CDHA CAAR

May 12, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 12, 2015

Targeting {beta}-arrestin2 in the treatment of L-DOPA–induced dyskinesia in Parkinson’s disease,” by Nikhil M. Urs, Simone Bido, Sean M. Peterson, Tanya L. Daigle, Caroline E. Bass, Raul R. Gainetdinov, Erwan Bezard, and Marc G. Caron (Vol. 112, No. 19, May 12, 2015, p. E2517–E2526).

www.pnas.org/content/112/19/E2517.abstract

April 28, 2015

CAAR – Nature Neuroscience Article Abstract – April 28, 2015

Filed under: Reports and Articles — Tags: — admin @ 4:40 pm

Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson’s disease,” by Coralie de Hemptinne, Nicole C. Swann, Jill L. Ostrem, Elena S. Ryapolova-Webb, Marta San Luciano, Nicholas B. Galifianakis & Philip A. Starr (Vol. 18, No. 5, May 2015, p. 779-786).

www.nature.com/neuro/journal/v18/n5/abs/nn.3997.html

April 24, 2015

CAAR – Public Library of Science (PLoS) Article – April 24, 2015

Filed under: Reports and Articles — Tags: — admin @ 4:41 pm

Motor Performance Assessment in Parkinson’s Disease: Association between Objective In-Clinic, Objective In-Home, and Subjective/Semi-Objective Measures,” by Nima Toosizadeh, Jane Mohler, Hong Lei, Saman Parvaneh, Scott Sherman, and Bijan Najafi (PLoS ONE 10(4): e0124763. doi:10.1371/journal.pone.0124763, XML, HTML, and .pdf format, 15p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0124763

April 23, 2015

CAAR – Public Library of Science (PLoS) Articles – April 23, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:27 pm

A. “Relationship between Adiponectin Gene Polymorphisms and Late-Onset Alzheimer’s Disease,” by Zhuling Yu, Wei Li, Deren Hou, Lin Zhou, Yanyao Deng, Mi Tian, and Xialu Feng (PLoS ONE 10(4): e0125186. doi:10.1371/journal.pone.0125186, XML, HTML, and .pdf format, 11p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0125186

B. “Digitomotography in Parkinson’s Disease: A Cross-Sectional and Longitudinal Study,” by Walter Maetzler, Maren Ellerbrock, Tanja Heger, Christian Sass, Daniela Berg, and Ralf Reilmann (PLoS ONE 10(4): e0123914. doi:10.1371/journal.pone.0123914, XML, HTML, and .pdf format, 9p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0123914

April 14, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 14, 2015

{alpha}-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation,” by Shijun Wang, Chun-Hsien Chu, Tessandra Stewart, Carmen Ginghina, Yifei Wang, Hui Nie, Mingri Guo, Belinda Wilson, Jau-Shyong Hong, and Jing Zhang (Vol. 112, No. 15, April 15, 2015, p. E1926-E1935).

www.pnas.org/content/112/15/E1926.abstract

March 30, 2015

CAAR – Public Library of Science (PLoS) Articles – March 30, 2015

A. “Hip Fracture in the Elderly: A Re-Analysis of the EPIDOS Study with Causal Bayesian Networks,” by Pascal Caillet, Sarah Klemm, Michel Ducher, Alexandre Aussem, and Anne-Marie Schott (PLoS ONE 10(3): e0120125. doi:10.1371/journal.pone.0120125, HTML, XML, and .pdf format, 12p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0120125

B. “Cognitive Functions and Stereopsis in Patients with Parkinson’s Disease and Alzheimer’s Disease Using 3-Dimensional Television: A Case Controlled Trial,” by Chan-Nyoung Lee, Deokwon Ko, Young-Woo Suh, and Kun-Woo Park (PLoS ONE 10(3): e0123229. doi:10.1371/journal.pone.0123229, XML, HTML, and .pdf format, 11p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0123229

February 24, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 24, 2015

A. “Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice,” by Changgui Gua, Claudia P. Coomans, Kun Hub, Frank A. J. L. Scheer, H. Eugene Stanley, and Johanna H. Meijer (Vol. 112, No. 8, February 24, 2015, p. 2320-2324).

www.pnas.org/content/112/8/2320.abstract

B. “C-terminal sequence of amyloid-resistant type F apolipoprotein A-II inhibits amyloid fibril formation of apolipoprotein A-II in mice,” by Jinko Sawashita, Beiru Zhang, Kazuhiro Hasegawa, Masayuki Mori, Hironobu Naiki, Fuyuki Kametani, and Keiichi Higuchi (Vol. 112, No. 8, February 24, 2015, p. E836–E845).

www.pnas.org/content/112/8/E836.abstract

C. “Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice,” by Byung Hee Han, Meng-liang Zhou, Andrew W. Johnson, Itender Singh, Fan Liao, Ananth K. Vellimana, James W. Nelson, Eric Milner, John R. Cirrito, Jacob Basak, Min Yoo, Hans H. Dietrich, David M. Holtzman, and Gregory Joseph Zipfel (Vol. 112, No. 8, February 24, 2015, p. E881–E890). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/8/E881.abstract

