“[beta}-Amyloid accumulation in the human brain after one night of sleep deprivation,” by Ehsan Shokri-Kojori, Gene-Jack Wang, Corinde E. Wiers, Sukru B. Demiral, Min Guo, Sung Won Kim, Elsa Lindgren, Veronica Ramirez, Amna Zehra, Clara Freeman, Gregg Miller, Peter Manza, Tansha Srivastava, Susan De Santi, Dardo Tomasi, Helene Benveniste and Nora D. Volkow (Vol. 115, No. 17, April 24, 2018, p. 4483-4488).
April 25, 2018
CAAR – Proceedings of the National Academies of Science Article Abstract – April 25, 2018
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April 12, 2018
CAAR – Public Library of Science (PLoS) Articles – April 12, 2018
A. “Memory deficiency, cerebral amyloid angiopathy, and amyloid-{beta} plaques in APP+PS1 double transgenic rat model of Alzheimer’s disease,” by Diana Klakotskaia, Cansu Agca, Rachel A. Richardson, Edward G. Stopa, Todd R. Schachtman, and Yuksel Agca (PLoS ONE 13(4): e0195469. doi.org/10.1371/journal.pone.0195469, XML, HTML, and .pdf format, 16p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0195469
B. “Inflammatory markers in postoperative delirium (POD) and cognitive dysfunction (POCD): A meta-analysis of observational studies,” by Xuling Liu, Yang Yu, and Shengmei Zhu (PLoS ONE 13(4): e0195659. doi.org/10.1371/journal.pone.0195659, XML, HTML, and .pdf format, p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0195659
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April 2, 2018
CAAR – Nature Neuroscience Article Abstract – April 2, 2018
“Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals,” by Heidi I. L. Jacobs, Trey Hedden, Aaron P. Schultz, Jorge Sepulcre, Rodrigo D. Perea, Rebecca E. Amariglio, Kathryn V. Papp, Dorene M. Rentz, Reisa A. Sperling & Keith A. Johnson (Vol. 21, No. 3, March 2018, p. 424-431).
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March 27, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 27, 2018
“Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality,” by Jatish Kumar, Hasier Erana, Elena López-Martínez, Nathalie Claes, Víctor F. Martín, Diego M. Solís, Sara Bals, Aitziber L. Cortajarena, Joaquín Castilla, and Luis M. Liz-Marzan (Vol. 115, No. 13, March 27, 2018, p. 3225-3230).
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March 6, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 6, 2018
A. “Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice,” by Kan Xie, Devon P. Ryan, Brandon L. Pearson, Kristin S. Henzel, Frauke Neff, Ramon O. Vidal, Magali Hennion, Isabelle Lehmann, Melvin Schleif, Susanne Schröder, Thure Adler, Birgit Rathkolb, Jan Rozman, Anna-Lena Schütz, Cornelia Prehn, Michel E. Mickael, Marco Weiergräber, Jerzy Adamski, Dirk H. Busch, Gerhard Ehninger, Anna Matynia, Walker S. Jackson, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Stefan Bonn, Martin Hrabe de Angelis and Dan Ehninger (Vol. 115, No. 10, March 6, 2018, p. E2348-E2357).
doi.org/10.1073/pnas.1707337115
B. “Environmental enrichment and exercise are better than social enrichment to reduce memory deficits in amyloid beta neurotoxicity,” by Mariza G. Prado Lima, Helen L. Schimidt, Alexandre Garcia, Letícia R. Daré, Felipe P. Carpes, Ivan Izquierdo and Pâmela B. Mello-Carpes (Vol. 115, No. 10, March 6, 2018, p. E2403-E2408).
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February 8, 2018
CAAR – Nature Letter Abstract – February 8, 2018
“High performance plasma amyloid-{beta} biomarkers for Alzheimer’s disease,” by Akinori Nakamura, Naoki Kaneko, Victor L. Villemagne, Takashi Kato, James Doecke, Vincent Doré, Chris Fowler, Qiao-Xin Li, Ralph Martins, Christopher Rowe, Taisuke Tomita, Katsumi Matsuzaki, Kenji Ishii, Kazunari Ishii, Yutaka Arahata, Shinichi Iwamoto, Kengo Ito, Koichi Tanaka, Colin L. Masters & Katsuhiko Yanagisawa (Vol. 554, No. , February 8, 2018, p. 249-254).
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January 23, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 23, 2018
A. “Structural heterogeneity and intersubject variability of A{beta} in familial and sporadic Alzheimer’s disease,” by Carlo Condello, Thomas Lemmin, Jan Stöhr, Mimi Nick, Yibing Wu, Alison M. Maxwell, Joel C. Watts, Christoffer D. Caro, Abby Oehler, C. Dirk Keene, Thomas D. Bird, Sjoerd G. van Duinen, Lars Lannfelt, Martin Ingelsson, Caroline Graff, Kurt Giles, William F. DeGrado, and Stanley B. Prusiner (Vol. 115, No. 4, January 23, 2018, .pdf and HTML format, p. E782-E791). Note: PNAS is providing open access to the full-text of this article.
www.pnas.org/content/115/4/E782.abstract
B. “GBA1 deficiency negatively affects physiological {alpha}-synuclein tetramers and related multimers,” by Sangjune Kim, Seung Pil Yun, Saebom Lee, George Essien Umanah, Veera Venkata Ratnam Bandaru, Xiling Yin, Peter Rhee, Senthilkumar S. Karuppagounder, Seung-Hwan Kwon, Hojae Lee, Xiaobo Mao, Donghoon Kim, Akhilesh Pandey, Gabsang Lee, Valina L. Dawson, Ted M. Dawson, and Han Seok Ko (Vol. 115, No. 4, January 23, 2018, p. 798-803).
www.pnas.org/content/115/4/798.abstract
C. “CFH and ARMS2 genetic risk determines progression to neovascular age-related macular degeneration after antioxidant and zinc supplementation,” by Demetrios G. Vavvas, Kent W. Small, Carl C. Awh, Brent W. Zanke, Robert J. Tibshirani, and Rafal Kustra (Vol. 115, No. 4, January 23, 2018, .pdf and HTML format, p. E696-E704). Note: PNAS is providing open access to the full-text of this article.
