CDHA CAAR

April 24, 2013

CAAR – Public Library of Science (PLoS) Articles – April 24, 2013

Filed under: Reports and Articles — Tags: , , — admin @ 4:15 pm

A. “FDG PET and MRI in Logopenic Primary Progressive Aphasia versus Dementia of the Alzheimer’s Type,” by Ajay Madhavan, Jennifer L. Whitwell, Stephen D. Weigand, Joseph R. Duffy, Edythe A. Strand, Mary M. Machulda, Nirubol Tosakulwong, Matthew L. Senjem, Jeffrey L. Gunter, Val J. Lowe, Ronald C. Petersen, Clifford R. Jack, and Keith A. Josephs (PLoS ONE 8(4): e62471. doi:10.1371/journal.pone.0062471, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062471

B. “TOM40 Mediates Mitochondrial Dysfunction Induced by {alpha}-Synuclein Accumulation in Parkinson’s Disease,” by Andreas Bender, Paula Desplats, Brian Spencer, Edward Rockenstein, Anthony Adame, Matthias Elstner, Christoph Laub, Sarina Mueller, Andrew O. Koob, Michael Mante, Emily Pham, Thomas Klopstock, and Eliezer Masliah (PLoS ONE 8(4): e62277. doi:10.1371/journal.pone.0062277, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062277

C. “Calcitriol Imparts Neuroprotection In Vitro to Midbrain Dopaminergic Neurons by Upregulating GDNF Expression,” by Rowan P. Orme, Manminder S. Bhangal, and Rosemary A. Fricker (PLoS ONE 8(4): e62040. doi:10.1371/journal.pone.0062040, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062040

D. “Population-Based 5-Year Follow-Up Study in Taiwan of Dementia and Risk of Stroke,” by Mu-En Liu, Shih-Jen Tsai, Wei-Chiao Chang, Chun-Hung Hsu, Ti Lu, Kuo-Sheng Hung, Wen-Ta Chiu, and Wei-Pin Chang (PLoS ONE 8(4): e61771. doi:10.1371/journal.pone.0061771, XML, HTML, and .pdf format, 6p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061771

April 19, 2013

CAAR – Public Library of Science (PLoS) Articles – April 19, 2013

A. “Bee Venom and Its Component Apamin as Neuroprotective Agents in a Parkinson Disease Mouse Model,” by Daniel Alvarez-Fischer, Carmen Noelker, Franca Vulinovic, Anne Grunewald, Caroline Chevarin, Christine Klein, Wolfgang H. Oertel, Etienne C. Hirsch, Patrick P. Michel, and Andreas Hartmann (PLoS ONE 8(4): e61700. doi:10.1371/journal.pone.0061700, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061700

B. “Social Participation and Dental Health Status among Older Japanese Adults: A Population-Based Cross-Sectional Study,” by Kenji Takeuchi, Jun Aida, Katsunori Kondo, and Ken Osaka (PLoS ONE 8(4): e61741. doi:10.1371/journal.pone.0061741, XML, HTML, and .pdf format, 6p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061741

C. “Olfactory Training in Patients with Parkinson’s Disease,” by Antje Haehner, Clara Tosch, Martin Wolz, Lisa Klingelhoefer, Mareike Fauser, Alexander Storch, Heinz Reichmann, and Thomas Hummel (PLoS ONE 8(4): e61680. doi:10.1371/journal.pone.0061680, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061680

D. “Minocycline Attenuates Cognitive Impairment Induced by Isoflurane Anesthesia in Aged Rats,” by Feijuan Kong, Shuping Chen, Yuan Cheng, Leilei Ma, Huishun Lu, Honghai Zhang, and Wenwen Hu (PLoS ONE 8(4): e61385. doi:10.1371/journal.pone.0061385, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061385

E. “Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein,” by Jiang-Li Tan, Qiao-Xin Li, Giuseppe D. Ciccotosto, Peter John Crouch, Janetta Gladys Culvenor, Anthony Robert White, and Genevieve Evin (PLoS ONE 8(4): e61246. doi:10.1371/journal.pone.0061246, XML, HTML, and .pdf format, 14p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061246

