Current Awareness in Aging Research (CAAR) Report #584 -- April 21, 2011

CAAR (Current Awareness in Aging Research) is a weekly email report produced by the Center for Demography of Health and Aging at the University of Wisconsin-Madison that helps researchers keep up to date with the latest developments in the field. For more information, including an archive of back issues and subscription information see:


I. Data:


A. "Medicare Program Payments," (2010, tables 3.1-3.6, .zip compressed .pdf and Microsoft Excel format).

B. "Medicare Home Health Agencies," (2010, tables 7.1-7.7, .zip compressed .pdf and Microsoft Excel format).


2. HUMAN MORTALITY DATABASE: Note: HMD requires free registration before providing data. The following update has been added to the database:

- Data for Norway and Hungary were revised and updated through 2009 (Apr. 15, 2011).

- Data for Luxembourg and Italy were revised and updated through 2009 (Apr. 20, 2011).

Data Availability:

Data Access:


II. Reports and articles:


A. _SSI Monthly Statistics, March 2011_ (April 2011, HTML and .pdf format).

B. _Monthly Statistical Snapshot, March 2011_ (April 2011).

C. "Estimated Financial Effects of Three Proposals to Improve the Actuarial Status of the Social Security Program Requested by Senator Kay Bailey Hutchinson," (April 14, 2011, .pdf format, 7p.).

D. "Estimated Financial Effects of "The Social Security Solvency and Sustainability Act"; legislation introduced as S. 804 (112th Congress) on April 13, 2011 by Senator Lindsey Graham, Senator Rand Paul, and Senator Mike Lee," (April 13, 2011, .pdf format, 19p.).

E. "Estimated Financial Effects of "Retirement Security for Today's Four-Year- Olds Act of 2011"; legislation introduced as H.R. 867 (112th Congress) on March 2, 2011 by Representative Cynthia M. Lummis," (April 12, 2011, .pdf format, 7p.).


4. US DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF INSPECTOR GENERAL REPORT: "Medicare Payments for Diagnostic Radiology Services in Emergency Departments," (OEI-07-09-00450, April 2011, .pdf format, 24p.).


5. US NATIONAL INSTITUTES OF HEALTH PRESS RELEASE: "NIH-supported survey to study functional change in older adults," (April 20, 2011).


6. STATISTICS CANADA/STATISTIQUE CANADA ARTICLE: "How does personal bankruptcy affect retirement plans?" by Susan Crompton (Canadian Social Trends, No. 91, Summer 2011, .pdf and HTML format, p. 48-56).




7. UK NATIONAL STATISTICS OFFICE PENSION TRENDS UPDATE: The following chapters were recently updated (.pdf format): "Ch 9: Pension scheme funding and investment", "Ch 10: Saving for retirement", and "Ch 14: Pensions and the National Accounts."


8. EMPLOYEE BENEFIT RESEARCH INSTITUTE PERIODICAL: EBRI Notes (Vol. 32, No. 4, April 2011, .pdf format, 12p.). Note: The feature article in this issue is "Retirement Income Adequacy: Alternative Thresholds and the Importance of Future Eligibility in Defined Contribution Retirement Plans," by Jack VanDerhei.


9. INTERNATIONAL LONGEVITY CENTRE [UK] REPORT: "Narrowing World Health Disparities and Longevity," (April 2011, .pdf format, 22p.).


10. AARP REPORT: "Multigenerational Households Are Increasing," by Rodney Harrell, Enid Kassner, and Carlos Figueiredo (April 2011, .pdf format, 3p.).


11. KAISER FAMILY FOUNDATION BRIEF: "Proposed Changes to Medicare in "Path to Prosperity": Overview and Key Questions," (April 2011, .pdf format, 8p.).


12. FAMILY CAREGIVER ALLIANCE PERIODICAL: Caregiving Policy Digest (Vol. 11, No. 7, Apr. 13, 2011).


13. NATURE ARTICLE ABSTRACT: "Caspase signalling controls microglia activation and neurotoxicity," by Miguel A. Burguillos, Tomas Deierborg, Edel Kavanagh, Annette Persson, Nabil Hajji, Albert Garcia-Quintanilla, Josefina Cano, Patrik Brundin, Elisabet Englund, Jose L. Venero & Bertrand Joseph (Vol. 472, No. 7343, April 21, 2011, p. 319-324).



A. "Differential transformation capacity of Src family kinases during the initiation of prostate cancer," by Houjian Cai, Daniel A. Smith, Sanaz Memarzadeh, Clifford A. Lowell, Jonathan A. Cooper, and Owen N. Witte (Vol. 108, No. 16, April 20, 2011, .pdf and HTML format, p. 6579-6584). Note: _PNAS_ is providing open access to the full-text of this article.

