CDHA CAAR

October 5, 2017

CAAR – Science Report Article – October 5, 2017

Filed under: Reports and Articles — Tags: , — admin @ 3:44 pm

Fibril structure of amyloid-{beta}(1–42) by cryo–electron microscopy,” by Lothar Gremer, Daniel Scholzel, Carla Schenk, Elke Reinartz, Jorg Labahn, Raimond B. G. Ravelli, Markus Tusche, Carmen Lopez-Iglesias, Wolfgang Hoyer, Henrike Heise, Dieter Willbold, and Gunnar F. Schroder (Vol. 358, No. 6359, October 6, 2017, p. 116-119).

science.sciencemag.org/content/358/6359/116

August 16, 2017

CAAR – Proceedings of the National Academies of Sciences Article Abstract – August 16, 2017

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways,” by Aleksandra M. Wojtas, Silvia S. Kang, Benjamin M. Olley, Maureen Gatherer, Mitsuru Shinohara, Patricia A. Lozano, Chia-Chen Liu, Aishe Kurti, Kelsey E. Baker, Dennis W. Dickson, Mei Yue, Leonard Petrucelli, Guojun Bu, Roxana O. Carare, and John D. Fryer (Vol. 114, No. 33, August 15, 2017, p. E6962-E6971). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/33/E6962.abstract

June 15, 2017

CAAR – Journal of the American Medical Association Article – June 15, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 4:49 pm

Note: The link below is to the table of contents for the current issue of JAMA (Vol. 317, No. 22, June 13, 2017). Check with your organization’s information center for availability.

jamanetwork.com/journals/jama/issue/317/22

Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons,” by Michael C. Donohue, Reisa A. Sperling, Ronald Petersen, Chung-Kai Sun, Michael W. Weiner, and Paul S. Aisen, for the Alzheimer’s Disease Neuroimaging Initiative (p. 2305-2316).

May 11, 2017

CAAR – Lancet Neurology Article Abstract – May 11, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:18 pm

Age-specific and sex-specific prevalence of cerebral {beta}-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50–95 years: a cross-sectional study,” by Clifford R. Jack Jr., Heather J. Wiste, Stephen D. Weigand, Terry M. Therneau, David S. Knopman, Val Lowe, Prashanthi Vemuri, Michelle M. Mielke, Rosebud O. Roberts, Mary M. Machulda, Matthew L. Senjem, Jeffrey L. Gunter, Walter A. Rocca, and Ronald C. Petersen (Vol. 16, No. 6, June 2017, p. 435-444).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30077-7/abstract

February 10, 2017

CAAR – Public Library of Science (PLoS) Article – February 10, 2017

Filed under: Reports and Articles — Tags: , — admin @ 4:55 pm

{alpha}-Synuclein increases {beta}-amyloid secretion by promoting {beta}-/{gamma}-secretase processing of APP,” by Hazel L. Roberts, Bernard L. Schneider, and David R. Brown (PLoS ONE 12(2): e0171925. doi:10.1371/journal.pone.0171925, XML, HTML, and .pdf format, 22p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0171925

December 8, 2016

CAAR – Nature Article Abstract – December 8, 2016

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Gamma frequency entrainment attenuates amyloid load and modifies microglia,” by Hannah F. Iaccarino, Annabelle C. Singer, Anthony J. Martorell, Andrii Rudenko, Fan Gao, Tyler Z. Gillingham, Hansruedi Mathys, Jinsoo Seo, Oleg Kritskiy, Fatema Abdurrob, Chinnakkaruppan Adaikkan, Rebecca G. Canter, Richard Rueda, Emery N. Brown, Edward S. Boyden & Li-Huei Tsai (Vol. 540, No. 7632, December 8, 2016, p. 230-235).

www.nature.com/nature/journal/v540/n7632/abs/nature20587.html

November 18, 2016

CAAR – Science Letter Abstract – November 18, 2016

Filed under: Reports and Articles — Tags: , , , — admin @ 4:51 pm

Site-specific phosphorylation of tau inhibits amyloid-{beta} toxicity in Alzheimer’s mice,” by Arne Ittner, Sook Wern Chua, Josefine Bertz, Alexander Volkerling, Julia Van Der Hoven, Amadeus Gladbach, Magdalena Przybyla, Mian Bi, Annika Van Hummel, Claire H. Stevens, Stefania Ippati, Lisa S. Suh, Alexander Macmillan, Greg Sutherland, Jillian J. Kril, Ana P. G. Silva, Joel Mackay, Anne Poljak, Fabien Delerue, Yazi D. Ke, and Lars M. Ittner (Vol. 354, No. 6314, November 18, 2016, p. 904-908).

science.sciencemag.org/content/354/6314/904.abstract

November 9, 2016

CAAR – Public Library of Science (PLoS) Articles – November 9, 2016

Filed under: Reports and Articles — Tags: , , , — admin @ 4:44 pm

A. “Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-{beta} Peptide in Mice,” by Maressa Caldeira Morzelle, Jocelem Mastrodi Salgado, Milena Telles, Danilo Mourelle, Patricia Bachiega, Hudson Sousa Buck, and Tania Araujo Viel (PLoS ONE 11(11): e0166123. doi:10.1371/journal.pone.0166123, XML, HTML, and .pdf format, 20p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0166123