April 17, 2013

CAAR – Nature Letter Abstract – April 17, 2013

Filed under: Reports and Articles — Tags: — admin @ 4:37 pm

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization,” by Shireen A. Sarraf, Malavika Raman, Virginia Guarani-Pereira, Mathew E. Sowa, Edward L. Huttlin, Steven P. Gygi & J. Wade Harper (Vol. 496, No. 745, April 17, 2013, p. 372-376).

www.nature.com/nature/journal/v496/n7445/abs/nature12043.html

April 3, 2013

CAAR – Public Library of Science (PLoS) Articles – April 3, 2013

A. “Hunger in the Absence of Caloric Restriction Improves Cognition and Attenuates Alzheimer’s Disease Pathology in a Mouse Model,” by Emily J. Dhurandhar, David B. Allison, Thomas van Groen, and Inga Kadish (PLoS ONE 8(4): e60437. doi:10.1371/journal.pone.0060437, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0060437

B. “SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians,” by Akinori Miyashita, Asako Koike, Gyungah Jun, Li-San Wang, Satoshi Takahashi, Etsuro Matsubara, Takeshi Kawarabayashi, Mikio Shoji, Naoki Tomita, Hiroyuki Arai, Takashi Asada, Yasuo Harigaya, Masaki Ikeda, Masakuni Amari, Haruo Hanyu, Susumu Higuchi, Takeshi Ikeuchi, Masatoyo Nishizawa, Masaichi Suga, Yasuhiro Kawase, Hiroyasu Akatsu, Kenji Kosaka, Takayuki Yamamoto, Masaki Imagawa, Tsuyoshi Hamaguchi, Masahito Yamada, Takashi Moriaha, Masatoshi Takeda, Takeo Takao, Kenji Nakata, Yoshikatsu Fujisawa, Ken Sasaki, Ken Watanabe, Kenji Nakashima, Katsuya Urakami, Terumi Ooya, Mitsuo Takahashi, Takefumi Yuzuriha, Kayoko Serikawa, Seishi Yoshimoto, Ryuji Nakagawa, Jong-Won Kim, Chang-Seok Ki, Hong-Hee Won, Duk L. Na, Sang Won Seo, Inhee Mook-Jung, The Alzheimer Disease Genetics Consortium, Peter St. George-Hyslop, Richard Mayeux, Jonathan L. Haines, Margaret A. Pericak-Vance, Makiko Yoshida, Nao Nishida, Katsushi Tokunaga, Ken Yamamoto, Shoji Tsuji, Ichiro Kanazawa, Yasuo Ihara, Gerard D. Schellenberg, Lindsay A. Farrer, and Ryozo Kuwano (PLoS ONE 8(4): e58618. doi:10.1371/journal.pone.0058618, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0058618

C. “Age-Dependent Effects of A53T Alpha-Synuclein on Behavior and Dopaminergic Function,” by Adam W. Oaks, Maya Frankfurt, David I. Finkelstein, and Anita Sidhu (PLoS ONE 8(4): e60378. doi:10.1371/journal.pone.0060378, XML, HTML, and .pdf format, 15p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0060378

D. “Neuroinflammation and Neuronal Loss Precede A{beta} Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease,” by Amanda L. Wright, Raphael Zinn, Barbara Hohensinn, Lyndsey M. Konen, Sarah B. Beynon, Richard P. Tan, Ian A. Clark, Andrea Abdipranoto, and Bryce Vissel (PLoS ONE 8(4): e59586. doi:10.1371/journal.pone.0059586, XML, HTML, and .pdf format, 14p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0059586

E. “Time’s Up. Descriptive Epidemiology of Multi-Morbidity and Time Spent on Health Related Activity by Older Australians: A Time Use Survey,” by Tanisha Jowsey, Ian S. McRae, Jose M. Valderas, Paul Dugdale, Rebecca Phillips, Robin Bunton, James Gillespie, Michelle Banfield, Lesley Jones, Marjan Kljakovic, and Laurann Yen (PLoS ONE 8(4): e59379. doi:10.1371/journal.pone.0059379, XML, HTML, and .pdf format, 6p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0059379

