CDHA CAAR

April 5, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 5, 2016

Nanoscopic insights into seeding mechanisms and toxicity of {alpha}-synuclein species in neurons,” by Dorothea Pinotsi, Claire H. Michel, Alexander K. Buell, Romain F. Laine, Pierre Mahou, Christopher M. Dobson, Clemens F. Kaminski, and Gabriele S. Kaminski Schierle (Vol. 113, No. 14, April 5, 2016, p. 3815-3819).

www.pnas.org/content/113/14/3815.abstract.html?etoc

March 30, 2016

CAAR – Nature Neuroscience Brief Communications Abstract – March 30, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:42 pm

Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders,” by Wen Zhang, Lifeng Zhang, Bo Liang, David Schroeder, Zhong-wei Zhang, Gregory A Cox, Yun Li & Da-Ting Lin (Vol. 19, No. 4, April 2016, p. 557-559).

www.nature.com/neuro/journal/v19/n4/abs/nn.4257.html

March 29, 2016

CAAR – Public Library of Science (PLoS) Article – March 29, 2016

Filed under: Reports and Articles — Tags: — admin @ 5:02 pm

Statin Use and the Risk of Parkinson’s Disease: An Updated Meta-Analysis,” by Shuang Bai, Yi Song, Xin Huang, Lidan Peng, Jie Jia, Yu Liu, and Hong Lu (PLoS ONE 11(3): e0152564. doi:10.1371/journal.pone.0152564, XML, HTML, and .pdf format, 12p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0152564

March 15, 2016

CAAR – Public Library of Science (PLoS) Article – March 15, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:19 pm

Measuring the Burden of Hospitalization in Patients with Parkinson’s Disease in Spain,” by Ruth Gil-Prieto, Raquel Pascual-Garcia, Jesus San-Roman-Montero, Pablo Martinez-Martin, Javier Castrodeza-Sanz, and Angel Gil-de-Miguel (PLoS ONE 11(3): e0151563. doi:10.1371/journal.pone.0151563, XML, HTML, and .pdf format, 11p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0151563

March 1, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 1, 2016

A. “Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading,” by Marija Iljina, Gonzalo A. Garcia, Mathew H. Horrocks, Laura Tosatto, Minee L. Choi, Kristina A. Ganzinger, Andrey Y. Abramov, Sonia Gandhi, Nicholas W. Wood, Nunilo Cremades, Christopher M. Dobson, Tuomas P. J. Knowles, and David Klenerman (Vol. 113, No. 9, March 1, 2016, p. E1206–E1215).

www.pnas.org/content/113/9/E1206.abstract.html?etoc

B. “The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function,” by Samuel E. Marsh, Edsel M. Abud, Anita Lakatos, Alborz Karimzadeh, Stephen T. Yeung, Hayk Davtyan, Gianna M. Fote, Lydia Lau, Jason G. Weinger, Thomas E. Lane, Matthew A. Inlay, Wayne W. Poon, and Mathew Blurton-Jones (Vol. 113, No. 9, March 1, 2016, p. E1316–E1325).

www.pnas.org/content/113/9/E1316.abstract.html?etoc

February 17, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 17, 2017

A. “{alpha}-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models,” by Joseph R. Mazzulli, Friederike Zunke, Ole Isacson, Lorenz Studer, and Dimitri Krainc (Vol. 113, No. 7, February 16, 2016, p. 1931-1936).

www.pnas.org/content/113/7/1931.abstract

B. “Induction of de novo {alpha}-synuclein fibrillization in a neuronal model for Parkinson’s disease,” by Mohamed-Bilal Fares, Bohumil Maco, Abid Oueslati, Edward Rockenstein, Natalia Ninkina, Vladimir L. Buchman, Eliezer Masliah, and Hilal A. Lashuel (Vol. 113, No. 7, February 16, 2016, p. E912-E921).

www.pnas.org/content/113/7/E912.abstract

February 9, 2016

CAAR – Lancet Neurology Article Abstract – February 9, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:46 pm

Rivastigmine for gait stability in patients with Parkinson’s disease (ReSPonD): a randomised, double-blind, placebo-controlled, phase 2 trial,” by Emily J. Henderson, Stephen R. Lord, Matthew A. Brodie, Daisy M. Gaunt, Andrew D. Lawrence, Jacqueline C. T. Close, A. L. Whone, and Y. Ben-Shlomo (Vol. 15, No. 3, March 2016, p. 249-258).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(15)00389-0/abstract

February 3, 2016

CAAR – Nature Article, Letter Abstracts – February 3, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:42 pm

A. “Structural disorder of monomeric {alpha}-synuclein persists in mammalian cells,” by Francois-Xavier Theillet, Andres Binolfi, Beata Bekei, Andrea Martorana, Honor May Rose, Marchel Stuiver, Silvia Verzini, Dorothea Lorenz, Marleen van Rossum, Daniella Goldfarb & Philipp Selenko (Vol. 530, No. 7588, February 4, 2016, p. 45-50).

www.nature.com/nature/journal/v530/n7588/abs/nature16531.html

B. “The temporal scaling of Caenorhabditis elegans ageing,” by Nicholas Stroustrup, Winston E. Anthony, Zachary M. Nash, Vivek Gowda, Adam Gomez, Isaac F. López-Moyado, Javier Apfeld & Walter Fontana (Vol. 530, No. 7588, February 4, 2016, p. 103-107).

