Note: Check with your organization’s library for availability. “Structures of {alpha}-synuclein filaments from human brains with Lewy pathology,” by Yang Yang, Yang Shi, Manuel Schweighauser, Xianjun Zhang, Abhay Kotecha, Alexey G. Murzin, Holly J. Garringer, Patrick W. Cullinane, Yuko Saito, Tatiana Foroud, Thomas T. Warner, Kazuko Hasegawa, Ruben Vidal, Shigeo Murayama, Tamas Revesz, Bernardino Ghetti, Masato Hasegawa, Tammaryn Lashley, Sjors H. W. Scheres & Michel Goedert (Vol. 610, No. 7933, October 27, 2022, p. 791-795).
October 28, 2022
August 22, 2022
CAAR – Nature Article Abstracts – August 22, 2022
A. “GPNMB confers risk for Parkinson’s disease through interaction with {alpha}-synuclein,” by Maria E. Diaz-Ortiz, Yunji Seo, Marijan Posavimarc Carceles Cordon, Elisia Clark, Nimansha Jainrakshita Charan, Michael D. Gallagher, Travis L. Unger, Noor Amarir, Tyler Skrinak, Roseanne Davila-Rivera, Eliza M. Brody, Noah Han, Rebecca Zack, Vivianna M. Van Deerlin, Thomas F. Tropea, Kelvin C. Luk, Edward B. Lee, Daniel Weintrauband, and Alice S. Chen-Plotkin (Vol. 377, No. 6608, August 19, 2022).
www.science.org/doi/abs/10.1126/science.abk0637
B. “Functional regulatory variants implicate distinct transcriptional networks in dementia,” by Yonatan A. Cooper, Noam Teyssier, Nina M. Dräger, Qiuyu Guo, Jessica E. Davis, Sydney M. Sattler, Zhongan Yang, Abdulsamie Patel, Sarah Wu, Sriram Kosuri, Giovanni Coppola, Martin Kampmann, and Daniel H. Geschwind (Vol. 377, No. 6608, August 19, 2022).
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June 9, 2022
CAAR – Nature Article – June 9, 2022
Note: Check with your organization’s library for availability. “Clonal dynamics of haematopoiesis across the human lifespan,” by Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, Kevin J. Dawson, Nicole Mende, Emily F. Calderbank, Hyunchul Jung, Thomas Mitchell, Tim H. H. Coorens, David H. Spencer, Heather Machado, Henry Lee-Six, Megan Davies, Daniel Hayler, Margarete A. Fabre, Krishnaa Mahbubani, Federico Abascal, Alex Cagan, George S. Vassiliou, Joanna Baxter, Inigo Martincorena, Michael R. Stratton, David G. Kent, Krishna Chatterjee, Kourosh Saeb Parsy, Anthony R. Green, Jyoti Nangalia, Elisa Laurenti & Peter J. Campbell (Vol. 606, No. 7913, June 9, 2022, p. 345-350). Note: _Nature_ is providing open access to the full-text of this article.
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May 18, 2022
CAAR – Nature Article – May 18, 2022
Note: Check with your organization’s library for availability. “Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17,” by Tal Iram, Fabian Kern, Achint Kaur, Saket Myneni, Allison R. Morningstar, Heather Shin, Miguel A. Garcia, Lakshmi Yerra, Robert Palovics, Andrew C. Yang, Oliver Hahn, Nannan Lu, Steven R. Shuken, Michael S. Haney, Benoit Lehallier, Manasi Iyer, Jian Luo, Henrik Zetterberg, Andreas Keller, J. Bradley Zuchero & Tony Wyss-Coray (Vol. 605, No. 7910, May 19, 2022, p. 509-515).
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April 28, 2022
CAAR – Nature Article – April 28, 2022
Note: Check with your organization’s library for availability. “Somatic genomic changes in single Alzheimer’s disease neurons,” by Michael B. Miller, August Yue Huang, Junho Kim, Zinan Zhou, Samantha L. Kirkham, Eduardo A. Maury, Jennifer S. Ziegenfuss, Hannah C. Reed, Jennifer E. Neil, Lariza Rento, Steven C. Ryu, Chanthia C. Ma, Lovelace J. Luquette, Heather M. Ames, Derek H. Oakley, Matthew P. Frosch, Bradley T. Hyman, Michael A. Lodato, Eunjung Alice Lee & Christopher A. Walsh (Vol. 604, No. 7907, April 27, 2022, p. 714-722).
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April 21, 2022
CAAR – Nature Article – April 21, 2022
Note: Check with your organization’s library for availability. “Brain charts for the human lifespan,” by R. A. I. Bethlehem, J. Seidlitz, A. F. Alexander-Bloch, etc. (Vol. 604, No. 7906, April 21, 2022, p. 525-533).
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March 31, 2022
CAAR – Nature Article – March 31, 2022
Note: Check with your organization’s library for availability. “A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk,” by Andrew C. Yang, Ryan T. Vest, Fabian Kern, Davis P. Lee, Maayan Agam, Christina A. Maat, Patricia M. Losada, Michelle B. Chen, Nicholas Schaum, Nathalie Khoury, Angus Toland, Kruti Calcuttawala, Heather Shin, Róbert Pálovics, Andrew Shin, Elizabeth Y. Wang, Jian Luo, David Gate, Walter J. Schulz-Schaeffer, Pauline Chu, Julie A. Siegenthaler, M. Windy McNerney, Andreas Keller & Tony Wyss-Coray (Vol. 603, No. 7903, March 31, 2022, p. 885-892).