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January 18, 2018
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 18, 2018
A. “The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease,” by Chun Chen, Zhihao Wang, Zhentao Zhang, Xia Liu, Seong Su Kang, Ying Zhang, and Keqiang Ye (Vol. 115, No. 3, January 16, 2018, p. 578-583).
www.pnas.org/content/115/3/578.abstract
B. “Migration-based selections of antibodies that convert bone marrow into trafficking microglia-like cells that reduce brain amyloid {beta},” by Kyung Ho Han, Britni M. Arlian, Matthew S. Macauley, James C. Paulson, and Richard A. Lerner (Vol. 115, No. 3, January 16, 2018, p. E372-E381). Note: PNAS is providing open-access to the full-text of this article.
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January 9, 2018
CAAR – Nature Medicine Article Abstracts – January 9, 2018
A. “Amyloid-{beta} plaques enhance Alzheimer’s brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation,” by Zhuohao He, Jing L. Guo, Jennifer D. McBride, Sneha Narasimhan, Hyesung Kim, Lakshmi Changolkar, Bin Zhang, Ronald J. Gathagan, Cuiyong Yue, Christopher Dengler, Anna Stieber, Magdalena Nitla, Douglas A. Coulter, Ted Abel, Kurt R. Brunden, John Q. Trojanowski & Virginia M-Y Lee (Vol. 24, No. 1, January 2018, p. 29-38).
www.nature.com/articles/nm.4443
B. “cGAS drives noncanonical-inflammasome activation in age-related macular degeneration,” by Nagaraj Kerur, Shinichi Fukuda, Daipayan Banerjee, Younghee Kim, Dongxu Fu, Ivana Apicella, Akhil Varshney, Reo Yasuma, Benjamin J. Fowler, Elmira Baghdasaryan, Kenneth M. Marion, Xiwen Huang, Tetsuhiro Yasuma, Yoshio Hirano, Vlad Serbulea, Meenakshi Ambati, Vidya L. Ambati, Yuji Kajiwara, Kameshwari Ambati, Shuichiro Hirahara, Ana Bastos-Carvalho, Yuichiro Ogura, Hiroko Terasaki, Tetsuro Oshika, Kyung Bo Kim, David R. Hinton, Norbert Leitinger, John C. Cambier, Joseph D.Buxbaum, M. Cristina Kenney, S. Michal Jazwinski, Hiroshi Nagai, Isao Hara, A. Phillip West, Katherine A. Fitzgerald, SriniVas R. Sadda, Bradley D. Gelfand & Jayakrishna Ambati (Vol. 24, No. 1, January 2018, p. 50-61).
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December 14, 2017
CAAR – Nature Article Abstract – December 14, 2017
“Enhancing mitochondrial proteostasis reduces amyloid-{beta} proteotoxicity,” by Vincenzo Sorrentino, Mario Romani, Laurent Mouchiroud, John S. Beck, Hongbo Zhang, Davide D’Amico, Norman Moullan, Francesca Potenza, Adrien W. Schmid, Solene Rietsch, Scott E. Counts & Johan Auwerx (Vol. 552, No. 7684, December 14, 2017, p. 187-193).
www.nature.com/nature/journal/v552/n7684/abs/nature25143.html
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December 7, 2017
CAAR – Proceedings of the National Academies of Science Article Abstracts – December 7, 2017
A. “Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease,” by Jay Rasmussen, Jasmin Mahler, Natalie Beschorner, Stephan A. Kaeser, Lisa M. Häsler, Frank Baumann, Sofie Nyström, Erik Portelius, Kaj Blennow, Tammaryn Lashley, Nick C. Fox, Diego Sepulveda-Falla, Markus Glatzel, Adrian L. Oblak, Bernardino Ghetti, K. Peter R. Nilsson, Per Hammarström, Matthias Staufenbiel, Lary C. Walker, and Mathias Jucker (Vol. 114, No. 49, December 5, 2017, p. 13018-13023).
B. “Intercellular competition and the inevitability of multicellular aging,” by Paul Nelson and Joanna Masel (Vol. 114, No. 49, December 5, 2017, p. 12982–12987).