B. "Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism," by Francisco Ros-Bernal, Stephane Hunot, Maria Trinidad Herrero, Sebastien Parnadeau, Jean-Christophe Corvol, Lixia Lu, Daniel Alvarez-Fischer, Maria Angeles Carrillo-de Sauvage, Francoise Saurini, Christiane Coussieu, Kiyoka Kinugawa, Annick Prigent, Gunter Hoglinger, Michel Hamon, Francois Tronche, Etienne C. Hirsch, and Sheela Vyas (Vol. 108, No. 16, April 20, 2011, p. 6632-6637).


15. ALZHEIMER'S AND DEMENTIA: THE JOURNAL OF THE ALZHEIMER'S ASSOCIATION GUIDELINES: "New Criteria and Guidelines for Alzheimer's Disease Diagnosis," (April 2011, .pdf format).

Related NIA press release:



A. "Association of Plasma A{beta} Peptides with Blood Pressure in the Elderly," by Jean-Charles Lambert, Jean Dallongeville, Kathryn A. Ellis, Susanna Schraen-Maschke, James Lui, Simon Laws, Julie Dumont, Florence Richard, Dominique Cottel, Claudine Berr, David Ames, Colin L. Masters, Christopher C. Rowe, Cassandra Szoeke, Christophe Tzourio, Jean-Francois Dartigues, Luc Buee, Ralph Martins, and Philippe Amouyel (PLoS ONE 6(4): e18536. doi:10.1371/journal.pone.0018536, XML, HTML, and .pdf format, 6p.).

B. "Effect of a Nutrition Supplement and Physical Activity Program on Pneumonia and Walking Capacity in Chilean Older People: A Factorial Cluster Randomized Trial," by Alan D. Dangour, Cecilia Albala, Elizabeth Allen, Emily Grundy, Damian G. Walker, Cristian Aedo, Hugo Sanchez, Olivia Fletcher, Diana Elbourne, and Ricardo Uauy (PLoS Med 8(4): e1001023. doi:10.1371/journal.pmed.1001023, XML, HTML, and .pdf format, 12p.).

C. "Associated Factors for Falls among the Community-Dwelling Older People Assessed by Annual Geriatric Health Examinations," by Chung-Hao Lin, Kuo-Chen Liao, Shou-Jin Pu, Yung-Chang Chen, and Maw-Sen Liu (PLoS ONE 6(4): e18976. doi:10.1371/journal.pone.0018976, XML, HTML, and .pdf format, 5p.).

D. "A Cyclic Undecamer Peptide Mimics a Turn in Folded Alzheimer Amyloid {beta} and Elicits Antibodies against Oligomeric and Fibrillar Amyloid and Plaques," by Peter Hoogerhout, Willem Kamphuis, Humphrey F. Brugghe, Jacqueline A. Sluijs, Hans A. M. Timmermans, Janny Westdijk, Gijsbert Zomer, Claire J. P. Boog, Elly M. Hol, and Germie P. J. M. van den Dobbelsteen (PLoS ONE 6(4): e19110. doi:10.1371/journal.pone.0019110, XML, HTML, and .pdf format, 6p.).

E. "Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis," by Rebecca Craig-Schapiro, Max Kuhn, Chengjie Xiong, Eve H. Pickering, Jingxia Liu, Thomas P. Misko, Richard J. Perrin, Kelly R. Bales, Holly Soares, Anne M. Fagan, and David M. Holtzman (PLoS ONE 6(4): e18850. doi:10.1371/journal.pone.0018850, XML, HTML, and .pdf format, 15p.).

F. "Non-Esterified Fatty Acids Generate Distinct Low-Molecular Weight Amyloid-{beta} (A{beta}42) Oligomers along Pathway Different from Fibril Formation," by Amit Kumar, Rebekah L. Bullard, Pritesh Patel, Lea C. Paslay, Dipti Singh, Ewa A. Bienkiewicz, Sarah E. Morgan, and Vijayaraghavan Rangachari (PLoS ONE 6(4): e18759. doi:10.1371/journal.pone.0018759, XML, HTML, and .pdf format, 15p.).



A. "Cerebral amyloid-{beta} PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study," by Henryk Barthel, Hermann-Josef Gertz, Stefan Dresel, Oliver Peters, Peter Bartenstein, Katharina Buerger, Florian Hiemeyer, Sabine M. Wittemer-Rump, John Seibyl, Cornelia Reininger, and Osama Sabri, for the Florbetaben Study Group (Vol. 10, No. 5, May 2011, p. 424-435).

B. "A double-blind, delayed-start trial of rasagiline in Parkinson's disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes," by Olivier Rascol, Cheryl J. Fitzer-Attas, Robert Hauser, Joseph Jankovic, Anthony Lang, J. William Langston, Eldad Melamed, Werner Poewe, Fabrizio Stocchi, Eduardo Tolosa, Eli Eyal, Yoni M. Weiss, and C. Warren Olanow (Vol. 10, No. 5, May 2011, p. 415-423).



