“Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease,” by Arthur G. Fitzmaurice, Shannon L. Rhodes, Aaron Lulla, Niall P. Murphy, Hoa A. Lam, Kelley C. O’Donnell, Lisa Barnhill, John E. Casida, Myles Cockburn, Alvaro Sagasti, Mark C. Stahl, Nigel T. Maidment, Beate Ritz, and Jeff M. Bronstein (Vol. 110, No. 2, January 9, 2013, p. 636-641).
January 9, 2013
CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 9, 2013
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December 18, 2012
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – December 18, 2012
A. “Neural and behavioral bases of age differences in perceptions of trust,” by Elizabeth Castle, Naomi I. Eisenberger, Teresa E. Seeman, Wesley G. Moons, Ian A. Boggero, Mark S. Grinblatt, and Shelley E. Taylor (Vol. 109, No. 51, December 18, 2012, p. 20848-20852).
www.pnas.org/content/109/51/20848.abstract.html?etoc
B. “Out-of-register {beta}-sheets suggest a pathway to toxic amyloid aggregates,” by Cong Liu, Minglei Zhao, Lin Jiang, Pin-Nan Cheng, Jiyong Park, Michael R. Sawaya, Anna Pensalfini, Dawei Gou, Arnold J. Berk, Charles G. Glabe, James Nowick, and David Eisenberg (Vol. 109, No. 51, December 18, 2012, p. 20913-20918).
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October 30, 2012
CAAR – Proceedings of the National Academy of Sciences Article – October 30, 2012
“Human mortality improvement in evolutionary context,” by Oskar Burger, Annette Baudisch, and James W. Vaupel (Vol. 109, No. 44, Oct. 30, 2012, HTML and, .pdf format, p. 18210-18214). This article is available free of charge.
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September 27, 2012
CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 27, 2012
“Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease ,” by Maxime W. C. Rousseaux, Paul C. Marcogliese, Dianbo Qu, Sarah J. Hewitt, Sarah Seang, Raymond H. Kim, Ruth S. Slack, Michael G. Schlossmacher, Diane C. Lagace, Tak W. Mak, and David S. Park (Vol. 109, No. 39, September 25, 2012, .pdf and HTML format, p. 15918-15923). Note: PNAS is providing open access to the full-text of this article.
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August 21, 2012
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – August 21, 2012
A. “Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids,” by Peter X. Shaw, Li Zhang, Ming Zhang, Hongjun Du, Ling Zhao, Clara Lee, Seanna Grob, Siok Lam Lim, Guy Hughes, Janet Lee, Matthew Bedell, Mark H. Nelson, Fang Lu, Martin Krupa, Jing Luo, Hong Ouyang, Zhidan Tu, Zhiguang Su, Jin Zhu, Xinran Wei, Zishan Feng, Yaou Duan, Zhenglin Yang, Henry Ferreyra, Dirk-Uwe Bartsch, Igor Kozak, Liangfang Zhang, Feng Lin, Hui Sun, Hong Feng, and Kang Zhang (Vol. 109, No. 34, Aug. 21, 2012, p. 13757-13762).
www.pnas.org/content/109/34/13757.abstract
B. “ERK1/2 activation is a therapeutic target in age-related macular degeneration,” by Sami Dridi, Yoshio Hirano, Valeria Tarallo, Younghee Kim, Benjamin J. Fowler, Balamurali K. Ambati, Sasha Bogdanovich, Vince A. Chiodo, William W. Hauswirth, Jennifer F. Kugel, James A. Goodrich, Steven L. Ponicsan, David R. Hinton, Mark E. Kleinman, Judit Z. Baffi, Bradley D. Gelfand, and Jayakrishna Ambati (Vol. 109, No. 34, Aug. 21, 2012, p. 13781-13786).
www.pnas.org/content/109/34/13781.abstract
C. “Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer’s disease,” by Álvaro O. Ardiles, Cheril C. Tapia-Rojas, Madhuchhanda Mandal, Frédéric Alexandre, Alfredo Kirkwood, Nibaldo C. Inestrosa, and Adrian G. Palacios (Vol. 109, No. 34, Aug. 21, 2012, p. 13835-13840).
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June 19, 2012
CAAR – Proceedings of the National Academy Sciences Article Abstract – June 19, 2012
“Loss of functional GABAA receptors in the Alzheimer diseased brain,” by Agenor Limon, Jorge Mauricio Reyes-Ruiz, and Ricardo Miledi (Vol. 109, No. 25, June 19, 2012, p. 10071-10076).
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May 30, 2012
CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 30, 2012
“Critical role of soluble amyloid-{beta} for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease,” by Marc Aurel Busche, Xiaowei Chen, Horst A. Henning, Julia Reichwald, Matthias Staufenbiel, Bert Sakmann, and Arthur Konnerth (Vol. 109, No. 22, May 29, 2012, p. 8740-8745).
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May 15, 2012
CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 15, 2012
“Toxic fibrillar oligomers of amyloid-ß have cross-ß structure,” by James C. Stroud, Cong Liu, Poh K. Teng, and David Eisenberg (Vol. 109, No. 20, May 15, 2012, p. 7717-7722).