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November 30, 2017
CAAR – Public Library of Science (PLoS) Articles – November 30, 2017
A. “Assemblies of amyloid-{beta}<sub>30–36</sub> hexamer and its G33V/L34T mutants by replica-exchange molecular dynamics simulation,” by Zhenyu Qian, Qingwen Zhang, Yu Liu, and Peijie Chen (PLoS ONE 12(11): e0188794. doi.org/10.1371/journal.pone.0188794, XML, HTML, and .pdf format, 18p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0188794
B. “Elderly emergency patients presenting with non-specific complaints: Characteristics and outcomes,” by Joyce J. H. Wachelder, Patricia M. Stassen, Laura P. A. M. Hubens, Steffie H. A. Brouns, Suze L. E. Lambooij, Jeanne P. Dieleman, and Harm R. Haak (PLoS ONE 12(11): e0188954. doi.org/10.1371/journal.pone.0188954, XML, HTML, and .pdf format, 11p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0188954
C. “Identifying social factors amongst older individuals in linked electronic health records: An assessment in a population based study,” by Anu Jain, Albert J. van Hoek, Jemma L. Walker, Rohini Mathur, Liam Smeeth, and Sara L. Thomas (PLoS ONE 12(11): e0189038. doi.org/10.1371/journal.pone.0189038, XML, HTML, and .pdf format, 17p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0189038
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October 5, 2017
CAAR – Science Report Article – October 5, 2017
“Fibril structure of amyloid-{beta}(1–42) by cryo–electron microscopy,” by Lothar Gremer, Daniel Scholzel, Carla Schenk, Elke Reinartz, Jorg Labahn, Raimond B. G. Ravelli, Markus Tusche, Carmen Lopez-Iglesias, Wolfgang Hoyer, Henrike Heise, Dieter Willbold, and Gunnar F. Schroder (Vol. 358, No. 6359, October 6, 2017, p. 116-119).
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August 16, 2017
CAAR – Proceedings of the National Academies of Sciences Article Abstract – August 16, 2017
“Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways,” by Aleksandra M. Wojtas, Silvia S. Kang, Benjamin M. Olley, Maureen Gatherer, Mitsuru Shinohara, Patricia A. Lozano, Chia-Chen Liu, Aishe Kurti, Kelsey E. Baker, Dennis W. Dickson, Mei Yue, Leonard Petrucelli, Guojun Bu, Roxana O. Carare, and John D. Fryer (Vol. 114, No. 33, August 15, 2017, p. E6962-E6971). Note: PNAS is providing open access to the full-text of this article.
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June 15, 2017
CAAR – Journal of the American Medical Association Article – June 15, 2017
Note: The link below is to the table of contents for the current issue of JAMA (Vol. 317, No. 22, June 13, 2017). Check with your organization’s information center for availability.
jamanetwork.com/journals/jama/issue/317/22
“Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons,” by Michael C. Donohue, Reisa A. Sperling, Ronald Petersen, Chung-Kai Sun, Michael W. Weiner, and Paul S. Aisen, for the Alzheimer’s Disease Neuroimaging Initiative (p. 2305-2316).
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May 11, 2017
CAAR – Lancet Neurology Article Abstract – May 11, 2017
“Age-specific and sex-specific prevalence of cerebral {beta}-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50–95 years: a cross-sectional study,” by Clifford R. Jack Jr., Heather J. Wiste, Stephen D. Weigand, Terry M. Therneau, David S. Knopman, Val Lowe, Prashanthi Vemuri, Michelle M. Mielke, Rosebud O. Roberts, Mary M. Machulda, Matthew L. Senjem, Jeffrey L. Gunter, Walter A. Rocca, and Ronald C. Petersen (Vol. 16, No. 6, June 2017, p. 435-444).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30077-7/abstract
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February 10, 2017
CAAR – Public Library of Science (PLoS) Article – February 10, 2017
“{alpha}-Synuclein increases {beta}-amyloid secretion by promoting {beta}-/{gamma}-secretase processing of APP,” by Hazel L. Roberts, Bernard L. Schneider, and David R. Brown (PLoS ONE 12(2): e0171925. doi:10.1371/journal.pone.0171925, XML, HTML, and .pdf format, 22p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0171925
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December 8, 2016
CAAR – Nature Article Abstract – December 8, 2016
“Gamma frequency entrainment attenuates amyloid load and modifies microglia,” by Hannah F. Iaccarino, Annabelle C. Singer, Anthony J. Martorell, Andrii Rudenko, Fan Gao, Tyler Z. Gillingham, Hansruedi Mathys, Jinsoo Seo, Oleg Kritskiy, Fatema Abdurrob, Chinnakkaruppan Adaikkan, Rebecca G. Canter, Richard Rueda, Emery N. Brown, Edward S. Boyden & Li-Huei Tsai (Vol. 540, No. 7632, December 8, 2016, p. 230-235).
www.nature.com/nature/journal/v540/n7632/abs/nature20587.html
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November 18, 2016
CAAR – Science Letter Abstract – November 18, 2016
“Site-specific phosphorylation of tau inhibits amyloid-{beta} toxicity in Alzheimer’s mice,” by Arne Ittner, Sook Wern Chua, Josefine Bertz, Alexander Volkerling, Julia Van Der Hoven, Amadeus Gladbach, Magdalena Przybyla, Mian Bi, Annika Van Hummel, Claire H. Stevens, Stefania Ippati, Lisa S. Suh, Alexander Macmillan, Greg Sutherland, Jillian J. Kril, Ana P. G. Silva, Joel Mackay, Anne Poljak, Fabien Delerue, Yazi D. Ke, and Lars M. Ittner (Vol. 354, No. 6314, November 18, 2016, p. 904-908).
