Vol. 114, No. 18, May 2, 2017, p. E3679–E3688).

www.pnas.org/content/114/18/E3679.abstract.html?etoc

April 26, 2017

CAAR – Nature Neuroscience Article Abstract – April 26, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:18 pm

{alpha}-Synuclein promotes dilation of the exocytotic fusion pore,” by Todd Logan, Jacob Bendor, Chantal Toupin, Kurt Thorn & Robert H. Edwards (Vol. 20, No. 5, May 2017, p. 681-689).

www.nature.com/neuro/journal/v20/n5/abs/nn.4529.html

April 13, 2017

CAAR – Public Library of Science (PLoS) Article – April 13, 2017

Filed under: Reports and Articles — Tags: — admin @ 4:48 pm

Parkinson’s disease-associated genetic variation is linked to quantitative expression of inflammatory genes,” by Steven Pierce and Gerhard A. Coetzee (PLoS ONE 12(4): e0175882. doi.org/10.1371/journal.pone.0175882, XML, HTML, and .pdf format, 11p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0175882

April 12, 2017

CAAR – Lancet Neurology Article Abstracts – April 12, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:07 pm

A. “Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies,” by Dr. Daryl J. Wile, Pankaj A. Agarwal, Prof. Michael Schulzer, Edwin Mak, Katherine Dinelle, Elham Shahinfard, Nasim Vafai, Kazuko Hasegawa, Prof. Jing Zhang, Jessamyn McKenzie, Nicole Neilson, Audrey Strongosky, Prof. Ryan J. Uitti, Mark Guttman, Cyrus P. Zabetian, Prof. Yu-Shin Ding, Mike Adam, Prof. Jan Aasly, Prof. Zbigniew K. Wszolek, Prof. Matthew Farrer, Prof. Vesna Sossi, and Prof. A. Jon Stoessl (Vol. 16, No. 5, May 2017, p. 351–359).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30056-X/abstract

B. “Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial,” by Sandrine Andrieu, Sophie Guyonnet, Nicola Coley, Christelle Cantet, Marc Bonnefoy, Serge Bordes, Lawrence Bories, Marie-Noelle Cufi, Thierry Dantoine, Jean-François Dartigues, Françoise Desclaux, Audrey Gabelle, Yannick Gasnier, Alain Pesce, Kristel Sudres, Jacques Touchon, Philippe Robert, Olivier Rouaud, Philippe Legrand, Pierre Payoux, Jean-Paul Caubere, Michael Weiner, Isabelle Carrié, Pierre-Jean Ousset, and Bruno Vellas for the MAPT Study Group (Vol. 16, No. 5, May 2017, p. 377–389).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30040-6/abstract

April 11, 2017

CAAR – Public Library of Science (PLoS) Article – April 11, 2017

Filed under: Reports and Articles — Tags: , — admin @ 5:01 pm

Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson’s disease,” by Ismael Huertas, Silvia Jesus, Francisco Javier García-Gomez, Jose Antonio Lojo, Inmaculada Bernal-Bernal, Marta Bonilla-Toribio, Juan Francisco Martín-Rodriguez, David García-Solís, Pilar Gómez-Garre, and Pablo Mir (PLoS ONE 12(4): e0175560. doi.org/10.1371/journal.pone.0175560, XML, HTML, and .pdf format, 11p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0175560

March 14, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 14, 2017

Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease,” by Amy R. Dunn, Kristen A. Stout, Minagi Ozawa, Kelly M. Lohr, Carlie A. Hoffman, Alison I. Bernstein, Yingjie Li, Minzheng Wang, Carmelo Sgobio, Namratha Sastry, Huaibin Cai, W. Michael Caudle, and Gary W. Miller (Vol. 114, No. 11, March 14, 2017, p. E2253–E2262).

www.pnas.org/content/114/11/E2253.abstract.html?etoc

March 7, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 7, 2017

A. “Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models,” by S. Pablo Sardi, Catherine Viel, Jennifer Clarke, Christopher M. Treleaven, Amy M. Richards, Hyejung Park, Maureen A. Olszewski, James C. Dodge, John Marshall, Elina Makino, Bing Wang, Richard L. Sidman, Seng H. Cheng, and Lamya S. Shihabuddin (Vol. 114, No. 10, March 7, 2017, p. 2699–2704).