B. “Rehabilitation Profiles of Older Adult Stroke Survivors Admitted to Intermediate Care Units: A Multi-Centre Study,” by Laura M. Perez, Marco Inzitari, Terence J. Quinn, Joan Montaner, Ricard Gavalda, Esther Duarte, Laura Coll-Planas, Merce Cerda, Sebastià Santaeugenia, Conxita Closa, and Miquel Gallofre (PLoS ONE 11(11): e0166304. doi:10.1371/journal.pone.0166304, XML, HTML, and .pdf format, 13p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0166304

October 26, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – October 26, 2016

A. “Functional connectivity with the retrosplenial cortex predicts cognitive aging in rats,” by Jessica A. Ash, Hanbing Lu, Lisa R. Taxier, Jeffrey M. Long, Yihong Yang, Elliot A. Stein, and Peter R. Rapp (Vol. 113, No. 43, October 26, 2016, p. 12286-12291).

www.pnas.org/content/113/43/12286.abstract

B. “PPAR{gamma}-coactivator-1{alpha} gene transfer reduces neuronal loss and amyloid-{beta| generation by reducing {beta}-secretase in an Alzheimer’s disease model,” by Loukia Katsouri, Yau M. Lim, Katrin Blondrath, Ioanna Eleftheriadou, Laura Lombardero, Amy M. Birch, Nazanin Mirzaei, Elaine E. Irvine, Nicholas D. Mazarakis, and Magdalena Sastre (Vol. 113, No. 43, October 26, 2016, p. 12292–12297).

www.pnas.org/content/113/43/12292.abstract.html?etoc

October 18, 2016

CAAR – Proceedings of the National Academy Sciences Article Abstracts – October 18, 2016

A. “Exploring the aggregation free energy landscape of the amyloid-{beta} protein (1–40),” by Weihua Zheng, Min-Yeh Tsai, Mingchen Chen, and Peter G. Wolynes (Vol. 113, No. 42, October 18, 2016, p. 11835–11840).

www.pnas.org/content/113/42/11835.abstract.html?etoc

B. “Lifespan adversity and later adulthood telomere length in the nationally representative US Health and Retirement Study,” by Eli Puterman, Alison Gemmill, Deborah Karasek, David Weir, Nancy E. Adler, Aric A. Prather, and Elissa S. Epel (Vol. 113, No. 42, October 18, 2016, p. E6335–E6342).

www.pnas.org/content/113/42/11835.abstract.html?etoc

C. “Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK,” by Takafumi Ogawa, Ryohei Tsubakiyama, Muneyoshi Kanai, Tetsuya Koyama, Tsutomu Fujii, Haruyuki Iefuji, Tomoyoshi Soga, Kazunori Kume, Tokichi Miyakawa, Dai Hirata, and Masaki Mizunuma (Vol. 113, No. 42, October 18, 2016, p. 11913–11918).

www.pnas.org/content/113/42/11913.abstract.html?etoc

D. “Amyloid-{beta} effects on synapses and memory require AMPA receptor subunit GluA3,” by Niels R. Reinders, Yvonne Pao, Maria C. Renner, Carla M. da Silva-Matos, Tessa R. Lodder, Roberto Malinow, and Helmut W. Kessels (Vol. 113, No. 42, October 18, 2016, p. E6526–E6534).

www.pnas.org/content/113/42/E6526.abstract.html?etoc

E. “Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer’s disease,” by Xiuming Zhang, Elizabeth C. Mormino, Nanbo Sun, Reisa A. Sperling, Mert R. Sabuncu, B. T. Thomas Yeo, and the Alzheimer’s Disease Neuroimaging Initiative (Vol. 113, No. 42, October 18, 2016, p. E6535–E6544).

www.pnas.org/content/113/42/E6535.abstract.html?etoc

September 27, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 27, 2016

A{beta}42 assembles into specific {beta}-barrel pore-forming oligomers in membrane-mimicking environments,” by Montserrat Serra-Batiste, Martí Ninot-Pedrosa, Mariam Bayoumi, Margarida Gairí, Giovanni Maglia, and Natàlia Carulla (Vol. 113, No. 39, September 28, 2016, p. 10866–10871).

www.pnas.org/content/113/39/10866.abstract.html?etoc

CAAR – Public Library of Science (PLoS) Article – September 27, 2016

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The Role of Neutrophil Proteins on the Amyloid Beta-RAGE Axis,” by Amanda J. Stock, Anne Kasus-Jacobi, Jonathan D. Wren, Virginie H. Sjoelund, Glenn D. Prestwich, and H. Anne Pereira (PLoS ONE 11(9): e0163330. doi:10.1371/journal.pone.0163330, XML, HTML, and .pdf format, 29p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0163330

September 1, 2016

CAAR – Nature Article Abstract – September 1, 2016

Filed under: Reports and Articles — Tags: , , — admin @ 4:39 pm

The antibody aducanumab reduces A{beta} plaques in Alzheimer’s disease,” by Jeff Sevigny, Ping Chiao, Thierry Bussière, Paul H. Weinreb, Leslie Williams, Marcel Maier, Robert Dunstan, Stephen Salloway, Tianle Chen, Yan Ling, John O’Gorman, Fang Qian, Mahin Arastu, Mingwei Li, Sowmya Chollate, Melanie S. Brennan, Omar Quintero-Monzon, Robert H. Scannevin, H. Moore Arnold, Thomas Engber, Kenneth Rhodes, James Ferrero, Yaming Hang, Alvydas Mikulskis, Jan Grimm, Christoph Hock, Roger M. Nitsch & Alfred Sandrock (Vol. 537, No. 7618, September 1, 2016, p. 50-56).