www.nature.com/nature/journal/v530/n7588/abs/nature16550.html

February 2, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 2, 2016

A. “Nicastrin functions to sterically hinder {gamma}-secretase–substrate interactions driven by substrate transmembrane domain,” by David M. Bolduc, Daniel R. Montagna, Yongli Gu, Dennis J. Selkoe, and Michael S. Wolfe (Vol. 113, No. 5, February 2, 2016, p. E509-E518).

www.pnas.org/content/113/5/E509.abstract

B. “Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila,” by Sonita Afschar, Janne M. Toivonen, Julia Marianne Hoffmann, Luke Stephen Tain, Daniela Wieser, Andrew John Finlayson, Yasmine Driege, Nazif Alic, Sahar Emran, Julia Stinn, Jenny Froehlich, Matthew D. Piper, and Linda Partridge (Vol. 113, No. 5, February 2, 2016, p. 1321-1326).

www.pnas.org/content/113/5/1321.abstract.html?etoc

C. “Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice,” by Roberta Marongiu, Margarita Arango-Lievano, Veronica Francardo, Peter Morgenstern, Xiaoqun Zhang, M. Angela Cenci, Per Svenningsson, Paul Greengard, and Michael G. Kaplitt (Vol. 113, No. 5, February 2, 2016, p. 1423-1428).

www.pnas.org/content/113/5/1423.abstract.html?etoc

D. “p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism,” by Nicoletta Schintu, Xiaoqun Zhang, Alexandra Alvarsson, Roberta Marongiu, Michael G. Kaplitt, Paul Greengard, and Per Svenningsson (Vol. 113, No. 5, February 2, 2016, p. 1429-1434).

www.pnas.org/content/113/5/1429.abstract.html?etoc

January 12, 2016

CAAR – Lancet Neurology Article Abstract – January 12, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:52 pm

Opicapone as an adjunct to levodopa in patients with Parkinson’s disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial,” by Joaquim J Ferreira, Andrew Lees, José-Francisco Rocha, Werner Poewe, Olivier Rascol, and Patrício Soares-da-Silva, Bi-Park 1 investigators (Vol. 15, No. 2, February 2016, p. 154-165).

www.thelancet.com/journals/laneur/article/PIIS1474-4422%2815%2900336-1/abstract

January 6, 2016

CAAR – Nature Medicine Article Abstracts – January 16, 2016

Filed under: Reports and Articles — Tags: , , — admin @ 4:19 pm

A. “Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling,” by Natura Myeku, Catherine L. Clelland, Sheina Emrani, Nikolay V. Kukushkin, Wai Haung Yu, Alfred L. Goldberg & Karen E. Duff (Vol. 22, No. 1, January 2016, p. 46-53).

www.nature.com/nm/journal/v22/n1/abs/nm.4011.html

B. “Parkinson’s disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes,” by Wenzhang Wang, Xinglong Wang, Hisashi Fujioka, Charles Hoppel, Alan L Whone, Maeve A. Caldwell, Peter J. Cullen, Jun Liu & Xiongwei Zhu (Vol. 22, No. 1, January 2016, p. 54-63).

www.nature.com/nm/journal/v22/n1/abs/nm.3983.html

December 17, 2015

CAAR – Public Library of Science (PLoS) Articles – December 17, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:57 pm

A. “Omega-3 Fatty Acid Supplementation for 12 Weeks Increases Resting and Exercise Metabolic Rate in Healthy Community-Dwelling Older Females,” by Samantha L. Logan and Lawrence L. Spriet (PLoS ONE 10(12): e0144828. doi:10.1371/journal.pone.0144828, XML, HTML, and .pdf format, 18p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0144828

B. “Freezing of Gait in Parkinson’s Disease: An Overload Problem?” by Eric N. Beck, Kaylena A. Ehgoetz Martens, and Quincy J. Almeida (PLoS ONE 10(12): e0144986. doi:10.1371/journal.pone.0144986, XML, HTML, and .pdf format, 28p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0144986

November 13, 2015

CAAR – Lancet Neurology Article Abstracts – November 13, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:24 pm

A. “Prolonged-release oxycodone–naloxone for treatment of severe pain in patients with Parkinson’s disease (PANDA): a double-blind, randomised, placebo-controlled trial,” by Claudia Trenkwalder, K. Ray Chaudhuri, Pablo Martinez-Martin, Olivier Rascol, Reinhard Ehret, Martin Valis, Maria Sátori, Anna Krygowska-Wajs, Maria J. Marti, Karen Reimer, Alexander Oksche, Mark Lomax, Julia DeCesare, and Michael Hopp, PANDA study group (Vol. 14, No. 12, December 2015, p. 1161-1170).

www.thelancet.com/journals/laneur/article/PIIS1474-4422%2815%2900243-4/abstract

B. “Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer’s Disease (DOMINO-AD) trial: secondary and post-hoc analyses,” by Robert Howard, Rupert McShane, James Lindesay, Craig Ritchie, Ashley Baldwin, Robert Barber, Alistair Burns, Tom Dening, David Findlay, Clive Holmes, Robert Jones, Roy Jones, Ian McKeith, Ajay Macharouthu, John O’Brien, Bart Sheehan, Edmund Juszczak, Cornelius Katona, Robert Hills, Martin Knapp, Clive Ballard, Richard G Brown, Sube Banerjee, Jessica Adams, Tony Johnson, Peter Bentham, and Patrick P. J. Phillips (Vol. 14, No. 12, December 2015, p. 1171-1181).