D. “Metabolic resting-state brain networks in health and disease,” by Phoebe G. Spetsieris, Ji Hyun Ko, Chris C. Tang, Amir Nazem, Wataru Sako, Shichun Peng, Yilong Ma, Vijay Dhawan, and David Eidelberg (Vol. 112, No. 8, February 24, 2015, p. 2563–2568).

www.pnas.org/content/112/8/2563.abstract

February 20, 2015

CAAR – Tables of Contents – February 20, 2015

Filed under: Journal Table of Contents — Tags: , — admin @ 4:43 pm

Journals of Gerontology (A): Biological Sciences (Vol. 70A, No. 3, March 2015).

biomedgerontology.oxfordjournals.org/content/70/3.toc

Journal of Parkinson’s Disease (Vol. 5, No. 1, February 2015).

iospress.metapress.com/content/jlg77g0q44w2/

February 17, 2015

CAAR – Proccedings of the National Academy of Sciences Article Abstract – February 17, 2015

Network-based metaanalysis identifies HNF4A and PTBP1 as longitudinally dynamic biomarkers for Parkinson’s disease,” by Jose A. Santiago and Judith A. Potashkin (Vol. 112, No. 7, February 17, 2015, p. 2257-2262).

www.pnas.org/content/112/7/2257.abstract

February 16, 2015

CAAR – Lancet Neurology Article Abstracts – February 16, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:49 pm

Note: Lancet requires free registration prior to providing content.

A. “Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis,” by Jonathan D. Rohrer, Jennifer M. Nicholas, David M. Cash, John van Swieten, Elise Dopper, Lize Jiskoot, Rick van Minkelen, Serge A. Rombouts, M. Jorge Cardoso, Shona Clegg, Miklos Espak, Simon Mead, David L Thomas, Enrico De Vita, Mario Masellis, Sandra E. Black, Morris Freedman, Ron Keren, Bradley J. MacIntosh, Ekaterina Rogaeva, David Tang-Wai, Maria Carmela Tartaglia, Robert Laforce, Fabrizio Tagliavini, Pietro Tiraboschi, Veronica Redaelli, Sara Prioni, Marina Grisoli, Barbara Borroni, Alessandro Padovani, Daniela Galimberti, Elio Scarpini, Andrea Arighi, Giorgio Fumagalli, James B. Rowe, Ian Coyle-Gilchrist, Caroline Graff, Marie Fallström, Vesna Jelic, Anne Kinhult Stahlbom, Christin Andersson, Hakan Thonberg, Lena Lilius, Giovanni B. Frisoni, Michela Pievani, Martina Bocchetta, Luisa Benussi, Roberta Ghidoni, Elizabeth Finger, Sandro Sorbi, Benedetta Nacmias, Gemma Lombardi, Cristina Polito, Jason D. Warren, Sebastien Ourselin, Nick C. Fox, and Martin N. Rossor (Vol. 15, No. 3, March 2015, p. 253-262).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70324-2/abstract

B. “CHCHD2 mutations in autosomal dominant late-onset Parkinson’s disease: a genome-wide linkage and sequencing study,” by Manabu Funayama, Kenji Ohe, Taku Amo, Norihiko Furuya, Junji Yamaguchi, Shinji Saiki, Yuanzhe Li, Kotaro Ogaki, Maya Ando, Hiroyo Yoshino, Hiroyuki Tomiyama, Kenya Nishioka, Kazuko Hasegawa, Hidemoto Saiki, Wataru Satake, Kaoru Mogushi, Ryogen Sasaki, Yasumasa Kokubo, Shigeki Kuzuhara, Tatsushi Toda, Yoshikuni Mizuno, Yasuo Uchiyama, Kinji Ohno, and Nobutaka Hattori (Vol. 15, No. 3, March 2015, p. 274-282).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70266-2/abstract

February 10, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 10, 2015

Filed under: Reports and Articles — Tags: — admin @ 4:20 pm

Therapeutic mechanisms of high-frequency stimulation in Parkinson’s disease and neural restoration via loop-based reinforcement,” by Sabato Santaniello, Michelle M. McCarthy, Erwin B. Montgomery Jr., John T. Gale, Nancy Kopell, and Sridevi V. Sarma (Vol. 112, No. 6, February 10, 2015, p. E586-E595).

www.pnas.org/content/112/6/E586.abstract.html?etoc

February 9, 2015

CAAR – Public Library of Science (PLoS) Article – February 9, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:49 pm

Prediction of Falls and/or Near Falls in People with Mild Parkinson’s Disease,” by Beata Lindholm, Peter Hagell, Oskar Hansson, and Maria H. Nilsson (PLoS ONE 10(1): e0117018. doi:10.1371/journal.pone.0117018, HTML, XML, and .pdf format, 11p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0117018

