CDHA CAAR

December 1, 2021

CAAR – Public Library of Science (PLoS) Articles – December 1, 2021

Filed under: Reports and Articles — Tags: , , — admin @ 5:58 pm

A. “Risk and protective factors of neurocognitive disorders in older adults in Central and Eastern Europe: A systematic review of population-based studies,” by Katrin Wolfova, Matej Kucera, and Pavla Cermakova (PLoS ONE 16(11): e0260549. doi.org/10.1371/journal.pone.0260549, XML, HTML, and .pdf format, 17p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0260549

B. “The association between metabolic syndrome and successful aging- using an extended definition of successful aging,” by Yi-Hsuan Lin, Jeng-Min Chiou, Ta-Fu Chen, Liang-Chuan Lai, Jen-Hau Chen, and Yen-Ching Chen (PLoS ONE 16(11): e0260550. doi.org/10.1371/journal.pone.0260550, HTML, XML, and .pdf format, 15p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0260550

August 25, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 25, 2021

Filed under: Reports and Articles — Tags: , , — admin @ 6:31 pm

“Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration,” by Chenyin Wang, Chun Yin Lau, Fuqiang Ma, and Chaogu Zheng (Vol. 118, No. 34, August 24, 2021, e2106504118).

www.pnas.org/content/118/34/e2106504118.abstract?etoc

July 30, 2021

CAAR – US House Committee on Energy and Commerce, Subcommittee on Health Hearing Testimony – July 30, 2021

Filed under: Legislation Information Updates — Tags: — admin @ 5:36 pm

“The Path Forward: Advancing Treatments and Cures for Neurodegenerative Diseases,” a hearing held July 29, 2021 (hearing testimony available in .pdf format, video of the full hearing available at the site, running time 5 hours 11 minutes). Note: Panel 1 starts at the 13:30 mark and ends at the 2:19:15 mark. Panel 2 starts at the 6:47:00 mark.

energycommerce.house.gov/committee-activity/hearings/hearing-on-the-path-forward-advancing-treatments-and-cures-for

February 9, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 9, 2021

Filed under: Reports and Articles — Tags: , — admin @ 6:04 pm

“Developmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration,” by Dávid Nagy, Katelin A. Ennis, Ru Wei, Susan C. Su, Christopher A. Hinckley, Rong-Fang Gu, Benbo Gao, Ramiro H. Massol, Chris Ehrenfels, Luke Jandreski, Ankur M. Thomas, Ashley Nelson, Stefka Gyoneva, Mihály Hajós, and Linda C. Burkly (Vol. 118, No. 6, February 9, 2021, e2001679118).

www.pnas.org/content/118/6/e2001679118.abstract?etoc

 

June 20, 2019

CAAR – Journal of the American Medical Association Article Abstract – June 20, 2019

Filed under: uncategorized — Tags: , , , — admin @ 6:35 pm

“Associations of Amyloid, Tau, and Neurodegeneration Biomarker Profiles With Rates of Memory Decline Among Individuals Without Dementia,” by Clifford R. Jack Jr., Heather J. Wiste, Terry M. Therneau, Stephen D. Weigand, David S. Knopman, Michelle M. Mielke, Val J. Lowe, Prashanthi Vemuri, Mary M. Machulda, Christopher G. Schwarz, Jeffrey L. Gunter, Matthew L. Senjem, Jonathan Graff-Radford, David T. Jones, Rosebud O. Roberts, Walter A. Rocca, and Ronald C. Petersen, (Vol. 321, No. 23, June 18, 2019, p. 2316-2325).

jamanetwork.com/journals/jama/article-abstract/2735818

February 25, 2019

CAAR – Proceedings of the National Academies of Sciences Article Abstract – February 25, 2019

Filed under: Reports and Articles — Tags: , — admin @ 5:23 pm

“Hippocampal atrophy and intrinsic brain network dysfunction relate to alterations in mind wandering in neurodegeneration,” by Claire O’Callaghan, James M. Shine, John R. Hodges, Jessica R. Andrews-Hanna, and Muireann Irish (Vol. 116, No. 8, February 19, 2019, p. 3316-3321).

www.pnas.org/content/116/8/3316

February 8, 2019

CAAR – Nature Medicine Letter Abstracts – February 8, 2019

Filed under: Reports and Articles — Tags: , , , — admin @ 4:56 pm

A. “Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction,” by Daniel A. Nation, Melanie D. Sweeney, Axel Montagne, Abhay P. Sagare, Lina M. D’Orazio, Maricarmen Pachicano, Farshid Sepehrband, Amy R. Nelson, David P. Buennagel, Michael G. Harrington, Tammie L. S. Benzinger, Anne M. Fagan, John M. Ringman, Lon S. Schneider, John C. Morris, Helena C. Chui, Meng Law, Arthur W. Toga & Berislav V. Zlokovic (Vol. 25, No. 2, February 2019, p. 270-276).