www.pnas.org/content/114/10/2699.abstract.html?etoc

B. “Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson’s disease,” by Holly Green, Xiaoqun Zhang, Katarina Tiklova, Nikolaos Volakakis, Lovisa Brodin, Louise Berg, Paul Greengard, Thomas Perlmann, and Per Svenningsson (Vol. 114, No. 10, March 7, 2017, p. 2735–2740).

www.pnas.org/content/114/10/2735.abstract.html?etoc

February 28, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 28, 2017

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases {alpha}-synuclein aggregation,” by Sarah Jinn, Robert E. Drolet, Paige E. Cramer, Andus Hon-Kit Wong, Dawn M. Toolan, Cheryl A. Gretzula, Bhavya Voleti, Galya Vassileva, Jyoti Disa, Marija Tadin-Strapps, and David J. Stone (Vol. 114, No. 9, February 28, 2017, .pdf and HTML format, p. 2389-2394). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/9/2389.abstract

February 17, 2017

CAAR – Lancet Article Abstract – February 17, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:00 pm

Living near major roads and the incidence of dementia, Parkinson’s disease, and multiple sclerosis: a population-based cohort study,” by Hong Chen, Jeffrey C Kwong, Ray Copes, Karen Tu, Paul J. Villeneuve, Aaron van Donkelaar, Perry Hystad, Randall V. Martin, Brian J. Murray, Barry Jessiman, Andrew S. Wilton, Alexander Kopp, and Richard T. Burnett (Vol. 389, No. 10070, February 18, 2017, p. 718-726).

www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)32399-6/abstract

February 8, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 8, 2017

A. “Gleevec shifts APP processing from a {beta}-cleavage to a nonamyloidogenic cleavage,” by William J. Netzer, Karima Bettayeb, Subhash C. Sinha, Marc Flajolet, Paul Greengard, and Victor Bustos (Vol. 114, No. 6, February 7, 2017, p. 1389-1394).

www.pnas.org/content/114/6/1389.abstract

B. “A natural product inhibits the initiation of {alpha}-synuclein aggregation and suppresses its toxicity,” by Michele Perni, Céline Galvagnion, Alexander Maltsev, Georg Meisl, Martin B. D. Müller, Pavan K. Challa, Julius B. Kirkegaard, Patrick Flagmeier, Samuel I. A. Cohen, Roberta Cascella, Serene W. Chen, Ryan Limboker, Pietro Sormanni, Gabriella T. Heller, Francesco A. Aprile, Nunilo Cremades, Cristina Cecchi, Fabrizio Chiti, Ellen A. A. Nollen, Tuomas P. J. Knowles, Michele Vendruscolo, Adriaan Bax, Michael Zasloff, and Christopher M. Dobson (Vol. 114, No. 6, February 7, 2017, p. E1009-E1017). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/6/E1009.abstract

January 31, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 31, 2017

A. “Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry,” by Palaniappan S. Chetty, Leland Mayne, Sissel Lund-Katz, S. Walter Englander, and Michael C. Phillips (Vol. 114, No. 5, January 31, 2017, p. 968-973).

www.pnas.org/content/114/5/968.abstract.html?etoc

B. “Nrf2 mitigates LRRK2- and {alpha}-synuclein–induced neurodegeneration by modulating proteostasis,” by Gaia Skibinski, Vicky Hwang, Dale Michael Ando, Aaron Daub, Alicia K. Lee, Abinaya Ravisankar, Sara Modan, Mariel M. Finucane, Benjamin A. Shaby, and Steven Finkbeiner (Vol. 114, No. 5, January 31, 2017, p. 1165–1170).

www.pnas.org/content/114/5/1165.abstract.html?etoc

C. “{alpha}-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation,” by Seong Su Kang, Zhentao Zhang, Xia Liu, Fredric P. Manfredsson, Li He, P. Michael Iuvone, Xuebing Cao, Yi E. Sun, Lingjing Jin, and Keqiang Ye (Vol. 114, No. 5, January 31, 2017, p. 1183–1185).

www.pnas.org/content/114/5/1183.abstract.html?etoc

December 8, 2016

CAAR – Lancet Neurology Article Abstract – December 8, 2016

Filed under: Reports and Articles — Tags: , , — admin @ 3:07 pm

Clinical variables and biomarkers in prediction of cognitive impairment in patients with newly diagnosed Parkinson’s disease: a cohort study,” by Anette Schrag, Uzma Faisal Siddiqui, Zacharias Anastasiou, Daniel Weintraub, and Jonathan M. Schott (Vol. 17, No. 1, January 2017, p. 66-75).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(16)30328-3/abstract