www.thelancet.com/journals/laneur/article/PIIS1474-4422%2815%2900258-6/abstract

September 22, 2015

CAAR – Proceedings of the National Academies of Science Article Abstracts – September 22, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 4:48 pm

A. “Peptide dimer structure in an A{beta}(1–42) fibril visualized with cryo-EM,” by Matthias Schmidt, Alexis Rohou, Keren Lasker, Jay K. Yadav, Cordelia Schiene-Fischer, Marcus Fändrich, and Nikolaus Grigorieff (Vol. 112, No. 38, September 22, 2015, .pdf and HTML format, p. 11858-11863). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/38/11858.abstract

B. “Evidence for {alpha}-synuclein prions causing multiple system atrophy in humans with parkinsonism,” by Stanley B. Prusiner, Amanda L. Woerman, Daniel A. Mordes, Joel C. Watts, Ryan Rampersaud, David B. Berry, Smita Patel, Abby Oehler, Jennifer K. Lowe, Stephanie N. Kravitz, Daniel H. Geschwind, David V. Glidden, Glenda M. Halliday, Lefkos T. Middleton, Steve M. Gentleman, Lea T. Grinberg, and Kurt Giles (Vol. 112, No. 38, September 22, 2015, p. 11858-11863).

www.pnas.org/content/112/38/E5308.abstract

C. “Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer’s disease pathogenesis,” by Li Zhu, Minghao Zhong, Gregory A. Elder, Mary Sano, David M. Holtzman, Sam Gandy, Christopher Cardozo, Vahram Haroutunian, Nikolaos K. Robakis, and Dongming Cai (Vol. 112, No. 38, September 22, 2015, .pdf and HTML format, p. 11965-11970). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/38/11965.abstract

September 2, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 2, 2015

Propagation of prions causing synucleinopathies in cultured cells,” by Amanda L. Woerman, Jan Stohr, Atsushi Aoyagi, Ryan Rampersaud, Zuzana Krejciova, Joel C. Watts, Takao Ohyama, Smita Patel, Kartika Widjaja, Abby Oehler, David W. Sanders, Marc I. Diamond, William W. Seeley, Lefkos T. Middleton, Steve M. Gentleman, Daniel A. Mordes, Thomas C. Südhof, Kurt Giles, and Stanley B. Prusiner (Vol. 112, No. 35, September 1, 2015, p. E4949–E4958).

www.pnas.org/content/112/35/E4949.abstract

August 31, 2015

CAAR – Nature Neuroscience Article Abstract – August 31, 2015

Filed under: Reports and Articles — Tags: — admin @ 4:47 pm

Dynamic rewiring of neural circuits in the motor cortex in mouse models of Parkinson’s disease,” by Lili Guo, Huan Xiong, Jae-Ick Kim, Yu-Wei Wu, Rupa R. Lalchandani, Yuting Cui, Yu Shu, Tonghui Xu & Jun B. Ding (Vol. 18, No. 9, September 2015, p. 1299-1309).

www.nature.com/neuro/journal/v18/n9/abs/nn.4082.html

August 13, 2015

CAAR – Public Library of Science (PLoS) Article – August 13, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:52 pm

Influence of Dopaminergic Medication on Conditioned Pain Modulation in Parkinson’s Disease Patients,” by Wiebke Grashorn, Odette Schunke, Carsten Buhmann, Katarina Forkmann, Sabrina Diedrich, Katharina Wesemann, and Ulrike Bingel (PLoS ONE 10(8): e0135287. doi:10.1371/journal.pone.0135287, XML, HTML, and .pdf format, 16p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0135287

July 29, 2015

CAAR – Public Library of Science (PLoS) Articles – July 29, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:59 pm

A. “Did {alpha}-Synuclein and Glucocerebrosidase Coevolve? Implications for Parkinson’s Disease,” by James M. Gruschus (PLoS ONE 10(7): e0133863. doi:10.1371/journal.pone.0133863, XML, HTML, and .pdf format, 21p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0133863

B. “The Clinical Effectiveness and Cost-Effectiveness of Screening for Age-Related Macular Degeneration in Japan: A Markov Modeling Study,” by Hiroshi Tamura, Rei Goto, Yoko Akune, Yoshimune Hiratsuka, Shusuke Hiragi, and Masakazu Yamada (PLoS ONE 10(7): e0133628. doi:10.1371/journal.pone.0133628, XML, HTML, and .pdf format, 20p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0133628

C. “Enrichment of Minor Alleles of Common SNPs and Improved Risk Prediction for Parkinson’s Disease,” by Zuobin Zhu, Dejian Yuan, Denghui Luo, Xitong Lu, and Shi Huang (PLoS ONE 10(7): e0133421. doi:10.1371/journal.pone.0133421, XML, HTML, and .pdf format, 11p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0133421

July 28, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 28, 2015

A. “Quantification of biological aging in young adults,” by Daniel W. Belsky, Avshalom Caspi, Renate Houts, Harvey J. Cohen, David L. Corcoran, Andrea Danese, HonaLee Harrington, Salomon Israel, Morgan E. Levine, Jonathan D. Schaefer, Karen Sugden, Ben Williams, Anatoli I. Yashin, Richie Poulton, and
Terrie E. Moffitt (Vol. 112, No. 30, July 28, 2015, p. E4104–E4110).