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November 9, 2016
CAAR – Public Library of Science (PLoS) Articles – November 9, 2016
A. “Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-{beta} Peptide in Mice,” by Maressa Caldeira Morzelle, Jocelem Mastrodi Salgado, Milena Telles, Danilo Mourelle, Patricia Bachiega, Hudson Sousa Buck, and Tania Araujo Viel (PLoS ONE 11(11): e0166123. doi:10.1371/journal.pone.0166123, XML, HTML, and .pdf format, 20p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0166123
B. “Rehabilitation Profiles of Older Adult Stroke Survivors Admitted to Intermediate Care Units: A Multi-Centre Study,” by Laura M. Perez, Marco Inzitari, Terence J. Quinn, Joan Montaner, Ricard Gavalda, Esther Duarte, Laura Coll-Planas, Merce Cerda, Sebastià Santaeugenia, Conxita Closa, and Miquel Gallofre (PLoS ONE 11(11): e0166304. doi:10.1371/journal.pone.0166304, XML, HTML, and .pdf format, 13p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0166304
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October 26, 2016
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – October 26, 2016
A. “Functional connectivity with the retrosplenial cortex predicts cognitive aging in rats,” by Jessica A. Ash, Hanbing Lu, Lisa R. Taxier, Jeffrey M. Long, Yihong Yang, Elliot A. Stein, and Peter R. Rapp (Vol. 113, No. 43, October 26, 2016, p. 12286-12291).
www.pnas.org/content/113/43/12286.abstract
B. “PPAR{gamma}-coactivator-1{alpha} gene transfer reduces neuronal loss and amyloid-{beta| generation by reducing {beta}-secretase in an Alzheimer’s disease model,” by Loukia Katsouri, Yau M. Lim, Katrin Blondrath, Ioanna Eleftheriadou, Laura Lombardero, Amy M. Birch, Nazanin Mirzaei, Elaine E. Irvine, Nicholas D. Mazarakis, and Magdalena Sastre (Vol. 113, No. 43, October 26, 2016, p. 12292–12297).
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October 18, 2016
CAAR – Proceedings of the National Academy Sciences Article Abstracts – October 18, 2016
A. “Exploring the aggregation free energy landscape of the amyloid-{beta} protein (1–40),” by Weihua Zheng, Min-Yeh Tsai, Mingchen Chen, and Peter G. Wolynes (Vol. 113, No. 42, October 18, 2016, p. 11835–11840).
www.pnas.org/content/113/42/11835.abstract.html?etoc
B. “Lifespan adversity and later adulthood telomere length in the nationally representative US Health and Retirement Study,” by Eli Puterman, Alison Gemmill, Deborah Karasek, David Weir, Nancy E. Adler, Aric A. Prather, and Elissa S. Epel (Vol. 113, No. 42, October 18, 2016, p. E6335–E6342).
www.pnas.org/content/113/42/11835.abstract.html?etoc
C. “Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK,” by Takafumi Ogawa, Ryohei Tsubakiyama, Muneyoshi Kanai, Tetsuya Koyama, Tsutomu Fujii, Haruyuki Iefuji, Tomoyoshi Soga, Kazunori Kume, Tokichi Miyakawa, Dai Hirata, and Masaki Mizunuma (Vol. 113, No. 42, October 18, 2016, p. 11913–11918).
www.pnas.org/content/113/42/11913.abstract.html?etoc
D. “Amyloid-{beta} effects on synapses and memory require AMPA receptor subunit GluA3,” by Niels R. Reinders, Yvonne Pao, Maria C. Renner, Carla M. da Silva-Matos, Tessa R. Lodder, Roberto Malinow, and Helmut W. Kessels (Vol. 113, No. 42, October 18, 2016, p. E6526–E6534).
www.pnas.org/content/113/42/E6526.abstract.html?etoc
E. “Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer’s disease,” by Xiuming Zhang, Elizabeth C. Mormino, Nanbo Sun, Reisa A. Sperling, Mert R. Sabuncu, B. T. Thomas Yeo, and the Alzheimer’s Disease Neuroimaging Initiative (Vol. 113, No. 42, October 18, 2016, p. E6535–E6544).
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September 27, 2016
CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 27, 2016
“A{beta}42 assembles into specific {beta}-barrel pore-forming oligomers in membrane-mimicking environments,” by Montserrat Serra-Batiste, Martí Ninot-Pedrosa, Mariam Bayoumi, Margarida Gairí, Giovanni Maglia, and Natàlia Carulla (Vol. 113, No. 39, September 28, 2016, p. 10866–10871).
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CAAR – Public Library of Science (PLoS) Article – September 27, 2016
“The Role of Neutrophil Proteins on the Amyloid Beta-RAGE Axis,” by Amanda J. Stock, Anne Kasus-Jacobi, Jonathan D. Wren, Virginie H. Sjoelund, Glenn D. Prestwich, and H. Anne Pereira (PLoS ONE 11(9): e0163330. doi:10.1371/journal.pone.0163330, XML, HTML, and .pdf format, 29p.).
journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0163330
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September 1, 2016
CAAR – Nature Article Abstract – September 1, 2016
“The antibody aducanumab reduces A{beta} plaques in Alzheimer’s disease,” by Jeff Sevigny, Ping Chiao, Thierry Bussière, Paul H. Weinreb, Leslie Williams, Marcel Maier, Robert Dunstan, Stephen Salloway, Tianle Chen, Yan Ling, John O’Gorman, Fang Qian, Mahin Arastu, Mingwei Li, Sowmya Chollate, Melanie S. Brennan, Omar Quintero-Monzon, Robert H. Scannevin, H. Moore Arnold, Thomas Engber, Kenneth Rhodes, James Ferrero, Yaming Hang, Alvydas Mikulskis, Jan Grimm, Christoph Hock, Roger M. Nitsch & Alfred Sandrock (Vol. 537, No. 7618, September 1, 2016, p. 50-56).