November 7, 2016

CAAR – Public Library of Science (PLoS) Article – November 7, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:53 pm

Parkinson Patients’ Initial Trust in Avatars: Theory and Evidence,” by Andrija Javor, Gerhard Ransmayr, Walter Struhal, and Rene Riedl (PLoS ONE 11(11): e0165998. doi:10.1371/journal.pone.0165998, XML, HTML, and .pdf format, 21p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0165998

November 1, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 1, 2016

Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson’s disease,” by Istvan Horvath and Pernilla Wittung-Stafshede (Vol. 113, No. 44, November 1, 2016, p. 12473–12477).

www.pnas.org/content/113/44/12473.abstract

September 29, 2016

CAAR – Science Article Abstract – September 29, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:50 pm

Pathological {alpha}-synuclein transmission initiated by binding lymphocyte-activation gene 3,” by Xiaobo Mao, Michael Tianhao Ou, Senthilkumar S. Karuppagounder, Tae-In Kam, Xiling Yin, Yulan Xiong, Preston Ge, George Essien Umanah, Saurav Brahmachari, Joo-Ho Shin, Ho Chul Kang, Jianmin Zhang, Jinchong Xu, Rong Chen, Hyejin Park, Shaida A. Andrabi, Sung Ung Kang, Rafaella Araújo Gonçalves, Yu Liang, Shu Zhang, Chen Qi, Sharon Lam, James A. Keiler, Joel Tyson, Donghoon Kim, Nikhil Panicker, Seung Pil Yun, Creg J. Workman, Dario A. A. Vignali, Valina L. Dawson, Han Seok Ko, and Ted M. Dawson (Vol. 353, No. 6037, September 30, 2016).

science.sciencemag.org/content/353/6307/aah3374.abstract

September 13, 2016

CAAR – Proceedings of the National Academies of Sciences Article Abstract – September 13, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:44 pm

Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of {alpha}-synuclein aggregation,” by Patrick Flagmeier, Georg Meisl, Michele Vendruscolo, Tuomas P. J. Knowles, Christopher M. Dobson, Alexander K. Buell, and Celine Galvagnion (Vol. 113, No. 37, September 13, 2016, p. 10328–10333).

www.pnas.org/content/113/37/10328.abstract.html?etoc

CAAR – Public Library of Science (PLoS) Article – September 13, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:43 pm

AlphaSynuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant,” by Claire Hoenen, Audrey Gustin, Cindy Birck, Melanie Kirchmeyer, Nicolas Beaume, Paul Felten, Luc Grandbarbe, Paul Heuschling, and Tony Heurtaux (PLoS ONE 11(9): e0162717. doi:10.1371/journal.pone.0162717, XML, HTML, and .pdf format, 24p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162717

September 7, 2016

CAAR – Public Library of Science (PLoS) Articles – September 7, 2016

Filed under: Reports and Articles — Tags: , , , — admin @ 4:34 pm

A. “Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes,” by Jianjia Fan, Shahab Zareyan, Wenchen Zhao, Yoko Shimizu, Tom A. Pfeifer, Jun-Hyung Tak, Murray B. Isman, Bernard Van den Hoven, Mark E. Duggan, Michael W. Wood, Cheryl L. Wellington, and Iva Kulic (PLoS ONE 11(9): e0162384. doi:10.1371/journal.pone.0162384, XML, HTML, and .pdf format, 27p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162384

B. “Quantitative Susceptibility Mapping in Parkinson’s Disease,” by Christian Langkammer, Lukas Pirpamer, Stephan Seiler, Andreas Deistung, Ferdinand Schweser, Sebastian Franthal, Nina Homayoon, Petra Katschnig-Winter, Mariella Koegl-Wallner, Tamara Pendl, Eva Maria Stoegerer, Karoline Wenzel, Franz Fazekas, Stefan Ropele, Jurgen Rainer Reichenbach, Reinhold Schmidt, and Petra Schwingenschuh (PLoS ONE 11(9): e0162460. doi:10.1371/journal.pone.0162460, XML, HTML, and .pdf format, 13p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162460