A. "Clinical Characteristics and Outcomes of Medicare Patients Undergoing Total Hip Arthroplasty, 1991-2008," by Peter Cram, Xin Lu, Peter J. Kaboli, Mary S. Vaughan-Sarrazin, Xueya Cai, Brian R. Wolf, and Yue Li (Vol. 305, No. 15, April 20, 2011, p. 1560-1567).

B. "Detection of Chronic Kidney Disease With Creatinine, Cystatin C, and Urine Albumin-to-Creatinine Ratio and Association With Progression to End-Stage Renal Disease and Mortality," by Carmen A. Peralta, Michael G. Shlipak, Suzanne Judd, Mary Cushman, William McClellan, Neil A. Zakai, Monika M. Safford, Xiao Zhang, Paul Muntner, and David Warnock (Vol. 305, No. 15, April 20, 2011, p. 1545-1552).


III. Working Papers:

19. NATIONAL BUREAU OF ECONOMIC RESEARCH: "Technology Growth and Expenditure Growth in Health Care," by Amitabh Chandra and Jonathan S. Skinner (w16953, April 2011, .pdf format, 54p.).


In the United States, health care technology has contributed to rising survival rates, yet health care spending relative to GDP has also grown more rapidly than in any other country. We develop a model of patient demand and supplier behavior to explain these parallel trends in technology growth and cost growth. We show that health care productivity depends on the heterogeneity of treatment effects across patients, the shape of the health production function, and the cost structure of procedures such as MRIs with high fixed costs and low marginal costs. The model implies a typology of medical technology productivity: (I) highly cost-effective "home run" innovations with little chance of overuse, such as anti-retroviral therapy for HIV, (II) treatments highly effective for some but not for all (e.g. stents), and (III) "gray area" treatments with uncertain clinical value such as ICU days among chronically ill patients. Not surprisingly, countries adopting Category I and effective Category II treatments gain the greatest health improvements, while countries adopting ineffective Category II and Category III treatments experience the most rapid cost growth. Ultimately, economic and political resistance in the U.S. to ever-rising tax rates will likely slow cost growth, with uncertain effects on technology growth.


20. NEP-AGE: Working papers in the Economics of Aging are available through the bibliographic database provided by Research Papers in Economics (RePEc). The latest compilations are for April 2 and 9, 2011.


IV. Journal Tables of Contents (check your library for availability):

21. Age and Ageing (Vol. 40, No. 3, May 2011).

22. European Review of Aging and Physical Activity (Vol. 8, No. 1, April 2011).

23. Journal of Alzheimer's Disease (Vol. 24, No. 1, April 2011).

24. Journal of the American Geriatrics Society (Vol. 59, No. 4, April 2011).


25. AMEDEO MEDICAL LITERATURE: Note: "AMEDEO has been created to serve the needs of healthcare professionals, including physicians, nurses, pharmacists, administrators, other members of the health professions, and patients and their friends. They can easily access timely, relevant information within their respective fields... All AMEDEO services are free of charge. This policy was made possible thanks to generous unrestricted educational grants provided by AMGEN, Berlex, Eisai, Glaxo Wellcome, Novartis, Pfizer, Roche, and Schering AG."

A. Osteoporosis: Literature for the week of April 18, 2011:

B. Alzheimer's Disease: Literature for the week of April 18, 2011:

C. Parkinson's Disease: Literature for the week of April 18, 2011:

D. Prostate Cancer: Literature for the week of April 18, 2011:

E. Stem Cell Research: Literature for the week of April 18, 2011:

F. Ophthalmology: Literature for the week of April 18, 2011:

AMEDEO Literature Guide:


V. Books:

26. HUDSON STREET PRESS: The Longevity Project: Surprising Discoveries for Health and Long Life from the Landmark Eight-Decade Study, by Howard S. Friedman and Leslie R. Martin (March 2011, ISBN 9781594630750, 277p.).,,9781594630750,00.html


VI. Funding/Employment Opportunities:

27. US NATIONAL INSTITUTES OF HEALTH: "Predictive Multiscale Models for Biomedical, Biological, Behavioral, Environmental and Clinical Research (Interagency U01)," (PAR-11-203, a reissue of PAR-08-023, US National Institute on Aging, in conjunction with other agencies).


28. US ADMINISTRATION ON AGING: "Lifespan Respite Care Program - Competing Program Expansion Supplements," (HHS-2011-AoA-LR-1111, .pdf and Word format, 48p.). The deadline for applications is June 15, 2011.




29. AGEWORK.COM: AgeWork has updated its employment page with listings through April 19, 2011.





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