“Development and validation of a Hospital Frailty Risk Score focusing on older people in acute care settings using electronic hospital records: an observational study,” by Thomas Gilbert, Jenny Neuburger, Joshua Kraindler, Eilis Keeble, Paul Smith, Cono Ariti, Sandeepa Arora, Andrew Street, Stuart Parker, Helen C. Roberts, Martin Bardsley, and Simon Conroy (Vol. 391, No. 10132, May 5, 2018, p. 1775-1782).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30668-8/abstract
“The effect of APOE and other common genetic variants on the onset of Alzheimer’s disease and dementia: a community-based cohort study,” by Sven J. van der Lee, Frank J. Wolters, M. Kamran Ikram, Albert Hofman, M. Arfan Ikram, Najaf Amin, and Cornelia M. van Duijn (Vol. 17, No. 5, May 2018, p. 434-444).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(18)30053-X/abstract
“Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals,” by Nathalie Conrad, Prof. Andrew Judge, Jenny Tran, Hamid Mohseni, Deborah Hedgecott, Abel Perez Crespillo, Moira Allison, Prof. Harry Hemingway, Prof. John G. Cleland, MD, Prof John J. V. McMurray, and Prof. Kazem Rahimi (Vol. 391, No. 10120, February 10, 2018, p. 572-580). Note: The Lancet is providing open access to the full-text of this article.
www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32520-5/fulltext
“Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study,” by Rudy Sinharay, Jicheng Gong, Benjamin Barratt, Pamela Ohman-Strickland, Sabine Ernst, Prof. Frank J. Kelly, Prof. Junfeng (Jim) Zhang, Prof. Peter Collins, Prof. Paul Cullinan, and Prof. Kian Fan Chung (Vol. 391, No. 10118, January 27, 2018, p. 339-349).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32643-0/abstract
“Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial,” by David L. Kendler, Fernando Marin, Cristiano A. F. Zerbini, Luis A. Russo, Susan L. Greenspan, Vit Zikan, Alicia Bagur, Jorge Malouf-Sierra, Peter Lakatos, Astrid Fahrleitner-Pammer, Eric Lespessailles, Salvatore Minisola, Jean Jacques Body, Piet Geusens, Rüdiger Moricke, and Pedro López-Romero (Vol. 391, No. 10117, January 20, 2018, p. 230-240).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32137-2/abstract
A. “Exenatide once weekly versus placebo in Parkinson’s disease: a randomised, double-blind, placebo-controlled trial,” by Dilan Athauda, Kate Maclagan, Simon S Skene, Martha Bajwa-Joseph, Dawn Letchford, Kashfia Chowdhury, Steve Hibbert, Natalia Budnik, Luca Zampedri, John Dickson, Yazhou Li, Iciar Aviles-Olmos, Thomas T. Warner, Patricia Limousin, Andrew J. Lees, Nigel H. Greig, Susan Tebbs, and Thomas Foltynie (Vol. 390, No. 10103, October 7, 2017, p. 1664-1675).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31585-4/abstract
B. “Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS),” by Andrew Kingston, Pia Wohland, Raphael Wittenberg, Louise Robinson, Carol Brayne, Fiona E. Matthews, and Carol Jagger on behalf of the Cognitive Function and Ageing Studies collaboration (Vol. 390, No. 10103, October 7, 2017, p. 1676-1684).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31575-1/abstract
“Improving comfort around dying in elderly people: a cluster randomised controlled trial,” by Kim Beernaert, Tinne Smets, Joachim Cohen, Rebecca Verhofstede, Massimo Costantini, Kim Eecloo, Nele Van Den Noortgate, and Luc Deliens (Vol. 390, No. 10090, July 8, 2017, p. 125-134).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31265-5/abstract
“Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study,” by Yi Zeng, Qiushi Feng, Therese Hesketh, Kaare Christensen, and James W. Vaupel (Vol. 389, No. 10079, April 22, 2017, p. 1619-1629).
thelancet.com/journals/lancet/article/PIIS0140-6736(17)30548-2/abstract
“Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial,” by Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) Investigators (Vol. 380, No. 10078, April 15, 2017, p. 1519-1527).
thelancet.com/journals/lancet/article/PIIS0140-6736(17)30066-1/abstract
“The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study,” by Lee E. Bayliss, David Culliford, A. Paul Monk, Sion Glyn-Jones, Daniel Prieto-Alhambra, Andrew Judge, Cyrus Cooper, Andrew J. Carr, Nigel K. Arden, David J. Beard, and Andrew J. Price (Vol. 389, No. 10077, April 8, 2017, p. 1424-1430).