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March 2, 2022
CAAR – Nature Articles – March 2, 2022
Note: Check with your organization’s library for availability.
A. “TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A,” by Anna-Leigh Brown, Oscar G. Wilkins, Matthew J. Keuss, Sarah E. Hill, Matteo Zanovello, Weaverly Colleen Lee, Alexander Bampton, Flora C. Y. Lee, Laura Masino, Yue A. Qi, Sam Bryce-Smith, Ariana Gatt, Martina Hallegger, Delphine Fagegaltier, Hemali Phatnani, NYGC ALS Consortium, Jia Newcombe, Emil K. Gustavsson, Sahba Seddighi, Joel F. Reyes, Steven L. Coon, Daniel Ramos, Giampietro Schiavo, Elizabeth M. C. Fisher, Towfique Raj, Maria Secrier, Tammaryn Lashley, Jernej Ule, Emanuele Buratti, Jack Humphrey, Michael E. Ward & Pietro Fratta (Vol. 603, No. 7899, March 3, 2022, p. 124-130).
www.nature.com/articles/s41586-022-04424-7
B. “TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A,” Anna-Leigh Brown, Oscar G. Wilkins, Matthew J. Keuss, Sarah E. Hill, Matteo Zanovello, Weaverly Colleen Lee, Alexander Bampton, Flora C. Y. Lee, Laura Masino, Yue A. Qi, Sam Bryce-Smith, Ariana Gatt, Martina Hallegger, Delphine Fagegaltier, Hemali Phatnani, NYGC ALS Consortium, Jia Newcombe, Emil K. Gustavsson, Sahba Seddighi, Joel F. Reyes, Steven L. Coon, Daniel Ramos, Giampietro Schiavo, Elizabeth M. C. Fisher, Towfique Raj, Maria Secrier, Tammaryn Lashley, Jernej Ule, Emanuele Buratti, Jack Humphrey, Michael E. Ward & Pietro Fratta (Vol. 603, No. 7899, March 3, 2022, p. 131-137).
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December 27, 2021
CAAR – Nature Article – December 27, 2021
Note: Check with your organization’s library for availability. “Antigen-presenting innate lymphoid cells orchestrate neuroinflammation,” by John B. Grigg, Arthi Shanmugavadivu, Tommy Regen, Christopher N. Parkhurst, Anees Ahmed, Ann M. Joseph, Michael Mazzucco, Konrad Gronke, Andreas Diefenbach, Gerard Eberl, Timothy Vartanian, Ari Waisman & Gregory F. Sonnenberg (Vol. 600, No. 7890, December 23, 2021, p. 707-712).
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December 15, 2021
CAAR – Nature Article – December 15, 2021
Note: Check with your organization’s library for availability. “Exercise plasma boosts memory and dampens brain inflammation via clusterin,” by Zurine De Miguel, Nathalie Khoury, Michael J. Betley, Benoit Lehallier, Drew Willoughby, Niclas Olsson, Andrew C. Yang, Oliver Hahn, Nannan Lu, Ryan T. Vest, Liana N. Bonanno, Lakshmi Yerra, Lichao Zhang, Nay Lui Saw, J. Kaci Fairchild, Davis Lee, Hui Zhang, Patrick L. McAlpine, Kévin Contrepois, Mehrdad Shamloo, Joshua E. Elias, Thomas A. Rando & Tony Wyss-Coray (Vol. 600, Vol. 7889, December 16, 2021, p. 494-499).
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September 9, 2021
CAAR – Nature Article – September 9, 2021
Note: Check with your organization’s library for availability. “Aged skeletal stem cells generate an inflammatory degenerative niche,” by Thomas H. Ambrosi, Owen Marecic, Adrian McArdle, Rahul Sinha, Gunsagar S. Gulati, Xinming Tong, Yuting Wang, Holly M. Steininger, Malachia Y. Hoover, Lauren S. Koepke, Matthew P. Murphy, Jan Sokol, Eun Young Seo, Ruth Tevlin, Michael Lopez, Rachel E. Brewer, Shamik Mascharak, Laura Lu, Oyinkansola Ajanaku, Stephanie D. Conley, Jun Seita, Maurizio Morri, Norma F. Neff, Debashis Sahoo, Fan Yang, Irving L. Weissman, Michael T. Longaker & Charles K. F. Chan (Vol. 597, No. 7875, September 9, 2021, p. 256-262).
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August 13, 2021
CAAR – Nature Article – August 13, 2021
Note: Check with your organization’s library for availability. “Rewiring of the ubiquitinated proteome determines ageing in C. elegans,” by Seda Koyuncu, Rute Loureiro, Hyun Ju Lee, Prerana Wagle, Marcus Krueger & David Vilchez (Vol. 596, No. 7871, August 12, 2021, p. 285-290).