www.nature.com/nature/journal/v537/n7618/abs/nature19323.html

August 30, 2016

CAAR – Proceedings of the National Academy of Science Article Abstracts – August 30, 2016

A. “Holdase activity of secreted Hsp70 masks amyloid-{beta}42 neurotoxicity in Drosophila,” by Pedro Fernandez-Funez, Jonatan Sanchez-Garcia, Lorena de Mena, Yan Zhang, Yona Levites, Swati Khare, Todd E. Golde, and Diego E. Rincon-Limas (Vol. 113, No. 35, August 30, 2016, p. E5212–E5221).

www.pnas.org/content/113/35/E5212.abstract.html?etoc

B. “Glimpse of natural selection of long-lived T-cell clones in healthy life,” by Baojun Zhang, Qingzhu Jia, Cheryl Bock, Gang Chen, Haili Yu, Qingshan Ni, Ying Wan, Qijing Li, and Yuan Zhuang (Vol. 113, No. 35, August 30, 2016, p. 9858–9863).

www.pnas.org/content/113/35/9858.abstract.html?etoc

May 17, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 17, 2016

Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits,” by Marius Kollmer, Katrin Meinhardt, Christian Haupt, Falk Liberta, Melanie Wulff, Julia Linder, Lisa Handl, Liesa Heinrich, Cornelia Loos, Matthias Schmidt, Tatiana Syrovets, Thomas Simmet, Per Westermark, Gunilla T. Westermark, Uwe Horn, Volker Schmidt, Paul Walther, and Marcus Fandrich (Vol. 113, No. 3, May 17, 2016, p. 5604-5609).

www.pnas.org/content/113/20/5604.abstract

January 28, 2016

CAAR – Public Library of Science (PLoS) Article – January 28, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:53 pm

The Amyloid Precursor Protein of Alzheimer’s Disease Clusters at the Organelle/Microtubule Interface on Organelles that Bind Microtubules in an ATP Dependent Manner,” by James W. Stevenson, Eliza A. Conaty, Rylie B. Walsh, Paul J. Poidomani, Colin M. Samoriski, Brianne J. Scollins, and Joseph A. DeGiorgis (PLoS ONE 11(1): e0147808. doi:10.1371/journal.pone.0147808, XML, HTML, and .pdf format, 17p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0147808

January 8, 2016

CAAR – Public Library of Science (PLoS) Articles – January 8, 2016

Filed under: Reports and Articles — Tags: , , — admin @ 5:02 pm

A. “A Monte Carlo Study of the Early Steps of Functional Amyloid Formation,” by Pengfei Tian, Kresten Lindorff-Larsen, Wouter Boomsma, Mogens Hogh Jensen, and Daniel Erik Otzen (PLoS ONE 11(1): e0146096. doi:10.1371/journal.pone.0146096, XML, HTML, and .pdf format, 18p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0146096

B. “RAGE and AGEs in Mild Cognitive Impairment of Diabetic Patients: A Cross-Sectional Study,” by Pin Wang, Rong Huang, Sen Lu, Wenqing Xia, Rongrong Cai, Haixia Sun, and Shaohua Wang (PLoS ONE 11(1): e0145521. doi:10.1371/journal.pone.0145521, XML, HTML, and .pdf format, 15p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0145521

December 8, 2015

CAAR – Lancet Neurology Article Abstract – December 8, 2015

Filed under: Reports and Articles — Tags: , — admin @ 5:00 pm

Transition rates between amyloid and neurodegeneration biomarker states and to dementia: a population-based, longitudinal cohort study,” by Clifford R. Jack Jr., Terry M. Therneau, Heather J. Wiste, Stephen D. Weigand, David S. Knopman, Val J. Lowe, Michelle M. Mielke, Prashanthi Vemuri, Rosebud O. Roberts, Mary M. Machulda, Matthew L. Senjem, Jeffrey L. Gunter, Walter A. Rocca, and Ronald C. Petersen (Vol. 15, No. 1, January 2016, p. 56-64).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(15)00323-3/abstract

November 30, 2015

CAAR – Public Library of Science (PLoS) Article – November 30, 2015

Filed under: Reports and Articles — Tags: — admin @ 5:04 pm

Amyloid Precursor Protein Translation Is Regulated by a 3’UTR Guanine Quadruplex,” by Ezekiel Crenshaw, Brian P. Leung, Chun Kit Kwok, Michal Sharoni, Kalee Olson, Neeraj P. Sebastian, Sara Ansaloni, Reinhard Schweitzer-Stenner, Michael R. Akins, Philip C. Bevilacqua, and Aleister J. Saunders (PLoS ONE 10(11): e0143160. doi:10.1371/journal.pone.0143160, HTML, XML, and .pdf format, 18p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0143160

November 25, 2015

CAAR – Nature Neuroscience Brief Communications Abstract – November 25, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:14 pm

Decreased amyloid-{beta} and increased neuronal hyperactivity by immunotherapy in Alzheimer’s models,” by Marc Aurel Busche, Christine Grienberger, Aylin D. Keskin, Beomjong Song, Ulf Neumann, Matthias Staufenbiel, Hans Forstl & Arthur Konnerth (Vol. 18, No. 12, December 2015, p. 1725-1727).

www.nature.com/neuro/journal/v18/n12/abs/nn.4163.html

October 27, 2015

CAAR – Nature Neuroscience Brief Communication, Article Abstracts – October 27, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:42 pm

