CDHA CAAR

May 27, 2015

CAAR – Nature Letter Abstract – May 27, 2015

Filed under: Reports and Articles — Tags: , — admin @ 5:06 pm

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans,” by Konstantinos Palikaras, Eirini Lionaki & Nektarios Tavernarakis (Vol. 521, No. 7553, May 28, 2015, p. 525-528).

www.nature.com/nature/journal/v521/n7553/abs/nature14300.html

February 25, 2015

CAAR – Nature Letter Abstract – February 25, 2015

Filed under: Reports and Articles — Tags: , — admin @ 5:00 pm

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia,” by Terrence N. Wong, Giridharan Ramsingh, Andrew L. Young, Christopher A. Miller, Waseem Touma, John S. Welch, Tamara L. Lamprecht, Dong Shen, Jasreet Hundal, Robert S. Fulton, Sharon Heath, Jack D. Baty, Jeffery M. Klco, Li Ding, Elaine R. Mardis, Peter Westervelt, John F. DiPersio, Matthew J. Walter, Timothy A. Graubert, Timothy J. Ley, Todd E. Druley, Daniel C. Link & Richard K. Wilson (Vol. 518, No. 7540, February 26, 2015, p. 552-555).

www.nature.com/nature/journal/v518/n7540/abs/nature13968.html

February 18, 2015

CAAR – Nature Letter Abstract – February 18, 2015

Filed under: Reports and Articles — Tags: , — admin @ 5:00 pm

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease,” by Elizabeta Gjoneska, Andreas R. Pfenning, Hansruedi Mathys, Gerald Quon, Anshul Kundaje, Li-Huei Tsai & Manolis Kellis (Vol. 518, No. 7539, February 17, 2015, p. 365-369).

www.nature.com/nature/journal/v518/n7539/abs/nature14252.html

February 11, 2015

CAAR – Nature Letter Abstract – February 11, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:46 pm

RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration,” by Diego Peretti, Amandine Bastide, Helois Radford, Nicholas Verity, Colin Molloy, Maria Guerra Martin, Julie A. Moreno, Joern R. Steinert, Tim Smith, David Dinsdale, Anne E. Willis & Giovanna R. Mallucci (Vol. 518, No. 7538, February 12, 2015, p. 236-239).

www.nature.com/nature/journal/v518/n7538/abs/nature14142.html

December 4, 2014

CAAR – Nature Medicine Article, Letter Abstracts – December 4, 2014

Filed under: Reports and Articles — Tags: , , — admin @ 4:29 pm

A. “Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia,” by Eduardo Gascon, Kelleen Lynch, Hongyu Ruan, Sandra Almeida, Jamie M. Verheyden, William W. Seeley, Dennis W. Dickson, Leonard Petrucelli, Danqiong Sun, Jian Jiao, Hongru Zhou, Mira Jakovcevski, Schahram Akbarian, Wei-Dong Yao & Fen-Biao Gao (Vol. 20, No. 12, December 2014, p. 1444-1451).

www.nature.com/nm/journal/v20/n12/abs/nm.3717.html

B. “A rare mutation in UNC5C predisposes to late-onset Alzheimer’s disease and increases neuronal cell death,” by Monica K. Wetzel-Smith, Julie Hunkapiller, Tushar R. Bhangale, Karpagam Srinivasan, Janice A. Maloney, Jasvinder K. Atwal, Susan M. Sa, Murat B. Yaylaoglu, Oded Foreman, Ward Ortmann, Nisha Rathore, David V. Hansen, Marc Tessier-Lavigne, Alzheimer’s Disease Genetics Consortium, Richard Mayeux, Margaret Pericak-Vance, Jonathan Haines, Lindsay A. Farrer, Gerard D. Schellenberg, Alison Goate, Timothy W. Behrens, Carlos Cruchaga, Ryan J. Watts & Robert R. Graham (Vol. 20, No. 12, December 2014, p. 1452-1457).

www.nature.com/nm/journal/v20/n12/abs/nm.3736.html

November 12, 2014

CAAR – Nature Letter Abstract – November 12, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:27 pm

A three-dimensional human neural cell culture model of Alzheimer’s disease,” by Se Hoon Choi, Young Hye Kim, Matthias Hebisch, Christopher Sliwinski, Seungkyu Lee, Carla D’Avanzo, Hechao Chen, Basavaraj Hooli, Caroline Asselin, Julien Muffat, Justin B. Klee, Can Zhang, Brian J. Wainger, Michael Peitz, Dora M. Kovacs, Clifford J. Woolf, Steven L. Wagner, Rudolph E. Tanzi & Doo Yeon Kim (Vol. 515, No. 7526, November 12, 2014, p. 274-278).