CAAR – Nature Biotechnology Article Abstract – February 9, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:48 pm

Optogenetics enables functional analysis of human embryonic stem cell–derived grafts in a Parkinson’s disease model,” by Julius A. Steinbeck, Se Joon Choi, Ana Mrejeru, Yosif Ganat, Karl Deisseroth, David Sulzer, Eugene V. Mosharov & Lorenz Studer (Vol. 33, No. 2, February 2015, p. 204-209).

www.nature.com/nbt/journal/v33/n2/abs/nbt.3124.html

February 5, 2015

CAAR – Wisconsin Alzheimer’s Disease Research Center Conference – February 5, 2015

Filed under: Conferences — Tags: , — admin @ 4:15 pm

Alzheimer’s & Parkinson’s Research Day 2015,” (March 5, 2015; Madison, Wisconsin). Note: The deadline for abstracts is Feb. 15, 2015.

www.adrc.wisc.edu/adpd-research-day

January 27, 2015

CAAR – Proceedings of National Academy of Science Article Abstract – January 27, 2015

Filed under: Reports and Articles — Tags: — admin @ 4:45 pm

STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease,” by Pradeep K. Kurup, Jian Xu, Rita Alexandra Videira, Chimezie Ononenyi, Graca Baltazar, Paul J. Lombroso, and Angus C. Nairn (Vol. 112, No. 4, January 27, 2015, p. 1202-1207).

www.pnas.org/content/112/4/1202.abstract

January 16, 2015

CAAR – Lancet Neurology Article Abstract – January 16, 2015

Filed under: Reports and Articles — Tags: , — admin @ 3:56 pm

Note: Lancet requires free registration prior to providing content. “Efficacy of rasagiline in patients with the parkinsonian variant of multiple system atrophy: a randomised, placebo-controlled trial,” by Prof. Werner Poewe, Prof, Klaus Seppi, Cheryl J. Fitzer-Attas, Prof. Gregor K. Wenning, Sid Gilman, Prof. Phillip A. Low, Prof. Nir Giladi, Prof. Paolo Barone, Prof. Cristina Sampaio, Eli Eyal, and Prof. Olivier Rascol, MD, for the Rasagiline-for-MSA investigators (Vol. 14, No. 2, February 2015, p. 145-152).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70288-1/abstract

January 5, 2015

CAAR – Lancet Neurology Article Abstract – January 5, 2015

Filed under: Reports and Articles — Tags: — admin @ 4:29 pm

Prediagnostic presentations of Parkinson’s disease in primary care: a case-control study,” by D.r Anette Schrag, Laura Horsfall, Kate Walters, Alastair Noyce, and Irene Petersen (Vol. 14, No. 1, January 2015, p. 57-64).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70287-X/abstract

December 23, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 23, 2014

Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease,” by Hilal Unal Gulsuner, Suleyman Gulsuner, Fatma Nazli Mercan, Onur Emre Onat, Tom Walsh, Hashem Shahin, Ming K. Lee, Okan Dogu, Tulay Kansu, Haluk Topaloglu, Bulent Elibol, Cenk Akbostanci, Mary-Claire King, Tayfun Ozcelik, and Ayse B. Tekinay (Vol. 111, No. 51, December 23, 2014, p. 18285-18290).

www.pnas.org/content/111/51/18285.abstract.html?etoc

December 15, 2014

CAAR – Journal Tables of Contents – December 15, 2014

Filed under: Journal Table of Contents — Tags: , , — admin @ 4:11 pm

Age and Ageing (Vol. 44, No. 1, January 2014; Vol. 43, No 6, November 2014  Supplement 2, October 2014). The topic of the supplement is: “British Geriatrics Society Communications to the Spring Meeting, 23 – 25 April 2014 Manchester.”

January 2015:

ageing.oxfordjournals.org/content/44/1?etoc

November 2014:

ageing.oxfordjournals.org/content/43/6?etoc

Supplement 2:

ageing.oxfordjournals.org/content/43/suppl_2?etoc

Archives of Gerontology and Geriatrics (Vol. 59, No. 3, November/December 2014; Vol. 60, No. 1, January/February 2015).

November/December:

www.sciencedirect.com/science/journal/01674943/59/3

January/February:

www.sciencedirect.com/science/journal/01674943/60/1

American Journal of Epidemiology (Vol. 180, No. 11, Dec. 1, 2014).

aje.oxfordjournals.org/content/180/11?etoc

Experimental Aging Research (Vol. 41, No. 1, 2015).

www.tandfonline.com/toc/uear20/41/1

 

Journal of Aging and Health (Vol. 26, No. 8, December 2014).

jah.sagepub.com/content/26/8?etoc

Journal of Parkinson’s Disease (Vol. 4, No. 4, December 2014).

iospress.metapress.com/content/j375266xwjwp/

Journal of Population Ageing (Vol. 7, No. 4, December 2014).

link.springer.com/journal/12062/7/4/page/1

 

Public Health (Vol. 128, No. 10-11, October-December 2014).