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April 27, 2012
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – April 27, 2012
A. “Summer temperature variability and long-term survival among elderly people with chronic disease,” by Antonella Zanobetti, Marie S. O’Neill, Carina J. Gronlund, and Joel D. Schwartz (Vol. 109, No. 17, Apr. 24, 2012, p. 6608-6613).
www.pnas.org/content/109/17/6608.abstract
B. “Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk,” by Francesca Demichelis, Sunita R. Setlur, Samprit Banerjee, Dimple Chakravarty, Jin Yun Helen Chen, Chen X. Chen, Julie Huang, Himisha Beltran, Derek A. Oldridge, Naoki Kitabayashi, Birgit Stenzel, Georg Schaefer, Wolfgang Horninger, Jasmin Bektic, Arul M. Chinnaiyan, Sagit Goldenberg, Javed Siddiqui, Meredith M. Regan, Michale Kearney, T. David Soong, David S. Rickman, Olivier Elemento, John T. Wei, Douglas S. Scherr, Martin A. Sanda, Georg Bartsch, Charles Lee, Helmut Klocker, and Mark A. Rubin (Vol. 109, No. 17, Apr. 24, 2012, p. 6686-6691).
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April 16, 2012
CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 16, 2012
“Superoxide dismutase is dispensable for normal animal lifespan,” by Jeremy Michael Van Raamsdonk and Siegfried Hekimi (Vol. 109, No. 15, Apr. 10, 2012, p. 5785-5790).
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March 28, 2012
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 28, 2012
“Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform,” by Sung Sik Lee, Ima Avalos Vizcarra, Daphne H.E.W. Huberts, Luke P. Lee, and Matthias Heinemann (Vol. 109, No. 13, Mar. 27, 2012, p. 4916-4920).
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March 20, 2012
CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 20, 2012
“Antiparallel beta-sheet architecture in Iowa-mutant beta-amyloid fibrils,” by Wei Qiang, Wai-Ming Yau, Yongquan Luo, Mark P. Mattson, and Robert Tycko (Vol. 109, No. 12, March 20, 2012, p. 4443-4448).
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March 14, 2012
CAAR – Proceedings of the National Academy of Sciences Article – March 14, 2012
Proceedings of the National Academy of Sciences Article Abstracts:
A. “Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms,” by Thomas C.J. Tan, Ruman Rahman, Farah Jaber-Hijazi, Daniel A. Felix, Chen Chen, Edward J. Louis, and Aziz Aboobaker (Vol. 109, No. 11, Mar. 13, 2012, HTML and .pdf format, p. 4209-4214). This article is available free of charge.
www.pnas.org/content/109/11/4209.full
B. ”ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila,” by Andrew J. Petersen, Stacey A. Rimkus, and David A. Wassarman (Vol. 109, No. 11, March 14, 2012, p. E656-E664).
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February 21, 2012
CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 21, 2012
A. “Skeletal muscle transcriptional coactivator PGC-1a mediates mitochondrial, but not metabolic, changes during calorie restriction,” by Lydia W. S. Finley, Jaewon Lee, Amanda Souza, Valerie Desquiret-Dumas, Kevin Bullock, Glenn C. Rowe, Vincent Procaccio, Clary B. Clish, Zoltan Arany, and Marcia C. Haigis (Vol. 109, No. 8, February 22, 2012, p. 2931-2936).
www.pnas.org/content/109/8/2931.abstract
B. “Inactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesis,” by Zehua Wang, Zemin Wang, Jianhui Guo, Yingchun Li, Jasmin H. Bavarva, Chiping Qian, M. Christiane Brahimi-Horn, Deyong Tan, and Wanguo Liu (Vol. 109, No. 8, February 22, 2012, p. 3053-3058).
www.pnas.org/content/109/8/3053.abstract
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February 15, 2012
CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 15, 2012
“Decreased osteoclastogenesis in serotonin-deficient mice,” by Yasmine Chabbi-Achengli, Amelie E. Coudert, Jacques Callebert, Valerie Geoffroy, Francine Coted, Corinne Collet, and Marie-Christine de Vernejoul (Vol. 109, No. 7, February 14, 2012, p. 2567-2572).
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February 1, 2012
CAAR – Proceedings of the National Academy of Sciences Articles, Article Abstract – February 1, 2012
A. “Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression,” by Justin M. Drake, Nicholas A. Graham, Tanya Stoyanova, Amir Sedghi, Andrew S. Goldstein, Houjian Cai, Daniel A. Smith, Hong Zhang, Evangelia Komisopoulou, Jiaoti Huang, Thomas G. Graeber, and Owen N. Witte (Vol. 109, No. 5, Jan. 31, 2012, HTML and .pdf format, p. 1643-1648). This article is available free of charge.
www.pnas.org/content/109/5/1643.full
B. “Telomere length in early life predicts lifespan,” by Britt J. Heidinger, Jonathan D. Blount, Winnie Boner, Kate Griffiths, Neil B. Metcalfe, and Pat Monaghan Vol. 109, No. 5, Jan. 31, 2012, HTML and .pdf format, p. 1743-1748). This article is available free of charge.
www.pnas.org/content/109/5/1743.full
B. “Antagonists of growth hormone-releasing hormone inhibit growth of androgen-independent prostate cancer through inactivation of ERK and Akt kinases,” by Ferenc G. Rick, Andrew V. Schally, Luca Szalontay, Norman L. Block, Karoly Szepeshazi, Mehrdad Nadji, Marta Zarandi, Florian Hohla, Stefan Buchholz, and Stephan Seitz (Vol. 109, No. 5, Jan. 31, 2012, p. 1655-1660).
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