www.pnas.org/content/112/30/E4104.abstract.html?etoc

B. “Cysteine cathepsins are essential in lysosomal degradation of {alpha}-synuclein,” by Ryan P. McGlinchey and Jennifer C. Lee (Vol. 112, No. 30, July 28, 2015, p. 9322-9327).

www.pnas.org/content/112/30/9322.abstract

C. “Matrix cross-linking–mediated mechanotransduction promotes posttraumatic osteoarthritis,” by Jin-Hong Kim, Gyuseok Lee, Yoonkyung Won, Minju Lee, Ji-Sun Kwak, Churl-Hong Chun, and Jang-Soo Chun (Vol. 112, No. 30, July 28, 2015, .pdf and HTML format, p. 9322-9327). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/30/9424.abstract

July 16, 2015

CAAR – Lancet Neurology Article Abstracts – July 16, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:46 pm

Note: Lancet requirers free registration prior to providing content.

A. “Pioglitazone in early Parkinson’s disease: a phase 2, multicentre, double-blind, randomised trial,” by NINDS Exploratory Trials in Parkinson Disease (NET-PD) FS-ZONE Investigators (Vol. 14, No. 8, August 2015, .pdf format, p. 795-803).

www.thelancet.com/journals/laneur/article/PIIS1474-4422%2815%2900144-1/abstract

B. “Longitudinal assessment of neuroimaging and clinical markers in autosomal dominant Alzheimer’s disease: a prospective cohort study,” by Wai-Ying Wendy Yau, Dana L. Tudorascu, Eric M. McDade, Snezana Ikonomovic, Jeffrey A. James, Davneet Minhas, Wenzhu Mowrey, Lei K. Sheu, Beth E. Snitz, Lisa Weissfeld, Peter J. Gianaros, Howard J. Aizenstein, Julie C Price, Chester A. Mathis, Oscar L. Lopez, and William E. Klunk (Vol. 14, No. 8, August 2015, .pdf format, p. 804-813).

www.thelancet.com/journals/laneur/article/PIIS1474-4422%2815%2900135-0/abstract

C. “Mutations in ABCA7 in a Belgian cohort of Alzheimer’s disease patients: a targeted resequencing study,” by Elise Cuyvers, Arne De Roeck, Tobi Van den Bossche, Caroline Van Cauwenberghe, Karolien Bettens, Steven Vermeulen, Maria Mattheijssens, Karin Peeters, Sebastiaan Engelborghs, Mathieu Vandenbulcke, Rik Vandenberghe, Peter P De Deyn, Christine Van Broeckhoven, and Kristel Sleegers (Vol. 14, No. 8, August 2015, .pdf format, p. 814-822).

www.thelancet.com/journals/laneur/article/PIIS1474-4422%2815%2900133-7/abstract

CAAR – Public Library of Science (PLoS) Articles – July 16, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:45 pm

A. “Can Patients with Parkinson’s Disease Use Dry Powder Inhalers during Off Periods?” by M. Luinstra, A. W. F. Rutgers, H. Dijkstra, F. Grasmeijer, P. Hagedoorn, J. M. J. Vogelzang, H. W. Frijlink, and A. H. de Boer (PLoS ONE 10(7): e0132714. doi:10.1371/journal.pone.0132714, XML, HTML, and .pdf format, 12p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0132714

B. “Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers,” by Claustre Pont-Sunyer, Alex Iranzo, Carles Gaig, Ana Fernández-Arcos, Dolores Vilas, Francesc Valldeoriola, Yaroslau Compta, Ruben Fernández-Santiago, Manel Fernández, Angels Bayes, Matilde Calopa, Pilar Casquero, Oriol de Fàbregues, Serge Jaumà, Victor Puente, Manel Salamero, Maria José Martí, Joan Santamaría, and Eduard Tolosa (PLoS ONE 10(7): e0132368. doi:10.1371/journal.pone.0132368, XML, HTML, and .pdf format, 20p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0132368

C. “Systemic and Ocular Long Pentraxin 3 in Patients with Age-Related Macular Degeneration,” by Helene Bae Juel, Carsten Faber, Lea Munthe-Fog, Simone Bastrup-Birk, Alexander Lynge Reese-Petersen, Mads Kruger Falk, Amardeep Singh, Torben Lykke Sorensen, Peter Garred, and Mogens Holst Nissen (PLoS ONE 10(7): e0132800. doi:10.1371/journal.pone.0132800, XML, HTML, and .pdf format, p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0132800

June 9, 2015

CAAR – Lancet Neurology Article Abstract – June 9, 2015

Filed under: Reports and Articles — Tags: — admin @ 5:08 pm

Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson’s disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study,” by Prof. Lars Timmermann, Roshini Jain, Lilly Chen, Mohamed Maarouf, Michael T. Barbe, Niels Allert, Prof. Thomas Brucke, Iris Kaiser, Sebastian Beirer, Fernando Sejio, Esther Suarez, Beatriz Lozano, Claire Haegelen, Prof. Marc Verin, Mauro Porta, Domenico Servello, Prof. Steven Gill, Alan Whone, Nic Van Dyck, and Prof. Francois Alesch (Vol. 14, No. 7, July 2015, p. 693-701).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(15)00087-3/abstract