October:

www.sciencedirect.com/science/journal/00333506/128/10

November:

www.sciencedirect.com/science/journal/00333506/128/11

December:

www.sciencedirect.com/science/journal/00333506/128/12

Reviews in Clinical Gerontology (Vol. 24, No. 4, November 2014).

journals.cambridge.org/action/displayIssue?decade=2010&jid=RCG&volumeId=24&issueId=04&iid=9444127

 

November 21, 2014

CAAR – Statistics Canada/Statistique Canada Article – November 21, 2014

Filed under: Reports and Articles — Tags: — admin @ 5:04 pm

Parkinson’s disease: Prevalence, diagnosis and impact,” by Suzy L. Wong, Heather Gilmour and Pamela L. Ramage-Morin (Health Reports, Vol. 25, No. 11, November 2014, .pdf and HTML format).

www.statcan.gc.ca/pub/82-003-x/2014011/article/14112/abstract-resultat-eng.htm

November 6, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 6, 2014

Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo,” by Xinjiang Kang, Huadong Xu, Sasa Teng, Xiaoyu Zhang, Zijun Deng, Li Zhou, Panli Zuo, Bing Liu, Bin Liu, Qihui Wu, Li Wang, Meiqin Hu, Haiqiang Dou, Wei Liu, Feipeng Zhu, Qing Li, Shu Guo, Jingli Gu, Qian Lei, Jing Lu, Yu Mu, Mu Jin, Shirong Wang, Wei Jiang, Kun Liu, Changhe Wang, Wenlin Li, Kang Zhang, and Zhuan Zhou (Vol. 111, No. 44, November 4, 2014, p. 15804–15809)

www.pnas.org/content/111/44/15804.abstract

October 28, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – October 28, 2014

Filed under: Reports and Articles — Tags: , , — admin @ 4:51 pm

A. “Obesity accelerates epigenetic aging of human liver,” by Steve Horvath, Wiebke Erhart, Mario Brosch, Ole Ammerpohl, Witigo von Schönfels, Markus Ahrens, Nils Heits, Jordana T. Bell, Pei-Chien Tsai, Tim D. Spector, Panos Deloukas, Reiner Siebert, Bence Sipos, Thomas Becker, Christoph Rocken, Clemens Schafmayer, and Jochen Hampe (Vol. 111, No. 43, October 28, 2014, p. 15538-15543). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/111/43/15538.abstract

B. “LIMP-2 expression is critical for {beta}-glucocerebrosidase activity and {alphpa}-synuclein clearance,” by Michelle Rothaug, Friederike Zunke, Joseph R. Mazzulli, Michaela Schweizer, Hermann Altmeppen, Renate Lullmann-Rauch, Wouter W. Kallemeijn, Paulo Gaspar, Johannes M. Aerts, Markus Glatzel, Paul Saftig, Dimitri Krainc, Michael Schwake, and Judith Blanz (Vol. 111, No. 43, October 28, 2014, p. 15573-15578).

www.pnas.org/content/111/43/15573.abstract

October 20, 2014

CAAR – Public Library of Science (PLoS) Article – October 20, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:43 pm

Upregulation of GPR109A in Parkinson’s Disease,” by Chandramohan Wakade, Raymond Chong, Eric Bradley, Bobby Thomas, and John Morgan (PLoS ONE 9(10): e109818. doi:10.1371/journal.pone.0109818, HTML, XML, and .pdf format, 10p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0109818

October 7, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 7, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:44 pm

{alpha}-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation,” by Jacqueline Burrea, Manu Sharma, and Thomas C. Sudhof (Vol. 111, No. 40, October 7, 2014, p. E4274–E4283).

www.pnas.org/content/111/40/E4274.abstract

October 2, 2014

CAAR – Public Library of Science (PLoS) Article – October 2, 2014

Filed under: Reports and Articles — Tags: , , — admin @ 3:15 pm

Glaucoma, Alzheimer’s Disease, and Parkinson’s Disease: An 8-Year Population-Based Follow-Up Study,” by I-Chan Lin, Yuan-Hung Wang, Tsung-Jen Wang, I-Jong Wang, Yun-Den Shen, Nai-Fang Chi, and Li-Nien Chien (PLoS ONE 9(10): e108938. doi:10.1371/journal.pone.0108938, XML, HTML, and .pdf format, 6p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0108938

September 26, 2014

CAAR – Lancet Article Abstract – September 26, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:43 pm

Note: Lancet requires free registration prior to providing access. “Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson’s disease (PD MED): a large, open-label, pragmatic randomised trial PD MED Collaborative Group,” by PD MED Collaborative Group (Vol. 384, No. 9949, September 27, 2014, p. 1196-1205).