www.nature.com/nature/journal/v515/n7526/abs/nature13800.html

November 6, 2014

CAAR – Nature Medicine Article Abstracts – November 6, 2014

Filed under: Reports and Articles — Tags: , , — admin @ 4:49 pm

A. “Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease,” by Zhentao Zhang, Mingke Song, Xia Liu, Seong Su Kang, Il-Sun Kwon, Duc M. Duong, Nicholas T. Seyfried, William T. Hu, Zhixue Liu, Jian-Zhi Wang, Liming Cheng, Yi E. Sun, Shan Ping Yu, Allan I. Levey & Keqiang Ye (Vol. 20, No. 11, November 2014, p. 1254-1262).

www.nature.com/nm/journal/v20/n11/abs/nm.3700.html

B. “PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis,” by Hui Xie, Zhuang Cui, Long Wang, Zhuying Xia, Yin Hu, Lingling Xian, Changjun Li, Liang Xie, Janet Crane, Mei Wan, Gehua Zhen, Qin Bian, Bin Yu, Weizhong Chang, Tao Qiu, Maureen Pickarski, Le Thi Duong, Jolene J. Windle, Xianghang Luo, Eryuan Liao & Xu Cao (Vol. 20, No. 11, November 2014, p. 1270-1278).

www.nature.com/nm/journal/v20/n11/abs/nm.3668.html

September 25, 2013

CAAR – Nature Article Abstract – September 25, 2013

Filed under: Reports and Articles — Tags: , — admin @ 5:06 pm

The ubiquitin ligase parkin mediates resistance to intracellular pathogens,” by Paolo S. Manzanillo, Janelle S. Ayres, Robert O. Watson, Angela C. Collins, Gianne Souza, Chris S. Rae, David S. Schneider, Ken Nakamura, Michael U. Shiloh & Jeffery S. Cox (Vol. 501, No. 7468, September 25, 2013, p. 512-516).

www.nature.com/nature/journal/v501/n7468/abs/nature12566.html

July 31, 2013

CAAR – Nature Article Abstract – July 31, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:34 pm

Integrative genomics identifies APOE {epsilon}4 effectors in Alzheimer’s disease,” by Herve Rhinn, Ryousuke Fujita, Liang Qiang, Rong Cheng, Joseph H. Lee & Asa Abeliovich (Vol. 500, No. 7460, August 1, 2013, p. 45-50).

www.nature.com/nature/journal/v500/n7460/abs/nature12415.html

January 9, 2013

CAAR – Nature Letter Abstract – January 9, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:24 pm

COUP-TFII inhibits TGF-{beta}-induced growth barrier to promote prostate tumorigenesis,” by Jun Qin, San-Pin Wu, Chad J. Creighton, Fangyan Dai, Xin Xie, Chiang-Min Cheng, Anna Frolov, Gustavo Ayala, Xia Lin, Xin-Hua Feng, Michael M. Ittmann, Shaw-Jenq Tsai, Ming-Jer Tsai & Sophia Y. Tsai (Vol. 493, No. 7431, January 10, 2013, p. 236-240).

www.nature.com/nature/journal/v493/n7431/abs/nature11674.html

January 7, 2013

CAAR – Nature Medicine Article Abstract – January 7, 2013

Filed under: Reports and Articles — Tags: , — admin @ 3:33 pm

[beta]-arrestin 2 regulates A[beta] generation and [gamma]-secretase activity in Alzheimer’s disease,” by Amantha Thathiah, Katrien Horre, An Snellinx, Elke Vandewyer, Yunhong Huang, Marta Ciesielska, Gerdien De Kloe, Sebastian Munck & Bart De Strooper (Vol. 19, No. 1, January 2013, p. 43-49).

www.nature.com/nm/journal/v19/n1/abs/nm.3023.html

January 2, 2013

CAAR – Nature Article Abstract – January 2, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:50 pm

Structure of a presenilin family intramembrane aspartate protease,” by Xiaochun Li, Shangyu Dang, Chuangye Yan, Xinqi Gong, Jiawei Wang & Yigong Shi (Vol. 493, No. 7430, January 2, 2013, p. 56-61).

www.nature.com/nature/journal/v493/n7430/abs/nature11801.html

CAAR – Nature Cell Biology Article Abstract – January 2, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:49 pm

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan,” by Darren J. Baker, Meelad M. Dawlaty, Tobias Wijshake, Karthik B. Jeganathan, Liviu Malureanu, Janine H. van Ree, Ruben Crespo-Diaz, Santiago Reyes, Lauren Seaburg, Virginia Shapiro, Atta Behfar, Andre Terzic, Bart van de Sluis & Jan M. van Deursen (Vol. 15, No. 1, January 2013, p. 96-102).