April 2, 2013

CAAR – Tables of Contents – April 2, 2013

Filed under: Journal Table of Contents — Tags: , — admin @ 4:44 pm

Journal of Parkinson’s Disease (Vol. 3, No. 1, 2013).

iospress.metapress.com/content/x7246m80h058/

Research on Aging (Vol. 35, No. 3, May 2013).

roa.sagepub.com/content/35/3.toc

March 26, 2013

CAAR – Public Library of Science (PLoS) Articles – March 26, 2013

Filed under: Reports and Articles — Tags: , , , , — admin @ 4:58 pm

A. “Waist Circumference, Not Body Mass Index, Is Associated with Renal Function Decline in Korean Population: Hallym Aging Study,” by Hyunju Oh, Shan Ai Quan, Jin-Young Jeong, Soong-Nang Jang, Jung Eun Lee, and Dong-Hyun Kim (PLoS ONE 8(3): e59071. doi:10.1371/journal.pone.0059071, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0059071

B. “Mortality Risk amongst Nursing Home Residents Evacuated after the Fukushima Nuclear Accident: A Retrospective Cohort Study,” by Shuhei Nomura, Stuart Gilmour, Masaharu Tsubokura, Daisuke Yoneoka, Amina Sugimoto, Tomoyoshi Oikawa, Masahiro Kami, and Kenji Shibuya (PLoS ONE 8(3): e60192. doi:10.1371/journal.pone.0060192, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0060192

C. “Ovariectomy Induces a Shift in Fuel Availability and Metabolism in the Hippocampus of the Female Transgenic Model of Familial Alzheimer’s,” by Fan Ding, Jia Yao, Liqin Zhao, Zisu Mao, Shuhua Chen, and Roberta Diaz Brinton (PLoS ONE 8(3): e59825. doi:10.1371/journal.pone.0059825, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0059825

D. “Characterization of a Single-Chain Variable Fragment Recognizing a Linear Epitope of A{beta}: A Biotechnical Tool for Studies on Alzheimer’s Disease?” by Silke Dornieden, Andreas Müller-Schiffmann, Heinrich Sticht, Nan Jiang, Yeliz Cinar, Michael Wordehoff, Carsten Korth, Susanne Aileen Funke, and Dieter Willbold (PLoS ONE 8(3): e59820. doi:10.1371/journal.pone.0059820, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0059820

E. “Enhanced Functional Connectivity between Putamen and Supplementary Motor Area in Parkinson’s Disease Patients,” by Rongjun Yu, Bo Liu, Lingling Wang, Jun Chen, and Xian Liu (PLoS ONE 8(3): e59717. doi:10.1371/journal.pone.0059717, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0059717

CAAR – Nature Neuroscience Article Abstracts – March 26, 2013

Filed under: Reports and Articles — Tags: , , — admin @ 4:56 pm

A. “Interplay of LRRK2 with chaperone-mediated autophagy,” by Samantha J. Orenstein, Sheng-Han Kuo, Inmaculada Tasset, Esperanza Arias, Hiroshi Koga, Irene Fernandez-Carasa, Etty Cortes, Lawrence S Honig, William Dauer, Antonella Consiglio, Angel Raya, David Sulzer and Ana Maria Cuervo (Vol. 16, No. 4, April 2013, p. 394-406).

www.nature.com/neuro/journal/v16/n4/abs/nn.3350.html

B. “Low hippocampal PI(4,5)P2 contributes to reduced cognition in old mice as a result of loss of MARCKS,” by Laura Trovo, Tariq Ahmed, Zsuzsanna Callaerts-Vegh, Andrea Buzzi, Claudia Bagni, Marinee Chuah, Thierry VandenDriessche, Rudi D’Hooge, Detlef Balschun and Carlos G. Dotti (Vol. 16, No. 4, April 2013, p. 449-455).

www.nature.com/neuro/journal/v16/n4/abs/nn.3342.html

March 19, 2013

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 19, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:06 pm

