CDHA CAAR

September 9, 2021

CAAR – Nature Article – September 9, 2021

Filed under: Reports and Articles — Tags: , , — admin @ 7:36 pm

Note: Check with your organization’s library for availability. “Aged skeletal stem cells generate an inflammatory degenerative niche,” by Thomas H. Ambrosi, Owen Marecic, Adrian McArdle, Rahul Sinha, Gunsagar S. Gulati, Xinming Tong, Yuting Wang, Holly M. Steininger, Malachia Y. Hoover, Lauren S. Koepke, Matthew P. Murphy, Jan Sokol, Eun Young Seo, Ruth Tevlin, Michael Lopez, Rachel E. Brewer, Shamik Mascharak, Laura Lu, Oyinkansola Ajanaku, Stephanie D. Conley, Jun Seita, Maurizio Morri, Norma F. Neff, Debashis Sahoo, Fan Yang, Irving L. Weissman, Michael T. Longaker & Charles K. F. Chan (Vol. 597, No. 7875, September 9, 2021, p. 256-262).

www.nature.com/articles/s41586-021-03795-7

August 13, 2021

CAAR – Nature Article – August 13, 2021

Filed under: Reports and Articles — Tags: , — admin @ 4:35 pm

Note: Check with your organization’s library for availability. “Rewiring of the ubiquitinated proteome determines ageing in C. elegans,” by Seda Koyuncu, Rute Loureiro, Hyun Ju Lee, Prerana Wagle, Marcus Krueger & David Vilchez (Vol. 596, No. 7871, August 12, 2021, p. 285-290).

www.nature.com/articles/s41586-021-03781-z

June 17, 2021

CAAR – Nature Medicine Article – June 17, 2021

Filed under: Reports and Articles — Tags: , , — admin @ 7:40 pm

Note: Check with your organization’s library for availability. “Prediction of future Alzheimer’s disease dementia using plasma phospho-tau combined with other accessible measures,” by Sebastian Palmqvist, Pontus Tideman, Nicholas Cullen, Henrik Zetterberg, Kaj Blennow, the Alzheimer’s Disease Neuroimaging Initiative, Jeffery L. Dage, Erik Stomrud, Shorena Janelidze, Niklas Mattsson-Carlgren & Oskar Hansson (Vol. 27, No. 6, June 2021, p. 1034-1042).

www.nature.com/articles/s41591-021-01348-z

June 3, 2021

CAAR – Nature Article – June 3, 2021

Filed under: Reports and Articles — Tags: , — admin @ 5:40 pm

Note: Check with your organization’s library for availability. “An aged immune system drives senescence and ageing of solid organs,” by Matthew J. Yousefzadeh, Rafael R. Flores, Yi Zhu, Zoe C. Schmiechen, Robert W. Brooks, Christy E. Trussoni, Yuxiang Cui, Luise Angelini, Kyoo-A Lee, Sara J. McGowan, Adam L. Burrack, Dong Wang, Qing Dong, Aiping Lu, Tokio Sano, Ryan D. O’Kelly, Collin A. McGuckian, Jonathan I. Kato, Michael P. Bank, Erin A. Wade, Smitha P. S. Pillai, Jenna Klug, Warren C. Ladiges, Christin E. Burd, Sara E. Lewis, Nicholas F. LaRusso, Nam V. Vo, Yinsheng Wang, Eric E. Kelley, Johnny Huard, Ingunn M. Stromnes, Paul D. Robbins & Laura J. Niedernhofer (Vol. 594, No. 7861, June 3, 2021, p. 100-105).

www.nature.com/articles/s41586-021-03547-7

March 19, 2021

CAAR – Nature Medicine Article – March 19, 2021

Filed under: Reports and Articles — Tags: , , — admin @ 3:27 pm

Note: Check with your organization’s library for availability. “Life expectancy and mortality in 363 cities of Latin America,” by Usama Bilal, Philipp Hessel, Carolina Perez-Ferrer, Yvonne L. Michael, Tania Alfaro, Janeth Tenorio-Mucha, Amelia A. L. Friche, Maria Fatima Pina, Alejandra Vives, Harrison Quick, Marcio Alazraqui, Daniel A. Rodriguez, J. Jaime Miranda, Ana V. Diez-Roux & the SALURBAL group (Vol. 27, No. 3, March 2021, p. 463-470).

www.nature.com/articles/s41591-020-01214-4

February 4, 2021

CAAR – Nature Article – February 4, 2021

Filed under: Reports and Articles — Tags: , — admin @ 7:12 pm

Note: Check with your organization’s library for availability. “Restoring metabolism of myeloid cells reverses cognitive decline in ageing,” by Paras S. Minhas, Amira Latif-Hernandez, Melanie R. McReynolds, Aarooran S. Durairaj, Qian Wang, Amanda Rubin, Amit U. Joshi, Joy Q. He, Esha Gauba, Ling Liu, Congcong Wang, Miles Linde, Yuki Sugiura, Peter K. Moon, Ravi Majeti, Makoto Suematsu, Daria Mochly-Rosen, Irving L. Weissman, Frank M. Longo, Joshua D. Rabinowitz & Katrin I. Andreasson (Vol. 590, No. 7844, February 4, 2021, p. 122-128).