www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60683-8/abstract

September 23, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 23, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:37 pm

Phosphatidylethanolamine deficiency disrupts a-synuclein homeostasis in yeast and worm models of Parkinson disease,” by Shaoxiao Wang, Siyuan Zhang, Liang-Chun Liou, Qun Ren, Zhaojie Zhang, Guy A. Caldwell, Kim A. Caldwell, and Stephan N. Witt (Vol. 111, No. 38, September 23, 2014, p. E3976-E3985).

www.pnas.org/content/111/38/E3976.abstract

September 19, 2014

CAAR – Tables of Contents – September 19, 2014

Filed under: Journal Table of Contents — Tags: , , — admin @ 4:35 pm

Educational Gerontology (Vol. 41, No. 1, January 2015).

www.ingentaconnect.com/content/routledg/uedg/2015/00000041/00000001

Journal of Parkinson’s Disease (Vol. 4, No. 3, 2014).

iospress.metapress.com/content/w3776n454827

Research on Aging (Vol. 36, No. 6, November 2014).

roa.sagepub.com/content/36/6.toc

September 17, 2014

CAAR – Public Library of Science (PLoS) Article – September 17, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:43 pm

Quality of Life and Costs in Parkinson’s Disease: A Cross Sectional Study in Hungary,” by Gertrud Tamas, Laszlo Gulacsi, Daniel Bereczki, Petra Baji, Annamaria Takats, Valentin Brodszky, and Marta Pentek (PLoS ONE 9(9): e107704. doi:10.1371/journal.pone.0107704, XML, HTML, and .pdf format, p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0107704

July 28, 2014

CAAR – US National Institutes of Health Press Release – July 28, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:57 pm

NIH scientists find six new genetic risk factors for Parkinson’s,” (July 27, 2014).

www.nih.gov/news/health/jul2014/ninds-27.htm

July 22, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 22, 2014

Filed under: Reports and Articles — Tags: , , , — admin @ 4:58 pm

A. “Allosteric regulation of {gamma}-secretase activity by a phenylimidazole-type {gamma}-secretase modulator,” by Koji Takeo, Shun Tanimura, Takehiro Shinoda, Satoko Osawa, Ivan Krasmirov Zahariev, Naoki Takegami, Yoshiko Ishizuka-Katsura, Naoko Shinya, Shizuka Takagi-Niidome, Aya Tominaga, Noboru Ohsawa, Tomomi Kimura-Someya, Mikako Shirouzu, Satoshi Yokoshima, Shigeyuki Yokoyama, Tohru Fukuyama, Taisuke Tomita, and Takeshi Iwatsubo (Vol. 111, No. 29, July 22, 2014, p. 10544-10549).

www.pnas.org/content/111/29/10544.abstract

B. “Tif1{gamma} regulates the TGF-{beta}1 receptor and promotes physiological aging of hematopoietic stem cells,” by Ronan Quere, Laetitia Saint-Paul, Virginie Carmignac, Romain Z. Martin, Marie-Lorraine Chretien, Anne Largeot, Arlette Hammann, Jean-Paul Pais de Barros, Jean-Noel Bastie, and Laurent Delva (Vol. 111, No. 29, July 22, 2014, p. 10592-10597).

www.pnas.org/content/111/29/10592.abstract

C. “Intramuscular injection of {alpha}-synuclein induces CNS {alpha}-synuclein pathology and a rapid-onset motor phenotype in transgenic mice,” by Amanda N. Sacino, Mieu Brooks, Michael A. Thomas, Alex B. McKinney, Sooyeon Lee, Robert W. Regenhardt, Nicholas H. McGarvey, Jacob I. Ayers, Lucia Notterpek, David R. Borchelt, Todd E. Golde, and Benoit I. Giasson (Vol. 111, No. 29, July 22, 2014, p. 10732-10737).

www.pnas.org/content/111/29/10732.abstract

July 16, 2014

CAAR – Public Library of Science (PLoS) Articles – July 16, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:59 pm

A. “The Impact of Drug Reimbursement Policy on Rates of Testosterone Replacement Therapy among Older Men,” by Jolanta Piszczek, Muhammad Mamdani, Tony Antoniou, David N. Juurlink, and Tara Gomes (PLoS ONE 9(7): e98003. doi:10.1371/journal.pone.0098003, XML, HTML, and .pdf format, 6p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0098003

B. “FBXO7 Y52C Polymorphism as a Potential Protective Factor in Parkinson’s Disease,” by Chiung-Mei Chen, I-Cheng Chen, Yi-Cheng Huang, Hsueh-Fen Juan, Ying-Lin Chen, Yi-Chun Chen, Chih-Hsin Lin, Li-Ching Lee, Chi-Mei Lee, Guey-Jen Lee-Chen, Yun-Ju Lai, and Yih-Ru Wu (PLoS ONE 9(7): e101392. doi:10.1371/journal.pone.0101392, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0101392

July 14, 2014

CAAR – Lancet Neurology Article Abstracts – July 14, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:53 pm

Note: Lancet requires free registration prior to providing access.

