CDHA CAAR

March 24, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 24, 2021

Rapid initiation of cell cycle reentry processes protects neurons from amyloid-{beta} toxicity,” by Stefania Ippati, Yuanyuan Deng, Julia van der Hoven, Celine Heu, Annika van Hummel, Sook Wern Chua, Esmeralda Paric, Gabriella Chan, Astrid Feiten, Thomas Fath, Yazi D. Ke, Nikolas K. Haass, and Lars M. Ittner (Vol. 118, No. 12, March 23, 2021, e2011876118).

www.pnas.org/content/118/12/e2011876118.abstract?etoc

 

March 4, 2021

CAAR – Public Library of Science (PLoS) Articles – March 4, 2021

Filed under: Reports and Articles — Tags: , , , , — admin @ 7:01 pm

A. “The social support networks of elderly people in Slovenia during the Covid-19 pandemic,” by Marjan Cugmas, Anuška Ferligoj, Tina Kogovšek, and Zenel Batagelj (PLoS ONE 16(3): e0247993. doi.org/10.1371/journal.pone.0247993, XML, HTML, and .pdf format, 16p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0247993

B. “Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta,” by Maruf Mohammad Akbor, Nobuyuki Kurosawa, Hiroki Nakayama, Ayumi Nakatani, Koji Tomobe, Yoichi Chiba, Masaki Ueno, Masashi Tanaka, Yasuyuki Nomura, and Masaharu Isobe (PLoS ONE 16(3): e0248027. doi.org/10.1371/journal.pone.0248027, XML, HTML, and .pdf format, 23p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0248027

C. “Depression and frailty in older adults: A population-based cohort study,” by Fabiana Araújo Figueiredo Da Mata, Marilia Miranda Forte Gomes, Jair Lício Ferreira Santos, Yeda Aparecida de Oliveira Duarte, and Mauricio Gomes Pereira (PLoS ONE 16(3): e0247766. doi.org/10.1371/journal.pone.0247766, XML, HTML, and .pdf format, 15p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0247766

January 28, 2021

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 28, 2021

Filed under: Reports and Articles — Tags: , — admin @ 5:05 pm

A. “Molecular structure of a prevalent amyloid-{beta} fibril polymorph from Alzheimer’s disease brain tissue,” by Ujjayini Ghosh, Kent R. Thurber, Wai-Ming Yau, and Robert Tycko (Vol. 118, No. 4, January 26, 2021, e2023089118).

www.pnas.org/content/118/4/e2023089118.abstract?etoc

B. “Hydrogen sulfide is neuroprotective in Alzheimer’s disease by sulfhydrating GSK3{beta} and inhibiting Tau hyperphosphorylation,” by Daniel Giovinazzo, Biljana Bursac, Juan I. Sbodio, Sumedha Nalluru, Thibaut Vignane, Adele M. Snowman, Lauren M. Albacarys, Thomas W. Sedlak, Roberta Torregrossa, Matthew Whiteman, Milos R. Filipovic, Solomon H. Snyder, and Bindu D. Paul (Vol. 118, No. 4, January 26, 2021, e2017225118).

www.pnas.org/content/118/4/e2017225118.abstract?etoc

January 4, 2021

CAAR – Public Library of Science (PLoS) Article – January 4, 2021

Filed under: Reports and Articles — Tags: , — admin @ 6:26 pm

Aptamarker prediction of brain amyloid-{beta} status in cognitively normal individuals at risk for Alzheimer’s disease,” by Gregory Penner, Soizic Lecocq, Anaëlle Chopin, Ximena Vedoya, Simone Lista, Andrea Vergallo, Enrica Cavedo, Francois-Xavier Lejeune, Bruno Dubois, Harald Hampel, the INSIGHT-preAD study group, for the Alzheimer Precision Medicine Initiative (APMI) (PLoS ONE 16(1): e0243902. doi.org/10.1371/journal.pone.0243902, XML, HTML, and .pdf format, 14p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0243902

November 30, 2020

CAAR – Nature Neuroscience Articles – November 30, 2020

Filed under: Reports and Articles — Tags: , , , — admin @ 4:43 pm

Note: Check with your organization’s library for availability.

A. “Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease,” by Kevin Richetin, Pascal Steullet, Mathieu Pachoud, Romain Perbet, Enea Parietti, Mathischan Maheswaran, Sabiha Eddarkaoui, Séverine Bégard, Catherine Pythoud, Maria Rey, Raphaëlle Caillierez, Kim Q. Do, Sophie Halliez, Paola Bezzi, Luc Buée, Geneviève Leuba, Morvane Colin, Nicolas Toni & Nicole Déglon (Vol. 23, No. 12, December 2020, p. 1567-1579).

www.nature.com/articles/s41593-020-00728-x

B. “Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2- production,” by Heejung Chun, Hyeonjoo Im, You Jung Kang, Yunha Kim, Jin Hee Shin, Woojin Won, Jiwoon Lim, Yeonha Ju, Yongmin Mason Park, Sunpil Kim, Seung Eun Lee, Jaekwang Lee, Junsung Woo, Yujin Hwang, Hyesun Cho, Seonmi Jo, Jong-Hyun Park, Daesoo Kim, Doo Yeon Kim, Jeong-Sun Seo, Byoung Joo Gwag, Young Soo Kim, Ki Duk Park, Bong-Kiun Kaang, Hansang Cho, Hoon Ryu & C. Justin Lee (Vol. 23, No. 12, December 2020, p. 1555–1566).

www.nature.com/articles/s41593-020-00735-y

C. “Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life,” by Ruth E. Uhlmann, Christine Rother, Jay Rasmussen, Juliane Schelle, Carina Bergmann, Emily M. Ullrich Gavilanes, Sarah K. Fritschi, Anika Buehler, Frank Baumann, Angelos Skodras, Rawaa Al-Shaana, Natalie Beschorner, Lan Ye, Stephan A. Kaeser, Ulrike Obermüller, Søren Christensen, Fredrik Kartberg, Jeffrey B. Stavenhagen, Jens-Ulrich Rahfeld, Holger Cynis, Fang Qian, Paul H. Weinreb, Thierry Bussiere, Lary C. Walker, Matthias Staufenbiel & Mathias Jucker (Vol. 23, No. 12, December 2020, p. 1580-1588).