www.nature.com/articles/s41591-018-0297-y

B. “Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease,” by Oliver Preische, Stephanie A. Schultz, Anja Apel, Jens Kuhle, Stephan A. Kaeser, Christian Barro, Susanne Gräber, Elke Kuder-Buletta, Christian LaFougere, Christoph Laske, Jonathan Vöglein, Johannes Levin, Colin L. Masters, Ralph Martins, Peter R. Schofield, Martin N. Rossor, Neill R. Graff-Radford, Stephen Salloway, Bernardino Ghetti, John M. Ringman, James M. Noble, Jasmeer Chhatwal, Alison M. Goate, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, Guoqiao Wang, Anne M. Fagan, Eric M. McDade, Brian A. Gordon, Mathias Jucker, Ricardo Allegri, Fatima Amtashar, Randall Bateman, Tammie Benzinger, Sarah Berman, Courtney Bodge, Susan Brandon, William Brooks, Jill Buck, Virginia Buckles, Sochenda Chea, Jasmeer Chhatwal, Patricio Chrem, Helena Chui, Jake Cinco, Jack Clifford, Carlos Cruchaga, Mirelle D’Mello, Tamara Donahue, Jane Douglas, Noelia Edigo, Nilufer Erekin-Taner, Anne Fagan, Marty Farlow, Angela Farrar, Howard Feldman, Gigi Flynn, Nick Fox, Erin Franklin, Hisako Fujii, Cortaiga Gant, Samantha Gardener, Bernardino Ghetti, Alison Goate, Jill Goldman, Brian Gordon, Neill Graff-Radford, Julia Gray, Jenny Gurney, Jason Hassenstab, Mie Hirohara, David Holtzman, Russ Hornbeck, Siri Houeland DiBari, Takeshi Ikeuchi, Snezana Ikonomovic, Gina Jerome, Mathias Jucker, Celeste Karch, Kensaku Kasuga, Takeshi Kawarabayashi, William Klunk, Robert Koeppe, Elke Kuder-Buletta, Christoph Laske, Jae-Hong Lee, Johannes Levin, Daniel Marcus, Ralph Martins, Neal Scott Mason, Colin Masters, Denise Maue-Dreyfus, Eric McDade, Lucy Montoya, Hiroshi Mori, John Morris, Akem Nagamatsu, Katie Neimeyer, James Noble, Joanne Norton, Richard Perrin, Marc Raichle, John Ringman, Jee Hoon Roh, Stephen Salloway, Peter Schofield, Hiroyuki Shimada, Tomoyo Shiroto, Mikio Shoji, Wendy Sigurdson, Hamid Sohrabi, Paige Sparks, Kazushi Suzuki, Laura Swisher, Kevin Taddei, Jen Wang, Peter Wang, Mike Weiner, Mary Wolfsberger, Chengjie Xiong & Xiong Xu (Vol. 25, No. 2, February 2019, p. 277-283).

www.nature.com/articles/s41591-018-0304-3

August 7, 2018

CAAR – Nature Neuroscience Article Abstract – August 7, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 5:13 pm

“Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies,” by Wenyan Sun, Hanie Samimi, Maria Gamez, Habil Zare & Bess Frost (Vol. 21, No. 8, August 2018, p. 1038-1048).

www.nature.com/articles/s41593-018-0194-1

July 26, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – July 26, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 4:47 pm

“{alpha}-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies,” by Iryna Prots, Janina Grosch, Razvan-Marius Brazdis, Katrin Simmnacher, Vanesa Veber, Steven Havlicek, Christian Hannappel, Florian Krach, Mandy Krumbiegel, Oliver Schutz, Andre Reis, Wolfgang Wrasidlo, Douglas R. Galasko, Teja W. Groemer, Eliezer Masliah, Ursula Schlotzer-Schrehardt, Wei Xiang, Jürgen Winkler, and Beate Winner (Vol. 115, No. 30, July 24, 2018, p. 7813-7818).

www.pnas.org/content/115/30/7813

February 6, 2018

CAAR – Public Library of Science (PLoS) Articles – February 6, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 4:22 pm

A. “A mathematical model of multisite phosphorylation of tau protein,” by Alexander Stepanov, Tatiana Karelina, Nikolai Markevich, Oleg Demin, and Timothy Nicholas (PLoS ONE 13(2): e0192519. doi.org/10.1371/journal.pone.0192519, XML, HTML, and .pdf format, 17p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0192519

B. “Computational modelling of pathogenic protein spread in neurodegenerative diseases,” by Konstantinos Georgiadis, Selina Wray, Sébastien Ourselin, Jason D. Warren, and Marc Modat (PLoS ONE 13(2): e0192518. doi.org/10.1371/journal.pone.0192518, XML, HTML, and .pdf format, 15p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0192518

February 5, 2018

CAAR – Science Report Abstract – February 5, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 3:55 pm