May 27, 2015

CAAR – Nature Neuroscience Article, Perspectives Abstracts – May 27, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 5:05 pm

A. “Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson’s disease,” by Ariadna Laguna, Nicoletta Schintu, Andre Nobre, Alexandra Alvarsson, Nikolaos Volakakis, Jesper Kjaer Jacobsen, Marta Gomez-Galan, Elena Sopova, Eliza Joodmardi, Takashi Yoshitake, Qiaolin Deng, Jan Kehr, Johan Ericson, Per Svenningsson, Oleg Shupliakov & Thomas Perlmann (Vol. 18, No. 6, June 2015, p. 825-835).

www.nature.com/neuro/journal/v18/n6/abs/nn.4004.html

B. “The case for rejecting the amyloid cascade hypothesis,” by Karl Herrup (Vol. 18, No. 6, June 2015, p. 794-799).

www.nature.com/neuro/journal/v18/n6/abs/nn.4017.html

C. “Three dimensions of the amyloid hypothesis: time, space and ‘wingmen’,” by Erik S. Musiek & David M. Holtzman (Vol. 18, No. 6, June 2015, p. 800-806).

www.nature.com/neuro/journal/v18/n6/abs/nn.4018.html

May 12, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 12, 2015

Targeting {beta}-arrestin2 in the treatment of L-DOPA–induced dyskinesia in Parkinson’s disease,” by Nikhil M. Urs, Simone Bido, Sean M. Peterson, Tanya L. Daigle, Caroline E. Bass, Raul R. Gainetdinov, Erwan Bezard, and Marc G. Caron (Vol. 112, No. 19, May 12, 2015, p. E2517–E2526).

www.pnas.org/content/112/19/E2517.abstract

April 28, 2015

CAAR – Nature Neuroscience Article Abstract – April 28, 2015

Filed under: Reports and Articles — Tags: — admin @ 4:40 pm

Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson’s disease,” by Coralie de Hemptinne, Nicole C. Swann, Jill L. Ostrem, Elena S. Ryapolova-Webb, Marta San Luciano, Nicholas B. Galifianakis & Philip A. Starr (Vol. 18, No. 5, May 2015, p. 779-786).

www.nature.com/neuro/journal/v18/n5/abs/nn.3997.html

April 24, 2015

CAAR – Public Library of Science (PLoS) Article – April 24, 2015

Filed under: Reports and Articles — Tags: — admin @ 4:41 pm

Motor Performance Assessment in Parkinson’s Disease: Association between Objective In-Clinic, Objective In-Home, and Subjective/Semi-Objective Measures,” by Nima Toosizadeh, Jane Mohler, Hong Lei, Saman Parvaneh, Scott Sherman, and Bijan Najafi (PLoS ONE 10(4): e0124763. doi:10.1371/journal.pone.0124763, XML, HTML, and .pdf format, 15p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0124763

April 23, 2015

CAAR – Public Library of Science (PLoS) Articles – April 23, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:27 pm

A. “Relationship between Adiponectin Gene Polymorphisms and Late-Onset Alzheimer’s Disease,” by Zhuling Yu, Wei Li, Deren Hou, Lin Zhou, Yanyao Deng, Mi Tian, and Xialu Feng (PLoS ONE 10(4): e0125186. doi:10.1371/journal.pone.0125186, XML, HTML, and .pdf format, 11p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0125186

B. “Digitomotography in Parkinson’s Disease: A Cross-Sectional and Longitudinal Study,” by Walter Maetzler, Maren Ellerbrock, Tanja Heger, Christian Sass, Daniela Berg, and Ralf Reilmann (PLoS ONE 10(4): e0123914. doi:10.1371/journal.pone.0123914, XML, HTML, and .pdf format, 9p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0123914

April 14, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 14, 2015

{alpha}-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation,” by Shijun Wang, Chun-Hsien Chu, Tessandra Stewart, Carmen Ginghina, Yifei Wang, Hui Nie, Mingri Guo, Belinda Wilson, Jau-Shyong Hong, and Jing Zhang (Vol. 112, No. 15, April 15, 2015, p. E1926-E1935).

www.pnas.org/content/112/15/E1926.abstract

March 30, 2015

CAAR – Public Library of Science (PLoS) Articles – March 30, 2015

A. “Hip Fracture in the Elderly: A Re-Analysis of the EPIDOS Study with Causal Bayesian Networks,” by Pascal Caillet, Sarah Klemm, Michel Ducher, Alexandre Aussem, and Anne-Marie Schott (PLoS ONE 10(3): e0120125. doi:10.1371/journal.pone.0120125, HTML, XML, and .pdf format, 12p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0120125

B. “Cognitive Functions and Stereopsis in Patients with Parkinson’s Disease and Alzheimer’s Disease Using 3-Dimensional Television: A Case Controlled Trial,” by Chan-Nyoung Lee, Deokwon Ko, Young-Woo Suh, and Kun-Woo Park (PLoS ONE 10(3): e0123229. doi:10.1371/journal.pone.0123229, XML, HTML, and .pdf format, 11p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0123229

February 24, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 24, 2015

A. “Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice,” by Changgui Gua, Claudia P. Coomans, Kun Hub, Frank A. J. L. Scheer, H. Eugene Stanley, and Johanna H. Meijer (Vol. 112, No. 8, February 24, 2015, p. 2320-2324).