www.nature.com/articles/s41593-020-00737-w

November 19, 2020

CAAR – Nature Article – November 19, 2020

Filed under: Reports and Articles — Tags: , — admin @ 8:23 pm

Note: Check with your organization’s library for availability. “Molecular dissection of amyloid disaggregation by human HSP70,” by Anne S. Wentink, Nadinath B. Nillegoda, Jennifer Feufel, Gabriele Ubartaite, Carolyn P. Schneider, Paolo De Los Rios, Janosch Hennig, Alessandro Barducci & Bernd Bukau (Vol. 587, No. 7834, November 19, 2020, p. 483-488).

www.nature.com/articles/s41586-020-2904-6

 

September 29, 2020

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – September 29, 2020

Filed under: Reports and Articles — Tags: , — admin @ 7:36 pm

A. “Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors,” by Thomas C. T. Michaels, Andela Saric, Georg Meisl, Gabriella T. Heller, Samo Curk, Paolo Arosio, Sara Linse, Christopher M. Dobson, Michele Vendruscolo, and Tuomas P. J. Knowles (Vol. 117, No. 39, September 29, 2020, p. 24251-24257).

www.pnas.org/content/117/39/24251.abstract.html?etoc

B. “Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson’s disease,” by Eun Hee Ahn, Seong Su Kang, Qi Qi, Xia Liu, and Keqiang Ye (Vol. 117, No. 39, September 29, 2020, p. 24503-24513).

www.pnas.org/content/117/39/24503.abstract.html?etoc

September 23, 2020

CAAR – Public Library of Science (PLoS) Articles – September 23, 2020

Filed under: Reports and Articles — Tags: , — admin @ 8:02 pm

A. “Test-retest reliability of spatial navigation in adults at-risk of Alzheimer’s disease,” by Gillian Coughlan, Vaisakh Puthusseryppady, Ellen Lowry, Rachel Gillings, Hugo Spiers, Anne-Marie Minihane, and Michael Hornberger (PLoS ONE 15(9): e0239077. doi.org/10.1371/journal.pone.0239077, XML, HTML, and .pdf format, 13p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0239077

B. “Familial Alzheimer’s disease mutations at position 22 of the amyloid {beta}-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system,” by Christian Tackenberg, Luka Kulic, and Roger M. Nitsch (PLoS ONE 15(9): e0239584. doi.org/10.1371/journal.pone.0239584, XML, HTML, and .pdf format, 14p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0239584

August 19, 2020

CAAR – Proceedings of the National Academy of Sciences Articles – August 19, 2020

Filed under: Reports and Articles — Tags: , , — admin @ 5:37 pm

Note: Check with your organization’s library for availability.

A. “Differences in the free energies between the excited states of A{beta}40 and A{beta}42 monomers encode their aggregation propensities,” by Debayan Chakraborty, John E. Straub, and D. Thirumalai (Vol. 117, No. 33, August 18, 2020, p. 19926-19937).

www.pnas.org/content/117/33/19926

B. “Parkinson’s disease-related phosphorylation at Tyr39 rearranges {alpha}-synuclein amyloid fibril structure revealed by cryo-EM,” by Kun Zhao, Yeh-Jun Lim, Zhenying Liu, Houfang Long, Yunpeng Sun, Jin-Jian Hu, Chunyu Zhao, Youqi Tao, Xing Zhang, Dan Li, Yan-Mei Li, and Cong Liu (Vol. 117, No. 33, August 18, 2020, p. 20305-20315).

www.pnas.org/content/117/33/20305

June 23, 2020

CAAR – Proceedings of the National Academy of Sciences Article – June 23, 2020

Note: Check with your organization’s library for availability. “Cerebral amyloid angiopathy-linked {beta}-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen,” by Steven A. Cajamarca, Erin H. Norris, Louise van der Weerd, Sidney Strickland, and Hyung Jin Ahn (Vol. 117, No. 25, June 23, 2020, p. 14482-14492).

www.pnas.org/content/117/25/14482

May 27, 2020

CAAR – Proceedings of the National Academy of Science Article – May 27, 2020

Note: Check with your organization’s library for availability. “Ultrastructural evidence for self-replication of Alzheimer-associated A{beta}42 amyloid along the sides of fibrils,” by Mattias Törnquist, Risto Cukalevski, Ulrich Weininger, Georg Meisl, Tuomas P. J. Knowles, Thom Leiding, Anders Malmendal, Mikael Akke, and Sara Linse (Vol. 117, No. 21, May 26, 2020, p. 11265-11273).

www.pnas.org/content/117/21/11265

March 26, 2020

CAAR – Proceedings of the National Academy of Science Articles – March 26, 2020

Filed under: uncategorized — Tags: , , , — admin @ 5:11 pm

Note: Check with your organization’s library for availability.

A. “Disruption of cellular proteostasis by H1N1 influenza A virus causes alpha-synuclein aggregation,” by Rita Marreiros, Andreas Müller-Schiffmann, Svenja V. Trossbach, Ingrid Prikulis, Sebastian Hänsch, Stefanie Weidtkamp-Peters, Ana Raquel Moreira, Shriya Sahu, Irina Soloviev, Suganya Selvarajah, Vishwanath R. Lingappa, and Carsten Korth (Vol. 117, No. 12, March 24, 2020, p. 6741-6751).

www.pnas.org/content/117/12/6741.abstract?etoc

B. “Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM,” by Urszula Cendrowska, Paulo Jacob Silva, Nadine Ait-Bouziad, Marie Müller, Zekiye Pelin Guven, Sophie Vieweg, Anass Chiki, Lynn Radamaker, Senthil T. Kumar, Marcus Fändrich, Francesco Tavanti, Maria Cristina Menziani, Alfredo Alexander-Katz,
Francesco Stellacci, and Hilal A. Lashuel (Vol. 117, No. 12, March 24, 2020, p. 6866-6874).

www.pnas.org/content/117/12/6866.abstract?etoc

C. “Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain,” by Lindsay A. Welikovitch, Sonia Do Carmo, Zsófia Maglóczky, Janice C. Malcolm, János Loke, William L. Klein, Tamás Freund, and A. Claudio Cuello (Vol. 117, No. 12, March 24, 2020, p. 6844-6854).

www.pnas.org/content/117/12/6844.abstract?etoc

March 12, 2020

CAAR – Nature Medicine Article – March 12, 2020

Filed under: Reports and Articles — Tags: , , — admin @ 5:21 pm

Note: Check with your organization’s library for availability.

