“Development and validation of a Hospital Frailty Risk Score focusing on older people in acute care settings using electronic hospital records: an observational study,” by Thomas Gilbert, Jenny Neuburger, Joshua Kraindler, Eilis Keeble, Paul Smith, Cono Ariti, Sandeepa Arora, Andrew Street, Stuart Parker, Helen C. Roberts, Martin Bardsley, and Simon Conroy (Vol. 391, No. 10132, May 5, 2018, p. 1775-1782).
www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30668-8/abstract
“Frailty in a racially and socioeconomically diverse sample of middle-aged Americans in Baltimore,” by Felicia R. Griffin, Nicolle A. Mode, Ngozi Ejiogu, Alan B. Zonderman, and Michele K. Evans (PLoS ONE 13(4): e0195637. doi.org/10.1371/journal.pone.0195637, XML, HTML, and .pdf format, 12p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0195637
“Frailty is associated with objectively assessed sedentary behaviour patterns in older adults: Evidence from the Toledo Study for Healthy Aging (TSHA),” by Borja del Pozo-Cruz, Asier Manas, María Martín-García, Jorge Marín-Puyalto, Francisco J. García-García, Leocadio Rodriguez-Manas, Amelia Guadalupe-Grau, and Ignacio Ara (PLoS ONE 12(9): e0183911. doi.org/10.1371/journal.pone.0183911, XML, HTML, and .pdf format, 9p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0183911
“The Impact Of Frailty On Public Health Nurse Service Utilisation: Findings from The Irish Longitudinal Study on Ageing (TILDA),” by Lorna Roe, Aisling O’Halloran, Charles Normand, and Catriona Murphy (September 2016, .pdf format, 18p.).
tilda.tcd.ie/assets/pdf/2016_Roe%20et%20al_Frailty%20&%20Public%20Health%20Nursing.pdf
A. “Cognition and Indicators of Dietary Habits in Older Adults from Southern Brazil,” by Vivian Francielle Franca, Aline Rodrigues Barbosa, and Eleonora D’Orsi (PLoS ONE 11(2): e0147820. doi:10.1371/journal.pone.0147820, XML, HTML, and .pdf format, 12p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0147820
B. “Long Term Outcomes of a Geriatric Liaison Intervention in Frail Elderly Cancer Patients,” by Liesbeth Hempenius, Joris P. J. Slaets, Dieneke van Asselt, Truuske H. de Bock, Theo Wiggers, and Barbara L. van Leeuwen (PLoS ONE 11(2): e0143364. doi:10.1371/journal.pone.0143364, XML, HTML, and .pdf format, 13p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0143364
A. “JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age,” by Ming Xu, Tamara Tchkonia, Husheng Ding, Mikolaj Ogrodnik, Ellen R. Lubbers, Tamar Pirtskhalava, Thomas A. White, Kurt O. Johnson, Michael B. Stout, Vojtech Mezera, Nino Giorgadze, Michael D. Jensen, Nathan K. LeBrasseur, and James L. Kirkland (Vol. 112, No. 46, November 17, 2015, p. E6301–E6310).
www.pnas.org/content/112/46/E6301.abstract.html?etoc
B. “Automatic classification of prostate cancer Gleason scores from multiparametric magnetic resonance images,” by Duc Fehr, Harini Veeraraghavan, Andreas Wibmer, Tatsuo Gondo, Kazuhiro Matsumoto, Herbert Alberto Vargas, Evis Sala, Hedvig Hricak, and Joseph O. Deasy (Vol. 112, No. 46, November 17, 2015, p. E6265–E6273).
“Dementia, disability and frailty in later life – mid-life approaches to delay or prevent onset,” (October 2015, .pdf and HTML format, 61p.).
“Cost-Effectiveness of a Specialist Geriatric Medical Intervention for Frail Older People Discharged from Acute Medical Units: Economic Evaluation in a Two-Centre Randomised Controlled Trial (AMIGOS),” by Lukasz Tanajewski, Matthew Franklin, Georgios Gkountouras, Vladislav Berdunov, Judi Edmans, Simon Conroy, Lucy E. Bradshaw, John R. F. Gladman, and Rachel A. Elliott (PLoS ONE 10(5): e0121340. doi:10.1371/journal.pone.0121340, XML, HTML, and .pdf format, 18p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0121340
“Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia,” by Christopher S. Fry, Jonah D. Lee, Jyothi Mula, Tyler J. Kirby, Janna R. Jackson, Fujun Liu, Lin Yang, Christopher L. Mendias, Esther E. Dupont-Versteegden, John J. McCarthy & Charlotte A. Peterson (Vol. 21, No. 1, January 2015, p. 76-80).