“Aging and neurodegeneration are associated with increased mutations in single human neurons,” by Michael A. Lodato, Rachel E. Rodin, Craig L. Bohrson, Michael E. Coulter, Alison R. Barton, Minseok Kwon, Maxwell A. Sherman, Carl M. Vitzthum, Lovelace J. Luquette, Chandri N. Yandava, Pengwei Yang, Thomas W. Chittenden, Nicole E. Hatem, Steven C. Ryu, Mollie B. Woodworth, Peter J. Park, and Christopher A. Walsh (Vol. 359, No. 6375, February 2, 2018, p. 555-559).

science.sciencemag.org/content/359/6375/555

October 31, 2017

CAAR – Nature Neuroscience Article Abstracts – October 31, 2017

Filed under: Reports and Articles — Tags: , , , — admin @ 4:44 pm

A. “[alpha]-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B,” by Diana G Ferreira, Mariana Temido-Ferreira, Hugo Vicente Miranda, Vania L. Batalha, Joana E. Coelho, Eva M. Szego, Ines Marques-Morgado, Sandra H. Vaz, Jeong Seop Rhee, Matthias Schmitz, Inga Zerr, Luísa V. Lopes & Tiago F. Outeiro (Vol. 20, No. 11, November 2017, p. 1569-1579).

www.nature.com/neuro/journal/v20/n11/abs/nn.4648.html

B. “Dopamine induces soluble {alpha}-synuclein oligomers and nigrostriatal degeneration,” by Danielle E. Mor, Elpida Tsika, Joseph R. Mazzulli, Neal S. Gould, Hanna Kim, Malcolm J. Daniels, Shachee Doshi, Preetika Gupta, Jennifer L. Grossman, Victor X. Tan, Robert G. Kalb, Kim A Caldwell, Guy A. Caldwell, John H. Wolfe & Harry Ischiropoulos (Vol. 20, No. 11, November 2017, p. 1560-1568).

www.nature.com/neuro/journal/v20/n11/abs/nn.4641.html

September 20, 2017

CAAR – Nature Letter Abstract – September 20, 2017

Filed under: Reports and Articles — Tags: , — admin @ 5:04 pm

“A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease,” by Elvira Mass, Christian E. Jacome-Galarza, Thomas Blank, Tomi Lazarov, Benjamin H. Durham, Neval Ozkaya, Alessandro Pastore, Marius Schwabenland, Young Rock Chung, Marc K. Rosenblum, Marco Prinz, Omar Abdel-Wahab & Frederic Geissmann (Vol. 549, No. 7672, September 21, 2017, p. 389-393).Nature Letter Abstract: “A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease,” by Elvira Mass, Christian E. Jacome-Galarza, Thomas Blank, Tomi Lazarov, Benjamin H. Durham, Neval Ozkaya, Alessandro Pastore, Marius Schwabenland, Young Rock Chung, Marc K. Rosenblum, Marco Prinz, Omar Abdel-Wahab & Frederic Geissmann (Vol. 549, No. 7672, September 21, 2017, p. 389-393).

www.nature.com/nature/journal/v549/n7672/abs/nature23672.html

July 11, 2017

CAAR – Proceedings of the National Academies of Sciences Article Abstracts – July 11, 2017

Filed under: Reports and Articles — Tags: , , , , — admin @ 5:11 pm

A. “Poor caregiver mental health predicts mortality of patients with neurodegenerative disease,” by Sandy J. Lwi, Brett Q. Ford, James J. Casey, Bruce L. Miller, and Robert W. Levenson (Vol. 118, No. 28, July 11, 2017, p. 7319-7324).

www.pnas.org/content/114/28/7319.abstract

B. “Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease,” by Rishika Kundra, Prajwal Ciryam, Richard I. Morimoto, Christopher M. Dobson, and Michele Vendruscolo (Vol. 118, No. 28, July 11, 2017, p. E5703-E5711).

www.pnas.org/content/114/28/E5703.abstract

June 2, 2017

CAAR – Public Library of Science (PLoS) Article – June 2, 2017

Filed under: Reports and Articles — Tags: , — admin @ 5:03 pm

“Bacterial co-expression of human Tau protein with protein kinase A and 14-3-3 for studies of 14-3-3/phospho-Tau interaction,” by Kristina V. Tugaeva, Philipp O. Tsvetkov, and Nikolai N. Sluchanko (PLoS ONE 12(6): e0178933. doi.org/10.1371/journal.pone.0178933, XML, HTML, and .pdf format, p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0178933

May 11, 2017

CAAR – Lancet Neurology Article Abstract – May 11, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:18 pm

“Age-specific and sex-specific prevalence of cerebral {beta}-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50–95 years: a cross-sectional study,” by Clifford R. Jack Jr., Heather J. Wiste, Stephen D. Weigand, Terry M. Therneau, David S. Knopman, Val Lowe, Prashanthi Vemuri, Michelle M. Mielke, Rosebud O. Roberts, Mary M. Machulda, Matthew L. Senjem, Jeffrey L. Gunter, Walter A. Rocca, and Ronald C. Petersen (Vol. 16, No. 6, June 2017, p. 435-444).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30077-7/abstract

