A. “Early diagnosis and treatment of Alzheimer’s disease by targeting toxic soluble A[beta] oligomers,” by Maram Habashi, Suresh Vutla, Kuldeep Tripathi, Sudipta Senapati, Pradeep S. Chauhan, Anat Haviv-Chesner, Michal Richman, Samia-Ait Mohand, Véronique Dumulon-Perreault, Ramakotaiah Mulamreddy, Eitan Okun, Jordan H. Chill, Brigitte Guérin, William D. Lubell, and Shai Rahimipour (Vol. 119, No. 49, December 6, 2022, e2210766119).
www.pnas.org/doi/abs/10.1073/pnas.2210766119
B. “Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer’s disease,” by Sarah Mustaly-Kalimi, Wacey Gallegos, Robert A. Marr, Alice Gilman-Sachs, Daniel A. Peterson, Israel Sekler, and Grace E. Stutzmann (Vol. 119, No. 49, December 6, 2022, e2211999119).
www.pnas.org/doi/abs/10.1073/pnas.2211999119
C. “Age-related brain atrophy is not a homogenous process: Different functional brain networks associate differentially with aging and blood factors,” by Nikola T. Markov, Cutter A. Lindbergh, Adam M. Staffaroni, Kevin Perez, Michael Stevens, Khiem Nguyen, Natalia F. Murad, Corrina Fonseca, Judith Campisi, Joel Kramer, and David Furman (Vol. 119, No. 49, December 6, 2022, e2207181119).
www.pnas.org/doi/abs/10.1073/pnas.2207181119