www.pnas.org/content/112/8/2320.abstract

B. “C-terminal sequence of amyloid-resistant type F apolipoprotein A-II inhibits amyloid fibril formation of apolipoprotein A-II in mice,” by Jinko Sawashita, Beiru Zhang, Kazuhiro Hasegawa, Masayuki Mori, Hironobu Naiki, Fuyuki Kametani, and Keiichi Higuchi (Vol. 112, No. 8, February 24, 2015, p. E836–E845).

www.pnas.org/content/112/8/E836.abstract

C. “Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice,” by Byung Hee Han, Meng-liang Zhou, Andrew W. Johnson, Itender Singh, Fan Liao, Ananth K. Vellimana, James W. Nelson, Eric Milner, John R. Cirrito, Jacob Basak, Min Yoo, Hans H. Dietrich, David M. Holtzman, and Gregory Joseph Zipfel (Vol. 112, No. 8, February 24, 2015, p. E881–E890). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/8/E881.abstract

D. “Metabolic resting-state brain networks in health and disease,” by Phoebe G. Spetsieris, Ji Hyun Ko, Chris C. Tang, Amir Nazem, Wataru Sako, Shichun Peng, Yilong Ma, Vijay Dhawan, and David Eidelberg (Vol. 112, No. 8, February 24, 2015, p. 2563–2568).

www.pnas.org/content/112/8/2563.abstract

February 20, 2015

CAAR – Tables of Contents – February 20, 2015

Filed under: Journal Table of Contents — Tags: , — admin @ 4:43 pm

Journals of Gerontology (A): Biological Sciences (Vol. 70A, No. 3, March 2015).

biomedgerontology.oxfordjournals.org/content/70/3.toc

Journal of Parkinson’s Disease (Vol. 5, No. 1, February 2015).

iospress.metapress.com/content/jlg77g0q44w2/

February 17, 2015

CAAR – Proccedings of the National Academy of Sciences Article Abstract – February 17, 2015

Network-based metaanalysis identifies HNF4A and PTBP1 as longitudinally dynamic biomarkers for Parkinson’s disease,” by Jose A. Santiago and Judith A. Potashkin (Vol. 112, No. 7, February 17, 2015, p. 2257-2262).

www.pnas.org/content/112/7/2257.abstract

February 16, 2015

CAAR – Lancet Neurology Article Abstracts – February 16, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:49 pm

Note: Lancet requires free registration prior to providing content.

A. “Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis,” by Jonathan D. Rohrer, Jennifer M. Nicholas, David M. Cash, John van Swieten, Elise Dopper, Lize Jiskoot, Rick van Minkelen, Serge A. Rombouts, M. Jorge Cardoso, Shona Clegg, Miklos Espak, Simon Mead, David L Thomas, Enrico De Vita, Mario Masellis, Sandra E. Black, Morris Freedman, Ron Keren, Bradley J. MacIntosh, Ekaterina Rogaeva, David Tang-Wai, Maria Carmela Tartaglia, Robert Laforce, Fabrizio Tagliavini, Pietro Tiraboschi, Veronica Redaelli, Sara Prioni, Marina Grisoli, Barbara Borroni, Alessandro Padovani, Daniela Galimberti, Elio Scarpini, Andrea Arighi, Giorgio Fumagalli, James B. Rowe, Ian Coyle-Gilchrist, Caroline Graff, Marie Fallström, Vesna Jelic, Anne Kinhult Stahlbom, Christin Andersson, Hakan Thonberg, Lena Lilius, Giovanni B. Frisoni, Michela Pievani, Martina Bocchetta, Luisa Benussi, Roberta Ghidoni, Elizabeth Finger, Sandro Sorbi, Benedetta Nacmias, Gemma Lombardi, Cristina Polito, Jason D. Warren, Sebastien Ourselin, Nick C. Fox, and Martin N. Rossor (Vol. 15, No. 3, March 2015, p. 253-262).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70324-2/abstract

B. “CHCHD2 mutations in autosomal dominant late-onset Parkinson’s disease: a genome-wide linkage and sequencing study,” by Manabu Funayama, Kenji Ohe, Taku Amo, Norihiko Furuya, Junji Yamaguchi, Shinji Saiki, Yuanzhe Li, Kotaro Ogaki, Maya Ando, Hiroyo Yoshino, Hiroyuki Tomiyama, Kenya Nishioka, Kazuko Hasegawa, Hidemoto Saiki, Wataru Satake, Kaoru Mogushi, Ryogen Sasaki, Yasumasa Kokubo, Shigeki Kuzuhara, Tatsushi Toda, Yoshikuni Mizuno, Yasuo Uchiyama, Kinji Ohno, and Nobutaka Hattori (Vol. 15, No. 3, March 2015, p. 274-282).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70266-2/abstract

February 10, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 10, 2015

Filed under: Reports and Articles — Tags: — admin @ 4:20 pm

Therapeutic mechanisms of high-frequency stimulation in Parkinson’s disease and neural restoration via loop-based reinforcement,” by Sabato Santaniello, Michelle M. McCarthy, Erwin B. Montgomery Jr., John T. Gale, Nancy Kopell, and Sridevi V. Sarma (Vol. 112, No. 6, February 10, 2015, p. E586-E595).

www.pnas.org/content/112/6/E586.abstract.html?etoc

February 9, 2015

CAAR – Public Library of Science (PLoS) Article – February 9, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:49 pm