A. “CD33 modulates TREM2: convergence of Alzheimer loci,” by Gail Chan, Charles C White, Phoebe A. Winn, Maria Cimpean, Joseph M. Replogle, Laura R. Glick, Nicole E. Cuerdon, Katie J. Ryan, Keith A. Johnson, Julie A. Schneider, David A. Bennett, Lori B. Chibnik, Reisa A. Sperling, Elizabeth M. Bradshaw & Philip L. De Jager (Vol. 18, No. 11, November 2015, p. 1556-1558).

www.nature.com/neuro/journal/v18/n11/abs/nn.4126.html

B. “Persistence of A{beta} seeds in APP null mouse brain,” by Lan Ye, Sarah K. Fritschi, Juliane Schelle, Ulrike Obermüller, Karoline Degenhardt, Stephan A. Kaeser, Yvonne S. Eisele, Lary C. Walker, Frank Baumann, Matthias Staufenbiel & Mathias Jucker (Vol. 18, No. 11, November 2015, p. 1559-1561).

www.nature.com/neuro/journal/v18/n11/abs/nn.4117.html

C. “Rescue of long-range circuit dysfunction in Alzheimer’s disease models,” by Marc Aurel Busche, Maja Kekus, Helmuth Adelsberger, Takahiro Noda, Hans Forstl, Israel Nelken & Arthur Konnerth (Vol. 18, No. 11, November 2015, p. 1623-1630).

www.nature.com/neuro/journal/v18/n11/abs/nn.4137.html

October 14, 2015

CAAR – Nature Letter Abstract – October 14, 2015

Filed under: Reports and Articles — Tags: , — admin @ 5:15 pm

{Eta}-Secretase processing of APP inhibits neuronal activity in the hippocampus,” by Michael Willem, Sabina Tahirovic, Marc Aurel Busche, Saak V. Ovsepian, Magda Chafai, Scherazad Kootar, Daniel Hornburg, Lewis D. B. Evans, Steven Moore, Anna Daria, Heike Hampel, Veronika Muller, Camilla Giudici, Brigitte Nuscher, Andrea Wenninger-Weinzierl, Elisabeth Kremmer, Michael T. Heneka, Dietmar R. Thal, Vilmantas Giedraitis, Lars Lannfelt, Ulrike Muller, Frederick J. Livesey, Felix Meissner, Jochen Herms, Arthur Konnerth, Helene Marie & Christian Haass (Vol. 526, No. 7375, October 14, 2015, p. 443-447).

www.nature.com/nature/journal/v526/n7573/abs/nature14864.html

September 22, 2015

CAAR – Proceedings of the National Academies of Science Article Abstracts – September 22, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 4:48 pm

A. “Peptide dimer structure in an A{beta}(1–42) fibril visualized with cryo-EM,” by Matthias Schmidt, Alexis Rohou, Keren Lasker, Jay K. Yadav, Cordelia Schiene-Fischer, Marcus Fändrich, and Nikolaus Grigorieff (Vol. 112, No. 38, September 22, 2015, .pdf and HTML format, p. 11858-11863). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/38/11858.abstract

B. “Evidence for {alpha}-synuclein prions causing multiple system atrophy in humans with parkinsonism,” by Stanley B. Prusiner, Amanda L. Woerman, Daniel A. Mordes, Joel C. Watts, Ryan Rampersaud, David B. Berry, Smita Patel, Abby Oehler, Jennifer K. Lowe, Stephanie N. Kravitz, Daniel H. Geschwind, David V. Glidden, Glenda M. Halliday, Lefkos T. Middleton, Steve M. Gentleman, Lea T. Grinberg, and Kurt Giles (Vol. 112, No. 38, September 22, 2015, p. 11858-11863).

www.pnas.org/content/112/38/E5308.abstract

C. “Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer’s disease pathogenesis,” by Li Zhu, Minghao Zhong, Gregory A. Elder, Mary Sano, David M. Holtzman, Sam Gandy, Christopher Cardozo, Vahram Haroutunian, Nikolaos K. Robakis, and Dongming Cai (Vol. 112, No. 38, September 22, 2015, .pdf and HTML format, p. 11965-11970). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/38/11965.abstract

September 9, 2015

CAAR – Nature Letter Abstract – September 9, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 4:56 pm

Evidence for human transmission of amyloid-{beta} pathology and cerebral amyloid angiopathy,” by Zane Jaunmuktane, Simon Mead, Matthew Ellis, Jonathan D. F. Wadsworth, Andrew J. Nicoll, Joanna Kenny, Francesca Launchbury, Jacqueline Linehan, Angela Richard-Loendt, A. Sarah Walker, Peter Rudge, John Collinge & Sebastian Brandner (Vol. 525, No. 7568, September 9, 2015, p. 247-250).

www.nature.com/nature/journal/v525/n7568/abs/nature15369.html

September 4, 2015

CAAR – Nature Medicine Letter Abstract – September 4, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 4:52 pm

APP intracellular domain–WAVE1 pathway reduces amyloid-{beta} production,” by Ilaria Ceglia, Christiane Reitz, Jodi Gresack, Jung-Hyuck Ahn, Victor Bustos, Marina Bleck, Xiaozhu Zhang, Grant Martin, Sanford M. Simon, Angus C. Nairn, Paul Greengard & Yong Kim (Vol. 21, No. 9, September 2015, p. 1054-1059).