www.nature.com/nature/journal/v537/n7618/abs/nature19323.html
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August 30, 2016
CAAR – Proceedings of the National Academy of Science Article Abstracts – August 30, 2016
A. “Holdase activity of secreted Hsp70 masks amyloid-{beta}42 neurotoxicity in Drosophila,” by Pedro Fernandez-Funez, Jonatan Sanchez-Garcia, Lorena de Mena, Yan Zhang, Yona Levites, Swati Khare, Todd E. Golde, and Diego E. Rincon-Limas (Vol. 113, No. 35, August 30, 2016, p. E5212–E5221).
www.pnas.org/content/113/35/E5212.abstract.html?etoc
B. “Glimpse of natural selection of long-lived T-cell clones in healthy life,” by Baojun Zhang, Qingzhu Jia, Cheryl Bock, Gang Chen, Haili Yu, Qingshan Ni, Ying Wan, Qijing Li, and Yuan Zhuang (Vol. 113, No. 35, August 30, 2016, p. 9858–9863).
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May 17, 2016
CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 17, 2016
“Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits,” by Marius Kollmer, Katrin Meinhardt, Christian Haupt, Falk Liberta, Melanie Wulff, Julia Linder, Lisa Handl, Liesa Heinrich, Cornelia Loos, Matthias Schmidt, Tatiana Syrovets, Thomas Simmet, Per Westermark, Gunilla T. Westermark, Uwe Horn, Volker Schmidt, Paul Walther, and Marcus Fandrich (Vol. 113, No. 3, May 17, 2016, p. 5604-5609).
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January 28, 2016
CAAR – Public Library of Science (PLoS) Article – January 28, 2016
“The Amyloid Precursor Protein of Alzheimer’s Disease Clusters at the Organelle/Microtubule Interface on Organelles that Bind Microtubules in an ATP Dependent Manner,” by James W. Stevenson, Eliza A. Conaty, Rylie B. Walsh, Paul J. Poidomani, Colin M. Samoriski, Brianne J. Scollins, and Joseph A. DeGiorgis (PLoS ONE 11(1): e0147808. doi:10.1371/journal.pone.0147808, XML, HTML, and .pdf format, 17p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0147808
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January 8, 2016
CAAR – Public Library of Science (PLoS) Articles – January 8, 2016
A. “A Monte Carlo Study of the Early Steps of Functional Amyloid Formation,” by Pengfei Tian, Kresten Lindorff-Larsen, Wouter Boomsma, Mogens Hogh Jensen, and Daniel Erik Otzen (PLoS ONE 11(1): e0146096. doi:10.1371/journal.pone.0146096, XML, HTML, and .pdf format, 18p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0146096
B. “RAGE and AGEs in Mild Cognitive Impairment of Diabetic Patients: A Cross-Sectional Study,” by Pin Wang, Rong Huang, Sen Lu, Wenqing Xia, Rongrong Cai, Haixia Sun, and Shaohua Wang (PLoS ONE 11(1): e0145521. doi:10.1371/journal.pone.0145521, XML, HTML, and .pdf format, 15p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0145521
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December 8, 2015
CAAR – Lancet Neurology Article Abstract – December 8, 2015
“Transition rates between amyloid and neurodegeneration biomarker states and to dementia: a population-based, longitudinal cohort study,” by Clifford R. Jack Jr., Terry M. Therneau, Heather J. Wiste, Stephen D. Weigand, David S. Knopman, Val J. Lowe, Michelle M. Mielke, Prashanthi Vemuri, Rosebud O. Roberts, Mary M. Machulda, Matthew L. Senjem, Jeffrey L. Gunter, Walter A. Rocca, and Ronald C. Petersen (Vol. 15, No. 1, January 2016, p. 56-64).
www.thelancet.com/journals/laneur/article/PIIS1474-4422(15)00323-3/abstract
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November 30, 2015
CAAR – Public Library of Science (PLoS) Article – November 30, 2015
“Amyloid Precursor Protein Translation Is Regulated by a 3’UTR Guanine Quadruplex,” by Ezekiel Crenshaw, Brian P. Leung, Chun Kit Kwok, Michal Sharoni, Kalee Olson, Neeraj P. Sebastian, Sara Ansaloni, Reinhard Schweitzer-Stenner, Michael R. Akins, Philip C. Bevilacqua, and Aleister J. Saunders (PLoS ONE 10(11): e0143160. doi:10.1371/journal.pone.0143160, HTML, XML, and .pdf format, 18p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0143160
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November 25, 2015
CAAR – Nature Neuroscience Brief Communications Abstract – November 25, 2015
“Decreased amyloid-{beta} and increased neuronal hyperactivity by immunotherapy in Alzheimer’s models,” by Marc Aurel Busche, Christine Grienberger, Aylin D. Keskin, Beomjong Song, Ulf Neumann, Matthias Staufenbiel, Hans Forstl & Arthur Konnerth (Vol. 18, No. 12, December 2015, p. 1725-1727).