thelancet.com/journals/lancet/article/PIIS0140-6736(17)30059-4/abstract
“Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer’s disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial,” by Prof. Serge Gauthier, Prof. Howard H. Feldman, Prof. Lon S. Schneider, Prof. Gordon K. Wilcock, Prof. Giovanni B. Frisoni, Jiri H. Hardlund, Hans J. Moebius, Peter Bentham, Karin A. Kook, Damon J. Wischik, Prof. Bjoern O. Schelter, and Charles S. Davis, Roger T. Staff, Luc Bracoud, Kohkan Shamsi, Prof. John M. D. Storey, Charles R. Harrington, and Prof. Claude M. Wischik (Vol. 388, No. 10062, December 10, 2016, p. 2873–2884).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31275-2/abstract
“Clinical variables and biomarkers in prediction of cognitive impairment in patients with newly diagnosed Parkinson’s disease: a cohort study,” by Anette Schrag, Uzma Faisal Siddiqui, Zacharias Anastasiou, Daniel Weintraub, and Jonathan M. Schott (Vol. 17, No. 1, January 2017, p. 66-75).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(16)30328-3/abstract
“Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial,” by Xian Su, Zhao-Ting Meng, Xin-Hai Wu, Fan Cui, Hong-Liang Li, Dong-Xin Wang, Xi Zhu, Sai-Nan Zhu, Mervyn Maze, and Daqing Ma (Vol. 388, No. 10054, October 15, 2016, p. 1893-1902).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)30580-3/abstract
“Addition of a non-immersive virtual reality component to treadmill training to reduce fall risk in older adults (V-TIME): a randomised controlled trial,” by Anat Mirelman, Lynn Rochester, Inbal Maidan, Silvia Del Din, Lisa Alcock, Freek Nieuwhof, Marcel Olde Rikkert, Bastiaan R. Bloem, Elisa Pelosin, Laura Avanzino, Giovanni Abbruzzese, Kim Dockx, Esther Bekkers, Nir Giladi, Alice Nieuwboer, and Jeffrey M. Hausdorff (Vol. 388, No. 10050, September 17, 2016, p. 1170–1182).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31325-3/abstract
“Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis,” by Bruno R. da Costa, Stephan Reichenbach, Noah Keller, Linda Nartey, Simon Wandel, Peter Juni, and Sven Trelle (Vol. 387, No. 10033, May 21, 2016, p. 2093-2105).
www.thelancet.com/journals/lancet/article/PIIS0140-6736%2816%2930002-2/abstract
“Invasive versus conservative strategy in patients aged 80 years or older with non-ST-elevation myocardial infarction or unstable angina pectoris (After Eighty study): an open-label randomised controlled trial,” by Nicolai Tegn, Michael Abdelnoor, Lars Aaberge, Knut Endresen, Pal Smith, Svend Aakhus, Erik Gjertsen, Ola Dahl-Hofseth, Anette Hylen Ranhoff, Lars Gullestad, and Bjorn Bendz, After Eighty study investigators (Vol. 387, No. 10023, March 12, 2016, p. 1057-1065).
www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2901166-6/abstract
“Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition,” by GBD 2013 DALYs and HALE Collaborators (Vol. 386, No. 10009, November 28, 2015, p. 2145-2191).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)61340-X/abstract
“Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial,” by Benjamin Z. Leder, Joy N. Tsai, Alexander V. Uihlein, Paul M. Wallace, Hang Lee, Robert M. Neer, and Sherri-Ann M. Burnett-Bowie (Vol. 386, No. 9999, September 19, 2015, p. 1147-1155).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)61120-5/abstract
“Readmission destination and risk of mortality after major surgery: an observational cohort study,” by Dr. Benjamin S. Brooke, Philip P. Goodney, Prof. Larry W. Kraiss, Daniel J. Gottlieb, Prof. Matthew H. Samore, and Prof. Samuel R. G. Finlayson (Vol. 386, No. 9996, August 29, 2015, p. 884-895).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60087-3/abstract
Note: Lancet requires free registration prior to providing access. “Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013,” (Vol. 386, No. 9995, August 22, 2015, p. 743-800).