C. “Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis,” by Yoshihisa Okuchi, Masamichi Imajo, Rei Mizuno, Yuji Kamioka, Hiroyuki Miyoshi, Makoto Mark Taketo, Satoshi Nagayama, Yoshiharu Sakai, and Michiyuki Matsuda ( PLoS ONE 11(9): e0162300. doi:10.1371/journal.pone.0162300, XML, HTML, and .pdf format, 22p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162300

D. “Development of Clinical Vignettes to Describe Alzheimer’s Disease Health States: A Qualitative Study,” by Mark Oremus, Feng Xie, and Kathryn Gaebel (PLoS ONE 11(9): e0162422. doi:10.1371/journal.pone.0162422, XML, HTML, and .pdf format, 15p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162422

August 23, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – August 23, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:51 pm

A. “Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein {alpha}-synuclein,” by Wei Wang, Linh T. T. Nguyen, Christopher Burlak, Fariba Chegini, Feng Guo, Tim Chataway, Shulin Ju, Oriana S. Fisher, David W. Miller, Debajyoti Datta, Fang Wu, Chun-Xiang Wu, Anuradha Landeru, James A. Wells, Mark R. Cookson, Matthew B. Boxer, Craig J. Thomas, Wei Ping Gai, Dagmar Ringe, Gregory A. Petsko, and Quyen Q. Hoang (Vol. 113, No. 34, August 23, 2016, p. 9587–9592).

www.pnas.org/content/113/34/9587.abstract.html?etoc

B. “Human striatal recordings reveal abnormal discharge of projection neurons in Parkinson’s disease,” by Arun Singh, Klaus Mewes, Robert E. Gross, Mahlon R. DeLong, José A. Obeso, and Stella M. Papa (Vol. 113, No. 34, August 23, 2016, p. 9629–9634).

www.pnas.org/content/113/34/9629.abstract.html?etoc

August 17, 2016

CAAR – Public Library of Science (PLoS) Articles – August 17, 2016

Filed under: Reports and Articles — Tags: — admin @ 2:20 pm

A. “Premotor Symptoms as Predictors of Outcome in Parkinsons Disease: A Case-Control Study,” by Yu-Hsuan Wu, Wei-Ju Lee, Yi-Huei Chen, Ming-Hong Chang, and Ching-Heng Lin ( PLoS ONE 11(8): e0161271. doi:10.1371/journal.pone.0161271, XML, HTML, and .pdf format, 10p.)

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0161271

B. “Striatal Dopamine Depletion Patterns and Early Non-Motor Burden in Parkinsons Disease,” by Su Jin Chung, Jae Jung Lee, Jee Hyun Ham, Byoung Seok Ye, Phil Hyu Lee, and Young H. Sohn (PLoS ONE 11(8): e0161316. doi:10.1371/journal.pone.0161316, XML, HTML, and .pdf format, 10p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0161316

August 9, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – August 9, 2016

A. “Hhip haploinsufficiency sensitizes mice to age-related emphysema,” by Taotao Lao, Zhiqiang Jiang, Jeong Yun, Weiliang Qiu, Feng Guo, Chunfang Huang, John Dominic Mancini, Kushagra Gupta, Maria E. Laucho-Contreras, Zun Zar Chi Naing, Li Zhang, Mark A. Perrella, Caroline A. Owen, Edwin K. Silverman, and Xiaobo Zhou (Vol. 113, No. 32, August 9, 2016, p. E4681-E4687).

www.pnas.org/content/113/32/E4681.abstract

B. “Deubiquitinase Usp8 regulates {alpha}-synuclein clearance and modifies its toxicity in Lewy body disease,” by Zoi Alexopoulou, Johannes Lang, Rebecca M. Perrett, Myriam Elschami, Madeleine E. D. Hurry, Hyoung Tae Kim, Dimitra Mazaraki, Aron Szabo, Benedikt M. Kessler, Alfred Lewis Goldberg, Olaf Ansorge, Tudor A. Fulga, and George K. Tofaris (Vol. 113, No. 32, August 9, 2016, p. E4688-E4697).

www.pnas.org/content/113/32/E4688.abstract

C. “The neural chaperone proSAAS blocks {alpha}-synuclein fibrillation and neurotoxicity,” by Timothy S. Jarvela, Hoa A. Lam, Michael Helwig, Nikolai Lorenzen, Daniel E. Otzen, Pamela J. McLean, Nigel T. Maidment, and Iris Lindberg (Vol. 113, No. 32, August 9, 2016, p. E4708-E4715).