A. “Tozadenant (SYN115) in patients with Parkinson’s disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial,” by Dr. Robert A. Hauser, C. Warren Olanow, Karl D. Kieburtz, Emmanuelle Pourcher, Any Docu-Axelerad, Mark Lew, Olexandr Kozyolkin, Ann Neale, Chris Resburg, Uwe Meya, Christopher Kenney, and Stephen Bandak (Vol. 13, No. 7, July 2014, p. 767-776).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70148-6/abstract

B. “Potential for primary prevention of Alzheimer’s disease: an analysis of population-based data,” by Sam Norton, Fiona E Matthews, Deborah E Barnes, Kristine Yaffe, and Carol Brayne (Vol. 13, No. 7, July 2014, p. 788-794).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70136-X/abstract

July 9, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 9, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:25 pm

A. “Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease,” by Amy K. Y. Fu, Kwok-Wang Hung, Huiqian Huang, Shuo Gu, Yang Shen, Elaine Y. L. Cheng, Fanny C. F. Ip, Xuhui Huang, Wing-Yu Fu, and Nancy Y. Ip (Vol. 111, No. 27, July 8, 2014, .pdf and HTML format, p. 9959-9964). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/111/27/9959.abstract

B. “Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo,” by Kelly M. Lohr, Alison I. Bernstein, Kristen A. Stout, Amy R. Dunn, Carlos R. Lazo, Shawn P. Alter, Minzheng Wang, Yingjie Li, Xueliang Fan, Ellen J. Hess, Hong Yi, Laura M. Vecchio, David S. Goldstein, Thomas S. Guillot, Ali Salahpour, and Gary W. Miller (Vol. 111, No. 27, July 8, 2014, p. 9977-9982).

www.pnas.org/content/111/27/9977.abstract

July 1, 2014

CAAR – Public Library of Science (PLoS) Article – July 1, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:43 pm

Aerobic Exercise for Parkinson’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials,” by Hai-Feng Shu, Tao Yang, Si-Xun Yu, Hai-Dong Huang, Ling-Li Jiang, Jian-Wen Gu, and Yong-Qin Kuang (PLoS ONE 9(7): e100503. doi:10.1371/journal.pone.0100503, XML, HTML, and .pdf format, 10p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0100503

June 25, 2014

CAAR – Public Library of Science (PLoS) Articles – June 25, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:49 pm

A. “Amyloid Beta-Mediated Epigenetic Alteration of Insulin-Like Growth Factor Binding Protein 3 Controls Cell Survival in Alzheimer’s Disease,” by Hye Youn Sung, Eun Nam Choi, Dahyun Lyu, Inhee Mook-Jung, and Jung-Hyuck Ahn ( PLoS ONE 9(6): e99047. doi:10.1371/journal.pone.0099047, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099047

B. “N-Terminal Truncated UCH-L1 Prevents Parkinson’s Disease Associated Damage,” by Hee-Jung Kim, Hyun Jung Kim, Jae-Eun Jeong, Jeong Yeob Baek, Jaeho Jeong, Sun Kim, Young-Mee Kim, Youhwa Kim, Jin Han Nam, Sue Hee Huh, Jawon Seo, Byung Kwan Jin, and Kong-Joo Lee (PLoS ONE 9(6): e99654. doi:10.1371/journal.pone.0099654, XML, HMTL, and .pdf format, 17p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099654

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 25, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:48 pm

Abrogation of {alpha}-synuclein–mediated dopaminergic neurodegeneration in LRRK2-deficient rats,” by Joao P. L. Daher, Laura A. Volpicelli-Daley, Jonathan P. Blackburn, Mark S. Moehle, and Andrew B. West (Vol. 111, No. 2, June 24, 2014, p. 9289-9294).

www.pnas.org/content/111/25/9289.abstract

June 11, 2014

CAAR – Public Library of Science (PLoS) Article – June 11, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:27 pm

Antihypertensive Agents and Risk of Parkinson’s Disease: A Nationwide Cohort Study,” by Yen-Chieh Lee, Chin-Hsien Lin, Ruey-Meei Wu, Jou-Wei Lin, Chia-Hsuin Chang, and Mei-Shu Lai (PLoS ONE 9(6): e98961. doi:10.1371/journal.pone.0098961, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0098961

June 2, 2014

CAAR – Public Library of Science (PLoS) Article – June 2, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:36 pm

Olfactory Deficits in an Alpha-Synuclein Fly Model of Parkinson’s Disease,” by Alex Y. Chen, Shouzhen Xia, Paul Wilburn, and Tim Tully (PLoS ONE 9(5): e97758. doi:10.1371/journal.pone.0097758, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0097758