April 26, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 26, 2017

Filed under: Reports and Articles — Tags: , — admin @ 5:16 pm

“APC/CCdh1-Rock2 pathway controls dendritic integrity and memory,” by Veronica Bobo-Jimenez, María Delgado-Esteban, Julie Angibaud, Irene Sanchez-Moran, Antonio de la Fuente, Javier Yajeya, U. Valentin Nagerl, Jose Castillo, Juan P. Bolaños, and Angeles Almeida (Vol. 114, No. 17, April 26, 2017, p. 4513–4518).

www.pnas.org/content/114/17/4513.abstract.html?etoc

January 31, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 31, 2017

Filed under: Reports and Articles — Tags: , , , — admin @ 5:03 pm

A. “Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry,” by Palaniappan S. Chetty, Leland Mayne, Sissel Lund-Katz, S. Walter Englander, and Michael C. Phillips (Vol. 114, No. 5, January 31, 2017, p. 968-973).

www.pnas.org/content/114/5/968.abstract.html?etoc

B. “Nrf2 mitigates LRRK2- and {alpha}-synuclein–induced neurodegeneration by modulating proteostasis,” by Gaia Skibinski, Vicky Hwang, Dale Michael Ando, Aaron Daub, Alicia K. Lee, Abinaya Ravisankar, Sara Modan, Mariel M. Finucane, Benjamin A. Shaby, and Steven Finkbeiner (Vol. 114, No. 5, January 31, 2017, p. 1165–1170).

www.pnas.org/content/114/5/1165.abstract.html?etoc

C. “{alpha}-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation,” by Seong Su Kang, Zhentao Zhang, Xia Liu, Fredric P. Manfredsson, Li He, P. Michael Iuvone, Xuebing Cao, Yi E. Sun, Lingjing Jin, and Keqiang Ye (Vol. 114, No. 5, January 31, 2017, p. 1183–1185).

www.pnas.org/content/114/5/1183.abstract.html?etoc

January 17, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 17, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:01 pm

“Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation,” by William A. McEwan, Benjamin Falcon, Marina Vaysburd, Dean Clift, Adrian L. Oblak, Bernardino Ghetti, Michel Goedert, and Leo C. James (Vol. 114, No. 3, January 17, 2017, p. 574-579).

www.pnas.org/content/114/3/574.abstract

April 5, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 5, 2016

Filed under: Reports and Articles — Tags: , , , — admin @ 4:37 pm

“Nanoscopic insights into seeding mechanisms and toxicity of {alpha}-synuclein species in neurons,” by Dorothea Pinotsi, Claire H. Michel, Alexander K. Buell, Romain F. Laine, Pierre Mahou, Christopher M. Dobson, Clemens F. Kaminski, and Gabriele S. Kaminski Schierle (Vol. 113, No. 14, April 5, 2016, p. 3815-3819).

www.pnas.org/content/113/14/3815.abstract.html?etoc

March 30, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 30, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:40 pm

“Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice,” by Pavle Matak, Andrija Matak, Sarah Moustafa, Dipendra K. Aryal, Eric J. Benner, William Wetsel, and Nancy C. Andrews (Vol. 113, No. 13, March 30, 2016, p. 3428–3435).

www.pnas.org/content/113/13/3428.abstract.html?etoc

October 20, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 20, 2015

Filed under: Reports and Articles — Tags: , — admin @ 5:08 pm

“Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration,” by Lihong Zhao, Stefka Spassieva, Kenneth Gable, Sita D. Gupta, Lan-Ying Shi, Jieping Wang, Jacek Bielawski, Wanda L. Hicks, Mark P. Krebs, Juergen Naggert, Yusuf A. Hannun, Teresa M. Dunn, and Patsy M. Nishina (Vol. 112, No. 42, October 20, 2015, p. 12962-12967).

www.pnas.org/content/112/42/12962.abstract

October 7, 2015

CAAR – Nature Medicine Article Abstract – October 7, 2015

Filed under: Working Papers — Tags: , — admin @ 4:58 pm

“Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits,” by Sang-Won Min, Xu Chen, Tara E. Tracy, Yaqiao Li, Yungui Zhou, Chao Wang, Kotaro Shirakawa, S. Sakura Minami, Erwin Defensor, Sue Ann Mok, Peter Dongmin Sohn, Birgit Schilling, Xin Cong, Lisa Ellerby, Bradford W. Gibson, Jeffrey Johnson, Nevan Krogan, Mehrdad Shamloo, Jason Gestwicki, Eliezer Masliah, Eric Verdin & Li Gan (Vol. 21, No. 10, October 2015, p. 1154-1162).