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June 17, 2021
CAAR – Nature Medicine Article – June 17, 2021
Note: Check with your organization’s library for availability. “Prediction of future Alzheimer’s disease dementia using plasma phospho-tau combined with other accessible measures,” by Sebastian Palmqvist, Pontus Tideman, Nicholas Cullen, Henrik Zetterberg, Kaj Blennow, the Alzheimer’s Disease Neuroimaging Initiative, Jeffery L. Dage, Erik Stomrud, Shorena Janelidze, Niklas Mattsson-Carlgren & Oskar Hansson (Vol. 27, No. 6, June 2021, p. 1034-1042).
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June 3, 2021
CAAR – Nature Article – June 3, 2021
Note: Check with your organization’s library for availability. “An aged immune system drives senescence and ageing of solid organs,” by Matthew J. Yousefzadeh, Rafael R. Flores, Yi Zhu, Zoe C. Schmiechen, Robert W. Brooks, Christy E. Trussoni, Yuxiang Cui, Luise Angelini, Kyoo-A Lee, Sara J. McGowan, Adam L. Burrack, Dong Wang, Qing Dong, Aiping Lu, Tokio Sano, Ryan D. O’Kelly, Collin A. McGuckian, Jonathan I. Kato, Michael P. Bank, Erin A. Wade, Smitha P. S. Pillai, Jenna Klug, Warren C. Ladiges, Christin E. Burd, Sara E. Lewis, Nicholas F. LaRusso, Nam V. Vo, Yinsheng Wang, Eric E. Kelley, Johnny Huard, Ingunn M. Stromnes, Paul D. Robbins & Laura J. Niedernhofer (Vol. 594, No. 7861, June 3, 2021, p. 100-105).
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March 19, 2021
CAAR – Nature Medicine Article – March 19, 2021
Note: Check with your organization’s library for availability. “Life expectancy and mortality in 363 cities of Latin America,” by Usama Bilal, Philipp Hessel, Carolina Perez-Ferrer, Yvonne L. Michael, Tania Alfaro, Janeth Tenorio-Mucha, Amelia A. L. Friche, Maria Fatima Pina, Alejandra Vives, Harrison Quick, Marcio Alazraqui, Daniel A. Rodriguez, J. Jaime Miranda, Ana V. Diez-Roux & the SALURBAL group (Vol. 27, No. 3, March 2021, p. 463-470).
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February 4, 2021
CAAR – Nature Article – February 4, 2021
Note: Check with your organization’s library for availability. “Restoring metabolism of myeloid cells reverses cognitive decline in ageing,” by Paras S. Minhas, Amira Latif-Hernandez, Melanie R. McReynolds, Aarooran S. Durairaj, Qian Wang, Amanda Rubin, Amit U. Joshi, Joy Q. He, Esha Gauba, Ling Liu, Congcong Wang, Miles Linde, Yuki Sugiura, Peter K. Moon, Ravi Majeti, Makoto Suematsu, Daria Mochly-Rosen, Irving L. Weissman, Frank M. Longo, Joshua D. Rabinowitz & Katrin I. Andreasson (Vol. 590, No. 7844, February 4, 2021, p. 122-128).
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December 3, 2020
CAAR – Nature Article – December 3, 2020
Note: Check with your organization’s library for availability. “Reprogramming to recover youthful epigenetic information and restore vision,” by Yuancheng Lu, Benedikt Brommer, Xiao Tian, Anitha Krishnan, Margarita Meer, Chen Wang, Daniel L. Vera, Qiurui Zeng, Doudou Yu, Michael S. Bonkowski, Jae-Hyun Yang, Songlin Zhou, Emma M. Hoffmann, Margarete M. Karg, Michael B. Schultz, Alice E. Kane, Noah Davidsohn, Ekaterina Korobkina, Karolina Chwalek, Luis A. Rajman, George M. Church, Konrad Hochedlinger, Vadim N. Gladyshev, Steve Horvath, Morgan E. Levine, Meredith S. Gregory-Ksander, Bruce R. Ksander, Zhigang He & David A. Sinclair (Vol. 588, No. 7836, December 3, 2020, p. 124-129).
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November 30, 2020
CAAR – Nature Neuroscience Articles – November 30, 2020
Note: Check with your organization’s library for availability.
A. “Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease,” by Kevin Richetin, Pascal Steullet, Mathieu Pachoud, Romain Perbet, Enea Parietti, Mathischan Maheswaran, Sabiha Eddarkaoui, Séverine Bégard, Catherine Pythoud, Maria Rey, Raphaëlle Caillierez, Kim Q. Do, Sophie Halliez, Paola Bezzi, Luc Buée, Geneviève Leuba, Morvane Colin, Nicolas Toni & Nicole Déglon (Vol. 23, No. 12, December 2020, p. 1567-1579).
www.nature.com/articles/s41593-020-00728-x
B. “Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2- production,” by Heejung Chun, Hyeonjoo Im, You Jung Kang, Yunha Kim, Jin Hee Shin, Woojin Won, Jiwoon Lim, Yeonha Ju, Yongmin Mason Park, Sunpil Kim, Seung Eun Lee, Jaekwang Lee, Junsung Woo, Yujin Hwang, Hyesun Cho, Seonmi Jo, Jong-Hyun Park, Daesoo Kim, Doo Yeon Kim, Jeong-Sun Seo, Byoung Joo Gwag, Young Soo Kim, Ki Duk Park, Bong-Kiun Kaang, Hansang Cho, Hoon Ryu & C. Justin Lee (Vol. 23, No. 12, December 2020, p. 1555–1566).
www.nature.com/articles/s41593-020-00735-y
C. “Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life,” by Ruth E. Uhlmann, Christine Rother, Jay Rasmussen, Juliane Schelle, Carina Bergmann, Emily M. Ullrich Gavilanes, Sarah K. Fritschi, Anika Buehler, Frank Baumann, Angelos Skodras, Rawaa Al-Shaana, Natalie Beschorner, Lan Ye, Stephan A. Kaeser, Ulrike Obermüller, Søren Christensen, Fredrik Kartberg, Jeffrey B. Stavenhagen, Jens-Ulrich Rahfeld, Holger Cynis, Fang Qian, Paul H. Weinreb, Thierry Bussiere, Lary C. Walker, Matthias Staufenbiel & Mathias Jucker (Vol. 23, No. 12, December 2020, p. 1580-1588).