May 27, 2014

CAAR – Nature Neuroscience Article Abstract – May 27, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:37 pm

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase,” by Javier Sanchez-Padilla, Jaime N. Guzman, Ema Ilijic, Jyothisri Kondapalli, Daniel J. Galtieri, Ben Yang, Simon Schieber, Wolfgang Oertel, David Wokosin, Paul T. Schumacker & D. James Surmeier (Vol. 17, No. 6, June 2014, p. 832-840).

www.nature.com/neuro/journal/v17/n6/abs/nn.3717.html

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 27, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:36 pm

Solution conditions determine the relative importance of nucleation and growth processes in {alpha}-synuclein aggregation,” by Alexander K. Buell, Celine Galvagnion, Ricardo Gaspar, Emma Sparr, Michele Vendruscolo, Tuomas P. J. Knowles, Sara Linse, and Christopher M. Dobson (Vol. 111, No. 21, May 27, 2014, .pdf and HTML format, p. 7671-7676). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/111/21/7671.abstract

May 22, 2014

CAAR – Public Library of Science (PLoS) Articles – May 22, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:26 pm

A. “Risk for Femoral Fractures in Parkinson’s Disease Patients with and without Severe Functional Impairment,” by Petra Benzinger, Kilian Rapp, Walter Maetzler, Hans-Helmut Konig, Andrea Jaensch, Jochen Klenk, and Gisela Buchele (PLoS ONE 9(5): e97073. doi:10.1371/journal.pone.0097073, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0097073

B. “Parkinson’s Disease Subtypes Show a Specific Link between Dopaminergic and Glucose Metabolism in the Striatum,” by Carsten Eggers, Frank Schwartz, David J. Pedrosa, Lutz Kracht, and Lars Timmermann (PLoS ONE 9(5): e96629. doi:10.1371/journal.pone.0096629, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0096629

May 20, 2014

CAAR – Lancet Neurology Article Abstract – May 20, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:48 pm

Efficacy of occupational therapy for patients with Parkinson’s disease: a randomised controlled trial,” by Ingrid H. W. M. Sturkenboom, Maud J. L. Graff, Jan C. M. Hendriks, Yvonne Veenhuizen, Marten Munneke, Bastiaan R. Bloem, and Maria W. Nijhuis-van der Sanden, for the OTiP study group (Vol. 13, No. 6, June 2014, p. 557-566).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70055-9/abstract

April 28, 2014

CAAR – Public Library of Science (PLoS) Articles – April 28, 2014

Filed under: Reports and Articles — Tags: , , — admin @ 4:17 pm

A. “Specific Changes of Serum Proteins in Parkinson’s Disease Patients,” by Wenwen Lu, Xinhua Wan, Bin Liu, Xianfang Rong, Lei Zhu, Pingping Li, Jiang Li, Ling Wang, Liying Cui, and Xiaoliang Wang (PLoS ONE 9(4): e95684. doi:10.1371/journal.pone.0095684, HTML, XML, and .pdf format, 12p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0095684

B. “The Effects of Physical Exercise with Music on Cognitive Function of Elderly People: Mihama-Kiho Project,” by Masayuki Satoh, Jun-ichi Ogawa, Tomoko Tokita, Noriko Nakaguchi, Koji Nakao, Hirotaka Kida, and Hidekazu Tomimoto (PLoS ONE 9(4): e95230. doi:10.1371/journal.pone.0095230, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0095230

April 10, 2014

CAAR – US National Institutes of Health Press Release – April 10, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:41 pm

Too much protein may kill brain cells as Parkinson’s progresses,” (April 10, 2014).

www.nih.gov/news/health/apr2014/ninds-10.htm

March 31, 2014

CAAR – Lancet Article Abstract – March 31, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:40 pm

Note: Lancet requires free registration prior to providing content: “Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson’s disease: a dose escalation, open-label, phase 1/2 trial,” by Stephane Palfi, Jean Marc Gurruchaga, G Scott Ralph, Helene Lepetit, Sonia Lavisse, Philip C. Buttery, Colin Watts, James Miskin, Michelle Kelleher, Sarah Deeley, Hirokazu Iwamuro, Jean Pascal Lefaucheur, Claire Thiriez, Gilles Fenelon, Cherry Lucas, Pierre Brugieres, Inanna Gabriel, Kou Abhay, Xavier Drouot, Naoki Tani, Aurelie Kas, Bijan Ghaleh, Philippe Le Corvoisier, Patrice Dolphin, David P Breen, Sarah Mason, Natalie Valle Guzman, Nicholas D. Mazarakis, Pippa A. Radcliffe, Richard Harrop, Susan M. Kingsman, Olivier Rascol, Stuart Naylor, Roger A. Barker, Philippe Hantraye, Philippe Remy, Pierre Cesaro, and Kyriacos A. Mitrophanous (Vol. 383, No. 9923, March 29, 2014, p. 1138-1147).