www.nature.com/articles/s41586-020-03160-0

December 3, 2020

CAAR – Nature Article – December 3, 2020

Filed under: Reports and Articles — Tags: , , — admin @ 6:10 pm

Note: Check with your organization’s library for availability. “Reprogramming to recover youthful epigenetic information and restore vision,” by Yuancheng Lu, Benedikt Brommer, Xiao Tian, Anitha Krishnan, Margarita Meer, Chen Wang, Daniel L. Vera, Qiurui Zeng, Doudou Yu, Michael S. Bonkowski, Jae-Hyun Yang, Songlin Zhou, Emma M. Hoffmann, Margarete M. Karg, Michael B. Schultz, Alice E. Kane, Noah Davidsohn, Ekaterina Korobkina, Karolina Chwalek, Luis A. Rajman, George M. Church, Konrad Hochedlinger, Vadim N. Gladyshev, Steve Horvath, Morgan E. Levine, Meredith S. Gregory-Ksander, Bruce R. Ksander, Zhigang He & David A. Sinclair (Vol. 588, No. 7836, December 3, 2020, p. 124-129).

www.nature.com/articles/s41586-020-2975-4

November 30, 2020

CAAR – Nature Neuroscience Articles – November 30, 2020

Filed under: Reports and Articles — Tags: , , , — admin @ 4:43 pm

Note: Check with your organization’s library for availability.

A. “Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease,” by Kevin Richetin, Pascal Steullet, Mathieu Pachoud, Romain Perbet, Enea Parietti, Mathischan Maheswaran, Sabiha Eddarkaoui, Séverine Bégard, Catherine Pythoud, Maria Rey, Raphaëlle Caillierez, Kim Q. Do, Sophie Halliez, Paola Bezzi, Luc Buée, Geneviève Leuba, Morvane Colin, Nicolas Toni & Nicole Déglon (Vol. 23, No. 12, December 2020, p. 1567-1579).

www.nature.com/articles/s41593-020-00728-x

B. “Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2- production,” by Heejung Chun, Hyeonjoo Im, You Jung Kang, Yunha Kim, Jin Hee Shin, Woojin Won, Jiwoon Lim, Yeonha Ju, Yongmin Mason Park, Sunpil Kim, Seung Eun Lee, Jaekwang Lee, Junsung Woo, Yujin Hwang, Hyesun Cho, Seonmi Jo, Jong-Hyun Park, Daesoo Kim, Doo Yeon Kim, Jeong-Sun Seo, Byoung Joo Gwag, Young Soo Kim, Ki Duk Park, Bong-Kiun Kaang, Hansang Cho, Hoon Ryu & C. Justin Lee (Vol. 23, No. 12, December 2020, p. 1555–1566).

www.nature.com/articles/s41593-020-00735-y

C. “Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life,” by Ruth E. Uhlmann, Christine Rother, Jay Rasmussen, Juliane Schelle, Carina Bergmann, Emily M. Ullrich Gavilanes, Sarah K. Fritschi, Anika Buehler, Frank Baumann, Angelos Skodras, Rawaa Al-Shaana, Natalie Beschorner, Lan Ye, Stephan A. Kaeser, Ulrike Obermüller, Søren Christensen, Fredrik Kartberg, Jeffrey B. Stavenhagen, Jens-Ulrich Rahfeld, Holger Cynis, Fang Qian, Paul H. Weinreb, Thierry Bussiere, Lary C. Walker, Matthias Staufenbiel & Mathias Jucker (Vol. 23, No. 12, December 2020, p. 1580-1588).

www.nature.com/articles/s41593-020-00737-w

November 19, 2020

CAAR – Nature Article – November 19, 2020

Filed under: Reports and Articles — Tags: , — admin @ 8:23 pm

Note: Check with your organization’s library for availability. “Molecular dissection of amyloid disaggregation by human HSP70,” by Anne S. Wentink, Nadinath B. Nillegoda, Jennifer Feufel, Gabriele Ubartaite, Carolyn P. Schneider, Paolo De Los Rios, Janosch Hennig, Alessandro Barducci & Bernd Bukau (Vol. 587, No. 7834, November 19, 2020, p. 483-488).

www.nature.com/articles/s41586-020-2904-6

 

October 29, 2020

CAAR – Nature Article – October 29, 2020

Filed under: Reports and Articles — Tags: , — admin @ 6:16 pm

Note: Check with your organization’s library for availability. “The innate immunity protein IFITM3 modulates {gamma}-secretase in Alzheimer’s disease,” by Ji-Yeun Hur, Georgia R. Frost, Xianzhong Wu, Christina Crump, Si Jia Pan, Eitan Wong, Marilia Barros, Thomas Li, Pengju Nie, Yujia Zhai, Jen Chyong Wang, Julia TCW, Lei Guo, Andrew McKenzie, Chen Ming, Xianxiao Zhou, Minghui Wang, Yotam Sagi, Alan E. Renton, Bianca T. Esposito, Yong Kim, Katherine R. Sadleir, Ivy Trinh, Robert A. Rissman, Robert Vassar, Bin Zhang, Douglas S. Johnson, Eliezer Masliah, Paul Greengard, Alison Goate & Yue-Ming Li (Vol. 586, No. , October 30, 2020, p. 735-740).

www.nature.com/articles/s41586-020-2681-2

July 30, 2020

CAAR – Nature Neuroscience Articles – July 30, 2020

Filed under: Reports and Articles — Tags: , , — admin @ 6:29 pm

Note: Check with your organization’s library for availability.