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October 27, 2015
CAAR – Nature Neuroscience Brief Communication, Article Abstracts – October 27, 2015
A. “CD33 modulates TREM2: convergence of Alzheimer loci,” by Gail Chan, Charles C White, Phoebe A. Winn, Maria Cimpean, Joseph M. Replogle, Laura R. Glick, Nicole E. Cuerdon, Katie J. Ryan, Keith A. Johnson, Julie A. Schneider, David A. Bennett, Lori B. Chibnik, Reisa A. Sperling, Elizabeth M. Bradshaw & Philip L. De Jager (Vol. 18, No. 11, November 2015, p. 1556-1558).
www.nature.com/neuro/journal/v18/n11/abs/nn.4126.html
B. “Persistence of A{beta} seeds in APP null mouse brain,” by Lan Ye, Sarah K. Fritschi, Juliane Schelle, Ulrike Obermüller, Karoline Degenhardt, Stephan A. Kaeser, Yvonne S. Eisele, Lary C. Walker, Frank Baumann, Matthias Staufenbiel & Mathias Jucker (Vol. 18, No. 11, November 2015, p. 1559-1561).
www.nature.com/neuro/journal/v18/n11/abs/nn.4117.html
C. “Rescue of long-range circuit dysfunction in Alzheimer’s disease models,” by Marc Aurel Busche, Maja Kekus, Helmuth Adelsberger, Takahiro Noda, Hans Forstl, Israel Nelken & Arthur Konnerth (Vol. 18, No. 11, November 2015, p. 1623-1630).
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October 14, 2015
CAAR – Nature Letter Abstract – October 14, 2015
“{Eta}-Secretase processing of APP inhibits neuronal activity in the hippocampus,” by Michael Willem, Sabina Tahirovic, Marc Aurel Busche, Saak V. Ovsepian, Magda Chafai, Scherazad Kootar, Daniel Hornburg, Lewis D. B. Evans, Steven Moore, Anna Daria, Heike Hampel, Veronika Muller, Camilla Giudici, Brigitte Nuscher, Andrea Wenninger-Weinzierl, Elisabeth Kremmer, Michael T. Heneka, Dietmar R. Thal, Vilmantas Giedraitis, Lars Lannfelt, Ulrike Muller, Frederick J. Livesey, Felix Meissner, Jochen Herms, Arthur Konnerth, Helene Marie & Christian Haass (Vol. 526, No. 7375, October 14, 2015, p. 443-447).
www.nature.com/nature/journal/v526/n7573/abs/nature14864.html
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September 22, 2015
CAAR – Proceedings of the National Academies of Science Article Abstracts – September 22, 2015
A. “Peptide dimer structure in an A{beta}(1–42) fibril visualized with cryo-EM,” by Matthias Schmidt, Alexis Rohou, Keren Lasker, Jay K. Yadav, Cordelia Schiene-Fischer, Marcus Fändrich, and Nikolaus Grigorieff (Vol. 112, No. 38, September 22, 2015, .pdf and HTML format, p. 11858-11863). Note: PNAS is providing open access to the full-text of this article.
www.pnas.org/content/112/38/11858.abstract
B. “Evidence for {alpha}-synuclein prions causing multiple system atrophy in humans with parkinsonism,” by Stanley B. Prusiner, Amanda L. Woerman, Daniel A. Mordes, Joel C. Watts, Ryan Rampersaud, David B. Berry, Smita Patel, Abby Oehler, Jennifer K. Lowe, Stephanie N. Kravitz, Daniel H. Geschwind, David V. Glidden, Glenda M. Halliday, Lefkos T. Middleton, Steve M. Gentleman, Lea T. Grinberg, and Kurt Giles (Vol. 112, No. 38, September 22, 2015, p. 11858-11863).
www.pnas.org/content/112/38/E5308.abstract
C. “Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer’s disease pathogenesis,” by Li Zhu, Minghao Zhong, Gregory A. Elder, Mary Sano, David M. Holtzman, Sam Gandy, Christopher Cardozo, Vahram Haroutunian, Nikolaos K. Robakis, and Dongming Cai (Vol. 112, No. 38, September 22, 2015, .pdf and HTML format, p. 11965-11970). Note: PNAS is providing open access to the full-text of this article.
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September 9, 2015
CAAR – Nature Letter Abstract – September 9, 2015
“Evidence for human transmission of amyloid-{beta} pathology and cerebral amyloid angiopathy,” by Zane Jaunmuktane, Simon Mead, Matthew Ellis, Jonathan D. F. Wadsworth, Andrew J. Nicoll, Joanna Kenny, Francesca Launchbury, Jacqueline Linehan, Angela Richard-Loendt, A. Sarah Walker, Peter Rudge, John Collinge & Sebastian Brandner (Vol. 525, No. 7568, September 9, 2015, p. 247-250).
www.nature.com/nature/journal/v525/n7568/abs/nature15369.html
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September 4, 2015
CAAR – Nature Medicine Letter Abstract – September 4, 2015
“APP intracellular domain–WAVE1 pathway reduces amyloid-{beta} production,” by Ilaria Ceglia, Christiane Reitz, Jodi Gresack, Jung-Hyuck Ahn, Victor Bustos, Marina Bleck, Xiaozhu Zhang, Grant Martin, Sanford M. Simon, Angus C. Nairn, Paul Greengard & Yong Kim (Vol. 21, No. 9, September 2015, p. 1054-1059).