A. “Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia,” by Shorena Janelidze, Niklas Mattsson, Sebastian Palmqvist, Ruben Smith, Thomas G. Beach, Geidy E. Serrano, Xiyun Chai, Nicholas K. Proctor, Udo Eichenlaub, Henrik Zetterberg, Kaj Blennow, Eric M. Reiman, Erik Stomrud, Jeffrey L. Dage & Oskar Hansson (Vol. 26, No. 3, March 2020, p. 379-386).

www.nature.com/articles/s41591-020-0755-1

B. “Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration,” by Elisabeth H. Thijssen, Renaud La Joie, Amy Wolf, Amelia Strom, Ping Wang, Leonardo Iaccarino, Viktoriya Bourakova, Yann Cobigo, Hilary Heuer, Salvatore Spina, Lawren VandeVrede, Xiyun Chai, Nicholas K. Proctor, David C. Airey, Sergey Shcherbinin, Cynthia Duggan Evans, John R. Sims, Henrik Zetterberg, Kaj Blennow, Anna M. Karydas, Charlotte E. Teunissen, Joel H. Kramer, Lea T. Grinberg, William W. Seeley, Howie Rosen, Bradley F. Boeve, Bruce L. Miller, Gil D. Rabinovici, Jeffrey L. Dage, Julio C. Rojas, Adam L. Boxer, Leah Forsberg, David S. Knopman, Neill Graff-Radford, Murray Grossman, Edward H. Huey, Chiadi Onyike, Daniel Kaufer, Erik Roberson, Nupur Ghoshal, Sandra Weintraub, Brian Appleby, Irene Litvan, Diana Kerwin, Mario Mendez, Yvette Bordelon, Giovanni Coppola, Eliana Marisa Ramos, M. Carmela Tartaglia, Ging-Yuek Hsiung, Ian MacKenzie, Kimiko Domoto-Reilly, Tatiana Foroud & Bradford C. Dickerson (Vol. 26, No. 3, March 2020, p. 387-397).

www.nature.com/articles/s41591-020-0762-2

C. “A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease,” by Nicolas R. Barthélemy, Yan Li, Nelly Joseph-Mathurin, et. al. (Vol. 26, No. 3, March 2020, p. 398-407).

www.nature.com/articles/s41591-020-0781-z

March 11, 2020

CAAR – Proceedings of the National Academy of Sciences Articles

Note: Check with your organization’s library for availability.

A. “Mechanistic approaches for chemically modifying the coordination sphere of copper–amyloid-{beta} complexes,” by Jiyeon Han, Hyuck Jin Lee, Kyu Yeon Kim, Geewoo Nam, Junghyun Chae, and Mi Hee Lim (Vol. 117, No. 10, March 10, 2020, p. 5160-5167).

www.pnas.org/content/117/10/5160

B. “Dynamics of life expectancy and life span equality,” by José Manuel Aburto, Francisco Villavicencio, Ugofilippo Basellini, Søren Kjærgaard, and James W. Vaupel (Vol. 117, No. 10, March 10, 2020, p. 5250-5259).

www.pnas.org/content/117/10/5250

February 13, 2020

CAAR – Public Library of Science (PLoS) Article – February 13, 2020

Filed under: Reports and Articles — Tags: , — admin @ 5:51 pm

Cognitively unimpaired adults’ reactions to disclosure of amyloid PET scan results,” by Emily A. Largent, Kristin Harkins, Christopher H. van Dyck, Sara Hachey, Pamela Sankar, and Jason Karlawish (PLoS ONE 15(2): e0229137. doi.org/10.1371/journal.pone.0229137, HTML, XML, and .pdf format, 12p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0229137

November 14, 2019

CAAR – Proceedings of the National Academy of Science Brief Report, Article – November 14, 2019

A. “An antibody against HK blocks Alzheimer’s disease peptide {beta}-amyloid-induced bradykinin release in human plasma,” by Zu-Lin Chen, Pradeep Singh, Jyen Wong, Katharina Horn, Sidney Strickland, and Erin H. Norris (Vol. 116, No. 46, November 12, 2019, p. 22921-22923).

www.pnas.org/content/116/46/22921

B. “SERF engages in a fuzzy complex that accelerates primary nucleation of amyloid proteins,” by Ben A. Meinen, Varun V. Gadkari, Frederick Stull, Brandon T. Ruotolo, and James C. A. Bardwell (Vol. 116, No. 46, November 12, 2019, p. 23040-23049). Note: Check with you organization’s library for availability.

www.pnas.org/content/116/46/23040

October 15, 2019

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – October 15, 2019

A. “Amyloid-beta impairs TOM1-mediated IL-1R1 signaling,” by Alessandra Cadete Martini, Angela Gomez-Arboledas, Stefania Forner, Carlos J. Rodriguez-Ortiz, Amanda McQuade, Emma Danhash, Jimmy Phan, Dominic Javonillo, Jordan-Vu Ha, Melanie Tram, Laura Trujillo-Estrada, Celia da Cunha, Rahasson R. Ager, Jose C. Davila, Masashi Kitazawa, Mathew Blurton-Jones, Antonia Gutierrez, David Baglietto-Vargas, Rodrigo Medeiros, and Frank M. LaFerla (Vol. 116, No. 42, October 15, 2019, p. 21198-21206).

www.pnas.org/content/116/42/21198

B. “Gray Matter Age Prediction as a Biomarker for Risk of Dementia,” by Johnny Wang, Maria J. Knol, Aleksei Tiulpin, Florian Dubost, Marleen de Bruijne, Meike W. Vernooij, Hieab H. H. Adams, M. Arfan Ikram, Wiro J. Niessen, and Gennady V. Roshchupkin (Vol. 116, No. 42, October 15, 2019, p. 21213-21218).