A. “Memory trace interference impairs recall in a mouse model of Alzheimer’s disease,” by Stefanie Poll, Manuel Mittag, Fabrizio Musacchio, Lena C. Justus, Eleonora Ambrad Giovannetti, Julia Steffen, Jens Wagner, Lioba Zohren, Susanne Schoch, Boris Schmidt, Walker S. Jackson, Dan Ehninger & Martin Fuhrmann (Vol. 23, No. 8, August 2020, p. 952-958).

www.nature.com/articles/s41593-020-0652-4

B. “Alzheimer’s-associated PLC{gamma}2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia,” by Benjamin J. Andreone, Laralynne Przybyla, Ceyda Llapashtica, Anil Rana, Sonnet S. Davis, Bettina van Lengerich, Karin Lin, Ju Shi, Yuan Mei, Giuseppe Astarita, Gilbert Di Paolo, Thomas Sandmann, Kathryn M. Monroe & Joseph W. Lewcock (Vol. 23, No. 8, August 2020, p. 927-938).

www.nature.com/articles/s41593-020-0650-6

July 24, 2020

CAAR – Nature Article – July 24, 2020

Filed under: Reports and Articles — Tags: , — admin @ 5:06 pm

Note: Check with your organization’s library for availability. “Ageing hallmarks exhibit organ-specific temporal signatures,” by Nicholas Schaum, Benoit Lehallier, Oliver Hahn, Róbert Pálovics, Shayan Hosseinzadeh, Song E. Lee, Rene Sit, Davis P. Lee, Patricia Morán Losada, Macy E. Zardeneta, Tobias Fehlmann, James T. Webber, Aaron McGeever, Kruti Calcuttawala, Hui Zhang, Daniela Berdnik, Vidhu Mathur, Weilun Tan, Alexander Zee, Michelle Tan, The Tabula Muris Consortium, Angela Oliveira Pisco, Jim Karkanias, Norma F. Neff, Andreas Keller, Spyros Darmanis, Stephen R. Quake & Tony Wyss-Coray (Vol. 583, No. 9785, July 24, 2020, p. 596-602).

www.nature.com/articles/s41586-020-2499-y

July 16, 2020

CAAR – Nature Article – July 16, 2020

Filed under: Reports and Articles — Tags: , — admin @ 5:45 pm

Note: Check with your organization’s library for availability. “Physiological blood–brain transport is impaired with age by a shift in transcytosis,” by Andrew C. Yang, Marc Y. Stevens, Michelle B. Chen, Davis P. Lee, Daniel Stähli, David Gate, Kévin Contrepois, Winnie Chen, Tal Iram, Lichao Zhang, Ryan T. Vest, Aisling Chaney, Benoit Lehallier, Niclas Olsson, Haley du Bois, Ryan Hsieh, Haley C. Cropper, Daniela Berdnik, Lulin Li, Elizabeth Y. Wang, Gavin M. Traber, Carolyn R. Bertozzi, Jian Luo, Michael P. Snyder, Joshua E. Elias, Stephen R. Quake, Michelle L. James & Tony Wyss-Coray (Vol. 583, No. 7816, July 16, 2020, p. 425-430).

www.nature.com/articles/s41586-020-2453-z

June 25, 2020

CAAR – Nature Article – June 25, 2020

Filed under: Reports and Articles — Tags: , — admin @ 5:51 pm

Note: Check with your organization’s library for availability. “Reversing a model of Parkinson’s disease with in situ converted nigral neurons,” by Hao Qian, Xinjiang Kang, Jing Hu, Dongyang Zhang, Zhengyu Liang, Fan Meng, Xuan Zhang, Yuanchao Xue, Roy Maimon, Steven F. Dowdy, Neal K. Devaraj, Zhuan Zhou, William C. Mobley, Don W. Cleveland & Xiang-Dong Fu (Vol. 582, No. 7813, June 25, 2020, p. 550-556).

www.nature.com/articles/s41586-020-2388-4

June 24, 2020

CAAR – Nature Medicine Article – June 24, 2020

Filed under: Reports and Articles — Tags: , , — admin @ 5:06 pm

Note: Check with your organization’s library for availability. “Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes,” by Joel W. Blanchard, Michael Bula, Jose Davila-Velderrain, Leyla Anne Akay, Lena Zhu, Alexander Frank, Matheus B. Victor, Julia Maeve Bonner, Hansruedi Mathys, Yuan-Ta Lin, Tak Ko, David A. Bennett, Hugh P. Cam, Manolis Kellis & Li-Huei Tsai (Vol. 26, No. 7, July 2020, p. 952-963).

www.nature.com/articles/s41591-020-0886-4

June 3, 2020

CAAR – Nature Neuroscience Articles – June 3, 2020

Filed under: Reports and Articles — Tags: , — admin @ 5:18 pm

Note: Check with your organization’s library for availability.

A. “Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain,” by Aliza P. Wingo, Wen Fan, Duc M. Duong, Ekaterina S. Gerasimov, Eric B. Dammer, Yue Liu, Nadia V. Harerimana, Bartholomew White, Madhav Thambisetty, Juan C. Troncoso, Namhee Kim, Julie A. Schneider, Ihab M. Hajjar, James J. Lah, David A. Bennett, Nicholas T. Seyfried, Allan I. Levey & Thomas S. Wingo (Vol. 23, No. 6, June 2020, p. 696-700).

www.nature.com/articles/s41593-020-0635-5

B. “Disease-associated astrocytes in Alzheimer’s disease and aging,” by Naomi Habib, Cristin McCabe, Sedi Medina, Miriam Varshavsky, Daniel Kitsberg, Raz Dvir-Szternfeld, Gilad Green, Danielle Dionne, Lan Nguyen, Jamie L. Marshall, Fei Chen, Feng Zhang, Tommy Kaplan, Aviv Regev & Michal Schwartz (Vol. 23, No. 6, June 2020, p. 701-706).