www.nature.com/nm/journal/v21/n10/abs/nm.3951.html

September 3, 2015

CAAR – Public Library of Science (PLoS) Articles – September 3, 2015

Filed under: Reports and Articles — Tags: , , , , — admin @ 4:33 pm

A. “Gender-Specific Differences in the Relationship between Autobiographical Memory and Intertemporal Choice in Older Adults,” by Maayke Seinstra, Katharina Grzymek, and Tobias Kalenscher (PLoS ONE 10(9): e0137061. doi:10.1371/journal.pone.0137061, XML, HTML, and .pdf format, 22p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0137061

B. “Comparative Incidence of Conformational, Neurodegenerative Disorders,” by Jesús de Pedro-Cuesta, Alberto Rábano, Pablo Martínez-Martín, María Ruiz-Tovar, Enrique Alcalde-Cabero, Javier Almazán-Isla, Fuencisla Avellanal, and Miguel Calero (PLoS ONE 10(9): e0137342. doi:10.1371/journal.pone.0137342, XML, HTML, and .pdf format, 15p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0137342

September 2, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 2, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 5:06 pm

“Propagation of prions causing synucleinopathies in cultured cells,” by Amanda L. Woerman, Jan Stohr, Atsushi Aoyagi, Ryan Rampersaud, Zuzana Krejciova, Joel C. Watts, Takao Ohyama, Smita Patel, Kartika Widjaja, Abby Oehler, David W. Sanders, Marc I. Diamond, William W. Seeley, Lefkos T. Middleton, Steve M. Gentleman, Daniel A. Mordes, Thomas C. Südhof, Kurt Giles, and Stanley B. Prusiner (Vol. 112, No. 35, September 1, 2015, p. E4949–E4958).

www.pnas.org/content/112/35/E4949.abstract

July 23, 2015

CAAR – Nature Article Abstract – July 23, 2015

Filed under: Reports and Articles — Tags: , — admin @ 5:04 pm

“Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy,” by Asami Kondo, Koorosh Shahpas, Rebekah Mannix, Jianhua Qiu, Juliet Moncaster, Chun-Hau Chen, Yandan Yao, Yu-Min Lin, Jane A. Driver, Yan Sun, Shuo Wei, Man-Li Luo, Onder Albayram, Pengyu Huang, Alexander Rotenberg, Akihide Ryo, Lee E. Goldstein, Alvaro Pascual-Leone, Ann C. McKee, William Meehan, Xiao Zhen Zhou & Kun Ping Lu (Vol. 523, No. 7561, July 23, 2015, p. 431-436).

www.nature.com/nature/journal/v523/n7561/abs/nature14658.html

June 17, 2015

CAAR – Nature Letter Abstract – June 17, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:52 pm

“{alpha}-Synuclein strains cause distinct synucleinopathies after local and systemic administration,” by W. Peelaerts, L. Bousset, A. Van der Perren, A. Moskalyuk, R. Pulizzi, M. Giugliano, C. Van den Haute, R. Melki & V. Baekelandt (Vol. 522, No. 7556, June 18, 2015, p. 340-344).

www.nature.com/nature/journal/v522/n7556/abs/nature14547.html

June 9, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – June 9, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 5:07 pm

A. “Regulation of age-related macular degeneration-like pathology by complement factor H,” by Christopher B. Toomey, Una Kelly, Daniel R. Saban, and Catherine Bowes Rickman (Vol. 112, No. 23, June 9, 2015, .pdf and HTML format, p. E3040–E3049). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/23/E3040.abstract

B. “Overlapping functions of stonin 2 and SV2 in sorting of the calcium sensor synaptotagmin 1 to synaptic vesicles,” by Natalie Kaempf, Gaga Kochlamazashvili, Dmytro Puchkov, Tanja Maritzen, Sandra M. Bajjalieh, Natalia L. Kononenko, and Volker Hauck (Vol. 112, No. 23, June 9, 2015, .pdf and HTML format, p. 7297–7302). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/23/7297.abstract

May 26, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 26, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:21 pm

“Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid,” by Shang-Yi A. Tsai, Michael J. Pokrass, Neal R. Klauer, Hiroshi Nohara, and Tsung-Ping Su (Vol. 112, No. 21, May 26, 2015, .pdf and HTML format, p. 6742–6747). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/21/6742.abstract.html?etoc

April 21, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – April 21, 2015

Filed under: Reports and Articles — Tags: , , , — admin @ 4:42 pm

A. “Structural characterization of toxic oligomers that are kinetically trapped during {alpha}-synuclein fibril formation,” by Serene W. Chen, Srdja Drakulic, Emma Deas, Myriam Ouberai, Francesco A. Aprile, Rocío Arranz, Samuel Ness, Cintia Roodveldt, Tim Guilliams, Erwin J. De-Genst, David Klenerman, Nicholas W. Wood, Tuomas P.J. Knowles, Carlos Alfonso, Germán Rivas, Andrey Y. Abramov, Jose María Valpuesta, Christopher M. Dobson, and Nunilo Cremades (Vol. 112, No. 16, April 21, 2015, p. E1994–E2003).