www.nature.com/nm/journal/v21/n9/abs/nm.3924.html

August 6, 2015

CAAR – Public Library of Science (PLoS) Article – August 6, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 4:50 pm

Obesity and Hepatic Steatosis Are Associated with Elevated Serum Amyloid Beta in Metabolically Stressed APPswe/PS1dE9 Mice,” by Feng-Shiun Shie, Young-Ji Shiao, Chih-Wen Yeh, Chien-Hung Lin, Tsai-Teng Tzeng, Hao-Chieh Hsu, Fong-Lee Huang, Huey-Jen Tsay, and Hui-Kang Liu (PLoS ONE 10(8): e0134531. doi:10.1371/journal.pone.0134531, XML, HTML, and .pdf format, p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0134531

July 29, 2015

CAAR -Nature Neuroscience Resource Abstract – July 29, 2015

Filed under: Reports and Articles — Tags: , — admin @ 5:00 pm

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice,” by Meaghan Morris, Giselle M. Knudsen, Sumihiro Maeda, Jonathan C. Trinidad, Alexandra Ioanoviciu, Alma L. Burlingame & Lennart Mucke (Vol. 18, No. 8, August 2015, p. 1183-1189).

www.nature.com/neuro/journal/v18/n8/abs/nn.4067.html

July 14, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 14, 2015

A. “Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques,” by Swetha Gowrishankar, Peng Yuan, Yumei Wu, Matthew Schrag, Summer Paradise, Jaime Grutzendler, Pietro De Camilli, and Shawn M. Ferguson (Vol. 112, No. 28, July 14, 2015, p. 8768–8773).

www.pnas.org/content/112/28/8768.abstract.html?etoc

B. “Neural activity and CaMKII protect mitochondria from fragmentation in aging Caenorhabditis elegans neurons,” by Hao-Ching Jiang, Jiun-Min Hsu, Chien-Ping Yen, Chi-Chao Chao, Ruey-Hwa Chen, and Chun-Liang Pan (Vol. 112, No. 28, July 14, 2015, p. E3699–E3708).

www.pnas.org/content/112/28/E3699.abstract.html?etoc

July 7, 2015

CAAR – Nature Medicine Letter Abstract – July 7, 2015

Filed under: Reports and Articles — Tags: , — admin @ 5:12 pm

Inhibition of amyloid-[beta] plaque formation by [alpha]-synuclein,” by Teresa Bachhuber, Natalie Katzmarski, Joanna F McCarter, Desiree Loreth, Sabina Tahirovic, Frits Kamp, Claudia Abou-Ajram, Brigitte Nuscher, Alberto Serrano-Pozo, Alexandra Muller, Marco Prinz, Harald Steiner, Bradley T. Hyman, Christian Haass & Melanie Meyer-Luehmann (Vol. 21, No. 7, July 2015, p. 802-807).

www.nature.com/nm/journal/v21/n7/abs/nm.3885.html

June 25, 2015

CAAR – Nature Neuroscience Article Abstracts – June 25, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:40 pm

A. “Central role for PICALM in amyloid-[beta] blood-brain barrier transcytosis and clearance,” by Zhen Zhao, Abhay P. Sagare, Qingyi Ma, Matthew R. Halliday, Pan Kong, Kassandra Kisler, Ethan A. Winkler, Anita Ramanathan, Takahisa Kanekiyo, Guojun Bu, Nelly Chuqui Owens, Sanket V. Rege, Gabriel Si, Ashim Ahuja, Donghui Zhu, Carol A. Miller, Julie A. Schneider, Manami Maeda, Takahiro Maeda, Tohru Sugawara, Justin K. Ichida & Berislav V. Zlokovic (Vol. 18, No. 7, July 2015, p. 978-987).

www.nature.com/neuro/journal/v18/n7/abs/nn.4025.html

B. “[beta]-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation,” by Bryce A. Mander, Shawn M. Marks, Jacob W. Vogel, Vikram Rao, Brandon Lu, Jared M. Saletin, Sonia Ancoli-Israel, William J. Jagust & Matthew P. Walker (Vol. 18, No. 7, July 2015, p. 1051-1057).

www.nature.com/neuro/journal/v18/n7/abs/nn.4035.html

May 27, 2015

CAAR – Nature Neuroscience Article, Perspectives Abstracts – May 27, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 5:05 pm

A. “Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson’s disease,” by Ariadna Laguna, Nicoletta Schintu, Andre Nobre, Alexandra Alvarsson, Nikolaos Volakakis, Jesper Kjaer Jacobsen, Marta Gomez-Galan, Elena Sopova, Eliza Joodmardi, Takashi Yoshitake, Qiaolin Deng, Jan Kehr, Johan Ericson, Per Svenningsson, Oleg Shupliakov & Thomas Perlmann (Vol. 18, No. 6, June 2015, p. 825-835).

www.nature.com/neuro/journal/v18/n6/abs/nn.4004.html

B. “The case for rejecting the amyloid cascade hypothesis,” by Karl Herrup (Vol. 18, No. 6, June 2015, p. 794-799).

www.nature.com/neuro/journal/v18/n6/abs/nn.4017.html

C. “Three dimensions of the amyloid hypothesis: time, space and ‘wingmen’,” by Erik S. Musiek & David M. Holtzman (Vol. 18, No. 6, June 2015, p. 800-806).

www.nature.com/neuro/journal/v18/n6/abs/nn.4018.html

May 19, 2015

CAAR – Journal of the American Medical Association Articles – May 19, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 4:25 pm

Note: The link below is to the table of contents for the current issue of JAMA (Vol. 313, No. 19, May 19, 2015). Check with your organization’s information center/library for availability.