Prediction of Falls and/or Near Falls in People with Mild Parkinson’s Disease,” by Beata Lindholm, Peter Hagell, Oskar Hansson, and Maria H. Nilsson (PLoS ONE 10(1): e0117018. doi:10.1371/journal.pone.0117018, HTML, XML, and .pdf format, 11p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0117018

CAAR – Nature Biotechnology Article Abstract – February 9, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:48 pm

Optogenetics enables functional analysis of human embryonic stem cell–derived grafts in a Parkinson’s disease model,” by Julius A. Steinbeck, Se Joon Choi, Ana Mrejeru, Yosif Ganat, Karl Deisseroth, David Sulzer, Eugene V. Mosharov & Lorenz Studer (Vol. 33, No. 2, February 2015, p. 204-209).

www.nature.com/nbt/journal/v33/n2/abs/nbt.3124.html

February 5, 2015

CAAR – Wisconsin Alzheimer’s Disease Research Center Conference – February 5, 2015

Filed under: Conferences — Tags: , — admin @ 4:15 pm

Alzheimer’s & Parkinson’s Research Day 2015,” (March 5, 2015; Madison, Wisconsin). Note: The deadline for abstracts is Feb. 15, 2015.

www.adrc.wisc.edu/adpd-research-day

January 27, 2015

CAAR – Proceedings of National Academy of Science Article Abstract – January 27, 2015

Filed under: Reports and Articles — Tags: — admin @ 4:45 pm

STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease,” by Pradeep K. Kurup, Jian Xu, Rita Alexandra Videira, Chimezie Ononenyi, Graca Baltazar, Paul J. Lombroso, and Angus C. Nairn (Vol. 112, No. 4, January 27, 2015, p. 1202-1207).

www.pnas.org/content/112/4/1202.abstract

January 16, 2015

CAAR – Lancet Neurology Article Abstract – January 16, 2015

Filed under: Reports and Articles — Tags: , — admin @ 3:56 pm

Note: Lancet requires free registration prior to providing content. “Efficacy of rasagiline in patients with the parkinsonian variant of multiple system atrophy: a randomised, placebo-controlled trial,” by Prof. Werner Poewe, Prof, Klaus Seppi, Cheryl J. Fitzer-Attas, Prof. Gregor K. Wenning, Sid Gilman, Prof. Phillip A. Low, Prof. Nir Giladi, Prof. Paolo Barone, Prof. Cristina Sampaio, Eli Eyal, and Prof. Olivier Rascol, MD, for the Rasagiline-for-MSA investigators (Vol. 14, No. 2, February 2015, p. 145-152).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70288-1/abstract

January 5, 2015

CAAR – Lancet Neurology Article Abstract – January 5, 2015

Filed under: Reports and Articles — Tags: — admin @ 4:29 pm

Prediagnostic presentations of Parkinson’s disease in primary care: a case-control study,” by D.r Anette Schrag, Laura Horsfall, Kate Walters, Alastair Noyce, and Irene Petersen (Vol. 14, No. 1, January 2015, p. 57-64).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70287-X/abstract

December 23, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstract – December 23, 2014

Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease,” by Hilal Unal Gulsuner, Suleyman Gulsuner, Fatma Nazli Mercan, Onur Emre Onat, Tom Walsh, Hashem Shahin, Ming K. Lee, Okan Dogu, Tulay Kansu, Haluk Topaloglu, Bulent Elibol, Cenk Akbostanci, Mary-Claire King, Tayfun Ozcelik, and Ayse B. Tekinay (Vol. 111, No. 51, December 23, 2014, p. 18285-18290).

www.pnas.org/content/111/51/18285.abstract.html?etoc

December 15, 2014

CAAR – Journal Tables of Contents – December 15, 2014

Filed under: Journal Table of Contents — Tags: , , — admin @ 4:11 pm

Age and Ageing (Vol. 44, No. 1, January 2014; Vol. 43, No 6, November 2014  Supplement 2, October 2014). The topic of the supplement is: “British Geriatrics Society Communications to the Spring Meeting, 23 – 25 April 2014 Manchester.”

January 2015:

ageing.oxfordjournals.org/content/44/1?etoc

November 2014:

ageing.oxfordjournals.org/content/43/6?etoc

Supplement 2:

ageing.oxfordjournals.org/content/43/suppl_2?etoc

Archives of Gerontology and Geriatrics (Vol. 59, No. 3, November/December 2014; Vol. 60, No. 1, January/February 2015).

November/December:

www.sciencedirect.com/science/journal/01674943/59/3

January/February:

www.sciencedirect.com/science/journal/01674943/60/1

American Journal of Epidemiology (Vol. 180, No. 11, Dec. 1, 2014).

aje.oxfordjournals.org/content/180/11?etoc

Experimental Aging Research (Vol. 41, No. 1, 2015).

www.tandfonline.com/toc/uear20/41/1

 

Journal of Aging and Health (Vol. 26, No. 8, December 2014).

jah.sagepub.com/content/26/8?etoc

Journal of Parkinson’s Disease (Vol. 4, No. 4, December 2014).

iospress.metapress.com/content/j375266xwjwp/

Journal of Population Ageing (Vol. 7, No. 4, December 2014).

link.springer.com/journal/12062/7/4/page/1

 

Public Health (Vol. 128, No. 10-11, October-December 2014).