A. “Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity,” by Neda Jahanshad, Priya Rajagopalan, Xue Hua, Derrek P. Hibar, Talia M. Nir, Arthur W. Toga, Clifford R. Jack, Jr, Andrew J. Saykin, Robert C. Green, Michael W. Weiner, Sarah E. Medland, Grant W. Montgomery, Narelle K. Hansell, Katie L. McMahon, Greig I. de Zubicaray, Nicholas G. Martin, Margaret J. Wright, Paul M. Thompson, and the Alzheimer’s Disease Neuroimaging Initiative (Vol. 110, No. 12, March 19, 2013, .pdf and HTML format, p. 4768-4773). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/110/12/4768.abstract.html?etoc

B. “Exaggerated phase-amplitude coupling in the primary motor cortex in Parkinson disease,” by Coralie de Hemptinne, Elena S. Ryapolova-Webb, Ellen L. Air, Paul A. Garcia, Kai J. Miller, Jeffrey G. Ojemann, Jill L. Ostrem, Nicholas B. Galifianakis, and Philip A. Starr (Vol. 110, No. 12, March 19, 2013, p. 4780-4785).

www.pnas.org/content/110/12/4780.abstract.html?etoc

March 18, 2013

CAAR – Lancet Neurology Article Abstracts – March 18, 2013

Filed under: Reports and Articles — Tags: , — admin @ 3:46 pm

Note: Lancet requires free registration prior to providing content.

A. “Amyloid {beta} deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer’s disease: a prospective cohort study,” by Victor L. Villemagne, Samantha Burnham, Pierrick Bourgeat, Belinda Brown, Kathryn A. Ellis, Olivier Salvado, Cassandra Szoeke, S. Lance Macaulay, Ralph Martins, Paul Maruff, David Ames, Christopher C. Rowe, and Colin L. Masters, for the Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group (Vol. 12, No. 4, April 4, p. 357-367).

www.thelancet.com/journals/laneur/article/PIIS1474-4422%2813%2970044-9/abstract

B. “Extended-release carbidopa-levodopa (IPX066) compared with immediate-release carbidopa-levodopa in patients with Parkinson’s disease and motor fluctuations: a phase 3 randomised, double-blind trial,” by Robert A. Hauser, Ann Hsu, Sherron Kell, Alberto J. Espay, Kapil Sethi, Mark Stacy, William Ondo, Martin O’Connell, and Suneel Gupta, for the IPX066 ADVANCE-PD investigators (Vol. 12, No. 4, April 4, p. 346-356).

www.thelancet.com/journals/laneur/article/PIIS1474-4422%2813%2970025-5/abstract

March 12, 2013

CAAR – Public Library of Science (PLoS) Articles – March 12, 2013

A. “Subclinical Thyroid Dysfunction and Cognitive Decline in Old Age,” by Liselotte W. Wijsman, Anton J. M. de Craen, Stella Trompet, Jacobijn Gussekloo, David J. Stott, Nicolas Rodondi, Paul Welsh, J. Wouter Jukema, Rudi G. J. Westendorp, and Simon P. Mooijaart (PLoS ONE 8(3): e59199. doi:10.1371/journal.pone.0059199, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0059199

B. “PINCH in the Cellular Stress Response to Tau-Hyperphosphorylation,” by Ahmet Yunus Ozdemir, Inna Rom, Jane Kovalevich, William Yen, Radhika Adiga, Rajnish S. Dave, and Dianne Langford (PLoS ONE 8(3): e58232. doi:10.1371/journal.pone.0058232, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0058232

C. “Single-Subject Grey Matter Graphs in Alzheimer’s Disease,” by Betty M. Tijms, Christiane Moller, Hugo Vrenken, Alle Meije Wink, Willem de Haan, Wiesje M. van der Flier, Cornelis J. Stam, Philip Scheltens, and Frederik Barkhof (PLoS ONE 8(3): e58921. doi:10.1371/journal.pone.0058921, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0058921

D. “United States Acculturation and Cancer Patients’ End-of-Life Care,” by Alexi A. Wright, Heather Stieglitz, Yankel M. Kupersztoch, M. Elizabeth Paulk, Yookyung Kim, Ingrid T. Katz, Francisco Munoz, Rachel B. Jimenez, Jan Mutchler, Lorna Rivera, Anthony L. Back, and Holly G. Prigerson (PLoS ONE 8(3): e58663. doi:10.1371/journal.pone.0058663, XML, HTML, and .pdf format, 10p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0058663