A. “Prevalence of Amyloid PET Positivity in Dementia Syndromes: A Meta-analysis,” by Rik Ossenkoppele, Willemijn J. Jansen, Gil D. Rabinovici, Dirk L. Knol, Wiesje M. van der Flier, Bart N. M. van Berckel, Philip Scheltens, Pieter Jelle Visser, and the Amyloid PET Study Group (p. 1939-1949).

B. “Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia: A Meta-analysis,” by Willemijn J. Jansen, Rik Ossenkoppele, Dirk L. Knol, Betty M. Tijms, Philip Scheltens, Frans R. J. Verhey, Pieter Jelle Visser, and the Amyloid Biomarker Study Group (p. 1924-1938).

jama.jamanetwork.com/issue.aspx

May 5, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 5, 2015

pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers,” by Kevin W. Tipping, Theodoros K. Karamanos, Toral Jakhria, Matthew G. Iadanza, Sophia C. Goodchild, Roman Tuma, Neil A. Ranson, Eric W. Hewitt, and Sheena E. Radford (Vol. 112, No. 18, May 6, 2015, p. 5691–5696).

www.pnas.org/content/112/18/5691.abstract

April 28, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 28, 2015

Filed under: Reports and Articles — Tags: — admin @ 4:41 pm

Zinc as chaperone-mimicking agent for retardation of amyloid {beta} peptide fibril formation,” by Axel Abelein, Astrid Graslund, and Jens Danielsson (Vol. 112, No. 17, April 28, 2015, p. 5407-5412).

www.pnas.org/content/112/17/5407.abstract

April 21, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – April 21, 2015

A. “Structural characterization of toxic oligomers that are kinetically trapped during {alpha}-synuclein fibril formation,” by Serene W. Chen, Srdja Drakulic, Emma Deas, Myriam Ouberai, Francesco A. Aprile, Rocío Arranz, Samuel Ness, Cintia Roodveldt, Tim Guilliams, Erwin J. De-Genst, David Klenerman, Nicholas W. Wood, Tuomas P.J. Knowles, Carlos Alfonso, Germán Rivas, Andrey Y. Abramov, Jose María Valpuesta, Christopher M. Dobson, and Nunilo Cremades (Vol. 112, No. 16, April 21, 2015, p. E1994–E2003).

www.pnas.org/content/112/16/E1994.abstract

B. “Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive deficits,” by Shu-Sheng Jiao, Xiu-Qing Yao, Yu-Hui Liu, Qing-Hua Wang, Fan Zeng, Jian-Jun Lu, Jia Liu, Chi Zhu, Lin-Lin Shen, Cheng-Hui Liu, Ye-Ran Wang, Gui-Hua Zeng, Ankit Parikh, Jia Chen, Chun-Rong Liang, Yang Xiang, Xian-Le Bu, Juan Deng, Jing Li, Juan Xu, Yue-Qin Zeng, Xiang Xu, Hai-Wei Xu, Jin-Hua Zhong, Hua-Dong Zhou, Xin-Fu Zhou, and Yan-Jiang Wang (Vol. 112, No. 16, April 21, 2015, p. 5225-5230). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/16/5225.abstract

March 17, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 17, 2015

Filed under: Reports and Articles — Tags: , , , — admin @ 4:45 pm

A. “Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH Open,” by Shangyu Dang, Shenjie Wu, Jiawei Wang, Hongbo Li, Min Huang, Wei He, Yue-Ming Li, Catherine C. L. Wong, and Yigong Shi (Vol. 112, No. 11, March 17, 2015, .pdf and HTML format, p. 3344–3349). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/11/3344.abstract.html?etoc

B. “Insulin resistance in brain alters dopamine turnover and causes behavioral disorders,” by Andre Kleinridders, Weikang Cai, Laura Cappellucci, Armen Ghazarian, William R. Collins, Sara G. Vienberg, Emmanuel N. Pothos, and C. Ronald Kahn (Vol. 112, No. 11, March 17, 2015, p. 3463–3468).

www.pnas.org/content/112/11/3463.abstract.html?etoc

February 24, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 24, 2015

A. “Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice,” by Changgui Gua, Claudia P. Coomans, Kun Hub, Frank A. J. L. Scheer, H. Eugene Stanley, and Johanna H. Meijer (Vol. 112, No. 8, February 24, 2015, p. 2320-2324).

www.pnas.org/content/112/8/2320.abstract

B. “C-terminal sequence of amyloid-resistant type F apolipoprotein A-II inhibits amyloid fibril formation of apolipoprotein A-II in mice,” by Jinko Sawashita, Beiru Zhang, Kazuhiro Hasegawa, Masayuki Mori, Hironobu Naiki, Fuyuki Kametani, and Keiichi Higuchi (Vol. 112, No. 8, February 24, 2015, p. E836–E845).

www.pnas.org/content/112/8/E836.abstract

C. “Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice,” by Byung Hee Han, Meng-liang Zhou, Andrew W. Johnson, Itender Singh, Fan Liao, Ananth K. Vellimana, James W. Nelson, Eric Milner, John R. Cirrito, Jacob Basak, Min Yoo, Hans H. Dietrich, David M. Holtzman, and Gregory Joseph Zipfel (Vol. 112, No. 8, February 24, 2015, p. E881–E890). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/8/E881.abstract