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August 6, 2015
CAAR – Public Library of Science (PLoS) Article – August 6, 2015
“Obesity and Hepatic Steatosis Are Associated with Elevated Serum Amyloid Beta in Metabolically Stressed APPswe/PS1dE9 Mice,” by Feng-Shiun Shie, Young-Ji Shiao, Chih-Wen Yeh, Chien-Hung Lin, Tsai-Teng Tzeng, Hao-Chieh Hsu, Fong-Lee Huang, Huey-Jen Tsay, and Hui-Kang Liu (PLoS ONE 10(8): e0134531. doi:10.1371/journal.pone.0134531, XML, HTML, and .pdf format, p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0134531
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July 29, 2015
CAAR -Nature Neuroscience Resource Abstract – July 29, 2015
“Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice,” by Meaghan Morris, Giselle M. Knudsen, Sumihiro Maeda, Jonathan C. Trinidad, Alexandra Ioanoviciu, Alma L. Burlingame & Lennart Mucke (Vol. 18, No. 8, August 2015, p. 1183-1189).
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July 14, 2015
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 14, 2015
A. “Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques,” by Swetha Gowrishankar, Peng Yuan, Yumei Wu, Matthew Schrag, Summer Paradise, Jaime Grutzendler, Pietro De Camilli, and Shawn M. Ferguson (Vol. 112, No. 28, July 14, 2015, p. 8768–8773).
www.pnas.org/content/112/28/8768.abstract.html?etoc
B. “Neural activity and CaMKII protect mitochondria from fragmentation in aging Caenorhabditis elegans neurons,” by Hao-Ching Jiang, Jiun-Min Hsu, Chien-Ping Yen, Chi-Chao Chao, Ruey-Hwa Chen, and Chun-Liang Pan (Vol. 112, No. 28, July 14, 2015, p. E3699–E3708).
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July 7, 2015
CAAR – Nature Medicine Letter Abstract – July 7, 2015
“Inhibition of amyloid-[beta] plaque formation by [alpha]-synuclein,” by Teresa Bachhuber, Natalie Katzmarski, Joanna F McCarter, Desiree Loreth, Sabina Tahirovic, Frits Kamp, Claudia Abou-Ajram, Brigitte Nuscher, Alberto Serrano-Pozo, Alexandra Muller, Marco Prinz, Harald Steiner, Bradley T. Hyman, Christian Haass & Melanie Meyer-Luehmann (Vol. 21, No. 7, July 2015, p. 802-807).
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June 25, 2015
CAAR – Nature Neuroscience Article Abstracts – June 25, 2015
A. “Central role for PICALM in amyloid-[beta] blood-brain barrier transcytosis and clearance,” by Zhen Zhao, Abhay P. Sagare, Qingyi Ma, Matthew R. Halliday, Pan Kong, Kassandra Kisler, Ethan A. Winkler, Anita Ramanathan, Takahisa Kanekiyo, Guojun Bu, Nelly Chuqui Owens, Sanket V. Rege, Gabriel Si, Ashim Ahuja, Donghui Zhu, Carol A. Miller, Julie A. Schneider, Manami Maeda, Takahiro Maeda, Tohru Sugawara, Justin K. Ichida & Berislav V. Zlokovic (Vol. 18, No. 7, July 2015, p. 978-987).
www.nature.com/neuro/journal/v18/n7/abs/nn.4025.html
B. “[beta]-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation,” by Bryce A. Mander, Shawn M. Marks, Jacob W. Vogel, Vikram Rao, Brandon Lu, Jared M. Saletin, Sonia Ancoli-Israel, William J. Jagust & Matthew P. Walker (Vol. 18, No. 7, July 2015, p. 1051-1057).
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May 27, 2015
CAAR – Nature Neuroscience Article, Perspectives Abstracts – May 27, 2015
A. “Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson’s disease,” by Ariadna Laguna, Nicoletta Schintu, Andre Nobre, Alexandra Alvarsson, Nikolaos Volakakis, Jesper Kjaer Jacobsen, Marta Gomez-Galan, Elena Sopova, Eliza Joodmardi, Takashi Yoshitake, Qiaolin Deng, Jan Kehr, Johan Ericson, Per Svenningsson, Oleg Shupliakov & Thomas Perlmann (Vol. 18, No. 6, June 2015, p. 825-835).
www.nature.com/neuro/journal/v18/n6/abs/nn.4004.html
B. “The case for rejecting the amyloid cascade hypothesis,” by Karl Herrup (Vol. 18, No. 6, June 2015, p. 794-799).
www.nature.com/neuro/journal/v18/n6/abs/nn.4017.html
C. “Three dimensions of the amyloid hypothesis: time, space and ‘wingmen’,” by Erik S. Musiek & David M. Holtzman (Vol. 18, No. 6, June 2015, p. 800-806).
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May 19, 2015
CAAR – Journal of the American Medical Association Articles – May 19, 2015
Note: The link below is to the table of contents for the current issue of JAMA (Vol. 313, No. 19, May 19, 2015). Check with your organization’s information center/library for availability.
A. “Prevalence of Amyloid PET Positivity in Dementia Syndromes: A Meta-analysis,” by Rik Ossenkoppele, Willemijn J. Jansen, Gil D. Rabinovici, Dirk L. Knol, Wiesje M. van der Flier, Bart N. M. van Berckel, Philip Scheltens, Pieter Jelle Visser, and the Amyloid PET Study Group (p. 1939-1949).
B. “Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia: A Meta-analysis,” by Willemijn J. Jansen, Rik Ossenkoppele, Dirk L. Knol, Betty M. Tijms, Philip Scheltens, Frans R. J. Verhey, Pieter Jelle Visser, and the Amyloid Biomarker Study Group (p. 1924-1938).