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November 19, 2020
CAAR – Nature Article – November 19, 2020
Note: Check with your organization’s library for availability. “Molecular dissection of amyloid disaggregation by human HSP70,” by Anne S. Wentink, Nadinath B. Nillegoda, Jennifer Feufel, Gabriele Ubartaite, Carolyn P. Schneider, Paolo De Los Rios, Janosch Hennig, Alessandro Barducci & Bernd Bukau (Vol. 587, No. 7834, November 19, 2020, p. 483-488).
www.nature.com/articles/s41586-020-2904-6
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October 29, 2020
CAAR – Nature Article – October 29, 2020
Note: Check with your organization’s library for availability. “The innate immunity protein IFITM3 modulates {gamma}-secretase in Alzheimer’s disease,” by Ji-Yeun Hur, Georgia R. Frost, Xianzhong Wu, Christina Crump, Si Jia Pan, Eitan Wong, Marilia Barros, Thomas Li, Pengju Nie, Yujia Zhai, Jen Chyong Wang, Julia TCW, Lei Guo, Andrew McKenzie, Chen Ming, Xianxiao Zhou, Minghui Wang, Yotam Sagi, Alan E. Renton, Bianca T. Esposito, Yong Kim, Katherine R. Sadleir, Ivy Trinh, Robert A. Rissman, Robert Vassar, Bin Zhang, Douglas S. Johnson, Eliezer Masliah, Paul Greengard, Alison Goate & Yue-Ming Li (Vol. 586, No. , October 30, 2020, p. 735-740).
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July 30, 2020
CAAR – Nature Neuroscience Articles – July 30, 2020
Note: Check with your organization’s library for availability.
A. “Memory trace interference impairs recall in a mouse model of Alzheimer’s disease,” by Stefanie Poll, Manuel Mittag, Fabrizio Musacchio, Lena C. Justus, Eleonora Ambrad Giovannetti, Julia Steffen, Jens Wagner, Lioba Zohren, Susanne Schoch, Boris Schmidt, Walker S. Jackson, Dan Ehninger & Martin Fuhrmann (Vol. 23, No. 8, August 2020, p. 952-958).
www.nature.com/articles/s41593-020-0652-4
B. “Alzheimer’s-associated PLC{gamma}2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia,” by Benjamin J. Andreone, Laralynne Przybyla, Ceyda Llapashtica, Anil Rana, Sonnet S. Davis, Bettina van Lengerich, Karin Lin, Ju Shi, Yuan Mei, Giuseppe Astarita, Gilbert Di Paolo, Thomas Sandmann, Kathryn M. Monroe & Joseph W. Lewcock (Vol. 23, No. 8, August 2020, p. 927-938).
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July 24, 2020
CAAR – Nature Article – July 24, 2020
Note: Check with your organization’s library for availability. “Ageing hallmarks exhibit organ-specific temporal signatures,” by Nicholas Schaum, Benoit Lehallier, Oliver Hahn, Róbert Pálovics, Shayan Hosseinzadeh, Song E. Lee, Rene Sit, Davis P. Lee, Patricia Morán Losada, Macy E. Zardeneta, Tobias Fehlmann, James T. Webber, Aaron McGeever, Kruti Calcuttawala, Hui Zhang, Daniela Berdnik, Vidhu Mathur, Weilun Tan, Alexander Zee, Michelle Tan, The Tabula Muris Consortium, Angela Oliveira Pisco, Jim Karkanias, Norma F. Neff, Andreas Keller, Spyros Darmanis, Stephen R. Quake & Tony Wyss-Coray (Vol. 583, No. 9785, July 24, 2020, p. 596-602).
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July 16, 2020
CAAR – Nature Article – July 16, 2020
Note: Check with your organization’s library for availability. “Physiological blood–brain transport is impaired with age by a shift in transcytosis,” by Andrew C. Yang, Marc Y. Stevens, Michelle B. Chen, Davis P. Lee, Daniel Stähli, David Gate, Kévin Contrepois, Winnie Chen, Tal Iram, Lichao Zhang, Ryan T. Vest, Aisling Chaney, Benoit Lehallier, Niclas Olsson, Haley du Bois, Ryan Hsieh, Haley C. Cropper, Daniela Berdnik, Lulin Li, Elizabeth Y. Wang, Gavin M. Traber, Carolyn R. Bertozzi, Jian Luo, Michael P. Snyder, Joshua E. Elias, Stephen R. Quake, Michelle L. James & Tony Wyss-Coray (Vol. 583, No. 7816, July 16, 2020, p. 425-430).