E. “Force Control Deficits in Individuals with Parkinson’s Disease, Multiple Systems Atrophy, and Progressive Supranuclear,” by Palsy Kristina A. Neely, Peggy J. Planetta, Janey Prodoehl, Daniel M. Corcos, Cynthia L. Comella, Christopher G. Goetz, Kathleen L. Shannon, and David E. Vaillancourt (PLoS ONE 8(3): e58403. doi:10.1371/journal.pone.0058403, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0058403

March 8, 2013

CAAR – British Medical Journal Articles – March 8, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:54 pm

A. “Promotion of physical activity and fitness in sedentary patients with Parkinson’s disease: randomised controlled trial,” by Marlies van Nimwegen, Arlene D. Speelman, Sebastiaan Overeem, Bart P. van de Warrenburg, Katrijn Smulders, Manon L. Dontje, George F. Borm, Frank J. G. Backx, Bastiaan R. Bloem, and Marten Munneke, on behalf of the ParkFit Study Group (Vol. 346, No. 7898, BMJ 2013;346:f576, .pdf and HTML format).

www.bmj.com/content/346/bmj.f576

B. “Income inequality and 30 day outcomes after acute myocardial infarction, heart failure, and pneumonia: retrospective cohort study,” by Peter K. Lindenauer, Tara Lagu, Michael B. Rothberg, Jill Avrunin, Penelope S. Pekow, Yongfei Wang, and Harlan M. Krumholz (Vol. 346, No. 7898, BMJ 2013;346:f521, .pdf and HTML format).

www.bmj.com/content/346/bmj.f521

CAAR – Public Library of Science (PLoS) Articles – March 8, 2013

A. “Organisational Culture in Residential Aged Care Facilities: A Cross-Sectional Observational Study,” by Christopher Etherton-Beer, Lorraine Venturato, and Barbara Horner (PLoS ONE 8(3): e58002. doi:10.1371/journal.pone.0058002, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0058002

B. “Site-Specific Perturbations of Alpha-Synuclein Fibril Structure by the Parkinson’s Disease Associated Mutations A53T and E46K,” by Luisel R. Lemkau, Gemma Comellas, Shin W. Lee, Lars K. Rikardsen, Wendy S. Woods, Julia M. George, and Chad M. Rienstra (PLoS ONE 8(3): e49750. doi:10.1371/journal.pone.0049750, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0049750

C. “Ginsenoside Rg1 Decreases A{beta}1-42 Level by Upregulating PPAR? and IDE Expression in the Hippocampus of a Rat Model of Alzheimer’s Disease,” by QianKun Quan, Jue Wang, Xi Li, and Yi Wang (PLoS ONE 8(3): e59155. doi:10.1371/journal.pone.0059155, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0059155

D. “Oleuropein Aglycone Protects Transgenic C. elegans Strains Expressing A{beta}42 by Reducing Plaque Load and Motor Deficit,” by Luisa Diomede, Stefania Rigacci, Margherita Romeo, Massimo Stefani, and Mario Salmona (PLoS ONE 8(3): e58893. doi:10.1371/journal.pone.0058893, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0058893

E. “The Proton-Pump Inhibitor Lansoprazole Enhances Amyloid Beta Production,” by Nahuai Badiola, Victor Alcalde, Albert Pujol, Lisa-Marie Munter, Gerd Multhaup, Alberto Lleo, Mireia Coma, Montserrat Soler-Lopez, and Patrick Aloy (PLoS ONE 8(3): e58837. doi:10.1371/journal.pone.0058837, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0058837

F. “Socio-Economic Position Has No Effect on Improvement in Health-Related Quality of Life and Patient Satisfaction in Total Hip and Knee Replacement: A Cohort Study,” by J. Christiaan Keurentjes, David Blane, Melanie Bartley, Johan J. B. Keurentjes, Marta Fiocco, and Rob G. Nelissen (PLoS ONE 8(3): e56785. doi:10.1371/journal.pone.0056785, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056785

March 5, 2013

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 5, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:27 pm

