CDHA CAAR

August 30, 2017

CAAR – Nature Letter Abstract – August 30, 2017

Filed under: Reports and Articles — Tags: , — admin @ 4:57 pm

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model,” by Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita, Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar & Jun Takahashi (Vol. 548, No. 7669, August 31, 2017, p. 592-596).Nature Letter Abstract: “Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model,” by Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita, Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar & Jun Takahashi (Vol. 548, No. 7669, August 31, 2017, p. 592-596).

www.nature.com/nature/journal/v548/n7669/abs/nature23664.html

December 14, 2016

CAAR – Nature Letter Abstract – December 14, 2016

Filed under: Reports and Articles — Tags: , , — admin @ 5:05 pm

Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals,” by Simon Schwörer, Friedrich Becker, Christian Feller, Ali H. Baig, Ute Kober, Henriette Henze, Johann M. Kraus, Beibei Xin, André Lechel, Daniel B. Lipka, Christy S. Varghese, Manuel Schmidt, Remo Rohs, Ruedi Aebersold, Kay L. Medina, Hans A. Kestler, Francesco Neri, Julia von Maltzahn, Stefan Tumpel & K. Lenhard Rudolph (Vol. 540, No. 7633, December 15, 2016, p. 428-432).

www.nature.com/nature/journal/v540/n7633/abs/nature20603.html

October 12, 2016

CAAR – Nature Letter Abstracts – October 12, 2016

Filed under: Reports and Articles — Tags: , , , — admin @ 5:15 pm

A. “Evidence for a limit to human lifespan,” by Xiao Dong, Brandon Milholland & Jan Vijg (Vol. 538, No. 7624, October 13, 2016, p. 257-259).

www.nature.com/nature/journal/v538/n7624/abs/nature19793.html

B. “Tissue-specific mutation accumulation in human adult stem cells during life,” by Francis Blokzijl, Joep de Ligt, Myrthe Jager, Valentina Sasselli, Sophie Roerink, Nobuo Sasaki, Meritxell Huch, Sander Boymans, Ewart Kuijk, Pjotr Prins, Isaac J. Nijman, Inigo Martincorena, Michal Mokry, Caroline L. Wiegerinck, Sabine Middendorp, Toshiro Sato, Gerald Schwank, Edward E. S. Nieuwenhuis, Monique M. A. Verstegen, Luc J. W. van der Laan, Jeroen de Jonge, Jan N. M. IJzermans, Robert G. Vries, Marc van de Wetering, Michael R. Stratton, Hans Clevers, Edwin Cuppen & Ruben van Boxtel (Vol. 538, No. 7624, October 13, 2016, p. 260-264).

www.nature.com/nature/journal/v538/n7624/abs/nature19768.html

August 4, 2016

CAAR – Nature Medicine Article Abstracts – August 4, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:51 pm

A. “Targeting [beta]1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice,” by Michelle Rozo, Liangji Li and Chen-Ming Fan (Vol. 22, No. 8, August 2016, p. 889-896).

www.nature.com/nm/journal/v22/n8/abs/nm.4116.html

B. “Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents,” by Dongryeol Ryu, Laurent Mouchiroud, Penelope A. Andreux, Elena Katsyuba, Norman Moullan, Amandine A. Nicolet-dit-Felix, Evan G. Williams, Pooja Jha, Giuseppe Lo Sasso, Damien Huzard, Patrick Aebischer, Carmen Sandi, Chris Rinsch & Johan Auwerx (Vol. 22, No. 8, August 2016, p. 879-888).

www.nature.com/nm/journal/v22/n8/abs/nm.4132.html

C. “Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice,” by Laura Lukjanenko, M. Juliane Jung, Nagabhooshan Hegde, Claire Perruisseau-Carrier, Eugenia Migliavacca, Michelle Rozo, Sonia Karaz, Guillaume Jacot, Manuel Schmidt, Liangji Li, Sylviane Metairon, Frederic Raymond, Umji Lee, Federico Sizzano, David H. Wilson, Nicolas A. Dumont, Alessio Palini, Reinhard Fässler, Pascal Steiner, Patrick Descombes, Michael A. Rudnicki, Chen-Ming Fan, Julia von Maltzahn, Jerome N. Feige & C. Florian Bentzinger (Vol. 22, No. 8, August 2016, p. 897-905).

www.nature.com/nm/journal/v22/n8/abs/nm.4126.html

July 26, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 26, 2016

A. “Equity and length of lifespan are not the same,” by Benjamin Seligman, Gabi Greenberg, and Shripad Tuljapurkar (Vol. 113, No. 30, July 26, 2016, p. 8420-8423).

www.pnas.org/content/113/30/8420.abstract

B. “FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice,” by Henrik Ahlenius, Soham Chanda, Ashley E. Webb, Issa Yousif, Jesse Karmazin, Stanley B. Prusiner, Anne Brunet, Thomas C. Sudhof, and Marius Wernig (Vol. 113, No. 30, July 26, 2016, p. 8514-8519).

www.pnas.org/content/113/30/8514.abstract

C. “Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts,” by Giambattista Guaitoli, Francesco Raimondi, Bernd K. Gilsbach, Yacob Gomez-Llorente, Egon Deyaert, Fabiana Renzi, Xianting Li, Adam Schaffner, Pravin Kumar Ankush Jagtap, Karsten Boldt, Felix von Zweydorf, Katja Gotthardt, Donald D. Lorimer, Zhenyu Yue, Alex Burgin, Nebojsa Janjic, Michael Sattler, Wim Versees, Marius Ueffing, Iban Ubarretxena-Belandia, Arjan Kortholt, and Christian Johannes Gloeckner (Vol. 113, No. 30, July 26, 2016, .pdf and HTML format, p. E4357-E4366). Note: _PNAS_ is providing open access to the full-text of this article.