www.nature.com/articles/s41593-020-0624-8

May 6, 2020

CAAR – Nature Article – May 6, 2020

Filed under: Reports and Articles — Tags: , , — admin @ 5:39 pm

Note: Check with your organization’s library for availability. “APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline,” by Axel Montagne, Daniel A. Nation, Abhay P. Sagare, Giuseppe Barisano, Melanie D. Sweeney, Ararat Chakhoyan, Maricarmen Pachicano, Elizabeth Joe, Amy R. Nelson, Lina M. D’Orazio, David P. Buennagel, Michael G. Harrington, Tammie L. S. Benzinger, Anne M. Fagan, John M. Ringman, Lon S. Schneider, John C. Morris, Eric M. Reiman, Richard J. Caselli, Helena C. Chui, Julia TCW, Yining Chen, Judy Pa, Peter S. Conti, Meng Law, Arthur W. Toga & Berislav V. Zlokovic (Vol. 581, No. 7806, May 7, 2020, p. 71-76).

www.nature.com/articles/s41586-020-2247-3

January 16, 2020

CAAR – Nature Article – January 16, 2020

Filed under: Reports and Articles — Tags: , — admin @ 6:21 pm

Note: Check with your organization’s library for availability. “Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease,” by David Gate, Naresha Saligrama, Olivia Leventhal, Andrew C. Yang, Michael S. Unger, Jinte Middeldorp, Kelly Chen, Benoit Lehallier, Divya Channappa, Mark B. De Los Santos, Alisha McBride, John Pluvinage, Fanny Elahi, Grace Kyin-Ye Tam, Yongha Kim, Michael Greicius, Anthony D. Wagner, Ludwig Aigner, Douglas R. Galasko, Mark M. Davis & Tony Wyss-Coray (Vol. 577, No. 7790, January 16, 2020, p. 399-404).

www.nature.com/articles/s41586-019-1895-7

January 6, 2020

CAAR – Nature Article – January 6, 2020

Filed under: Reports and Articles — Tags: , — admin @ 4:37 pm

Note: Check with your organization’s library for availability. “Regulation of {alpha}-synuclein by chaperones in mammalian cells,” by Björn M. Burmann, Juan A. Gerez, Irena Matecko-Burmann, Silvia Campioni, Pratibha Kumari, Dhiman Ghosh, Adam Mazur, Emelie E. Aspholm, Darius Šulskis, Magdalena Wawrzyniuk, Thomas Bock, Alexander Schmidt, Stefan G. D. Rüdiger, Roland Riek & Sebastian Hiller (Vol. 577, No. 7788, January 2, 2020, p. 127-132).

www.nature.com/articles/s41586-019-1808-9

December 6, 2019

CAAR – Nature Medicine Letter – December 6, 2019

Filed under: Reports and Articles — Tags: , — admin @ 4:54 pm

Note: Check with your organization’s library for availability. “Undulating changes in human plasma proteome profiles across the lifespan,” by Benoit Lehallier, David Gate, Nicholas Schaum, Tibor Nanasi, Song Eun Lee, Hanadie Yousef, Patricia Moran Losada, Daniela Berdnik, Andreas Keller, Joe Verghese, Sanish Sathyan, Claudio Franceschi, Sofiya Milman, Nir Barzilai & Tony Wyss-Coray (Vol. 25, No. 12, December 2019, p. 1843-1850).

www.nature.com/articles/s41591-019-0673-2

October 17, 2019

CAAR – Nature Article Abstract – October 17, 2019

Filed under: Reports and Articles — Tags: , — admin @ 5:42 pm

Regulation of lifespan by neural excitation and REST,” by Joseph M. Zullo, Derek Drake, Liviu Aron, Patrick O’Hern, Sameer C. Dhamne, Noah Davidsohn, Chai-An Mao, William H. Klein, Alexander Rotenberg, David A. Bennett, George M. Church, Monica P. Colaiácovo & Bruce A. Yankner (Vol. 574, No. 7778, October 17, 2019, p. 359-364).

www.nature.com/articles/s41586-019-1647-8

June 20, 2019

CAAR – Nature Article Abstract – June 20, 2019

Filed under: Reports and Articles — Tags: , — admin @ 6:34 pm

Single-cell transcriptomic analysis of Alzheimer’s disease,” by Hansruedi Mathys, Jose Davila-Velderrain, Zhuyu Peng, Fan Gao, Shahin Mohammadi, Jennie Z. Young, Madhvi Menon, Liang He, Fatema Abdurrob, Xueqiao Jiang, Anthony J. Martorell, Richard M. Ransohoff, Brian P. Hafler, David A. Bennett, Manolis Kellis & Li-Huei Tsa (Vol. 570, No. 7761, June 20, 2019, p. 332-337).

www.nature.com/articles/s41586-019-1195-2

April 18, 2019

CAAR – Nature Article Abstract – April 18, 2019

Filed under: Reports and Articles — Tags: , — admin @ 5:28 pm

Stem cell competition orchestrates skin homeostasis and ageing,” by Nan Liu, Hiroyuki Matsumura, Tomoki Kato, Shizuko Ichinose, Aki Takada, Takeshi Namiki, Kyosuke Asakawa, Hironobu Morinaga, Yasuaki Mohri, Adèle De Arcangelis, Elisabeth Geroges-Labouesse, Daisuke Nanba & Emi K. Nishimura (Vol. 568, No. 7752, April 18, 2019, p. 344-350).

www.nature.com/articles/s41586-019-1085-7

April 10, 2019

CAAR – Nature Article Abstract – April 10, 2019

Filed under: Reports and Articles — Tags: , — admin @ 5:09 pm

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains,” by John V. Pluvinage, Michael S. Haney, Benjamin A. H. Smith, Jerry Sun, Tal Iram, Liana Bonanno, Lulin Li, Davis P. Lee, David W. Morgens, Andrew C. Yang, Steven R. Shuken, David Gate, Madeleine Scott, Purvesh Khatri, Jian Luo, Carolyn R. Bertozzi, Michael C. Bassik & Tony Wyss-Coray (Vol. 568, No. 7751, April 11, 2019, p. 187-192).