www.pnas.org/content/113/32/E4708.abstract

July 26, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 26, 2016

A. “Equity and length of lifespan are not the same,” by Benjamin Seligman, Gabi Greenberg, and Shripad Tuljapurkar (Vol. 113, No. 30, July 26, 2016, p. 8420-8423).

www.pnas.org/content/113/30/8420.abstract

B. “FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice,” by Henrik Ahlenius, Soham Chanda, Ashley E. Webb, Issa Yousif, Jesse Karmazin, Stanley B. Prusiner, Anne Brunet, Thomas C. Sudhof, and Marius Wernig (Vol. 113, No. 30, July 26, 2016, p. 8514-8519).

www.pnas.org/content/113/30/8514.abstract

C. “Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts,” by Giambattista Guaitoli, Francesco Raimondi, Bernd K. Gilsbach, Yacob Gomez-Llorente, Egon Deyaert, Fabiana Renzi, Xianting Li, Adam Schaffner, Pravin Kumar Ankush Jagtap, Karsten Boldt, Felix von Zweydorf, Katja Gotthardt, Donald D. Lorimer, Zhenyu Yue, Alex Burgin, Nebojsa Janjic, Michael Sattler, Wim Versees, Marius Ueffing, Iban Ubarretxena-Belandia, Arjan Kortholt, and Christian Johannes Gloeckner (Vol. 113, No. 30, July 26, 2016, .pdf and HTML format, p. E4357-E4366). Note: _PNAS_ is providing open access to the full-text of this article.

www.pnas.org/content/113/30/E4357.abstract

June 17, 2016

CAAR – Public Library of Science (PLoS) Articles – June 17, 2016

Filed under: Reports and Articles — Tags: , , — admin @ 4:38 pm

A. “Association between Thigh Muscle Volume and Leg Muscle Power in Older Women,” by Ulrich Lindemann, Christian Mohr, Juergen Machann, Konstantinos Blatzonis, Kilian Rapp, and Clemens Becker (PLoS ONE 11(6): e0157885. doi:10.1371/journal.pone.0157885, .pdf, HTML, and XML format, 10p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0157885

B. “Structural Brain Alterations in Motor Subtypes of Parkinson’s Disease: Evidence from Probabilistic Tractography and Shape,” by Griet Vervoort, Inge Leunissen, Michael Firbank, Elke Heremans, Evelien Nackaerts, Wim Vandenberghe, and Alice Nieuwboer (PLoS ONE 11(6): e0157743. doi:10.1371/journal.pone.0157743, .pdf, HTML, and XML format, 17p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0157743

June 7, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 7, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:53 pm

Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain,” by Wen Li, Elisabet Englund, Håkan Widner, Bengt Mattsson, Danielle van Westen, Jimmy Lätt, Stig Rehncrona, Patrik Brundin, Anders Bjorklund, Olle Lindvall, and Jia-Yi Li (Vol. 113, No. 23, June 7, 2016, .pdf and HTML format, p. 6544-6549). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/113/23/6544.abstract

May 4, 2016

CAAR – Nature Letter Abstract – May 4, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:48 pm

Parkinson-associated risk variant in distal enhancer of {alpha}-synuclein modulates target gene expression,” by Frank Soldner, Yonatan Stelzer, Chikdu S. Shivalila, Brian J. Abraham, Jeanne C. Latourelle, M. Inmaculada Barrasa, Johanna Goldmann, Richard H. Myers, Richard A. Young & Rudolf Jaenisch (Vol. 533, No. 7601, May 5, 2016, p. 95-99).

www.nature.com/nature/journal/v533/n7601/abs/nature17939.html

April 5, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 5, 2016

Nanoscopic insights into seeding mechanisms and toxicity of {alpha}-synuclein species in neurons,” by Dorothea Pinotsi, Claire H. Michel, Alexander K. Buell, Romain F. Laine, Pierre Mahou, Christopher M. Dobson, Clemens F. Kaminski, and Gabriele S. Kaminski Schierle (Vol. 113, No. 14, April 5, 2016, p. 3815-3819).

www.pnas.org/content/113/14/3815.abstract.html?etoc

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