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June 25, 2020
CAAR – Nature Article – June 25, 2020
Note: Check with your organization’s library for availability. “Reversing a model of Parkinson’s disease with in situ converted nigral neurons,” by Hao Qian, Xinjiang Kang, Jing Hu, Dongyang Zhang, Zhengyu Liang, Fan Meng, Xuan Zhang, Yuanchao Xue, Roy Maimon, Steven F. Dowdy, Neal K. Devaraj, Zhuan Zhou, William C. Mobley, Don W. Cleveland & Xiang-Dong Fu (Vol. 582, No. 7813, June 25, 2020, p. 550-556).
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June 24, 2020
CAAR – Nature Medicine Article – June 24, 2020
Note: Check with your organization’s library for availability. “Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes,” by Joel W. Blanchard, Michael Bula, Jose Davila-Velderrain, Leyla Anne Akay, Lena Zhu, Alexander Frank, Matheus B. Victor, Julia Maeve Bonner, Hansruedi Mathys, Yuan-Ta Lin, Tak Ko, David A. Bennett, Hugh P. Cam, Manolis Kellis & Li-Huei Tsai (Vol. 26, No. 7, July 2020, p. 952-963).
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June 3, 2020
CAAR – Nature Neuroscience Articles – June 3, 2020
Note: Check with your organization’s library for availability.
A. “Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain,” by Aliza P. Wingo, Wen Fan, Duc M. Duong, Ekaterina S. Gerasimov, Eric B. Dammer, Yue Liu, Nadia V. Harerimana, Bartholomew White, Madhav Thambisetty, Juan C. Troncoso, Namhee Kim, Julie A. Schneider, Ihab M. Hajjar, James J. Lah, David A. Bennett, Nicholas T. Seyfried, Allan I. Levey & Thomas S. Wingo (Vol. 23, No. 6, June 2020, p. 696-700).
www.nature.com/articles/s41593-020-0635-5
B. “Disease-associated astrocytes in Alzheimer’s disease and aging,” by Naomi Habib, Cristin McCabe, Sedi Medina, Miriam Varshavsky, Daniel Kitsberg, Raz Dvir-Szternfeld, Gilad Green, Danielle Dionne, Lan Nguyen, Jamie L. Marshall, Fei Chen, Feng Zhang, Tommy Kaplan, Aviv Regev & Michal Schwartz (Vol. 23, No. 6, June 2020, p. 701-706).
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May 6, 2020
CAAR – Nature Article – May 6, 2020
Note: Check with your organization’s library for availability. “APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline,” by Axel Montagne, Daniel A. Nation, Abhay P. Sagare, Giuseppe Barisano, Melanie D. Sweeney, Ararat Chakhoyan, Maricarmen Pachicano, Elizabeth Joe, Amy R. Nelson, Lina M. D’Orazio, David P. Buennagel, Michael G. Harrington, Tammie L. S. Benzinger, Anne M. Fagan, John M. Ringman, Lon S. Schneider, John C. Morris, Eric M. Reiman, Richard J. Caselli, Helena C. Chui, Julia TCW, Yining Chen, Judy Pa, Peter S. Conti, Meng Law, Arthur W. Toga & Berislav V. Zlokovic (Vol. 581, No. 7806, May 7, 2020, p. 71-76).
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January 16, 2020
CAAR – Nature Article – January 16, 2020
Note: Check with your organization’s library for availability. “Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease,” by David Gate, Naresha Saligrama, Olivia Leventhal, Andrew C. Yang, Michael S. Unger, Jinte Middeldorp, Kelly Chen, Benoit Lehallier, Divya Channappa, Mark B. De Los Santos, Alisha McBride, John Pluvinage, Fanny Elahi, Grace Kyin-Ye Tam, Yongha Kim, Michael Greicius, Anthony D. Wagner, Ludwig Aigner, Douglas R. Galasko, Mark M. Davis & Tony Wyss-Coray (Vol. 577, No. 7790, January 16, 2020, p. 399-404).
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January 6, 2020
CAAR – Nature Article – January 6, 2020
Note: Check with your organization’s library for availability. “Regulation of {alpha}-synuclein by chaperones in mammalian cells,” by Björn M. Burmann, Juan A. Gerez, Irena Matecko-Burmann, Silvia Campioni, Pratibha Kumari, Dhiman Ghosh, Adam Mazur, Emelie E. Aspholm, Darius Šulskis, Magdalena Wawrzyniuk, Thomas Bock, Alexander Schmidt, Stefan G. D. Rüdiger, Roland Riek & Sebastian Hiller (Vol. 577, No. 7788, January 2, 2020, p. 127-132).
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December 6, 2019
CAAR – Nature Medicine Letter – December 6, 2019
Note: Check with your organization’s library for availability. “Undulating changes in human plasma proteome profiles across the lifespan,” by Benoit Lehallier, David Gate, Nicholas Schaum, Tibor Nanasi, Song Eun Lee, Hanadie Yousef, Patricia Moran Losada, Daniela Berdnik, Andreas Keller, Joe Verghese, Sanish Sathyan, Claudio Franceschi, Sofiya Milman, Nir Barzilai & Tony Wyss-Coray (Vol. 25, No. 12, December 2019, p. 1843-1850).