www.nature.com/ncb/journal/v15/n1/abs/ncb2643.html

December 13, 2012

CAAR – Nature Letter Abstract – December 13, 2012

Filed under: Reports and Articles — Tags: , — admin @ 3:52 pm

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast,” by Adam L. Hughes and Daniel E. Gottschling (Vol. 492, No. 7428, December 12, 2012, p. 261-265).

www.nature.com/nature/journal/v492/n7428/abs/nature11654.html

October 17, 2012

CAAR – Nature Article Abstract – October 17, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 4:20 pm

The aged niche disrupts muscle stem cell quiescence,” by Joe V. Chakkalakal, Kieran M. Jones, M. Albert Basson & Andrew S. Brack (Vol. 490, No. 7420, October 18, 2012, p. 355-360).

www.nature.com/nature/journal/v490/n7420/abs/nature11438.html

August 8, 2012

CAAR – Nature Article Abstract – August 8, 2012

Filed under: Reports and Articles — Tags: — admin @ 4:18 pm

Gut microbiota composition correlates with diet and health in the elderly,” by Marcus J. Claesson, Ian B. Jeffery, Susana Conde, Susan E. Power, Eibhlis M. O’Connor, Siobhan Cusack, Hugh M. B. Harris, Mairead Coakley, Bhuvaneswari Lakshminarayanan, Orla O’Sullivan, Gerald F. Fitzgerald, Jennifer Deane, Michael O’Connor, Norma Harnedy, Kieran O’Connor, Denis O’Mahony, Douwe van Sinderen, Martina Wallace, Lorraine Brennan, Catherine Stanton, Julian R. Marchesi, Anthony P. Fitzgerald, Fergus Shanahan, Colin Hill, R. Paul Ross & Paul W. O’Toole (Vol. 488, No. 7410, August 9, 2012, p. 178-184).

www.nature.com/nature/journal/v488/n7410/abs/nature11319.html

May 30, 2012

CAAR – Nature Article, Letter Abstract – May 30, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 3:34 pm

Nature Article, Letter Abstract:

A. “The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche,” by Hila Toledano, Cecilia D’Alterio, Benjamin Czech, Erel Levine & D. Leanne Jones (Vol. 485, No. 7400, May 31, 2012, p. 605-610).

www.nature.com/nature/journal/v485/n7400/abs/nature11061.html

B. “Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-{beta},” by Justin M. Nussbaum, Stephan Schilling, Holger Cynis, Antonia Silva, Eric Swanson, Tanaporn Wangsanut, Kaycie Tayler, Brian Wiltgen, Asa Hatami, Raik Rönicke, Klaus Reymann, Birgit Hutter-Paier, Anca Alexandru, Wolfgang Jagla, Sigrid Graubner, Charles G. Glabe, Hans-Ulrich Demuth & George S. Bloom (Vol. 485, No. 7400, May 31, 2012, p. 651-655).

www.nature.com/nature/journal/v485/n7400/abs/nature11060.html

May 23, 2012

CAAR – Nature Letter Abstracts – May 23, 2012

Filed under: Reports and Articles — Tags: , , , — admin @ 3:30 pm

A. “Apolipoprotein E controls cerebrovascular integrity via cyclophilin A,” by Robert D. Bell, Ethan A. Winkler, Itender Singh, Abhay P. Sagare, Rashid Deane, Zhenhua Wu, David M. Holtzman, Christer Betsholtz, Annika Armulik, Jan Sallstrom, Bradford C. Berk, & Berislav V. Zlokovic (Vol. 485, No. 7399, May 24, 2012, p. 512-516).

www.nature.com/nature/journal/v485/n7399/abs/nature11087.html

B. “Sustained translational repression by eIF2a-P mediates prion neurodegeneration,” by Julie A. Moreno, Helois Radford, Diego Peretti, Joern R. Steinert, Nicholas Verity, Maria Guerra Martin, Mark Halliday, Jason Morgan, David Dinsdale, Catherine A. Ortori, David A. Barrett, Pavel Tsaytler, Anne Bertolotti, Anne E. Willis, Martin Bushell, & Giovanna R. Mallucci (Vol. 485, No. 7399, May 24, 2012, p. 507-511).