www.pnas.org/content/116/42/21213

August 9, 2019

CAAR – Science Article Abstract – August 9, 2019

Filed under: Reports and Articles — Tags: , — admin @ 5:41 pm

A vicious cycle of {beta} amyloid–dependent neuronal hyperactivation,” by By Benedikt Zott, Manuel M. Simon, Wei Hong, Felix Unger, Hsing-Jung Chen-Engerer, Matthew P. Frosch, Bert Sakmann, Dominic M. Walsh, and Arthur Konnerth (Vol. 365, No. 6453, August 9, 2019, p. 559-565).

science.sciencemag.org/content/365/6453/559.abstract

July 18, 2019

CAAR – Science Article Abstract – July 18, 2019

Filed under: Reports and Articles — Tags: , , — admin @ 5:33 pm

Amyloid {beta} oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes,” by Ross Nortley, Nils Korte, Pablo Izquierdo, Chanawee Hirunpattarasilp, Anusha Mishra, Zane Jaunmuktane, Vasiliki Kyrargyri, Thomas Pfeiffer, Lila Khennouf, Christian Madry, Hui Gong, Angela Richard-Loendt, Wenhui Huang, Takashi Saito, Takaomi C. Saido, Sebastian Brandner, Huma Sethi, and David Attwel (Vol. 365, No. 6450, July 19, 2019).

science.sciencemag.org/content/365/6450/eaav9518.editor-summary

June 20, 2019

CAAR – Journal of the American Medical Association Article Abstract – June 20, 2019

Filed under: uncategorized — Tags: , , , — admin @ 6:35 pm

Associations of Amyloid, Tau, and Neurodegeneration Biomarker Profiles With Rates of Memory Decline Among Individuals Without Dementia,” by Clifford R. Jack Jr., Heather J. Wiste, Terry M. Therneau, Stephen D. Weigand, David S. Knopman, Michelle M. Mielke, Val J. Lowe, Prashanthi Vemuri, Mary M. Machulda, Christopher G. Schwarz, Jeffrey L. Gunter, Matthew L. Senjem, Jonathan Graff-Radford, David T. Jones, Rosebud O. Roberts, Walter A. Rocca, and Ronald C. Petersen, (Vol. 321, No. 23, June 18, 2019, p. 2316-2325).

jamanetwork.com/journals/jama/article-abstract/2735818

May 14, 2019

CAAR – Public Library of Science (PLoS) Articles – May 14, 2019

Filed under: Reports and Articles — Tags: , , , — admin @ 5:42 pm

A. “Biomarker profiles of Alzheimer’s disease and dynamic of the association between cerebrospinal fluid levels of {beta}-amyloid peptide and tau,” by Aysha S. Mohamed Lafirdeen, Emmanuel Cognat, Severine Sabia, Claire Hourregue, Matthieu Lilamand, Aline Dugravot, Elodie Bouaziz-Amar, Jean-Louis Laplanche, Jacques Hugon, Archana Singh-Manoux, Claire Paquet, and Julien Dumurgier (PLoS ONE 14(5): e0217026. doi.org/10.1371/journal.pone.0217026, XML, HTML, and .pdf format, 13p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0217026

B. “Experiences and views of older people on their participation in a nurse-led health promotion intervention: “Community Health Consultation Offices for Seniors”,” by Anne Esther Marcus-Varwijk, Dónya S. Madjdian, Emely de Vet, Monique W. M. Mensen, Tommy L. S. Visscher, Adelita V. Ranchor, Joris P. J. Slaets, and Carolien H. M. Smits (PLoS ONE 14(5): e0216494. doi.org/10.1371/journal.pone.0216494, XML, HTML, and .pdf format, 17p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0216494

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 14, 2019

Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy,” by Takayuki Inoue, Satoshi Saito, Masashi Tanaka, Hajime Yamakage, Toru Kusakabe, Akira Shimatsu, Masafumi Ihara, and Noriko Satoh-Asahara (Vol. 116, No. 20, May 14, 2019, p. 10031-10038).

www.pnas.org/content/116/20/10031

April 29, 2019

CAAR – Nature Neuroscience Article Abstracts – April 29, 2019

Filed under: Reports and Articles — Tags: , , , — admin @ 5:31 pm

A. “Senolytic therapy alleviates A{beta}-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model,” by Peisu Zhang, Yuki Kishimoto, Ioannis Grammatikakis, Kamalvishnu Gottimukkala, Roy G. Cutler, Shiliang Zhang, Kotb Abdelmohsen, Vilhelm A. Bohr, Jyoti Misra Sen, Myriam Gorospe & Mark P. Mattson (Vol. 22, No. 5, May 2019, p. 719-728).

www.nature.com/articles/s41593-019-0372-9

B. “Working memory revived in older adults by synchronizing rhythmic brain circuits,” by Robert M. G. Reinhart & John A. Nguyen (Vol. 22, No. 5, May 2019, p. 820-827).

www.nature.com/articles/s41593-019-0371-x

 

March 1, 2019

CAAR – Nature Neuroscience Article Abstracts – March 1, 2019

Filed under: Reports and Articles — Tags: , , — admin @ 12:36 pm

A. “Mitophagy inhibits amyloid-{beta} and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease,” by Evandro F. Fang, Yujun Hou, Konstantinos Palikaras, Bryan A. Adriaanse, Jesse S. Kerr, Beimeng Yang, Sofie Lautrup, Md Mahdi Hasan-Olive, Domenica Caponio, Xiuli Dan, Paula Rocktäschel, Deborah L. Croteau, Mansour Akbari, Nigel H. Greig, Tormod Fladby, Hilde Nilsen, M. Zameel Cader, Mark P. Mattson, Nektarios Tavernarakis & Vilhelm A. Bohr (Vol. 22, No. 3, March 2019, p. 401-412).