October:

www.sciencedirect.com/science/journal/00333506/128/10

November:

www.sciencedirect.com/science/journal/00333506/128/11

December:

www.sciencedirect.com/science/journal/00333506/128/12

Reviews in Clinical Gerontology (Vol. 24, No. 4, November 2014).

journals.cambridge.org/action/displayIssue?decade=2010&jid=RCG&volumeId=24&issueId=04&iid=9444127

 

November 21, 2014

CAAR – Statistics Canada/Statistique Canada Article – November 21, 2014

Filed under: Reports and Articles — Tags: — admin @ 5:04 pm

Parkinson’s disease: Prevalence, diagnosis and impact,” by Suzy L. Wong, Heather Gilmour and Pamela L. Ramage-Morin (Health Reports, Vol. 25, No. 11, November 2014, .pdf and HTML format).

www.statcan.gc.ca/pub/82-003-x/2014011/article/14112/abstract-resultat-eng.htm

November 6, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 6, 2014

Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo,” by Xinjiang Kang, Huadong Xu, Sasa Teng, Xiaoyu Zhang, Zijun Deng, Li Zhou, Panli Zuo, Bing Liu, Bin Liu, Qihui Wu, Li Wang, Meiqin Hu, Haiqiang Dou, Wei Liu, Feipeng Zhu, Qing Li, Shu Guo, Jingli Gu, Qian Lei, Jing Lu, Yu Mu, Mu Jin, Shirong Wang, Wei Jiang, Kun Liu, Changhe Wang, Wenlin Li, Kang Zhang, and Zhuan Zhou (Vol. 111, No. 44, November 4, 2014, p. 15804–15809)

www.pnas.org/content/111/44/15804.abstract

October 28, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – October 28, 2014

Filed under: Reports and Articles — Tags: , , — admin @ 4:51 pm

A. “Obesity accelerates epigenetic aging of human liver,” by Steve Horvath, Wiebke Erhart, Mario Brosch, Ole Ammerpohl, Witigo von Schönfels, Markus Ahrens, Nils Heits, Jordana T. Bell, Pei-Chien Tsai, Tim D. Spector, Panos Deloukas, Reiner Siebert, Bence Sipos, Thomas Becker, Christoph Rocken, Clemens Schafmayer, and Jochen Hampe (Vol. 111, No. 43, October 28, 2014, p. 15538-15543). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/111/43/15538.abstract

B. “LIMP-2 expression is critical for {beta}-glucocerebrosidase activity and {alphpa}-synuclein clearance,” by Michelle Rothaug, Friederike Zunke, Joseph R. Mazzulli, Michaela Schweizer, Hermann Altmeppen, Renate Lullmann-Rauch, Wouter W. Kallemeijn, Paulo Gaspar, Johannes M. Aerts, Markus Glatzel, Paul Saftig, Dimitri Krainc, Michael Schwake, and Judith Blanz (Vol. 111, No. 43, October 28, 2014, p. 15573-15578).

www.pnas.org/content/111/43/15573.abstract

October 20, 2014

CAAR – Public Library of Science (PLoS) Article – October 20, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:43 pm

Upregulation of GPR109A in Parkinson’s Disease,” by Chandramohan Wakade, Raymond Chong, Eric Bradley, Bobby Thomas, and John Morgan (PLoS ONE 9(10): e109818. doi:10.1371/journal.pone.0109818, HTML, XML, and .pdf format, 10p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0109818

October 7, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 7, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:44 pm

{alpha}-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation,” by Jacqueline Burrea, Manu Sharma, and Thomas C. Sudhof (Vol. 111, No. 40, October 7, 2014, p. E4274–E4283).

www.pnas.org/content/111/40/E4274.abstract

October 2, 2014

CAAR – Public Library of Science (PLoS) Article – October 2, 2014

Filed under: Reports and Articles — Tags: , , — admin @ 3:15 pm

Glaucoma, Alzheimer’s Disease, and Parkinson’s Disease: An 8-Year Population-Based Follow-Up Study,” by I-Chan Lin, Yuan-Hung Wang, Tsung-Jen Wang, I-Jong Wang, Yun-Den Shen, Nai-Fang Chi, and Li-Nien Chien (PLoS ONE 9(10): e108938. doi:10.1371/journal.pone.0108938, XML, HTML, and .pdf format, 6p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0108938

September 26, 2014

CAAR – Lancet Article Abstract – September 26, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:43 pm

Note: Lancet requires free registration prior to providing access. “Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson’s disease (PD MED): a large, open-label, pragmatic randomised trial PD MED Collaborative Group,” by PD MED Collaborative Group (Vol. 384, No. 9949, September 27, 2014, p. 1196-1205).

www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60683-8/abstract

September 23, 2014

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 23, 2014

Filed under: Reports and Articles — Tags: — admin @ 4:37 pm

Phosphatidylethanolamine deficiency disrupts a-synuclein homeostasis in yeast and worm models of Parkinson disease,” by Shaoxiao Wang, Siyuan Zhang, Liang-Chun Liou, Qun Ren, Zhaojie Zhang, Guy A. Caldwell, Kim A. Caldwell, and Stephan N. Witt (Vol. 111, No. 38, September 23, 2014, p. E3976-E3985).

www.pnas.org/content/111/38/E3976.abstract

Older Posts »

Powered by WordPress