CDHA CAAR

October 31, 2017

CAAR – Nature Neuroscience Article Abstracts – October 31, 2017

Filed under: Reports and Articles — Tags: , , , — admin @ 4:44 pm

A. “[alpha]-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B,” by Diana G Ferreira, Mariana Temido-Ferreira, Hugo Vicente Miranda, Vania L. Batalha, Joana E. Coelho, Eva M. Szego, Ines Marques-Morgado, Sandra H. Vaz, Jeong Seop Rhee, Matthias Schmitz, Inga Zerr, Luísa V. Lopes & Tiago F. Outeiro (Vol. 20, No. 11, November 2017, p. 1569-1579).

www.nature.com/neuro/journal/v20/n11/abs/nn.4648.html

B. “Dopamine induces soluble {alpha}-synuclein oligomers and nigrostriatal degeneration,” by Danielle E. Mor, Elpida Tsika, Joseph R. Mazzulli, Neal S. Gould, Hanna Kim, Malcolm J. Daniels, Shachee Doshi, Preetika Gupta, Jennifer L. Grossman, Victor X. Tan, Robert G. Kalb, Kim A Caldwell, Guy A. Caldwell, John H. Wolfe & Harry Ischiropoulos (Vol. 20, No. 11, November 2017, p. 1560-1568).

www.nature.com/neuro/journal/v20/n11/abs/nn.4641.html

September 26, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 26, 2017

Modeling Parkinson’s disease pathology by combination of fibril seeds and {alpha}-synuclein overexpression in the rat brain,” by Poonam Thakur, Ludivine S. Breger, Martin Lundblad, Oi Wan Wan, Bengt Mattsson, Kelvin C. Luk, Virginia M. Y. Lee, John Q. Trojanowski, and Anders Bjorklund (Vol. 114, No. 39, September 26, 2017, p. E8284–E8293).

www.pnas.org/content/114/39/E8284.abstract.html?etoc

September 5, 2017

CAAR – Science Article Abstract – September 5, 2017

Filed under: Reports and Articles — Tags: , — admin @ 4:07 pm

{beta}2-Adrenoreceptor is a regulator of the {alpha}-synuclein gene driving risk of Parkinson’s disease,” by Shuchi Mittal, Kjetil Bjornevik, Doo Soon Im, Adrian Flierl, Xianjun Dong, Joseph J. Locascio, Kristine M. Abo, Elizabeth Long, Ming Jin, Bing Xu, Yang K. Xiang, Jean-Christophe Rochet, Anders Engeland, Patrizia Rizzu, Peter Heutink, Tim Bartels, Dennis J. Selkoe, Barbara J. Caldarone, Marcie A. Glicksman, Vikram Khurana, Birgitt Schule, David S. Park, Trond Riise, and Clemens R. Scherzer (Vol. 357, No. 6354, September 1, 2017, p. 891-898).

science.sciencemag.org/content/357/6354/891

June 28, 2017

CAAR – Nature Letter Abstract – June 28, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:15 pm

T cells from patients with Parkinson’s disease recognize {alpha}-synuclein peptides,” by David Sulzer, Roy N. Alcalay, Francesca Garretti, Lucien Cote, Ellen Kanter, Julian Agin-Liebes, Christopher Liong, Curtis McMurtrey, William H. Hildebrand, Xiaobo Mao, Valina L. Dawson, Ted M. Dawson, Carla Oseroff, John Pham, John Sidney, Myles B. Dillon, Chelsea Carpenter, Daniela Weiskopf, Elizabeth Phillips, Simon Mallal, Bjoern Peters, April Frazier, Cecilia S. Lindestam Arlehamn & Alessandro Sette (Vol. 546, No. 7660, June 29, 2017, p. 656-661).

www.nature.com/nature/journal/v546/n7660/abs/nature22815.html

June 20, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 20, 2017

Treatment with diphenyl–pyrazole compound anle138b/c reveals that {alpha}-synuclein protects melanoma cells from autophagic cell death,” by Elisa Turriani, Diana F. Lazaro, Sergey Ryazanov, Andrei Leonov, Armin Giese, Margarete Schon, Michael P. Schon, Christian Griesinger, Tiago F. Outeiro, Donna J. Arndt-Jovin, and Dorothea Becker (Vol. 114, No. 25, June 21, 2017, p. E4971–E4977).

www.pnas.org/content/114/25/E4971.abstract.html?etoc

June 6, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 6, 2017

Selective lowering of synapsins induced by oligomeric {alpha}-synuclein exacerbates memory deficits,” by Megan E. Larson, Susan J. Greimel, Fatou Amar, Michael LaCroix, Gabriel Boyle, Mathew A. Sherman, Hallie Schley, Camille Miel, Julie A. Schneider, Rakez Kayed, Fabio Benfenati, Michael K. Lee, David A. Bennett, and Sylvain E. Lesne (Vol. 114, No. 23, June 7, 2017, p. E4648-E4657).

www.pnas.org/content/114/23/E4648.abstract

April 26, 2017

CAAR – Nature Neuroscience Article Abstract – April 26, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:18 pm

{alpha}-Synuclein promotes dilation of the exocytotic fusion pore,” by Todd Logan, Jacob Bendor, Chantal Toupin, Kurt Thorn & Robert H. Edwards (Vol. 20, No. 5, May 2017, p. 681-689).

www.nature.com/neuro/journal/v20/n5/abs/nn.4529.html

February 28, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 28, 2017

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases {alpha}-synuclein aggregation,” by Sarah Jinn, Robert E. Drolet, Paige E. Cramer, Andus Hon-Kit Wong, Dawn M. Toolan, Cheryl A. Gretzula, Bhavya Voleti, Galya Vassileva, Jyoti Disa, Marija Tadin-Strapps, and David J. Stone (Vol. 114, No. 9, February 28, 2017, .pdf and HTML format, p. 2389-2394). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/9/2389.abstract

February 10, 2017

CAAR – Public Library of Science (PLoS) Article – February 10, 2017

Filed under: Reports and Articles — Tags: , — admin @ 4:55 pm

{alpha}-Synuclein increases {beta}-amyloid secretion by promoting {beta}-/{gamma}-secretase processing of APP,” by Hazel L. Roberts, Bernard L. Schneider, and David R. Brown (PLoS ONE 12(2): e0171925. doi:10.1371/journal.pone.0171925, XML, HTML, and .pdf format, 22p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0171925

January 31, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 31, 2017

A. “Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry,” by Palaniappan S. Chetty, Leland Mayne, Sissel Lund-Katz, S. Walter Englander, and Michael C. Phillips (Vol. 114, No. 5, January 31, 2017, p. 968-973).

www.pnas.org/content/114/5/968.abstract.html?etoc

B. “Nrf2 mitigates LRRK2- and {alpha}-synuclein–induced neurodegeneration by modulating proteostasis,” by Gaia Skibinski, Vicky Hwang, Dale Michael Ando, Aaron Daub, Alicia K. Lee, Abinaya Ravisankar, Sara Modan, Mariel M. Finucane, Benjamin A. Shaby, and Steven Finkbeiner (Vol. 114, No. 5, January 31, 2017, p. 1165–1170).

www.pnas.org/content/114/5/1165.abstract.html?etoc

C. “{alpha}-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation,” by Seong Su Kang, Zhentao Zhang, Xia Liu, Fredric P. Manfredsson, Li He, P. Michael Iuvone, Xuebing Cao, Yi E. Sun, Lingjing Jin, and Keqiang Ye (Vol. 114, No. 5, January 31, 2017, p. 1183–1185).

www.pnas.org/content/114/5/1183.abstract.html?etoc

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