www.nature.com/articles/s41593-018-0332-9

B. “Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models,” by Jean C. Cruz Hernández, Oliver Bracko, Calvin J. Kersbergen, Victorine Muse, Mohammad Haft-Javaherian, Maxime Berg, Laibaik Park, Lindsay K. Vinarcsik, Iryna Ivasyk, Daniel A. Rivera, Yiming Kang, Marta Cortes-Canteli, Myriam Peyrounette, Vincent Doyeux, Amy Smith, Joan Zhou, Gabriel Otte, Jeffrey D. Beverly, Elizabeth Davenport, Yohan Davit, Charles P. Lin, Sidney Strickland, Costantino Iadecola, Sylvie Lorthois, Nozomi Nishimura & Chris B. Schaffer (Vol. 22, No. 3, March 2019, p. 413-420).

www.nature.com/articles/s41593-018-0329-4

February 18, 2019

CAAR – Science Article Abstract – February 18, 2019

Filed under: Reports and Articles — Tags: , , — admin @ 5:49 pm

Recognition of the amyloid precursor protein by human {gamma}-secretase,” by Rui Zhou, Guanghui Yang, Xuefei Guo, Qiang Zhou, Jianlin Lei, and Yigong Shi (Vol. 363, No. 6428, February 15, 2019).

science.sciencemag.org/content/363/6428/eaaw0930.abstract

February 7, 2019

CAAR – Nature Neuroscience Article Abstract – February 7, 2019

Filed under: Reports and Articles — Tags: , — admin @ 4:33 pm

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE,” by Samira Parhizkar, Thomas Arzberger, Matthias Brendel, Gernot Kleinberger, Maximilian Deussing, Carola Focke, Brigitte Nuscher, Monica Xiong, Alireza Ghasemigharagoz, Natalie Katzmarski, Susanne Krasemann, Stefan F. Lichtenthaler, Stephan A. Müller, Alessio Colombo, Laura Sebastian Monasor, Sabina Tahirovic, Jochen Herms, Michael Willem, Nadine Pettkus, Oleg Butovsky, Peter Bartenstein, Dieter Edbauer, Axel Rominger, Ali Ertürk, Stefan A. Grathwohl, Jonas J. Neher, David M. Holtzman, Melanie Meyer-Luehmann & Christian Haass (Vol. 22, No. 2, February 2019, p. 191-204).

www.nature.com/articles/s41593-018-0296-9

December 19, 2018

CAAR – Nature Neuroscience Article Abstract – December 19, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 5:37 pm

A. “Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains,” by Hans-Ulrich Klein, Cristin McCabe, Elizabeta Gjoneska, Sarah E. Sullivan, Belinda J. Kaskow, Anna Tang, Robert V. Smith, Jishu Xu, Andreas R. Pfenning, Bradley E. Bernstein, Alexander Meissner, Julie A. Schneider, Sara Mostafavi, Li-Huei Tsai, Tracy L. Young-Pearse, David A. Bennett & Philip L. De Jage (Vol. 22, No. 1, January 2019, p. 37-46).

www.nature.com/articles/s41593-018-0291-1

B. “A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology,” by Hongjun Fu, Andrea Possenti, Rosie Freer, Yoshikazu Nakano, Nancy C. Hernandez Villegas, Maoping Tang, Paula V. M. Cauhy, Benjamin A. Lassus, Shuo Chen, Stephanie L. Fowler, Helen Y. Figueroa, Edward D. Huey, Gail V. W. Johnson, Michele Vendruscolo & Karen E. Duff (Vol. 22, No. 1, January 2019, p. 47-56).

www.nature.com/articles/s41593-018-0298-7

C. “Tau impairs neural circuits, dominating amyloid-{beta} effects, in Alzheimer models in vivo,” by Marc Aurel Busche, Susanne Wegmann, Simon Dujardin, Caitlin Commins, Julia Schiantarelli, Naomi Klickstein, Tarun V. Kamath, George A. Carlson, Israel Nelken & Bradley T. Hyman (Vol. 22, No. 1, January 2019, p. 57-64).

www.nature.com/articles/s41593-018-0289-8

December 18, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 18, 2018

Probing the mechanism of inhibition of amyloid-{beta}(1–42)–induced neurotoxicity by the chaperonin GroEL,” by Marielle A. Walti, Joseph Steiner, Fanjie Meng, Hoi Sung Chung, John M. Louis, Rodolfo Ghirlando, Vitali Tugarinov, Avindra Nath, and G. Marius Clore (Vol. 115, No. 51, December 18, 2018, p. E11924-E11932).

doi.org/10.1073/pnas.1817477115

CAAR – Public Library of Science (PLoS) Articles – December 18, 2018

Filed under: Reports and Articles — Tags: , , , — admin @ 5:52 pm

A. “Improvement of the performance of survival prediction in the ageing blunt trauma population: A cohort study,” by Leonie de Munter, Nancy C. W. ter Bogt, Suzanne Polinder, Charlie A. Sewalt, Ewout W. Steyerberg, and Mariska A. C. de Jongh (PLoS ONE 13(12): e0209099. doi.org/10.1371/journal.pone.0209099, HTML, XML, and .pdf format, 12p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0209099

B. “Small-molecule induction of A{beta}-42 peptide production in human cerebral organoids to model Alzheimer’s disease associated phenotypes,” by Serena Pavoni, Rafika Jarray, Ferid Nassor, Anne-Cécile Guyot, Steve Cottin, Jessica Rontard, Jacqueline Mikol, Aloïse Mabondzo, Jean-Philippe Deslys, and Frank Yates (PLoS ONE 13(12): e0209150. doi.org/10.1371/journal.pone.0209150, HTML, XML, and .pdf format, 15p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0209150

December 10, 2018

CAAR – Nature Medicine Article Abstract – December 10, 2018

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Neurogenetic contributions to amyloid beta and tau spreading in the human cortex,” by Jorge Sepulcre, Michel J. Grothe, Federico d’Oleire Uquillas, Laura Ortiz-Terán, Ibai Diez, Hyun-Sik Yang, Heidi I. L. Jacobs, Bernard J. Hanseeuw, Quanzheng Li, Georges El-Fakhri, Reisa A. Sperling & Keith A. Johnson (Vol. 24, No. 12, December 7, 2018, p. 1910-1918).

www.nature.com/articles/s41591-018-0206-4

November 20, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 20, 2018

A. “Role of income mobility for the measurement of inequality in life expectancy,” by Claus Thustrup Kreiner, Torben Heien Nielsen, and Benjamin Ly Serena (Vol. 115, No. 46, November 13, 2018, p. 11754-11759).