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May 5, 2015
CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 5, 2015
“pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers,” by Kevin W. Tipping, Theodoros K. Karamanos, Toral Jakhria, Matthew G. Iadanza, Sophia C. Goodchild, Roman Tuma, Neil A. Ranson, Eric W. Hewitt, and Sheena E. Radford (Vol. 112, No. 18, May 6, 2015, p. 5691–5696).
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April 28, 2015
CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 28, 2015
“Zinc as chaperone-mimicking agent for retardation of amyloid {beta} peptide fibril formation,” by Axel Abelein, Astrid Graslund, and Jens Danielsson (Vol. 112, No. 17, April 28, 2015, p. 5407-5412).
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April 21, 2015
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – April 21, 2015
A. “Structural characterization of toxic oligomers that are kinetically trapped during {alpha}-synuclein fibril formation,” by Serene W. Chen, Srdja Drakulic, Emma Deas, Myriam Ouberai, Francesco A. Aprile, Rocío Arranz, Samuel Ness, Cintia Roodveldt, Tim Guilliams, Erwin J. De-Genst, David Klenerman, Nicholas W. Wood, Tuomas P.J. Knowles, Carlos Alfonso, Germán Rivas, Andrey Y. Abramov, Jose María Valpuesta, Christopher M. Dobson, and Nunilo Cremades (Vol. 112, No. 16, April 21, 2015, p. E1994–E2003).
www.pnas.org/content/112/16/E1994.abstract
B. “Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive deficits,” by Shu-Sheng Jiao, Xiu-Qing Yao, Yu-Hui Liu, Qing-Hua Wang, Fan Zeng, Jian-Jun Lu, Jia Liu, Chi Zhu, Lin-Lin Shen, Cheng-Hui Liu, Ye-Ran Wang, Gui-Hua Zeng, Ankit Parikh, Jia Chen, Chun-Rong Liang, Yang Xiang, Xian-Le Bu, Juan Deng, Jing Li, Juan Xu, Yue-Qin Zeng, Xiang Xu, Hai-Wei Xu, Jin-Hua Zhong, Hua-Dong Zhou, Xin-Fu Zhou, and Yan-Jiang Wang (Vol. 112, No. 16, April 21, 2015, p. 5225-5230). Note: PNAS is providing open access to the full-text of this article.
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March 17, 2015
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 17, 2015
A. “Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH Open,” by Shangyu Dang, Shenjie Wu, Jiawei Wang, Hongbo Li, Min Huang, Wei He, Yue-Ming Li, Catherine C. L. Wong, and Yigong Shi (Vol. 112, No. 11, March 17, 2015, .pdf and HTML format, p. 3344–3349). Note: PNAS is providing open access to the full-text of this article.
www.pnas.org/content/112/11/3344.abstract.html?etoc
B. “Insulin resistance in brain alters dopamine turnover and causes behavioral disorders,” by Andre Kleinridders, Weikang Cai, Laura Cappellucci, Armen Ghazarian, William R. Collins, Sara G. Vienberg, Emmanuel N. Pothos, and C. Ronald Kahn (Vol. 112, No. 11, March 17, 2015, p. 3463–3468).
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February 24, 2015
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 24, 2015
A. “Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice,” by Changgui Gua, Claudia P. Coomans, Kun Hub, Frank A. J. L. Scheer, H. Eugene Stanley, and Johanna H. Meijer (Vol. 112, No. 8, February 24, 2015, p. 2320-2324).
www.pnas.org/content/112/8/2320.abstract
B. “C-terminal sequence of amyloid-resistant type F apolipoprotein A-II inhibits amyloid fibril formation of apolipoprotein A-II in mice,” by Jinko Sawashita, Beiru Zhang, Kazuhiro Hasegawa, Masayuki Mori, Hironobu Naiki, Fuyuki Kametani, and Keiichi Higuchi (Vol. 112, No. 8, February 24, 2015, p. E836–E845).
www.pnas.org/content/112/8/E836.abstract
C. “Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice,” by Byung Hee Han, Meng-liang Zhou, Andrew W. Johnson, Itender Singh, Fan Liao, Ananth K. Vellimana, James W. Nelson, Eric Milner, John R. Cirrito, Jacob Basak, Min Yoo, Hans H. Dietrich, David M. Holtzman, and Gregory Joseph Zipfel (Vol. 112, No. 8, February 24, 2015, p. E881–E890). Note: PNAS is providing open access to the full-text of this article.
www.pnas.org/content/112/8/E881.abstract
D. “Metabolic resting-state brain networks in health and disease,” by Phoebe G. Spetsieris, Ji Hyun Ko, Chris C. Tang, Amir Nazem, Wataru Sako, Shichun Peng, Yilong Ma, Vijay Dhawan, and David Eidelberg (Vol. 112, No. 8, February 24, 2015, p. 2563–2568).
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January 29, 2015
CAAR – Public Library of Science (PLoS) Article – January 29, 2015
“The Resveratrol Trimer Miyabenol C Inhibits {beta}-Secretase Activity and {beta}-Amyloid Generation,” by Jin Hu, Ting Lin, Yuehong Gao, Junyue Xu, Chao Jiang, Guanghui Wang, Guojun Bu, Huaxi Xu, Haifeng Chen, and Yun-wu Zhang (PLoS ONE 10(1): e0115973. doi:10.1371/journal.pone.0115973, XML, HTML, and .pdf format, 13p.).
journals.plos.org/plosone/article?id=10.1371/journal.pone.0115973
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