“Fraility and Disability,” by Ms Siobhan Scarlett, Dr. Bellinda L. King-Kallimanis, Professor Ian Young, Professor Rose Anne Kenny, and Dr. Matthew D.L. O’Connell (November 2014, .pdf format, 11p.).
www.cardi.ie/publications/frailtyanddisabilityinirelandnorthandsouth
A. “Patterns of Frailty in Older Adults: Comparing Results from Higher and Lower Income Countries Using the Survey of Health, Ageing and Retirement in Europe (SHARE) and the Study on Global AGEing and Adult Health (SAGE),” by Kenneth Harttgen, Paul Kowal, Holger Strulik, Somnath Chatterji, and Sebastian Vollmer (PLoS ONE 8(10): e75847. doi:10.1371/journal.pone.0075847, XML, HTML, and .pdf format, 11p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0075847
B. “Altered Resting State Brain Networks in Parkinson’s Disease,” by Martin Gottlich, Thomas F. Munte, Marcus Heldmann, Meike Kasten, Johann Hagenah, and Ulrike M. Kramer (PLoS ONE 8(10): e77336. doi:10.1371/journal.pone.0077336, XML, HTML and .pdf format, 13p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0077336
“Validation of an index to estimate the prevalence of frailty among community-dwelling seniors,” by Melanie Hoover, Michelle Rotermann, Claudia Sanmartin and Julie Bernier (Health Reports, Vol. 24, No. 9, September 2013, .pdf and HTML format, p. 10-17).
www.statcan.gc.ca/pub/82-003-x/2013009/article/11864-eng.htm
“Frailty in Transition: Variation and Vulnerability in Aging Populations,” by Michal Engelman, Vladimir Canudas-Romo and Emily M. Agree (2013-10, 2013, .pdf format, 34p.).
Abstract:
This paper asks how the demographic and epidemiologic transitions of the past century and a half have influenced patterns of survival and health in aging populations. We hypothesize that survival improvements at younger ages may yield an older population with a more heterogeneous health profile relative to previous cohorts with higher early-life mortality. To test this hypothesis, we develop a theoretical and statistical rationale for a frailty model designed to examine changes in the composition of successive aging cohorts. The model incorporates a cohort-specific frailty indicator into an equation describing the mortality hazard trajectory across the full lifespan, and its parameters are estimated using life table data for cohorts born 1885-1919. The findings indicate that more recent cohorts are more homogeneous with respect to the timing of mortality than earlier ones – but also less selected, as death culls fewer individuals in early life. We argue that due to ongoing survival improvements, delayed mortality selection has shifted disparities into later life, where they manifest in increasing mortality variability and growing heterogeneity in health.
A. “Alcohol Consumption, Types of Alcohol, and Parkinson’s Disease,” by Rui Liu, Xuguang Guo, Yikyung Park, Jian Wang, Xuemei Huang, Albert Hollenbeck, Aaron Blair, and Honglei Chen (PLoS ONE 8(6): e66452. doi:10.1371/journal.pone.0066452, HTML, XML, and .pdf format, 7p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0066452
B. “Longitudinal Assessment of Amyloid Pathology in Transgenic ArcA{beta} Mice Using Multi-Parametric Magnetic Resonance Imaging,” by Jan Klohs, Igna Wojtyna Politano, Andreas Deistung, Joanes Grandjean, Anna Drewek, Marco Dominietto, Ruth Keist, Ferdinand Schweser, Jurgen R. Reichenbach, Roger M. Nitsch, Irene Knuesel, and Markus Rudin (PLoS ONE 8(6): e66097. doi:10.1371/journal.pone.0066097, XML, HTML, and .pdf format, 12p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0066097
C. “Outcomes of a Geriatric Liaison Intervention to Prevent the Development of Postoperative Delirium in Frail Elderly Cancer Patients: Report on a Multicentre, Randomized, Controlled Trial,” by Liesbeth Hempenius, Joris P. J. Slaets, Dieneke van Asselt, Geertruida H. de Bock, Theo Wiggers, and Barbara L. van Leeuwen (PLoS ONE 8(6): e64834. doi:10.1371/journal.pone.0064834, XML, HTML, and .pdf format, 11p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0064834
“On the Socio-Economic Determinants of Frailty: Findings from Panel and Retrospective Data from SHARE,” by Nicolas Sirven (IRDES Working Paper No. 52, April 2013, .pdf format, 31p.).
Abstract:
Recent studies on the demand for long-term care emphasised the role of frailty as a specific precursor of disability besides chronic diseases. Frailty is defined as vulnerable health status resulting from the reduction of individuals’ reserve capacity. This medical concept is brought here in an economic framework in order to investigate the role social policies may play in preventing disability or maintaining life quality of people in a disablement process.