www.pnas.org/content/115/46/11754

B. “Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy,” by Jonathan S. Wall, Angela D. Williams, James S. Foster, Tina Richey, Alan Stuckey, Sallie Macy, Craig Wooliver, Shawn R. Campagna, Eric D. Tague, Abigail T. Farmer, Ronald H. Lands, Emily B. Martin, R. Eric Heidel, and Stephen J. Kennel (Vol. 115, No. 46, November 13, 2018, p. E10839-E10848).

www.pnas.org/content/115/46/E10839

November 13, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – November 13, 2018

A. “Role of income mobility for the measurement of inequality in life expectancy,” by Claus Thustrup Kreiner, Torben Heien Nielsen, and Benjamin Ly Serena (Vol. 115, No. 46, November 13, 2018, p. 11754-11759).

www.pnas.org/content/115/46/11754

B. “Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy,” by Jonathan S. Wall, Angela D. Williams, James S. Foster, Tina Richey, Alan Stuckey, Sallie Macy, Craig Wooliver, Shawn R. Campagna, Eric D. Tague, Abigail T. Farmer, Ronald H. Lands, Emily B. Martin, R. Eric Heidel, and Stephen J. Kennel (Vol. 115, No. 46, November 13, 2018, p. E10839-E10848).

www.pnas.org/content/115/46/E10839

September 5, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – September 5, 2018

A. “Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice,” by Te-Chen Tzeng, Yuto Hasegawa, Risa Iguchi, Amy Cheung, Daniel R. Caffrey, Elizabeth Jeanne Thatcher, Wenjie Mao, Gail Germain, Nelsy DePaula Tamburro, Shigeo Okabe, Michael T. Heneka, Eicke Latz, Kensuke Futai, and Douglas T. Golenbock (Vol. 115, No. 36, September 4, 2018, p. 9002-9007).

www.pnas.org/content/115/36/9002

B. “Local field potentials of subthalamic nucleus contain electrophysiological footprints of motor subtypes of Parkinson’s disease,” by Ilknur Telkes, Ashwin Viswanathan, Joohi Jimenez-Shahed, Aviva Abosch, Musa Ozturk, Akshay Gupte, Joseph Jankovic, and Nuri F. Ince (Vol. 115, No. 36, September 4, 2018, p. E8567-E8576).

www.pnas.org/content/115/36/E8567

July 19, 2018

CAAR – Public Library of Science (PLoS) Articles – July 19, 2018

A. “Wishes and needs of community-dwelling older persons concerning general practice: A qualitative study,” by Sophie C. E. van Blijswijk, Claudia S. de Waard, Petra G. van Peet, Dagmar Keizer, Margaret von Faber, Margot W. M. de Waal, Wendy P. J. den Elzen, Jacobijn Gussekloo, and Jeanet W. Blom (PLoS ONE 13(7): e0200614. doi.org/10.1371/journal.pone.0200614, XML and .pdf format, 14p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0200614

B. “Age-related macular degeneration and progression of coronary artery calcium: The Multi-Ethnic Study of Atherosclerosis,” by Antonio B. Fernandez, Kevin D. Ballard, Tien Y. Wong, Mengye Guo, Robyn L. McClelland, Gregory Burke, Mary Frances Cotch, Barbara Klein, Matthew Allison, and Ronald Klein (PLoS ONE 13(7): e0201000. doi.org/10.1371/journal.pone.0201000, XML and .pdf format, 10p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0201000

C. “Amyloidogenic cross-seeding of Tau protein: Transient emergence of structural variants of fibrils,” by Bartosz Nizynski, Hanna Nieznanska, Robert Dec, Solomiia Boyko, Wojciech Dzwolak, and Krzysztof Nieznanski (PLoS ONE 13(7): e0201182. doi.org/10.1371/journal.pone.0201182, XML and .pdf format, 18p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0201182

July 12, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 12, 2018

A. “Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid {alpha}-synuclein fibrils,” by Francesco Simone Ruggeri, Fabrizio Benedetti, Tuomas P. J. Knowles, Hilal A. Lashuel, Sergey Sekatskii, and Giovanni Dietler (Vol. 115 No. 28, July 10, 2018, p. 7230-7235).

www.pnas.org/content/115/28/7230

B. “Declining mental health among disadvantaged Americans,” by Noreen Goldman, Dana A. Glei, and Maxine Weinstein (Vol. 115 No. 28, July 10, 2018, p. 7290-7295).

www.pnas.org/content/115/28/7290

C. “Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH,” by Hari Prasad and Rajini Rao (Vol. 115 No. 28, July 10, 2018, p. E6640-E6649).

www.pnas.org/content/115/28/E6640

July 10, 2018

CAAR – Public Library of Science (PLoS) Article – July 10, 2018

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Soluble amyloid-beta buffering by plaques in Alzheimer disease dementia versus high-pathology controls,” by Thomas J. Esparza, Mihika Gangolli, Nigel J. Cairns, and David L. Brody (PLoS ONE 13(7): e0200251. doi.org/10.1371/journal.pone.0200251, XML, HTML, and .pdf format, 13p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0200251

April 25, 2018

CAAR – Proceedings of the National Academies of Science Article Abstract – April 25, 2018

[beta}-Amyloid accumulation in the human brain after one night of sleep deprivation,” by Ehsan Shokri-Kojori, Gene-Jack Wang, Corinde E. Wiers, Sukru B. Demiral, Min Guo, Sung Won Kim, Elsa Lindgren, Veronica Ramirez, Amna Zehra, Clara Freeman, Gregg Miller, Peter Manza, Tansha Srivastava, Susan De Santi, Dardo Tomasi, Helene Benveniste and Nora D. Volkow (Vol. 115, No. 17, April 24, 2018, p. 4483-4488).

doi.org/10.1073/pnas.1721694115

April 12, 2018

CAAR – Public Library of Science (PLoS) Articles – April 12, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 5:04 pm