www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2960692-4/abstract
Note: Lancet requires free registration prior to providing content. “A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial,” by Tiia Ngandu, Jenni Lehtisalo, Alina Solomon, Esko Levalahti, Satu Ahtiluoto, Riitta Antikainen, Lars Backman, Tuomo Hanninen, Antti Jula, Tiina Laatikainen, Jaana Lindstrom, Francesca Mangialasche, Teemu Paajanen, Satu Pajala, Markku Peltonen, Rainer Rauramaa, Anna Stigsdotter-Neely, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, and Miia Kivipelto (Vol. 385, No. 9984, June 6, 2015, p. 2255-2263).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60461-5/abstract
Note: Lancet requires free registration prior to providing access to content. “Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies,” by Collaborative Group on Epidemiological Studies of Ovarian Cancer (Vol. 385, No. 9980, May 8, 2015, p. 1835-1842).
www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%2961687-1/abstract
“Comprehensive geriatric care for patients with hip fractures: a prospective, randomised, controlled trial,” by Anders Prestmo, Gunhild Hagen, Olav Sletvold, Jorunn L. Helbostad, Pernille Thingstad, Kristin Taraldsen, Stian Lydersen, Vidar Halsteinli, Turi Saltnes, Sarah E. Lamb, Lars G. Johnsen, and Ingvild Saltvedt (Vol. 385, No. 9978, April 25, 2015, p. 1623-1633).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)62409-0/abstract
Note: Lancet requires free registration prior to providing content.
A. “Causes of international increases in older age life expectancy,” by Colin D. Mathers, Gretchen A. Stevens, Ties Boerma, Richard A. White, and Martin I. Tobias (Vol. 385, No. 9967, February 7, 2015, p. 540-548).
www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%2960569-9/abstract
B. “The burden of disease in older people and implications for health policy and practice,” by Martin J. Prince, Fan Wu, Yanfei Guo, Luis M. Gutierrez Robledo, Martin O’Donnell, Richard Sullivan, and Salim Yusuf (Vol. 385, No. 9967, February 7, 2015, p. 549-562).
www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%2961347-7/abstract
C. “Health, functioning, and disability in older adults—present status and future implications,” by Somnath Chatterji, Julie Byles, David Cutler, Teresa Seeman, and Emese Verdes (Vol. 385, No. 9967, February 7, 2015, p. 563-5).
www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%2961462-8/abstract
Note: Lancet requires free registration prior to providing content. “Efficacy of rasagiline in patients with the parkinsonian variant of multiple system atrophy: a randomised, placebo-controlled trial,” by Prof. Werner Poewe, Prof, Klaus Seppi, Cheryl J. Fitzer-Attas, Prof. Gregor K. Wenning, Sid Gilman, Prof. Phillip A. Low, Prof. Nir Giladi, Prof. Paolo Barone, Prof. Cristina Sampaio, Eli Eyal, and Prof. Olivier Rascol, MD, for the Rasagiline-for-MSA investigators (Vol. 14, No. 2, February 2015, p. 145-152).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70288-1/abstract
Note: Lancet requires free registration prior to providing content. “Home modifications to reduce injuries from falls in the Home Injury Prevention Intervention (HIPI) study: a cluster-randomised controlled trial,” by Michael D. Keall, Nevil Pierse, Philippa Howden-Chapman, Chris Cunningham, Malcolm Cunningham, Jagadish Guria, and Michael G. Baker (Vol. 385, No. 9964, January 17, 2015, p. 231-238).
www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%2961006-0/abstract
Note: Lancet requires free registration prior to providing content. “Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up,” by Fritz H Schroder, Jonas Hugosson, Monique J. Roobol, Teuvo L. J. Tammela, Marco Zappa, Vera Nelen, Maciej Kwiatkowski, Marcos Lujan, Liisa Maattanen, Hans Lilja, Louis J. Denis, Franz Recker, Alvaro Paez, Chris H. Bangma, Sigrid Carlsson, Donella Puliti, Arnauld Villers, Xavier Rebillard, Matti Hakama, Ulf-Hakan Stenman, Paula Kujala, Kimmo Taari, Gunnar Aus, Andreas Huber, Theo H. van der Kwast, Ron H. N. van Schaik, Harry J. de Koning, Sue M Moss, Anssi Auvinen, for the ERSPC Investigators (Vol. 384, No. 9959, December 6, 2014, p. 2027-2035).
www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%2960525-0/abstract
Note: Lancet requires free registration prior to providing access to content. On Nov. 6, 2014, the Lancet published a special online series of articles on ageing. The series includes five articles that address different areas of health care for older adults. The series can be accessed at:
Note: Lancet requires free registration prior to providing access.