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October 17, 2019
CAAR – Nature Article Abstract – October 17, 2019
“Regulation of lifespan by neural excitation and REST,” by Joseph M. Zullo, Derek Drake, Liviu Aron, Patrick O’Hern, Sameer C. Dhamne, Noah Davidsohn, Chai-An Mao, William H. Klein, Alexander Rotenberg, David A. Bennett, George M. Church, Monica P. Colaiácovo & Bruce A. Yankner (Vol. 574, No. 7778, October 17, 2019, p. 359-364).
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June 20, 2019
CAAR – Nature Article Abstract – June 20, 2019
“Single-cell transcriptomic analysis of Alzheimer’s disease,” by Hansruedi Mathys, Jose Davila-Velderrain, Zhuyu Peng, Fan Gao, Shahin Mohammadi, Jennie Z. Young, Madhvi Menon, Liang He, Fatema Abdurrob, Xueqiao Jiang, Anthony J. Martorell, Richard M. Ransohoff, Brian P. Hafler, David A. Bennett, Manolis Kellis & Li-Huei Tsa (Vol. 570, No. 7761, June 20, 2019, p. 332-337).
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April 18, 2019
CAAR – Nature Article Abstract – April 18, 2019
“Stem cell competition orchestrates skin homeostasis and ageing,” by Nan Liu, Hiroyuki Matsumura, Tomoki Kato, Shizuko Ichinose, Aki Takada, Takeshi Namiki, Kyosuke Asakawa, Hironobu Morinaga, Yasuaki Mohri, Adèle De Arcangelis, Elisabeth Geroges-Labouesse, Daisuke Nanba & Emi K. Nishimura (Vol. 568, No. 7752, April 18, 2019, p. 344-350).
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April 10, 2019
CAAR – Nature Article Abstract – April 10, 2019
“CD22 blockade restores homeostatic microglial phagocytosis in ageing brains,” by John V. Pluvinage, Michael S. Haney, Benjamin A. H. Smith, Jerry Sun, Tal Iram, Liana Bonanno, Lulin Li, Davis P. Lee, David W. Morgens, Andrew C. Yang, Steven R. Shuken, David Gate, Madeleine Scott, Purvesh Khatri, Jian Luo, Carolyn R. Bertozzi, Michael C. Bassik & Tony Wyss-Coray (Vol. 568, No. 7751, April 11, 2019, p. 187-192).
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February 8, 2019
CAAR – Nature Medicine Letter Abstracts – February 8, 2019
A. “Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction,” by Daniel A. Nation, Melanie D. Sweeney, Axel Montagne, Abhay P. Sagare, Lina M. D’Orazio, Maricarmen Pachicano, Farshid Sepehrband, Amy R. Nelson, David P. Buennagel, Michael G. Harrington, Tammie L. S. Benzinger, Anne M. Fagan, John M. Ringman, Lon S. Schneider, John C. Morris, Helena C. Chui, Meng Law, Arthur W. Toga & Berislav V. Zlokovic (Vol. 25, No. 2, February 2019, p. 270-276).
www.nature.com/articles/s41591-018-0297-y
B. “Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease,” by Oliver Preische, Stephanie A. Schultz, Anja Apel, Jens Kuhle, Stephan A. Kaeser, Christian Barro, Susanne Gräber, Elke Kuder-Buletta, Christian LaFougere, Christoph Laske, Jonathan Vöglein, Johannes Levin, Colin L. Masters, Ralph Martins, Peter R. Schofield, Martin N. Rossor, Neill R. Graff-Radford, Stephen Salloway, Bernardino Ghetti, John M. Ringman, James M. Noble, Jasmeer Chhatwal, Alison M. Goate, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, Guoqiao Wang, Anne M. Fagan, Eric M. McDade, Brian A. Gordon, Mathias Jucker, Ricardo Allegri, Fatima Amtashar, Randall Bateman, Tammie Benzinger, Sarah Berman, Courtney Bodge, Susan Brandon, William Brooks, Jill Buck, Virginia Buckles, Sochenda Chea, Jasmeer Chhatwal, Patricio Chrem, Helena Chui, Jake Cinco, Jack Clifford, Carlos Cruchaga, Mirelle D’Mello, Tamara Donahue, Jane Douglas, Noelia Edigo, Nilufer Erekin-Taner, Anne Fagan, Marty Farlow, Angela Farrar, Howard Feldman, Gigi Flynn, Nick Fox, Erin Franklin, Hisako Fujii, Cortaiga Gant, Samantha Gardener, Bernardino Ghetti, Alison Goate, Jill Goldman, Brian Gordon, Neill Graff-Radford, Julia Gray, Jenny Gurney, Jason Hassenstab, Mie Hirohara, David Holtzman, Russ Hornbeck, Siri Houeland DiBari, Takeshi Ikeuchi, Snezana Ikonomovic, Gina Jerome, Mathias Jucker, Celeste Karch, Kensaku Kasuga, Takeshi Kawarabayashi, William Klunk, Robert Koeppe, Elke Kuder-Buletta, Christoph Laske, Jae-Hong Lee, Johannes Levin, Daniel Marcus, Ralph Martins, Neal Scott Mason, Colin Masters, Denise Maue-Dreyfus, Eric McDade, Lucy Montoya, Hiroshi Mori, John Morris, Akem Nagamatsu, Katie Neimeyer, James Noble, Joanne Norton, Richard Perrin, Marc Raichle, John Ringman, Jee Hoon Roh, Stephen Salloway, Peter Schofield, Hiroyuki Shimada, Tomoyo Shiroto, Mikio Shoji, Wendy Sigurdson, Hamid Sohrabi, Paige Sparks, Kazushi Suzuki, Laura Swisher, Kevin Taddei, Jen Wang, Peter Wang, Mike Weiner, Mary Wolfsberger, Chengjie Xiong & Xiong Xu (Vol. 25, No. 2, February 2019, p. 277-283).