www.thelancet.com/journals/lancet/article/PIIS0140-6736%2813%2961939-X/abstract

March 18, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 18, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:40 pm

A. “Clioquinol promotes the degradation of metal-dependent amyloid-{beta} (A{beta}) oligomers to restore endocytosis and ameliorate A{beta} toxicity,” by Kent E. S. Matlack, Daniel F. Tardiff, Priyanka Narayan, Shusei Hamamichi, Kim A. Caldwell, Guy A. Caldwell, and Susan Lindquist (Vol. 111, No. 11, March 18, 2014, p. 4013-4018).

www.pnas.org/content/111/11/4013.abstract

B. “Parkinson disease-associated mutation R1441H in LRRK2 prolongs the ‘active state’ of its GTPase domain,” by Jingling Liao, Chun-Xiang Wu, Christopher Burlak, Sheng Zhang, Heather Sahm, Mu Wang, Zhong-Yin Zhang, Kurt W. Vogel, Mark Federici, Steve M. Riddle, R. Jeremy Nichols, Dali Liu, Mark R. Cookson, Todd A. Stone, and Quyen Q. Hoang (Vol. 111, No. 11, March 18, 2014, p. 4055-4060).

www.pnas.org/content/111/11/4055.abstract

February 27, 2014

CAAR – Public Library of Science (PLoS) Articles – February 27, 2014

Filed under: Reports and Articles — Tags: , , — admin @ 4:06 pm

A. “Sleep-Wake Cycle in Young and Older Persons with a Lifetime History of Mood Disorders,” by Rebecca Robillard, Sharon L. Naismith, Kristie Leigh Smith, Naomi L. Rogers, Django White, Zoe Terpening, Tony K. C. Ip, Daniel F. Hermens, Bradley Whitwell, Elizabeth M. Scott, and Ian B. Hickie (PLoS ONE 9(2): e87763. doi:10.1371/journal.pone.0087763, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0087763

B. “Differential Expression of Alpha-Synuclein in Hippocampal Neurons,” by Katsutoshi Taguchi, Yoshihisa Watanabe, Atsushi Tsujimura, Harutsugu Tatebe, Seiji Miyata, Takahiko Tokuda, Toshiki Mizuno, and Masaki Tanaka (PLoS ONE 9(2): e89327. doi:10.1371/journal.pone.0089327, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0089327

February 25, 2014

CAAR – Nature Neuroscience Article Abstracts – February 25, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:51 pm

A. “Tau promotes neurodegeneration through global chromatin relaxation,” by Bess Frost, Martin Hemberg, Jada Lewis and Mel B. Feany (Vol. 17, No. 3, March 2014, p. 357-366).

www.nature.com/neuro/journal/v17/n3/abs/nn.3639.html

B. “LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity,” by Loukia Parisiadou, Jia Yu, Carmelo Sgobio, Chengsong Xie, Guoxiang Liu, Lixin Sun, Xing-Long Gu, Xian Lin, Nicole A Crowley, David M Lovinger & Huaibin Cai (Vol. 17, No. 3, March 2014, p. 367-376).

www.nature.com/neuro/journal/v17/n3/abs/nn.3636.html

February 18, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 18, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:29 pm

A. “Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease,” by Alexandria Beilina, Iakov N. Rudenko, Alice Kaganovich, Laura Civiero, Hien Chau, Suneil K. Kalia, Lorraine V. Kalia, Evy Lobbestael, Ruth Chia, Kelechi Ndukwe, Jinhui Ding, Mike A. Nalls, International Parkinson’s Disease Genomics Consortium, North American Brain Expression Consortium, Maciej Olszewski, David N. Hauser, Ravindran Kumaran, Andres M. Lozano, Veerle Baekelandt, Lois E. Greene, Jean-Marc Taymans, Elisa Greggio, and Mark R. Cookson (Vol. 111, No. 7, February 18, 2014, p. 2626-2631).

www.pnas.org/content/111/7/2626.abstract

B. “Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-{beta} accumulation modifier,” by Takashi Morihara, Noriyuki Hayashi, Mikiko Yokokoji, Hiroyasu Akatsu, Michael A. Silverman, Nobuyuki Kimura, Masahiro Sato, Yuhki Saito, Toshiharu Suzuki, Kanta Yanagida, Takashi S. Kodama, Toshihisa Tanaka, Masayasu Okochi, Shinji Tagami, Hiroaki Kazui, Takashi Kudo, Ryota Hashimoto, Naohiro Itoh, Kouhei Nishitomi, Yumi Yamaguchi-Kabata, Tatsuhiko Tsunoda, Hironori Takamura, Taiichi Katayama, Ryo Kimura, Kouzin Kamino, Yoshio Hashizume, and Masatoshi Takeda (Vol. 111, No. 7, February 18, 2014, .pdf and HTML format, p. 2638-2643). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/111/7/2638.abstract

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