www.pnas.org/content/112/16/E1994.abstract

B. “Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive deficits,” by Shu-Sheng Jiao, Xiu-Qing Yao, Yu-Hui Liu, Qing-Hua Wang, Fan Zeng, Jian-Jun Lu, Jia Liu, Chi Zhu, Lin-Lin Shen, Cheng-Hui Liu, Ye-Ran Wang, Gui-Hua Zeng, Ankit Parikh, Jia Chen, Chun-Rong Liang, Yang Xiang, Xian-Le Bu, Juan Deng, Jing Li, Juan Xu, Yue-Qin Zeng, Xiang Xu, Hai-Wei Xu, Jin-Hua Zhong, Hua-Dong Zhou, Xin-Fu Zhou, and Yan-Jiang Wang (Vol. 112, No. 16, April 21, 2015, p. 5225-5230). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/16/5225.abstract

April 13, 2015

CAAR – Public Library of Science (PLoS) Article – April 13, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:45 pm

“The Vitamin D, Ionised Calcium and Parathyroid Hormone Axis of Cerebral Capillary Function: Therapeutic Considerations for Vascular-Based Neurodegenerative Disorders,” by Virginie Lam, Ryusuke Takechi, Menuka Pallabage-Gamarallage, Corey Giles, and John C. L. Mamo (PLoS ONE 10(4): e0125504. doi:10.1371/journal.pone.0125504, XML, HTML, and .pdf format, 20p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0125504

February 11, 2015

CAAR – Nature Letter Abstract – February 11, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:46 pm

“RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration,” by Diego Peretti, Amandine Bastide, Helois Radford, Nicholas Verity, Colin Molloy, Maria Guerra Martin, Julie A. Moreno, Joern R. Steinert, Tim Smith, David Dinsdale, Anne E. Willis & Giovanna R. Mallucci (Vol. 518, No. 7538, February 12, 2015, p. 236-239).

www.nature.com/nature/journal/v518/n7538/abs/nature14142.html

December 16, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 16, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:35 pm

“p53 prevents neurodegeneration by regulating synaptic genes,” by Paola Merlo, Bess Frost, Shouyong Peng, Yawei J. Yang, Peter J. Park, and Mel Feany (Vol. 111, No. 50, December 16, 2014, p. 18055-18060).

www.pnas.org/content/111/50/18055.abstract.html?etoc

September 9, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 9, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:22 pm

“Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor,” by Petur O. Heidarsson, Mohsin M. Naqvi, Mariela R. Otazo, Alessandro Mossa, Birthe B. Kragelund, and Ciro Cecconi (Vol. 111, No. 35, September 9, 2014, .pdf and HTML format, p. 13069–13074). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/111/36/13069.abstract

May 1, 2014

CAAR – Science Report Abstract – May 1, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:39 pm

“Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes,” by Towfique Raj, Katie Rothamel, Sara Mostafavi, Chun Ye, Mark N. Lee, Joseph M. Replogle, Ting Feng, Michelle Lee, Natasha Asinovski, Irene Frohlich, Selina Imboywa, Alina Von Korff, Yukinori Okada, Nikolaos A. Patsopoulos, Scott Davis, Cristin McCabe, Hyun-il Paik, Gyan P. Srivastava, Soumya Raychaudhuri, David A. Hafler, Daphne Koller, Aviv Regev, Nir Hacohen, Diane Mathis, Christophe Benoist, Barbara E. Stranger, and Philip L. De Jager (Vol. 433, No. 6183, May 2, 2014, p. 519-523).

www.sciencemag.org/content/344/6183/519.abstract

February 25, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 25, 2014

Filed under: Reports and Articles — Tags: , , — admin @ 4:49 pm

A. “Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging,” by Axel Kowald and Thomas B. L. Kirkwood (Vol. 111, No. 8, February 25, 2014, .pdf and HTML format, p. 2972-2977). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/111/8/2972.abstract

B. “HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response,” by Barak Rotblat, Amber L. Southwell, Dagmar E. Ehrnhoefer, Niels H. Skotte, Martina Metzler, Sonia Franciosi, Gabriel Leprivier, Syam Prakash Somasekharan, Adi Barokas, Yu Deng, Tiffany Tang, Joan Mathers, Naniye Cetinbas, Mads Daugaard, Brian Kwok, Liheng Li, Christopher J. Carnie, Dieter Fink, Roberto Nitsch, Jason D. Galpin, Christopher A. Ahern, Gerry Melino, Josef M. Penninger, Michael R. Hayden, and Poul H. Sorensen (Vol. 111, No. 8, February 25, 2014, .pdf and HTML format, p. 3032-3037). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/111/8/3032.abstract

February 6, 2014

CAAR – Nature Medicine Review Abstract – February 6, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:41 pm

“Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases,” by Jing L. Guo and Virginia M. Y. Lee (Vol. 20, No. 2, February 2014, p. 130-138).