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January 17, 2019
CAAR – Nature Article Abstract – January 17, 2019
“Age-related remodelling of oesophageal epithelia by mutated cancer drivers,” by Akira Yokoyama, Nobuyuki Kakiuchi, Tetsuichi Yoshizato, Yasuhito Nannya, Hiromichi Suzuki, Yasuhide Takeuchi, Yusuke Shiozawa, Yusuke Sato, Kosuke Aoki, Soo Ki Kim, Yoichi Fujii, Kenichi Yoshida, Keisuke Kataoka, Masahiro M. Nakagawa, Yoshikage Inoue, Tomonori Hirano, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Yoshitaka Nishikawa, Yusuke Amanuma, Shinya Ohashi, Ikuo Aoyama, Takahiro Horimatsu, Shin’ichi Miyamoto, Shigeru Tsunoda, Yoshiharu Sakai, Maiko Narahara, J. B. Brown, Yoshitaka Sato, Genta Sawada, Koshi Mimori, Sachiko Minamiguchi, Hironori Haga, Hiroshi Seno, Satoru Miyano, Hideki Makishima, Manabu Muto & Seishi Ogawa (Vol. 565, No.7739, January 17, 2019, p. 312-317).
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October 26, 2018
CAAR – Nature Letter Abstract – October 26, 2018
“Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline,” by Tyler J. Bussian, Asef Aziz, Charlton F. Meyer, Barbara L. Swenson, Jan M. van Deursen & Darren J. Baker (Vol. 562, No. 7728, October 25, 2018, p. ).
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September 6, 2018
CAAR – Nature Letter Abstract – September 6, 2018
“Structures of filaments from Pick’s disease reveal a novel tau protein fold,” Benjamin Falcon, Wenjuan Zhang, Alexey G. Murzin, Garib Murshudov, Holly J. Garringer, Ruben Vidal, R. Anthony Crowther, Bernardino Ghetti, Sjors H. W. Scheres & Michel Goedert (Vol. 561, No. 7721, September 6, 2018, p. 137-140).
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August 7, 2018
CAAR – Nature Neuroscience Article Abstract – August 7, 2018
“Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies,” by Wenyan Sun, Hanie Samimi, Maria Gamez, Habil Zare & Bess Frost (Vol. 21, No. 8, August 2018, p. 1038-1048).
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CAAR – Nature Medicine Article – August 7, 2018
“Senolytics improve physical function and increase lifespan in old age,” by Ming Xu, Tamar Pirtskhalava, Joshua N. Farr, Bettina M. Weigand, Allyson K. Palmer, Megan M. Weivoda, Christina L. Inman, Mikolaj B. Ogrodnik, Christine M. Hachfeld, Daniel G. Fraser, Jennifer L. Onken, Kurt O. Johnson, Grace C. Verzosa, Larissa G. P. Langhi, Moritz Weigl, Nino Giorgadze, Nathan K. LeBrasseur, Jordan D. Miller, Diana Jurk, Ravinder J. Singh, David B. Allison, Keisuke Ejima, Gene B. Hubbard, Yuji Ikeno, Hajrunisa Cubro, Vesna D. Garovic, Xiaonan Hou, S. John Weroha, Paul D. Robbins, Laura J. Niedernhofer, Sundeep Khosla, Tamara Tchkonia & James L. Kirkland (Vol. 24, No. 8, August 2018, p. 1246-1256).
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April 23, 2018
CAAR – Nature Article Abstract – April 23, 2018
“Innate immune memory in the brain shapes neurological disease hallmarks,” by Ann-Christin Wendeln, Karoline Degenhardt, Lalit Kaurani, Michael Gertig, Thomas Ulas, Gaurav Jain, Jessica Wagner, Lisa M. Hasler, Katleen Wild, Angelos Skodras, Thomas Blank, Ori Staszewski, Moumita Datta, Tonatiuh Pena Centeno, Vincenzo Capece, Md. Rezaul Islam, Cemil Kerimoglu, Matthias Staufenbiel, Joachim L. Schultze, Marc Beyer, Marco Prinz, Mathias Jucker, André Fischer & Jonas J. Neher (Vol. 556, No. 7701, April 19, 2018, p. 332-338).
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February 8, 2018
CAAR – Nature Letter Abstract – February 8, 2018
“High performance plasma amyloid-{beta} biomarkers for Alzheimer’s disease,” by Akinori Nakamura, Naoki Kaneko, Victor L. Villemagne, Takashi Kato, James Doecke, Vincent Doré, Chris Fowler, Qiao-Xin Li, Ralph Martins, Christopher Rowe, Taisuke Tomita, Katsumi Matsuzaki, Kenji Ishii, Kazunari Ishii, Yutaka Arahata, Shinichi Iwamoto, Kengo Ito, Koichi Tanaka, Colin L. Masters & Katsuhiko Yanagisawa (Vol. 554, No. , February 8, 2018, p. 249-254).