www.nature.com/articles/s41586-019-1088-4

February 8, 2019

CAAR – Nature Medicine Letter Abstracts – February 8, 2019

A. “Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction,” by Daniel A. Nation, Melanie D. Sweeney, Axel Montagne, Abhay P. Sagare, Lina M. D’Orazio, Maricarmen Pachicano, Farshid Sepehrband, Amy R. Nelson, David P. Buennagel, Michael G. Harrington, Tammie L. S. Benzinger, Anne M. Fagan, John M. Ringman, Lon S. Schneider, John C. Morris, Helena C. Chui, Meng Law, Arthur W. Toga & Berislav V. Zlokovic (Vol. 25, No. 2, February 2019, p. 270-276).

www.nature.com/articles/s41591-018-0297-y

B. “Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease,” by Oliver Preische, Stephanie A. Schultz, Anja Apel, Jens Kuhle, Stephan A. Kaeser, Christian Barro, Susanne Gräber, Elke Kuder-Buletta, Christian LaFougere, Christoph Laske, Jonathan Vöglein, Johannes Levin, Colin L. Masters, Ralph Martins, Peter R. Schofield, Martin N. Rossor, Neill R. Graff-Radford, Stephen Salloway, Bernardino Ghetti, John M. Ringman, James M. Noble, Jasmeer Chhatwal, Alison M. Goate, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, Guoqiao Wang, Anne M. Fagan, Eric M. McDade, Brian A. Gordon, Mathias Jucker, Ricardo Allegri, Fatima Amtashar, Randall Bateman, Tammie Benzinger, Sarah Berman, Courtney Bodge, Susan Brandon, William Brooks, Jill Buck, Virginia Buckles, Sochenda Chea, Jasmeer Chhatwal, Patricio Chrem, Helena Chui, Jake Cinco, Jack Clifford, Carlos Cruchaga, Mirelle D’Mello, Tamara Donahue, Jane Douglas, Noelia Edigo, Nilufer Erekin-Taner, Anne Fagan, Marty Farlow, Angela Farrar, Howard Feldman, Gigi Flynn, Nick Fox, Erin Franklin, Hisako Fujii, Cortaiga Gant, Samantha Gardener, Bernardino Ghetti, Alison Goate, Jill Goldman, Brian Gordon, Neill Graff-Radford, Julia Gray, Jenny Gurney, Jason Hassenstab, Mie Hirohara, David Holtzman, Russ Hornbeck, Siri Houeland DiBari, Takeshi Ikeuchi, Snezana Ikonomovic, Gina Jerome, Mathias Jucker, Celeste Karch, Kensaku Kasuga, Takeshi Kawarabayashi, William Klunk, Robert Koeppe, Elke Kuder-Buletta, Christoph Laske, Jae-Hong Lee, Johannes Levin, Daniel Marcus, Ralph Martins, Neal Scott Mason, Colin Masters, Denise Maue-Dreyfus, Eric McDade, Lucy Montoya, Hiroshi Mori, John Morris, Akem Nagamatsu, Katie Neimeyer, James Noble, Joanne Norton, Richard Perrin, Marc Raichle, John Ringman, Jee Hoon Roh, Stephen Salloway, Peter Schofield, Hiroyuki Shimada, Tomoyo Shiroto, Mikio Shoji, Wendy Sigurdson, Hamid Sohrabi, Paige Sparks, Kazushi Suzuki, Laura Swisher, Kevin Taddei, Jen Wang, Peter Wang, Mike Weiner, Mary Wolfsberger, Chengjie Xiong & Xiong Xu (Vol. 25, No. 2, February 2019, p. 277-283).

www.nature.com/articles/s41591-018-0304-3

January 17, 2019

CAAR – Nature Article Abstract – January 17, 2019

Filed under: Reports and Articles — Tags: , , — admin @ 5:30 pm

Age-related remodelling of oesophageal epithelia by mutated cancer drivers,” by Akira Yokoyama, Nobuyuki Kakiuchi, Tetsuichi Yoshizato, Yasuhito Nannya, Hiromichi Suzuki, Yasuhide Takeuchi, Yusuke Shiozawa, Yusuke Sato, Kosuke Aoki, Soo Ki Kim, Yoichi Fujii, Kenichi Yoshida, Keisuke Kataoka, Masahiro M. Nakagawa, Yoshikage Inoue, Tomonori Hirano, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Yoshitaka Nishikawa, Yusuke Amanuma, Shinya Ohashi, Ikuo Aoyama, Takahiro Horimatsu, Shin’ichi Miyamoto, Shigeru Tsunoda, Yoshiharu Sakai, Maiko Narahara, J. B. Brown, Yoshitaka Sato, Genta Sawada, Koshi Mimori, Sachiko Minamiguchi, Hironori Haga, Hiroshi Seno, Satoru Miyano, Hideki Makishima, Manabu Muto & Seishi Ogawa (Vol. 565, No.7739, January 17, 2019, p. 312-317).

www.nature.com/articles/s41586-018-0811-x

October 26, 2018

CAAR – Nature Letter Abstract – October 26, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 1:31 pm

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline,” by Tyler J. Bussian, Asef Aziz, Charlton F. Meyer, Barbara L. Swenson, Jan M. van Deursen & Darren J. Baker (Vol. 562, No. 7728, October 25, 2018, p. ).