Using four waves of panel data from the Survey on Health, Ageing, and Retirement in Europe (SHARE), a frailty index is created as a count measure for five physiologic criteria (Fried model) for respondents aged 50+ in 10 European countries, between 2004 and 2011.
The longitudinal dimension is explored in two ways. First, differences in frailty dynamics over a seven-year-time period are analysed through variables that are relevant for social policy (income maintenance, housing adaptation, and prevention of social isolation) in a panel model for count data with fixed effects. Second, the individual fixed effects are decomposed by means of a random effects model with Mundlak specification. SHARE additional retrospective data on life history (SHARELIFE) are then used to investigate differences in frailty levels.
The results reveal the presence of various sources of social inequalities over the life-course. Social Protection Systems thus appear to play a major role in accompanying, preventing or reducing the frailty process. Several policy implications are suggested.
www.irdes.fr/EspaceAnglais/Publications/WorkingPapers/DT52SocioEconomicDeterminantsFrailty.pdf
A. “Plasma Adiponectin Levels Correlate Positively with an Increasing Number of Components of Frailty in Male Elders,” by Jaw-Shiun Tsai, Chih-Hsun Wu, Su-Chiu Chen, Kuo-Chin Huang, Chin-Ying Chen, Ching-I Chang, Lee-Ming Chuang, and Ching-Yu Chen (PLoS ONE 8(2): e56250. doi:10.1371/journal.pone.0056250, XML, HTML, and .pdf format, 8p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056250
B. “The Effects of Aging on Conflict Detection,” by Giuliana Lucci, Marika Berchicci, Donatella Spinelli, Francesco Taddei, and Francesco Di Russo (PLoS ONE 8(2): e56566. doi:10.1371/journal.pone.0056566, XML, HTML, and .pdf format, 14p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056566
C. “Motor Matters: Tackling Heterogeneity of Parkinson’s Disease in Functional MRI Studies,” by Stefan Holiga, Karsten Mueller, Harald E. Moller, Tomas Sieger, Matthias L. Schroeter, Josef Vymazal, Evzen Ruzicka, and Robert Jech (PLoS ONE 8(2): e56133. doi:10.1371/journal.pone.0056133, XML, HTML, and .pdf format, 7p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056133
D. “Accelerated Cell Aging in Female APOE-{epsilon}4 Carriers: Implications for Hormone Therapy Use,” by Emily G. Jacobs, Candyce Kroenke, Jue Lin, Elissa S. Epel, Heather A. Kenna, Elizabeth H. Blackburn, and Natalie L. Rasgon (PLoS ONE 8(2): e54713. doi:10.1371/journal.pone.0054713, XML, HTML, and .pdf format, 7p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054713
E. “Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI2/Tau Transgenic Mice,” by Holly J. Garringer, Jill Murrell, Neeraja Sammeta, Anita Gnezda, Bernardino Ghetti, and Ruben Vidal ( PLoS ONE 8(2): e56426. doi:10.1371/journal.pone.0056426, XML, HTML, and .pdf format, 11p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056426
“On the Socio-Economic Determinants of Frailty: Findings from Panel and Retrospective Data from SHARE,” by Nicolas Sirven (Working Paper No. 52, December 2012, .pdf format, 29p.).
Abstract:
Recent studies on the demand for long-term care emphasised the role of frailty as a specific precursor of disability besides chronic diseases. Frailty is defined as vulnerable health status resulting from the reduction of individuals’ reserve capacity. This medical concept is brought here in an economic framework in order to investigate the role social policies may play in preventing disability or maintaining life quality of people in a disablement process.
Using four waves of panel data from the Survey on Health, Ageing, and Retirement in Europe (SHARE), a frailty index is created as a count measure for five physiologic criteria (Fried model) for respondents aged 50+ in 10 European countries, between 2004 and 2011.
The longitudinal dimension is explored in two ways. First, differences in frailty dynamics over a seven-year-time period are analysed through variables that are relevant for social policy (income maintenance, housing adaptation, and prevention of social isolation) in a panel model for count data with fixed effects. Second, the individual fixed effects are decomposed by means of a random effects model with Mundlak specification. SHARE additional retrospective data on life history (SHARELIFE) are then used to investigate differences in frailty levels.
The results reveal the presence of various sources of social inequalities over the life-course. Social Protection Systems thus appear to play a major role in accompanying, preventing or reducing the frailty process. Several policy implications are suggested.
www.irdes.fr/EspaceAnglais/Publications/WorkingPapers/DT52SocioEconomicDeterminantsFrailty.pdf
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