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December 14, 2017
CAAR – Nature Article Abstract – December 14, 2017
“Enhancing mitochondrial proteostasis reduces amyloid-{beta} proteotoxicity,” by Vincenzo Sorrentino, Mario Romani, Laurent Mouchiroud, John S. Beck, Hongbo Zhang, Davide D’Amico, Norman Moullan, Francesca Potenza, Adrien W. Schmid, Solene Rietsch, Scott E. Counts & Johan Auwerx (Vol. 552, No. 7684, December 14, 2017, p. 187-193).
www.nature.com/nature/journal/v552/n7684/abs/nature25143.html
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November 8, 2017
CAAR – Nature Article Abstract – November 8, 2017
“Genetic variation in glia–neuron signalling modulates ageing rate,” by Jiang-An Yin, Ge Gao, Xi-Juan Liu, Zi-Qian Hao, Kai Li, Xin-Lei Kang, Hong Li, Yuan-Hong Shan, Wen-Li Hu, Hai-Peng Li & Shi-Qing Cai (Vol. 551, No. 7679, November 9, 2017, p. 198-203).
www.nature.com/nature/journal/v551/n7679/abs/nature24463.html
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October 4, 2017
CAAR – Nature Letter Article – October 4, 2017
“Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing,” by Christina D. Camell, Jil Sander, Olga Spadaro, Aileen Lee, Kim Y. Nguyen, Allison Wing, Emily L. Goldberg, Yun-Hee Youm, Chester W. Brown, John Elsworth, Matthew S. Rodeheffer, Joachim L. Schultze & Vishwa Deep Dixit (Vol. 550, No. 7674, October 5, 2017, p. 119-123).
www.nature.com/nature/journal/v550/n7674/abs/nature24022.html
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September 29, 2017
CAAR – Nature Neuroscience Article Abstract – September 29, 2017
“Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single-cell imaging,” by Petra Fuger, Jasmin K. Hefendehl, Karthik Veeraraghavalu, Ann-Christin Wendeln, Christine Schlosser, Ulrike Obermüller, Bettina M Wegenast-Braun, Jonas J Neher, Peter Martus, Shinichi Kohsaka, Martin Thunemann, Robert Feil, Sangram S. Sisodia, Angelos Skodras & Mathias Jucker (Vol. 20, No. 10, October 2017, p. 1371-1376).
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September 20, 2017
CAAR – Nature Letter Abstract – September 20, 2017
“A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease,” by Elvira Mass, Christian E. Jacome-Galarza, Thomas Blank, Tomi Lazarov, Benjamin H. Durham, Neval Ozkaya, Alessandro Pastore, Marius Schwabenland, Young Rock Chung, Marc K. Rosenblum, Marco Prinz, Omar Abdel-Wahab & Frederic Geissmann (Vol. 549, No. 7672, September 21, 2017, p. 389-393).Nature Letter Abstract: “A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease,” by Elvira Mass, Christian E. Jacome-Galarza, Thomas Blank, Tomi Lazarov, Benjamin H. Durham, Neval Ozkaya, Alessandro Pastore, Marius Schwabenland, Young Rock Chung, Marc K. Rosenblum, Marco Prinz, Omar Abdel-Wahab & Frederic Geissmann (Vol. 549, No. 7672, September 21, 2017, p. 389-393).
www.nature.com/nature/journal/v549/n7672/abs/nature23672.html
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June 28, 2017
CAAR – Nature Letter Abstract – June 28, 2017
“T cells from patients with Parkinson’s disease recognize {alpha}-synuclein peptides,” by David Sulzer, Roy N. Alcalay, Francesca Garretti, Lucien Cote, Ellen Kanter, Julian Agin-Liebes, Christopher Liong, Curtis McMurtrey, William H. Hildebrand, Xiaobo Mao, Valina L. Dawson, Ted M. Dawson, Carla Oseroff, John Pham, John Sidney, Myles B. Dillon, Chelsea Carpenter, Daniela Weiskopf, Elizabeth Phillips, Simon Mallal, Bjoern Peters, April Frazier, Cecilia S. Lindestam Arlehamn & Alessandro Sette (Vol. 546, No. 7660, June 29, 2017, p. 656-661).
www.nature.com/nature/journal/v546/n7660/abs/nature22815.html
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April 26, 2017
CAAR – Nature Neuroscience Article Abstract – April 26, 2017
“{alpha}-Synuclein promotes dilation of the exocytotic fusion pore,” by Todd Logan, Jacob Bendor, Chantal Toupin, Kurt Thorn & Robert H. Edwards (Vol. 20, No. 5, May 2017, p. 681-689).
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March 8, 2017
CAAR – Nature Article Abstract – March 8, 2017
“Autophagy maintains the metabolism and function of young and old stem cells,” by Theodore T. Ho, Matthew R. Warr, Emmalee R. Adelman, Olivia M. Lansinger, Johanna Flach, Evgenia V. Verovskaya, Maria E. Figueroa & Emmanuelle Passegue (Vol. 543, No. 7644, March 9, 2017, p. 205-210).
www.nature.com/nature/journal/v543/n7644/abs/nature21388.html
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