www.nature.com/articles/s41586-018-0543-y

September 6, 2018

CAAR – Nature Letter Abstract – September 6, 2018

Filed under: Reports and Articles — Tags: , — admin @ 3:35 pm

Structures of filaments from Pick’s disease reveal a novel tau protein fold,” Benjamin Falcon, Wenjuan Zhang, Alexey G. Murzin, Garib Murshudov, Holly J. Garringer, Ruben Vidal, R. Anthony Crowther, Bernardino Ghetti, Sjors H. W. Scheres & Michel Goedert (Vol. 561, No. 7721, September 6, 2018, p. 137-140).

www.nature.com/articles/s41586-018-0454-y

August 7, 2018

CAAR – Nature Neuroscience Article Abstract – August 7, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 5:13 pm

Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies,” by Wenyan Sun, Hanie Samimi, Maria Gamez, Habil Zare & Bess Frost (Vol. 21, No. 8, August 2018, p. 1038-1048).

www.nature.com/articles/s41593-018-0194-1

CAAR – Nature Medicine Article – August 7, 2018

Filed under: Reports and Articles — Tags: , — admin @ 5:12 pm

Senolytics improve physical function and increase lifespan in old age,” by Ming Xu, Tamar Pirtskhalava, Joshua N. Farr, Bettina M. Weigand, Allyson K. Palmer, Megan M. Weivoda, Christina L. Inman, Mikolaj B. Ogrodnik, Christine M. Hachfeld, Daniel G. Fraser, Jennifer L. Onken, Kurt O. Johnson, Grace C. Verzosa, Larissa G. P. Langhi, Moritz Weigl, Nino Giorgadze, Nathan K. LeBrasseur, Jordan D. Miller, Diana Jurk, Ravinder J. Singh, David B. Allison, Keisuke Ejima, Gene B. Hubbard, Yuji Ikeno, Hajrunisa Cubro, Vesna D. Garovic, Xiaonan Hou, S. John Weroha, Paul D. Robbins, Laura J. Niedernhofer, Sundeep Khosla, Tamara Tchkonia & James L. Kirkland (Vol. 24, No. 8, August 2018, p. 1246-1256).

www.nature.com/articles/s41591-018-0092-9

April 23, 2018

CAAR – Nature Article Abstract – April 23, 2018

Filed under: Reports and Articles — Tags: , — admin @ 10:07 am

Innate immune memory in the brain shapes neurological disease hallmarks,” by Ann-Christin Wendeln, Karoline Degenhardt, Lalit Kaurani, Michael Gertig, Thomas Ulas, Gaurav Jain, Jessica Wagner, Lisa M. Hasler, Katleen Wild, Angelos Skodras, Thomas Blank, Ori Staszewski, Moumita Datta, Tonatiuh Pena Centeno, Vincenzo Capece, Md. Rezaul Islam, Cemil Kerimoglu, Matthias Staufenbiel, Joachim L. Schultze, Marc Beyer, Marco Prinz, Mathias Jucker, André Fischer & Jonas J. Neher (Vol. 556, No. 7701, April 19, 2018, p. 332-338).

www.nature.com/articles/s41586-018-0023-4

February 8, 2018

CAAR – Nature Letter Abstract – February 8, 2018

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High performance plasma amyloid-{beta} biomarkers for Alzheimer’s disease,” by Akinori Nakamura, Naoki Kaneko, Victor L. Villemagne, Takashi Kato, James Doecke, Vincent Doré, Chris Fowler, Qiao-Xin Li, Ralph Martins, Christopher Rowe, Taisuke Tomita, Katsumi Matsuzaki, Kenji Ishii, Kazunari Ishii, Yutaka Arahata, Shinichi Iwamoto, Kengo Ito, Koichi Tanaka, Colin L. Masters & Katsuhiko Yanagisawa (Vol. 554, No. , February 8, 2018, p. 249-254).

www.nature.com/articles/nature25456

December 14, 2017

CAAR – Nature Article Abstract – December 14, 2017

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Enhancing mitochondrial proteostasis reduces amyloid-{beta} proteotoxicity,” by Vincenzo Sorrentino, Mario Romani, Laurent Mouchiroud, John S. Beck, Hongbo Zhang, Davide D’Amico, Norman Moullan, Francesca Potenza, Adrien W. Schmid, Solene Rietsch, Scott E. Counts & Johan Auwerx (Vol. 552, No. 7684, December 14, 2017, p. 187-193).

www.nature.com/nature/journal/v552/n7684/abs/nature25143.html

November 8, 2017

CAAR – Nature Article Abstract – November 8, 2017

Filed under: Reports and Articles — Tags: , — admin @ 5:12 pm

Genetic variation in glia–neuron signalling modulates ageing rate,” by Jiang-An Yin, Ge Gao, Xi-Juan Liu, Zi-Qian Hao, Kai Li, Xin-Lei Kang, Hong Li, Yuan-Hong Shan, Wen-Li Hu, Hai-Peng Li & Shi-Qing Cai (Vol. 551, No. 7679, November 9, 2017, p. 198-203).

www.nature.com/nature/journal/v551/n7679/abs/nature24463.html

October 4, 2017

CAAR – Nature Letter Article – October 4, 2017

Filed under: Reports and Articles — Tags: , — admin @ 4:57 pm

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing,” by Christina D. Camell, Jil Sander, Olga Spadaro, Aileen Lee, Kim Y. Nguyen, Allison Wing, Emily L. Goldberg, Yun-Hee Youm, Chester W. Brown, John Elsworth, Matthew S. Rodeheffer, Joachim L. Schultze & Vishwa Deep Dixit (Vol. 550, No. 7674, October 5, 2017, p. 119-123).