A. “Memory deficiency, cerebral amyloid angiopathy, and amyloid-{beta} plaques in APP+PS1 double transgenic rat model of Alzheimer’s disease,” by Diana Klakotskaia, Cansu Agca, Rachel A. Richardson, Edward G. Stopa, Todd R. Schachtman, and Yuksel Agca (PLoS ONE 13(4): e0195469. doi.org/10.1371/journal.pone.0195469, XML, HTML, and .pdf format, 16p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0195469

B. “Inflammatory markers in postoperative delirium (POD) and cognitive dysfunction (POCD): A meta-analysis of observational studies,” by Xuling Liu, Yang Yu, and Shengmei Zhu (PLoS ONE 13(4): e0195659. doi.org/10.1371/journal.pone.0195659, XML, HTML, and .pdf format, p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0195659

April 2, 2018

CAAR – Nature Neuroscience Article Abstract – April 2, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 5:01 pm

Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals,” by Heidi I. L. Jacobs, Trey Hedden, Aaron P. Schultz, Jorge Sepulcre, Rodrigo D. Perea, Rebecca E. Amariglio, Kathryn V. Papp, Dorene M. Rentz, Reisa A. Sperling & Keith A. Johnson (Vol. 21, No. 3, March 2018, p. 424-431).

www.nature.com/articles/s41593-018-0070-z

March 27, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 27, 2018

Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality,” by Jatish Kumar, Hasier Erana, Elena López-Martínez, Nathalie Claes, Víctor F. Martín, Diego M. Solís, Sara Bals, Aitziber L. Cortajarena, Joaquín Castilla, and Luis M. Liz-Marzan (Vol. 115, No. 13, March 27, 2018, p. 3225-3230).

www.pnas.org/content/115/13/3225

March 6, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 6, 2018

A. “Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice,” by Kan Xie, Devon P. Ryan, Brandon L. Pearson, Kristin S. Henzel, Frauke Neff, Ramon O. Vidal, Magali Hennion, Isabelle Lehmann, Melvin Schleif, Susanne Schröder, Thure Adler, Birgit Rathkolb, Jan Rozman, Anna-Lena Schütz, Cornelia Prehn, Michel E. Mickael, Marco Weiergräber, Jerzy Adamski, Dirk H. Busch, Gerhard Ehninger, Anna Matynia, Walker S. Jackson, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Stefan Bonn, Martin Hrabe de Angelis and Dan Ehninger (Vol. 115, No. 10, March 6, 2018, p. E2348-E2357).

doi.org/10.1073/pnas.1707337115

B. “Environmental enrichment and exercise are better than social enrichment to reduce memory deficits in amyloid beta neurotoxicity,” by Mariza G. Prado Lima, Helen L. Schimidt, Alexandre Garcia, Letícia R. Daré, Felipe P. Carpes, Ivan Izquierdo and Pâmela B. Mello-Carpes (Vol. 115, No. 10, March 6, 2018, p. E2403-E2408).

doi.org/10.1073/pnas.1718435115

February 8, 2018

CAAR – Nature Letter Abstract – February 8, 2018

Filed under: Reports and Articles — Tags: , , — admin @ 4:49 pm

High performance plasma amyloid-{beta} biomarkers for Alzheimer’s disease,” by Akinori Nakamura, Naoki Kaneko, Victor L. Villemagne, Takashi Kato, James Doecke, Vincent Doré, Chris Fowler, Qiao-Xin Li, Ralph Martins, Christopher Rowe, Taisuke Tomita, Katsumi Matsuzaki, Kenji Ishii, Kazunari Ishii, Yutaka Arahata, Shinichi Iwamoto, Kengo Ito, Koichi Tanaka, Colin L. Masters & Katsuhiko Yanagisawa (Vol. 554, No. , February 8, 2018, p. 249-254).

www.nature.com/articles/nature25456

January 23, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 23, 2018

A. “Structural heterogeneity and intersubject variability of A{beta} in familial and sporadic Alzheimer’s disease,” by Carlo Condello, Thomas Lemmin, Jan Stöhr, Mimi Nick, Yibing Wu, Alison M. Maxwell, Joel C. Watts, Christoffer D. Caro, Abby Oehler, C. Dirk Keene, Thomas D. Bird, Sjoerd G. van Duinen, Lars Lannfelt, Martin Ingelsson, Caroline Graff, Kurt Giles, William F. DeGrado, and Stanley B. Prusiner (Vol. 115, No. 4, January 23, 2018, .pdf and HTML format, p. E782-E791). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/115/4/E782.abstract

B. “GBA1 deficiency negatively affects physiological {alpha}-synuclein tetramers and related multimers,” by Sangjune Kim, Seung Pil Yun, Saebom Lee, George Essien Umanah, Veera Venkata Ratnam Bandaru, Xiling Yin, Peter Rhee, Senthilkumar S. Karuppagounder, Seung-Hwan Kwon, Hojae Lee, Xiaobo Mao, Donghoon Kim, Akhilesh Pandey, Gabsang Lee, Valina L. Dawson, Ted M. Dawson, and Han Seok Ko (Vol. 115, No. 4, January 23, 2018, p. 798-803).

www.pnas.org/content/115/4/798.abstract

C. “CFH and ARMS2 genetic risk determines progression to neovascular age-related macular degeneration after antioxidant and zinc supplementation,” by Demetrios G. Vavvas, Kent W. Small, Carl C. Awh, Brent W. Zanke, Robert J. Tibshirani, and Rafal Kustra (Vol. 115, No. 4, January 23, 2018, .pdf and HTML format, p. E696-E704). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/115/4/E696.abstract

January 18, 2018

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 18, 2018

A. “The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease,” by Chun Chen, Zhihao Wang, Zhentao Zhang, Xia Liu, Seong Su Kang, Ying Zhang, and Keqiang Ye (Vol. 115, No. 3, January 16, 2018, p. 578-583).

www.pnas.org/content/115/3/578.abstract

B. “Migration-based selections of antibodies that convert bone marrow into trafficking microglia-like cells that reduce brain amyloid {beta},” by Kyung Ho Han, Britni M. Arlian, Matthew S. Macauley, James C. Paulson, and Richard A. Lerner (Vol. 115, No. 3, January 16, 2018, p. E372-E381). Note: PNAS is providing open-access to the full-text of this article.