www.nature.com/nature/journal/v485/n7399/abs/nature11058.html

May 9, 2012

CAAR – Nature Letter Abstract – May 9, 2012

Filed under: Reports and Articles — Tags: , — admin @ 3:12 pm

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure,” by Takafumi Oka, Shungo Hikoso, Osamu Yamaguchi, Manabu Taneike, Toshihiro Takeda, Takahito Tamai, Jota Oyabu, Tomokazu Murakawa, Hiroyuki Nakayama, Kazuhiko Nishida, Shizuo Akira, Akitsugu Yamamoto, Issei Komuro & Kinya Otsu (Vol. 485, No. 7397, May 10, 2012, p. 251-255).

www.nature.com/nature/journal/v485/n7397/abs/nature10992.html

March 8, 2012

CAAR – Nature Letter Abstract – March 8, 2012

Filed under: Reports and Articles — Tags: , , , — admin @ 11:26 am

A. “An epigenetic blockade of cognitive functions in the neurodegenerating brain,” by Johannes Gräff, Damien Rei, Ji-Song Guan, Wen-Yuan Wang, Jinsoo Seo, Krista M. Hennig, Thomas J. F. Nieland, Daniel M. Fass, Patricia F. Kao, Martin Kahn, Susan C. Su, Alireza Samiei, Nadine Joseph, Stephen J. Haggarty, Ivana Delalle, and Li-Huei Tsai (Vol. 483, No. 7388, Mar. 8, 2012, doi:10.1038/nature10849).

www.nature.com/nature/journal/vaop/ncurrent/abs/nature10849.html

B. “The sirtuin SIRT6 regulates lifespan in male mice,” by Yariv Kanfi, Shoshana Naiman, Gail Amir, Victoria Peshti, Guy Zinman, Liat Nahum, Ziv Bar-Joseph & Haim Y. Cohen (Vol. 483, No. 7388, Mar. 8, 2012, p. 218-221).

www.nature.com/nature/journal/v483/n7388/abs/nature10815.html

February 22, 2012

CAAR – Nature Letter Abstract – February 22, 2012

Filed under: Reports and Articles — Tags: , — admin @ 5:04 pm

The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila,” by Nan Liu, Michael Landreh, Kajia Cao, Masashi Abe, Gert-Jan Hendriks, Jason R. Kennerdell, Yongqing Zhu, Li-San Wang & Nancy M. Bonini (Vol. 482, No. 7386, February 23, 2012, p. 519-523).

www.nature.com/nature/journal/v482/n7386/abs/nature10810.html

February 8, 2012

CAAR – Nature Letter Abstracts – February 8, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 3:51 pm

A. “Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells,” by Mason A. Israel, Shauna H. Yuan, Cedric Bardy, Sol M. Reyna, Yangling Mu, Cheryl Herrera, Michael P. Hefferan, Sebastiaan Van Gorp, Kristopher L. Nazor, Francesca S. Boscolo, Christian T. Carson, Louise C. Laurent, Martin Marsala, Fred H. Gage, Anne M. Remes, Edward H. Koo and Lawrence S. B. Goldstein (Vol. 482, No. 7384, February 8, 2012, p. 216-220).

www.nature.com/nature/journal/v482/n7384/abs/nature10821.html

B. “Genetic contributions to stability and change in intelligence from childhood to old age,” by Ian J. Deary, Jian Yang, Gail Davies, Sarah E. Harris, Albert Tenesa, David Liewald, Michelle Luciano, Lorna M. Lopez, Alan J. Gow, Janie Corley, Paul Redmond, Helen C. Fox, Suzanne J. Rowe, Paul Haggarty, Geraldine McNeill, Michael E. Goddard, David J. Porteous, Lawrence J. Whalley, John M. Starr & Peter M. Visscher (Vol. 482, No. 7384, February 8, 2012, p. 216-220).

www.nature.com/nature/journal/v482/n7384/abs/nature10781.html

January 26, 2012

CAAR – Nature Letter Abstracts – January 26, 2012

Filed under: Reports and Articles — Tags: , , , — admin @ 12:41 pm

A. “Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells,” by Mason A. Israel, Shauna H. Yuan, Cedric Bardy, Sol M. Reyna, Yangling Mu, Cheryl Herrera, Michael P. Hefferan, Sebastiaan Van Gorp, Kristopher L. Nazor, Francesca S. Boscolo, Christian T. Carson, Louise C. Laurent, Martin Marsala, Fred H. Gage, Anne M. Remes, Edward H. Koo, and Lawrence S.B. Goldstein (doi:10.1038/nature10821, Jan. 25, 2012).

www.nature.com/nature/journal/vaop/ncurrent/abs/nature10821.html

B. “Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001,” by Natasha M. DeVore and Emily E. Scott (doi:10.1038/nature10743, Jan. 22, 2012).

www.nature.com/nature/journal/vaop/ncurrent/abs/nature10743.html

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