www.nature.com/nature/journal/v550/n7674/abs/nature24022.html

September 29, 2017

CAAR – Nature Neuroscience Article Abstract – September 29, 2017

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Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single-cell imaging,” by Petra Fuger, Jasmin K. Hefendehl, Karthik Veeraraghavalu, Ann-Christin Wendeln, Christine Schlosser, Ulrike Obermüller, Bettina M Wegenast-Braun, Jonas J Neher, Peter Martus, Shinichi Kohsaka, Martin Thunemann, Robert Feil, Sangram S. Sisodia, Angelos Skodras & Mathias Jucker (Vol. 20, No. 10, October 2017, p. 1371-1376).

www.nature.com/neuro/journal/v20/n10/abs/nn.4631.html

September 20, 2017

CAAR – Nature Letter Abstract – September 20, 2017

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A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease,” by Elvira Mass, Christian E. Jacome-Galarza, Thomas Blank, Tomi Lazarov, Benjamin H. Durham, Neval Ozkaya, Alessandro Pastore, Marius Schwabenland, Young Rock Chung, Marc K. Rosenblum, Marco Prinz, Omar Abdel-Wahab & Frederic Geissmann (Vol. 549, No. 7672, September 21, 2017, p. 389-393).Nature Letter Abstract: “A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease,” by Elvira Mass, Christian E. Jacome-Galarza, Thomas Blank, Tomi Lazarov, Benjamin H. Durham, Neval Ozkaya, Alessandro Pastore, Marius Schwabenland, Young Rock Chung, Marc K. Rosenblum, Marco Prinz, Omar Abdel-Wahab & Frederic Geissmann (Vol. 549, No. 7672, September 21, 2017, p. 389-393).

www.nature.com/nature/journal/v549/n7672/abs/nature23672.html

June 28, 2017

CAAR – Nature Letter Abstract – June 28, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:15 pm

T cells from patients with Parkinson’s disease recognize {alpha}-synuclein peptides,” by David Sulzer, Roy N. Alcalay, Francesca Garretti, Lucien Cote, Ellen Kanter, Julian Agin-Liebes, Christopher Liong, Curtis McMurtrey, William H. Hildebrand, Xiaobo Mao, Valina L. Dawson, Ted M. Dawson, Carla Oseroff, John Pham, John Sidney, Myles B. Dillon, Chelsea Carpenter, Daniela Weiskopf, Elizabeth Phillips, Simon Mallal, Bjoern Peters, April Frazier, Cecilia S. Lindestam Arlehamn & Alessandro Sette (Vol. 546, No. 7660, June 29, 2017, p. 656-661).

www.nature.com/nature/journal/v546/n7660/abs/nature22815.html

April 26, 2017

CAAR – Nature Neuroscience Article Abstract – April 26, 2017

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{alpha}-Synuclein promotes dilation of the exocytotic fusion pore,” by Todd Logan, Jacob Bendor, Chantal Toupin, Kurt Thorn & Robert H. Edwards (Vol. 20, No. 5, May 2017, p. 681-689).

www.nature.com/neuro/journal/v20/n5/abs/nn.4529.html

March 8, 2017

CAAR – Nature Article Abstract – March 8, 2017

Filed under: Reports and Articles — Tags: , — admin @ 5:26 pm

Autophagy maintains the metabolism and function of young and old stem cells,” by Theodore T. Ho, Matthew R. Warr, Emmalee R. Adelman, Olivia M. Lansinger, Johanna Flach, Evgenia V. Verovskaya, Maria E. Figueroa & Emmanuelle Passegue (Vol. 543, No. 7644, March 9, 2017, p. 205-210).

www.nature.com/nature/journal/v543/n7644/abs/nature21388.html

January 26, 2017

CAAR – Nature Article Abstract – January 26, 2017

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Neurotoxic reactive astrocytes are induced by activated microglia,” by Shane A. Liddelow, Kevin A. Guttenplan, Laura E. Clarke, Frederick C. Bennett, Christopher J. Bohlen, Lucas Schirmer, Mariko L. Bennett, Alexandra E. Münch, Won-Suk Chung, Todd C. Peterson, Daniel K. Wilton, Arnaud Frouin, Brooke A. Napier, Nikhil Panicker, Manoj Kumar, Marion S. Buckwalter, David H. Rowitch, Valina L. Dawson, Ted M. Dawson, Beth Stevens & Ben A. Barres (Vol. 541, No. 7638, January 26, 2017, p. 481-487).

www.nature.com/nature/journal/v541/n7638/abs/nature21029.html

December 14, 2016

CAAR – Nature Letter Abstract – December 14, 2016

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Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals,” by Simon Schwörer, Friedrich Becker, Christian Feller, Ali H. Baig, Ute Kober, Henriette Henze, Johann M. Kraus, Beibei Xin, André Lechel, Daniel B. Lipka, Christy S. Varghese, Manuel Schmidt, Remo Rohs, Ruedi Aebersold, Kay L. Medina, Hans A. Kestler, Francesco Neri, Julia von Maltzahn, Stefan Tumpel & K. Lenhard Rudolph (Vol. 540, No. 7633, December 15, 2016, p. 428-432).

www.nature.com/nature/journal/v540/n7633/abs/nature20603.html

December 8, 2016

CAAR – Nature Article Abstract – December 8, 2016

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Gamma frequency entrainment attenuates amyloid load and modifies microglia,” by Hannah F. Iaccarino, Annabelle C. Singer, Anthony J. Martorell, Andrii Rudenko, Fan Gao, Tyler Z. Gillingham, Hansruedi Mathys, Jinsoo Seo, Oleg Kritskiy, Fatema Abdurrob, Chinnakkaruppan Adaikkan, Rebecca G. Canter, Richard Rueda, Emery N. Brown, Edward S. Boyden & Li-Huei Tsai (Vol. 540, No. 7632, December 8, 2016, p. 230-235).