www.pnas.org/content/113/30/E4357.abstract

September 18, 2015

CAAR – Science Report Abstract – September 18, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 4:29 pm

A mechanism for the segregation of age in mammalian neural stem cells,” by D. L. Moore, G. A. Pilz1, M. J. Araúzo-Bravo, Y. Barral, and S. Jessberger (Vol. 349, No. 6254, September 19, 2015, p. 1334-1338).

www.sciencemag.org/content/349/6254/1334.abstract

August 19, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstract – August 19, 2015

Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells,” by Michael C. Velarde, Marco Demaria, Simon Melov, and Judith Campisi (Vol. 112, No. 33, August 18, 2015, p. 10407–10412).

www.pnas.org/content/112/33/10407.abstract.html?etoc

February 9, 2015

CAAR – Nature Biotechnology Article Abstract – February 9, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:48 pm

Optogenetics enables functional analysis of human embryonic stem cell–derived grafts in a Parkinson’s disease model,” by Julius A. Steinbeck, Se Joon Choi, Ana Mrejeru, Yosif Ganat, Karl Deisseroth, David Sulzer, Eugene V. Mosharov & Lorenz Studer (Vol. 33, No. 2, February 2015, p. 204-209).

www.nature.com/nbt/journal/v33/n2/abs/nbt.3124.html

March 6, 2014

CAAR – Nature Medicine Article Abstracts – March 6, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:22 pm

A. “Rejuvenation of the muscle stem cell population restores strength to injured aged muscles,” by Benjamin D. Cosgrove, Penney M. Gilbert, Ermelinda Porpiglia, Foteini Mourkioti, Steven P. Lee, Stephane Y. Corbel, Michael E. Llewellyn, Scott L. Delp & Helen M. Blau (Vol. 20, No. 3, March 2014, p. 255-264).

www.nature.com/nm/journal/v20/n3/abs/nm.3464.html

B. “p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice,” by Jennifer D. Bernet, Jason D. Doles, John K. Hall, Kathleen Kelly Tanaka, Thomas A. Carter & Bradley B. Olwin (Vol. 20, No. 3, March 2014, p. 265-271).

www.nature.com/nm/journal/v20/n3/abs/nm.3465.html

October 17, 2012

CAAR – Nature Article Abstract – October 17, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 4:20 pm

The aged niche disrupts muscle stem cell quiescence,” by Joe V. Chakkalakal, Kieran M. Jones, M. Albert Basson & Andrew S. Brack (Vol. 490, No. 7420, October 18, 2012, p. 355-360).

www.nature.com/nature/journal/v490/n7420/abs/nature11438.html

September 18, 2012

CAAR – Public Library of Science (PLoS) Articles – September 18, 2012

Filed under: Reports and Articles — Tags: , , , — admin @ 4:01 pm

A. “Does Multimorbidity Influence the Occurrence Rates of Chronic Conditions? A Claims Data Based Comparison of Expected and Observed Prevalence Rates,” by Ingmar Schafer (PLoS ONE 7(9): e45390. doi:10.1371/journal.pone.0045390, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0045390

B. “Stability of the Transthyretin Molecule as a Key Factor in the Interaction with A-Beta Peptide – Relevance in Alzheimer’s Disease,” by Carlos A. Ribeiro, Maria Joao Saraiva, and Isabel Cardoso (PLoS ONE 7(9): e45368. doi:10.1371/journal.pone.0045368, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0045368

C. “Mitochondrial Genomic Analysis of Late Onset Alzheimer’s Disease Reveals Protective Haplogroups H6A1A/H6A1B: The Cache County Study on Memory in Aging,” by Perry G. Ridge, Taylor J. Maxwell, Christopher D. Corcoran, Maria C. Norton, JoAnn T. Tschanz, Elizabeth O’Brien, Richard A. Kerber, Richard M. Cawthon, Ronald G. Munger, and John S. K. Kauwe (PLoS ONE 7(9): e45134. doi:10.1371/journal.pone.0045134, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0045134

D. “Aging Effect on Neurotrophic Activity of Human Mesenchymal Stem Cells,” by Maria Brohlin, Paul J. Kingham, Liudmila N. Novikova, Lev N. Novikov, and Mikael Wiberg (PLoS ONE 7(9): e45052. doi:10.1371/journal.pone.0045052, XML, HTML, and .pdf format, 10p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0045052

July 26, 2012

CAAR – Public Library of Science (PLoS) Articles – July 26, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 3:53 pm

A. “Establishment of Induced Pluripotent Stem Cells from Centenarians for Neurodegenerative Disease Research,” by Takuya Yagi, Arifumi Kosakai, Daisuke Ito, Wado Akamatsu, Yoshihiro Nihei, Akira Nabetani, Fuyuki Ishikawa, Yasumichi Arai, Nobuyoshi Hirose, Hideyuki Okano, and Norihiro Suzuki (PLoS ONE 7(7): e41572. doi:10.1371/journal.pone.0041572, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0041572

B. “Disruption of Arterial Perivascular Drainage of Amyloid-{beta} from the Brains of Mice Expressing the Human APOE e4 Allele,” by Cheryl A. Hawkes, Patrick M. Sullivan, Sarah Hands, Roy O. Weller, James A. R. Nicoll, and Roxana O. Carare (PLoS ONE 7(7): e41636. doi:10.1371/journal.pone.0041636, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0041636

July 5, 2012

CAAR – US National Institutes of Health Press Release – July 5, 2012

Filed under: Reports and Articles — Tags: , — admin @ 3:42 pm

Patient-derived stem cells could improve drug research for Parkinson’s,” (July 4, 2012).

www.nih.gov/news/health/jul2012/ninds-04.htm

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