www.nature.com/nm/journal/v20/n2/abs/nm.3457.html

December 13, 2013

CAAR – Institute of Medicine Monograph – December 13, 2013

Filed under: Books — Tags: — admin @ 4:34 pm

Neurodegeneration: Exploring Commonalities Across Diseases: Workshop Summary, Miriam Davis and Clare Stroud, Rapporteurs (National Academies Press, 978-0-309-28567-4, .pdf and OpenBook format, 106p.). Ordering information for a print copy is available at athe site. Note: NAP requires free registration before providing a .pdf copy.

www.nap.edu/catalog.php?record_id=18341

April 25, 2013

CAAR – Nature Neuroscience Article, Brief Communication Abstracts- April 25, 2013

Filed under: Reports and Articles — Tags: , , , , — admin @ 4:11 pm

A. “Spike bursts increase amyloid-{beta} 40/42 ratio by inducing a presenilin-1 conformational change,” by Iftach Dolev, Hilla Fogel, Hila Milshtein, Yevgeny Berdichevsky, Noa Lipstein, Nils Brose, Neta Gazit & Inna Slutsky (Vol. 16, No. 5, May 2013, p. 587-595).

www.nature.com/neuro/journal/v16/n5/abs/nn.3376.html

B. “Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-{beta},” by Elsa Suberbielle, Pascal E Sanchez, Alexxai V Kravitz, Xin Wang, Kaitlyn Ho, Kirsten Eilertson, Nino Devidze, Anatol C Kreitzer and Lennart Mucke (Vol. 16, No. 5, May 2013, p. 613-619).

www.nature.com/neuro/journal/v16/n5/abs/nn.3356.html

C. “Dopamine restores reward prediction errors in old age,” by Rumana Chowdhury, Marc Guitart-Masip, Christian Lambert, Peter Dayan, Quentin Huys, Emrah Düzel & Raymond J Dolan (Vol. 16, No. 5, May 2013, p. 648-653).

www.nature.com/neuro/journal/v16/n5/abs/nn.3364.html

D. “Activation of transposable elements during aging and neuronal decline in Drosophila,” by Wanhe Li, Lisa Prazak, Nabanita Chatterjee, Servan Gruninger, Lisa Krug, Delphine Theodorou & Josh Dubnau (Vol. 16, No. 5, May 2013, p. 529-531).

www.nature.com/neuro/journal/v16/n5/abs/nn.3368.html

April 23, 2013

CAAR – Public Library of Science (PLoS) Article – April 23, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:53 pm

“Molecular Ageing of Alpha- and Beta-Synucleins: Protein Damage and Repair Mechanisms,” by Vasanthy Vigneswara, Simon Cass, Declan Wayne, Edward L. Bolt, David E. Ray, and Wayne G. Carter (PLoS ONE 8(4): e61442. doi:10.1371/journal.pone.0061442, XML, HTML, and .pdf format, 12p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061442

April 19, 2013

CAAR – Lancet Neurology Article Abstract – April 19, 2013

Filed under: Reports and Articles — Tags: — admin @ 4:40 pm

“Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study,” by Dr. Alex Iranzo, Prof. Eduard Tolosa, Ellen Gelpi, Jose Luis Molinuevo, Francesc Valldeoriola, Monica Serradell, Raquel Sanchez-Valle, Isabel Vilaseca, Francisco Lomena, Dolores Vilas, Albert LLado, Carles Gaig, and Joan Santamaria (Vol. 12, No. 4, April 2013, p. 443-453).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(13)70056-5/abstract

July 26, 2012

CAAR – Public Library of Science (PLoS) Articles – July 26, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 3:53 pm

A. “Establishment of Induced Pluripotent Stem Cells from Centenarians for Neurodegenerative Disease Research,” by Takuya Yagi, Arifumi Kosakai, Daisuke Ito, Wado Akamatsu, Yoshihiro Nihei, Akira Nabetani, Fuyuki Ishikawa, Yasumichi Arai, Nobuyoshi Hirose, Hideyuki Okano, and Norihiro Suzuki (PLoS ONE 7(7): e41572. doi:10.1371/journal.pone.0041572, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0041572

B. “Disruption of Arterial Perivascular Drainage of Amyloid-{beta} from the Brains of Mice Expressing the Human APOE e4 Allele,” by Cheryl A. Hawkes, Patrick M. Sullivan, Sarah Hands, Roy O. Weller, James A. R. Nicoll, and Roxana O. Carare (PLoS ONE 7(7): e41636. doi:10.1371/journal.pone.0041636, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0041636