www.nature.com/nature/journal/v540/n7632/abs/nature20587.html

November 8, 2016

CAAR – Nature Medicine Article Abstract – November 8, 2016

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Caspase-2 cleavage of tau reversibly impairs memory,” by Xiaohui Zhao, Linda A. Kotilinek, Benjamin Smith, Chris Hlynialuk, Kathleen Zahs, Martin Ramsden, James Cleary & Karen H. Ashe (Vol. 22, No. 11, November 2016, p. 1268–1276).

www.nature.com/nm/journal/v22/n11/abs/nm.4199.html

October 12, 2016

CAAR – Nature Letter Abstracts – October 12, 2016

Filed under: Reports and Articles — Tags: , , , — admin @ 5:15 pm

A. “Evidence for a limit to human lifespan,” by Xiao Dong, Brandon Milholland & Jan Vijg (Vol. 538, No. 7624, October 13, 2016, p. 257-259).

www.nature.com/nature/journal/v538/n7624/abs/nature19793.html

B. “Tissue-specific mutation accumulation in human adult stem cells during life,” by Francis Blokzijl, Joep de Ligt, Myrthe Jager, Valentina Sasselli, Sophie Roerink, Nobuo Sasaki, Meritxell Huch, Sander Boymans, Ewart Kuijk, Pjotr Prins, Isaac J. Nijman, Inigo Martincorena, Michal Mokry, Caroline L. Wiegerinck, Sabine Middendorp, Toshiro Sato, Gerald Schwank, Edward E. S. Nieuwenhuis, Monique M. A. Verstegen, Luc J. W. van der Laan, Jeroen de Jonge, Jan N. M. IJzermans, Robert G. Vries, Marc van de Wetering, Michael R. Stratton, Hans Clevers, Edwin Cuppen & Ruben van Boxtel (Vol. 538, No. 7624, October 13, 2016, p. 260-264).

www.nature.com/nature/journal/v538/n7624/abs/nature19768.html

September 1, 2016

CAAR – Nature Article Abstract – September 1, 2016

Filed under: Reports and Articles — Tags: , , — admin @ 4:39 pm

The antibody aducanumab reduces A{beta} plaques in Alzheimer’s disease,” by Jeff Sevigny, Ping Chiao, Thierry Bussière, Paul H. Weinreb, Leslie Williams, Marcel Maier, Robert Dunstan, Stephen Salloway, Tianle Chen, Yan Ling, John O’Gorman, Fang Qian, Mahin Arastu, Mingwei Li, Sowmya Chollate, Melanie S. Brennan, Omar Quintero-Monzon, Robert H. Scannevin, H. Moore Arnold, Thomas Engber, Kenneth Rhodes, James Ferrero, Yaming Hang, Alvydas Mikulskis, Jan Grimm, Christoph Hock, Roger M. Nitsch & Alfred Sandrock (Vol. 537, No. 7618, September 1, 2016, p. 50-56).

www.nature.com/nature/journal/v537/n7618/abs/nature19323.html

July 27, 2016

CAAR – Nature Letter Abstract – July 27, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:24 pm

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing,” by Ana Latorre-Pellicer, Raquel Moreno-Loshuertos, Ana Victoria Lechuga-Vieco, Fatima Sanchez-Cabo, Carlos Torroja, Rebeca Acín-Perez, Enrique Calvo, Esther Aix, Andres Gonzalez-Guerra, Angela Logan, María Luisa Bernad-Miana, Eduardo Romanos, Raquel Cruz, Sara Cogliati, Beatriz Sobrino, Angel Carracedo, Acisclo Pérez-Martos, Patricio Fernandez-Silva, Jesús Ruíz-Cabello, Michael P. Murphy, Ignacio Flores, Jesus Vazquez & José Antonio Enríquez (Vol. 535, No. 7613, July 28, 2016, p. 561-565).

www.nature.com/nature/journal/v535/n7613/abs/nature18618.html

May 4, 2016

CAAR – Nature Letter Abstract – May 4, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:48 pm

Parkinson-associated risk variant in distal enhancer of {alpha}-synuclein modulates target gene expression,” by Frank Soldner, Yonatan Stelzer, Chikdu S. Shivalila, Brian J. Abraham, Jeanne C. Latourelle, M. Inmaculada Barrasa, Johanna Goldmann, Richard H. Myers, Richard A. Young & Rudolf Jaenisch (Vol. 533, No. 7601, May 5, 2016, p. 95-99).

www.nature.com/nature/journal/v533/n7601/abs/nature17939.html

April 21, 2016

CAAR – Nature Letter Abstract – April 21, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:59 pm

Age-dependent modulation of vascular niches for haematopoietic stem cells,” by Anjali P. Kusumbe, Saravana K. Ramasamy, Tomer Itkin, Maarja Andaloussi Mae, Urs H. Langen, Christer Betsholtz, Tsvee Lapidot & Ralf H. Adams (Vol. 532, No. 7599, April 21, 2016, p. 380-384).

www.nature.com/nature/journal/v532/n7599/abs/nature17638.html

March 23, 2016

CAAR – Nature Letter Abstract – March 23, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:51 pm

Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease,” by Dheeraj S. Roy, Autumn Arons, Teryn I. Mitchell, Michele Pignatelli, Tomas J. Ryan & Susumu Tonegawa (Vol. 531, No. 7595, March 24, 2016, p. 508-512).

www.nature.com/nature/journal/v531/n7595/abs/nature17172.html

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