D. “Metabolic resting-state brain networks in health and disease,” by Phoebe G. Spetsieris, Ji Hyun Ko, Chris C. Tang, Amir Nazem, Wataru Sako, Shichun Peng, Yilong Ma, Vijay Dhawan, and David Eidelberg (Vol. 112, No. 8, February 24, 2015, p. 2563–2568).

www.pnas.org/content/112/8/2563.abstract

January 29, 2015

CAAR – Public Library of Science (PLoS) Article – January 29, 2015

Filed under: Reports and Articles — Tags: , — admin @ 3:50 pm

The Resveratrol Trimer Miyabenol C Inhibits {beta}-Secretase Activity and {beta}-Amyloid Generation,” by Jin Hu, Ting Lin, Yuehong Gao, Junyue Xu, Chao Jiang, Guanghui Wang, Guojun Bu, Huaxi Xu, Haifeng Chen, and Yun-wu Zhang (PLoS ONE 10(1): e0115973. doi:10.1371/journal.pone.0115973, XML, HTML, and .pdf format, 13p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0115973

December 2, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 2, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:54 pm

{alpha}2A adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction,” by Yunjia Chen, Yin Peng, Pulin Che, Mary Gannon, Yin Liu, Ling Li, Guojun Bu, Thomas van Groen, Kai Jiao, and Qin Wang (Vol. 111, No. 18, December 2, 2014, p. 17296–17301).

www.pnas.org/content/111/48/17296.abstract

December 1, 2014

CAAR – Public Library of Science (PLoS) Article – December 1, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:48 pm

EGb761 Provides a Protective Effect against A{beta}1-42 Oligomer-Induced Cell Damage and Blood-Brain Barrier Disruption in an In Vitro bEnd.3 Endothelial Model,” by Wen-bin Wan, Lan Cao, Lu-mei Liu, Bill Kalionis, Chuan Chen, Xian-tao Tai, Ya-ming Li, and Shi-jin Xia (PLoS ONE 9(11): e113126. doi:10.1371/journal.pone.0113126, XML, HTML, and .pdf format, 8p.)

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0113126

October 14, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 14, 2014

A. “Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts,” by Massimo Ammirante, Shabnam Shalapour, Youngjin Kang, Christina A. M. Jamieson, and Michael Karin (Vol. 111, No. 41, October 14, 2014, p. 14776-14781).

www.pnas.org/content/111/41/14776.abstract

B. “Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues,” by Jennifer Honek, Takahiro Seki, Hideki Iwamoto, Carina Fischer, Jingrong Li, Sharon Lim, Nilesh J. Samani, Jingwu Zang, and Yihai Cao (Vol. 111, No. 41, October 14, 2014, p. 14906-14911).

www.pnas.org/content/111/41/14906.abstract

C. “Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats,” by Caitlin S. Latimer, Lawrence D. Brewer, James L. Searcy, Kuey-Chu Chen, Jelena Popovic, Susan D. Kraner, Olivier Thibault, Eric M. Blalock, Philip W. Landfield, and Nada M. Porter (Vol. 111, No. 41, October 14, 2014, p. E4359–E4366). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/111/41/E4359.abstract

D. “Proteopathic tau seeding predicts tauopathy in vivo,” by Brandon B. Holmes, Jennifer L. Furman, Thomas E. Mahan, Tritia R. Yamasaki, Hilda Mirbaha, William C. Eades, Larisa Belaygorod, Nigel J. Cairns, David M. Holtzman, and Marc I. Diamond (Vol. 111, No. 41, October 14, 2014, p. E4376–E4385).

www.pnas.org/content/111/41/E4376.abstract

October 9, 2014

CAAR – Nature Medicine Article Abstract – October 9, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:46 pm

Progranulin protects against amyloid {beta} deposition and toxicity in Alzheimer’s disease mouse models,” by S. Sakura Minami, Sang-Won Min, Grietje Krabbe, Chao Wang, Yungui Zhou, Rustam Asgarov, Yaqiao Li, Lauren H Martens, Lisa P. Elia, Michael E. Ward, Lennart Mucke, Robert V. Farese Jr. & Li Gan (Vol. 20, No. 10, October 2014, p. 1157-1164).

www.nature.com/nm/journal/v20/n10/abs/nm.3672.html

October 2, 2014

CAAR – Journal of Cerebral Blood Flow and Metabolism Article Abstract – October 2, 2014

Filed under: Reports and Articles — Tags: , — admin @ 3:16 pm

Cerebral vascular leak in a mouse model of amyloid neuropathology,” by Eric A. Tanifum, Zbigniew A. Starosolski, Stephanie W. Fowler, Joanna L Jankowsky, and Ananth V. Annapragada (Vol. 34, No. 10, October 2014, p. 1646-1654).

www.nature.com/jcbfm/journal/v34/n10/abs/jcbfm2014125a.html

September 25, 2014

CAAR – Nature Neuroscience Brief Communication Abstract – September 25, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:22 pm

Neural compensation in older people with brain amyloid-{beta} deposition,” by Jeremy A. Elman, Hwamee Oh, Cindee M. Madison, Suzanne L. Baker, Jacob W. Vogel, Shawn M. Marks, Sam Crowley, James P. O’Neil & William J. Jagust (Vol. 17, No. 10, October 2014, p. 1316-1318).