July 5, 2012

CAAR – Public Library of Science (PLoS) Articles – July 5, 2012

Filed under: Reports and Articles — Tags: , , , , — admin @ 3:37 pm

A. “25-Hydroxyvitamin D Depletion Does Not Exacerbate MPTP-Induced Dopamine Neuron Damage in Mice,” by E. Danielle Dean, Lydia M. Mexas, Natalie L. Capiro, Jeanne E. McKeon, Mahlon R. DeLong, Kurt D. Pennell, Jonathan A. Doorn, Vin Tangpricha, Gary W. Miller, and Marian L. Evatt (PLoS ONE 7(7): e39227. doi:10.1371/journal.pone.0039227, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0039227

B. “Plasma BDNF Levels Vary in Relation to Body Weight in Females,” by Anilkumar Pillai, Davide Bruno, Antero S. Sarreal, Raymundo T. Hernando, Leslie A. Saint-Louis, Jay Nierenberg, Stephen D. Ginsberg, Nunzio Pomara, Pankaj D. Mehta, Henrik Zetterberg, Kaj Blennow, and Peter F. Buckley (PLoS ONE 7(7): e39358. doi:10.1371/journal.pone.0039358, XML, HTML, and .pdf format, 6p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0039358

C. “Executive Function and Falls in Older Adults: New Findings from a Five-Year Prospective Study Link Fall Risk to Cognition,” by Anat Mirelman, Talia Herman, Marina Brozgol, Moran Dorfman, Elliot Sprecher, Avraham Schweiger, Nir Giladi, and Jeffrey M. Hausdorff (PLoS ONE 7(6): e40297. doi:10.1371/journal.pone.0040297, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0040297

D. “Sexual Dimorphism in Healthy Aging and Mild Cognitive Impairment: A DTI Study,” by Laurence O’Dwyer, Franck Lamberton, Arun L. W. Bokde, Michael Ewers, Yetunde O. Faluyi, Colby Tanner, Bernard Mazoyer, Desmond O’Neill, Mairead Bartley, Ronan Collins, Tara Coughlan, David Prvulovic, and Harald Hampel (PLoS ONE 7(7): e37021. doi:10.1371/journal.pone.0037021, XML, HTML, and .pdf format, 12p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0037021

May 23, 2012

CAAR – Nature Letter Abstracts – May 23, 2012

Filed under: Reports and Articles — Tags: , , , — admin @ 3:30 pm

A. “Apolipoprotein E controls cerebrovascular integrity via cyclophilin A,” by Robert D. Bell, Ethan A. Winkler, Itender Singh, Abhay P. Sagare, Rashid Deane, Zhenhua Wu, David M. Holtzman, Christer Betsholtz, Annika Armulik, Jan Sallstrom, Bradford C. Berk, & Berislav V. Zlokovic (Vol. 485, No. 7399, May 24, 2012, p. 512-516).

www.nature.com/nature/journal/v485/n7399/abs/nature11087.html

B. “Sustained translational repression by eIF2a-P mediates prion neurodegeneration,” by Julie A. Moreno, Helois Radford, Diego Peretti, Joern R. Steinert, Nicholas Verity, Maria Guerra Martin, Mark Halliday, Jason Morgan, David Dinsdale, Catherine A. Ortori, David A. Barrett, Pavel Tsaytler, Anne Bertolotti, Anne E. Willis, Martin Bushell, & Giovanna R. Mallucci (Vol. 485, No. 7399, May 24, 2012, p. 507-511).

www.nature.com/nature/journal/v485/n7399/abs/nature11058.html

March 14, 2012

CAAR – Proceedings of the National Academy of Sciences Article – March 14, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 3:33 pm

Proceedings of the National Academy of Sciences Article Abstracts:

A. “Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms,” by Thomas C.J. Tan, Ruman Rahman, Farah Jaber-Hijazi, Daniel A. Felix, Chen Chen, Edward J. Louis, and Aziz Aboobaker (Vol. 109, No. 11, Mar. 13, 2012, HTML and .pdf format, p. 4209-4214). This article is available free of charge.

www.pnas.org/content/109/11/4209.full

B. “ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila,” by Andrew J. Petersen, Stacey A. Rimkus, and David A. Wassarman (Vol. 109, No. 11, March 14, 2012, p. E656-E664).

www.pnas.org/content/109/11/E656.abstract

February 9, 2012

CAAR – Public Library of Science (PLoS) Articles – February 9, 2012

Filed under: Reports and Articles — Tags: , — admin @ 3:26 pm

A. “Creatine Protects against Excitoxicity in an In Vitro Model of Neurodegeneration,” by Just Genius, Johanna Geiger, Andreas Bender, Hans-Jurgen Moller, Thomas Klopstock, and Dan Rujescu (PLoS ONE 7(2): e30554. doi:10.1371/journal.pone.0030554, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0030554

B. “Massage Therapy for Osteoarthritis of the Knee: A Randomized Dose-Finding Trial,” by Adam I. Perlman, Ather Ali, Valentine Yanchou Njike, David Hom, Anna Davidi, Susan Gould-Fogerite, Carl Milak, and David L. Katz (PLoS ONE 7(2): e30248. doi:10.1371/journal.pone.0030248, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0030248

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