www.pnas.org/content/115/3/E372.abstract

January 9, 2018

CAAR – Nature Medicine Article Abstracts – January 9, 2018

Filed under: Reports and Articles — Tags: , , , — admin @ 4:57 pm

A. “Amyloid-{beta} plaques enhance Alzheimer’s brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation,” by Zhuohao He, Jing L. Guo, Jennifer D. McBride, Sneha Narasimhan, Hyesung Kim, Lakshmi Changolkar, Bin Zhang, Ronald J. Gathagan, Cuiyong Yue, Christopher Dengler, Anna Stieber, Magdalena Nitla, Douglas A. Coulter, Ted Abel, Kurt R. Brunden, John Q. Trojanowski & Virginia M-Y Lee (Vol. 24, No. 1, January 2018, p. 29-38).

www.nature.com/articles/nm.4443

B. “cGAS drives noncanonical-inflammasome activation in age-related macular degeneration,” by Nagaraj Kerur, Shinichi Fukuda, Daipayan Banerjee, Younghee Kim, Dongxu Fu, Ivana Apicella, Akhil Varshney, Reo Yasuma, Benjamin J. Fowler, Elmira Baghdasaryan, Kenneth M. Marion, Xiwen Huang, Tetsuhiro Yasuma, Yoshio Hirano, Vlad Serbulea, Meenakshi Ambati, Vidya L. Ambati, Yuji Kajiwara, Kameshwari Ambati, Shuichiro Hirahara, Ana Bastos-Carvalho, Yuichiro Ogura, Hiroko Terasaki, Tetsuro Oshika, Kyung Bo Kim, David R. Hinton, Norbert Leitinger, John C. Cambier, Joseph D.Buxbaum, M. Cristina Kenney, S. Michal Jazwinski, Hiroshi Nagai, Isao Hara, A. Phillip West, Katherine A. Fitzgerald, SriniVas R. Sadda, Bradley D. Gelfand & Jayakrishna Ambati (Vol. 24, No. 1, January 2018, p. 50-61).

www.nature.com/articles/nm.4450

December 14, 2017

CAAR – Nature Article Abstract – December 14, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 4:50 pm

Enhancing mitochondrial proteostasis reduces amyloid-{beta} proteotoxicity,” by Vincenzo Sorrentino, Mario Romani, Laurent Mouchiroud, John S. Beck, Hongbo Zhang, Davide D’Amico, Norman Moullan, Francesca Potenza, Adrien W. Schmid, Solene Rietsch, Scott E. Counts & Johan Auwerx (Vol. 552, No. 7684, December 14, 2017, p. 187-193).

www.nature.com/nature/journal/v552/n7684/abs/nature25143.html

December 7, 2017

CAAR – Proceedings of the National Academies of Science Article Abstracts – December 7, 2017

A. “Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease,” by Jay Rasmussen, Jasmin Mahler, Natalie Beschorner, Stephan A. Kaeser, Lisa M. Häsler, Frank Baumann, Sofie Nyström, Erik Portelius, Kaj Blennow, Tammaryn Lashley, Nick C. Fox, Diego Sepulveda-Falla, Markus Glatzel, Adrian L. Oblak, Bernardino Ghetti, K. Peter R. Nilsson, Per Hammarström, Matthias Staufenbiel, Lary C. Walker, and Mathias Jucker (Vol. 114, No. 49, December 5, 2017, p. 13018-13023).

B. “Intercellular competition and the inevitability of multicellular aging,” by Paul Nelson and Joanna Masel (Vol. 114, No. 49, December 5, 2017, p. 12982–12987).

www.pnas.org/content/114/49/12982.abstract

November 30, 2017

CAAR – Public Library of Science (PLoS) Articles – November 30, 2017

A. “Assemblies of amyloid-{beta}<sub>30–36</sub> hexamer and its G33V/L34T mutants by replica-exchange molecular dynamics simulation,” by Zhenyu Qian, Qingwen Zhang, Yu Liu, and Peijie Chen (PLoS ONE 12(11): e0188794. doi.org/10.1371/journal.pone.0188794, XML, HTML, and .pdf format, 18p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0188794

B. “Elderly emergency patients presenting with non-specific complaints: Characteristics and outcomes,” by Joyce J. H. Wachelder, Patricia M. Stassen, Laura P. A. M. Hubens, Steffie H. A. Brouns, Suze L. E. Lambooij, Jeanne P. Dieleman, and Harm R. Haak (PLoS ONE 12(11): e0188954. doi.org/10.1371/journal.pone.0188954, XML, HTML, and .pdf format, 11p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0188954

C. “Identifying social factors amongst older individuals in linked electronic health records: An assessment in a population based study,” by Anu Jain, Albert J. van Hoek, Jemma L. Walker, Rohini Mathur, Liam Smeeth, and Sara L. Thomas (PLoS ONE 12(11): e0189038. doi.org/10.1371/journal.pone.0189038, XML, HTML, and .pdf format, 17p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0189038

October 5, 2017

CAAR – Science Report Article – October 5, 2017

Filed under: Reports and Articles — Tags: , — admin @ 3:44 pm

Fibril structure of amyloid-{beta}(1–42) by cryo–electron microscopy,” by Lothar Gremer, Daniel Scholzel, Carla Schenk, Elke Reinartz, Jorg Labahn, Raimond B. G. Ravelli, Markus Tusche, Carmen Lopez-Iglesias, Wolfgang Hoyer, Henrike Heise, Dieter Willbold, and Gunnar F. Schroder (Vol. 358, No. 6359, October 6, 2017, p. 116-119).

science.sciencemag.org/content/358/6359/116

August 16, 2017

CAAR – Proceedings of the National Academies of Sciences Article Abstract – August 16, 2017

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways,” by Aleksandra M. Wojtas, Silvia S. Kang, Benjamin M. Olley, Maureen Gatherer, Mitsuru Shinohara, Patricia A. Lozano, Chia-Chen Liu, Aishe Kurti, Kelsey E. Baker, Dennis W. Dickson, Mei Yue, Leonard Petrucelli, Guojun Bu, Roxana O. Carare, and John D. Fryer (Vol. 114, No. 33, August 15, 2017, p. E6962-E6971). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/33/E6962.abstract

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