A. “45-day mortality after 467,779 knee replacements for osteoarthritis from the National Joint Registry for England and Wales: an observational study,” by Linda P. Hunt, Yoav Ben-Shlomo, Emma M. Clark, Paul Dieppe, Andrew Judge, Alex J. MacGregor, Jon H. Tobias, Kelly Vernon, and Ashley W. Blom, on behalf of the National Joint Registry for England and Wales (Vol. 384, No. 9952, October 18, 2014, p. 1429-1436).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60540-7/abstract
B. “Adverse outcomes after total and unicompartmental knee replacement in 101,330 matched patients: a study of data from the National Joint Registry for England and Wales,” by Alexander D. Liddle, Andrew Judge, Hemant Pandit, and David W. Murray (Vol. 384, No. 9952, October 18, 2014, p. 1437-1445).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60419-0/abstract
Note: Lancet requires free registration prior to providing access. “Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson’s disease (PD MED): a large, open-label, pragmatic randomised trial PD MED Collaborative Group,” by PD MED Collaborative Group (Vol. 384, No. 9949, September 27, 2014, p. 1196-1205).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60683-8/abstract
Note: Lancet requires free registration prior to providing access to content.
A. “Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial,” by Stephen J. Allen, Kathie Wareham, Duolao Wang, Caroline Bradley, Hayley Hutchings, Wyn Harris, Anjan Dhar, Helga Brown, Alwyn Foden, Michael B. Gravenor, and Dietrich Mack (Vol. 382, No. 9900, October 12, 2013, p. 1249-1257).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61218-0/abstract
B. “Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial,” by Usha Chakravarthy, Simon P. Harding, Chris A. Rogers, Susan M. Downes, Andrew J. Lotery, Lucy A. Culliford, and Barnaby C. Reeves, on behalf of the IVAN study investigators (Vol. 382, No. 9900, October 12, 2013, p. 1258-1267).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61501-9/abstract
Note: Lancet requires free registration prior to providing content. “Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): a 24 week, randomised, double-blind, placebo-controlled study,” by W. David Strain, Valentina Lukashevich, Wolfgang Kothny, Marie-Jose Hoellinger, and Paivi Maria Paldanius (Vol. 382, No. 9890, August 3, 2013, p. 407-416).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)60995-2/abstract
Note: Lancet requires free registration prior to providing access. “Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson’s disease (NSTAPS study): a randomised controlled trial,” by Vincent J.J. Odekerken, Teus van Laar, Michiel J. Staal, Arne Mosch, Carel F.E. Hoffmann, Peter C.G. Nijssen, Guus N. Beute, Jeroen P.P. van Vugt, Mathieu W.P.M. Lenders, M. Fiorella Contarino, Marieke S.J. Mink, Lo J. Bour, Pepijn van den Munckhof, Ben A. Schmand, Rob J. de Haan, P. Richard Schuurman, and Rob M.A. de Bie (Vol. 12, No. 1, January 2013, p. 37-44).
www.thelancet.com/journals/laneur/article/PIIS1474-4422%2812%2970264-8/abstract
Note: Lancet requires free registration before providing content. “Making Alzheimer’s and dementia research fit for populations,” by Carol Brayne and Daniel Davis (Vol. 380, No. 9851, Oct. 20, 2012, p. 1441-1443).
www.thelancet.com/journals/lancet/article/PIIS0140-6736%2812%2961803-0/fulltext
Note: Lancet requires free registration before providing articles.
“Age-related macular degeneration,” by Laurence S. Lim, Paul Mitchell, Johanna M. Seddon, Frank G. Holz, and Tien Y. Wong (Vol. 379, No. 9827, May 5, 2012, p. 1728-1738).
www.lancet.com/journals/lancet/article/PIIS0140-6736%2812%2960282-7/abstract
Lancet Article Abstract: Note: Lancet requires free registration before providing content. “Memantine for dementia in adults older than 40 years with Down’s syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial,” by Marisa Hanney, Vee Prasher, Nicola Williams, Emma L. Jones, Dag Aarsland, Anne Corbett, Dale Lawrence, Ly-Mee Yu, Stephen Tyrer, Paul T Francis, Tony Johnson, Roger Bullock, and Clive Ballard (Vol. 379, No. 9815, Feb. 11, 2012, p. 528-536).
www.lancet.com/journals/lancet/article/PIIS0140-6736(11)61676-0/abstract
Lancet requires free registration before providing content. “Bone-Density Testing Interval and Transition to Osteoporosis in Older Women,” by Margaret L. Gourlay, Jason P. Fine, John S. Preisser, Ryan C. May, Chenxi Li, Li-Yung Lui, David F. Ransohoff, Jane A. Cauley, and Kristine E. Ensrud (Vol. 366, No. 3, January 2012, p. 225-233).
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