www.nature.com/neuro/journal/v17/n10/abs/nn.3806.html

September 16, 2014

CAAR – Lancet Neurology Article Abstract – September 16, 2014

Filed under: Reports and Articles — Tags: , , — admin @ 4:36 pm

Note: Lancet requires free registration prior to providing access to content. “Age-specific population frequencies of cerebral {beta}-amyloidosis and neurodegeneration among people with normal cognitive function aged 50–89 years: a cross-sectional study,” by Clifford R. Jack, Heather J. Wiste, Stephen .D Weigand, Walter A. Rocca, David S. Knopman, Michelle M. Mielke, Val J. Lowe, Matthew L. Senjem, Jeffrey L. Gunter, Gregory M. Preboske, Vernon S. Pankratz, Prashanthi Vemuri, and Ronald C. Petersen (Vol. 13, No. 10, October 2014, p. 997-1005).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70194-2/abstract

September 11, 2014

CAAR – Public Library of Science (PLoS) Articles – September 11, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:04 pm

A. “Engineering Amyloid-Like Assemblies from Unstructured Peptides via Site-Specific Lipid Conjugation,” by María Pilar Lopez Deber, David T. Hickman, Deepak Nand, Marc Baldus, Andrea Pfeifer, and Andreas Muhs (PLoS ONE 9(9): e105641. doi:10.1371/journal.pone.0105641, XML, HTML, and .pdf format, 10p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0105641

B. “Might Cortical Hyper-Responsiveness in Aging Contribute to Alzheimer’s Disease?” by Michael S. Jacob and Charles J. Duffy (PLoS ONE 9(9): e105962. doi:10.1371/journal.pone.0105962, XML, HTML, and .pdf format, 10p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0105962

September 4, 2014

CAAR – Public Library of Science (PLoS) Article – September 4, 2014

Filed under: Reports and Articles — Tags: , , , — admin @ 4:28 pm

A. “‘I Try and Smile, I Try and Be Cheery, I Try Not to Be Pushy. I Try to Say ‘I’m Here for Help’ but I Leave Feeling… Worried’: A Qualitative Study of Perceptions of Interactions with Health Professionals by Community-Based Older Adults with Chronic Pain,” by Amanda Clarke, Denis Martin, Derek Jones, Patricia Schofield, Geraldine Anthony, Paul McNamee, Denise Gray, and Blair H. Smith (PLoS ONE 9(9): e105450. doi:10.1371/journal.pone.0105450, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0105450

B. “Brain Intraventricular Injection of Amyloid-{beta} in Zebrafish Embryo Impairs Cognition and Increases Tau Phosphorylation, Effects Reversed by Lithium,” by aura Roesler Nery, Natalia Silva Eltz, Cristiana Hackman, Raphaela Fonseca, Stefani Altenhofen, Heydi Noriega Guerra, Vanessa Morais Freitas, Carla Denise Bonan, and Monica Ryff Moreira Roca Vianna (PLoS ONE 9(9): e105862. doi:10.1371/journal.pone.0105862, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0105862

July 1, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstract – July 1, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:51 pm

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the A{beta}40 and A{beta}42 peptides,” by Georg Meisl, Xiaoting Yang, Erik Hellstrand, Birgitta Frohm, Julius B. Kirkegaard, Samuel I. A. Cohen, Christopher M. Dobson, Sara Linse, and Tuomas P. J. Knowles (Vol. 111, No. 26, July 1, 2014, p. 9384–9389).

www.pnas.org/content/111/26/9384.abstract

June 13, 2014

CAAR – Public Library of Science (PLoS) Articles – June 13, 2014

Filed under: Reports and Articles — Tags: , , — admin @ 5:02 pm

A. “Social Participation and the Prevention of Functional Disability in Older Japanese: The JAGES Cohort Study,” by Satoru Kanamori, Yuko Kai, Jun Aida, Katsunori Kondo, Ichiro Kawachi, Hiroshi Hirai, Kokoro Shirai, Yoshiki Ishikawa, and Kayo Suzuki, The JAGES Group (PLoS ONE 9(6): e99638. doi:10.1371/journal.pone.0099638, XML, HTML, and .pdf format, 10p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099638

B. “Inhibition of the Polyamine System Counteracts {beta}-Amyloid Peptide-Induced Memory Impairment in Mice: Involvement of Extrasynaptic NMDA Receptors,” by Guilherme Monteiro Gomes, Gerusa Duarte Dalmolin, Julia Bar, Anna Karpova, Carlos Fernando Mello, Michael R. Kreutz, and Maribel Antonello Rubin (PLoS ONE 9(6): e99184. doi:10.1371/journal.pone.0099184, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099184

April 24, 2014

CAAR – Public Library of Science (PLoS) Article – April 24, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:33 pm

Amyloid-{beta} and Proinflammatory Cytokines Utilize a Prion Protein-Dependent Pathway to Activate NADPH Oxidase and Induce Cofilin-Actin Rods in Hippocampal Neurons,” by Keifer P. Walsh, Laurie S. Minamide, Sarah J. Kane, Alisa E. Shaw, David R. Brown, Bruce Pulford, Mark D. Zabel, J. David Lambeth, Thomas B. Kuhn, and James R. Bamburg (PLoS ONE 9(4): e95995. doi:10.1371/journal.pone.0095995, XML, HTML, and .pdf format, 12p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0095995

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