A. “Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-{beta} species,” by Suk-Joon Hyung, Alaina S. DeToma, Jeffrey R. Brender, Sanghyun Lee, Subramanian Vivekanandan, Akiko Kochi, Jung-Suk Choi, Ayyalusamy Ramamoorthy, Brandon T. Ruotolo, and Mi Hee Lim (Vol. 110, No. 10, March 5, 2013, p. 3743-3748).

www.pnas.org/content/110/10/3743.abstract

B. “Metabotropic NMDA receptor function is required for {beta}-amyloid-induced synaptic depression,” by Helmut W. Kessels, Sadegh Nabavi, and Roberto Malinow (Vol. 110, No. 10, March 5, 2013, p. 4033-4038).

www.pnas.org/content/110/10/4033.abstract

C. “Large {alpha}-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking,” by Bong-Kyu Choi, Mal-Gi Choi, Jae-Yeol Kim, Yoosoo Yang, Ying Lai, Dae-Hyuk Kweon, Nam Ki Lee, and Yeon-Kyun Shin (Vol. 110, No. 10, March 5, 2013, p. 4087-4092).

www.pnas.org/content/110/10/4087.abstract

March 4, 2013

CAAR – Public Library of Science (PLoS) Articles – March 4, 2013

Filed under: Reports and Articles — Tags: , , — admin @ 4:21 pm

A. “Is R2* a New MRI Biomarker for the Progression of Parkinson’s Disease? A Longitudinal Follow-Up,” by Miguel Ulla, Jean Marie Bonny, Lemlih Ouchchane, Isabelle Rieu, Beatrice Claise, and Franck Durif (PLoS ONE 8(3): e57904. doi:10.1371/journal.pone.0057904, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0057904

B. “The Effects of Housework on the Health of Retired Older Adults: A Preliminary Investigation from the Tongji-Dongfeng Cohort Study,” by China Xiaopiao Wen, Yuan Liang, Jiang Zhu, and Tangchun Wu (PLoS ONE 8(3): e57232. doi:10.1371/journal.pone.0057232, XML, HTML, and .pdf format, 6p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0057232

February 28, 2013

CAAR – Public Library of Science (PLoS) Articles – February 28, 2013

Filed under: Reports and Articles — Tags: , , , — admin @ 4:13 pm

A. “Research on a Community-based Platform for Promoting Health and Physical Fitness in the Elderly Community,” by Tsai-Hsuan Tsai, Alice May-Kuen Wong, Chien-Lung Hsu, and Kevin C. Tseng (PLoS ONE 8(2): e57452. doi:10.1371/journal.pone.0057452, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0057452

B. “A Proposal for a Comprehensive Grading of Parkinson’s Disease Severity Combining Motor and Non-Motor Assessments: Meeting an Unmet Need,” by Kallol Ray Chaudhuri, Jose Manuel Rojo, Anthony H. V. Schapira, David J. Brooks, Fabrizio Stocchi, Per Odin, Angelo Antonini, Richard J. Brown, and Pablo Martinez-Martin (PLoS ONE 8(2): e57221. doi:10.1371/journal.pone.0057221, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0057221

C. “Detection of Amyloid Plaques Targeted by Bifunctional USPIO in Alzheimer’s Disease Transgenic Mice Using Magnetic Resonance Microimaging,” by Youssef Zaim Wadghiri, Jialin Li, Jinhuan Wang, Dung Minh Hoang, Yanjie Sun, Hong Xu, Wai Tsui, Yongsheng Li, Allal Boutajangout, Andrew Wang, Mony de Leon, and Thomas Wisniewski (PLoS ONE 8(2): e57097. doi:10.1371/journal.pone.0057097, XML, HTML, and .pdf format, 10p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0057097

February 26, 2013

CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 26, 2013

Filed under: Reports and Articles — Tags: — admin @ 4:27 pm

Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies,” by S. Pablo Sardi, Jennifer Clarke, Catherine Viel, Monyrath Chan, Thomas J. Tamsett, Christopher M. Treleaven, Jie Bu, Lindsay Sweet, Marco A. Passini, James C. Dodge, W. Haung Yu, Richard L. Sidman, Seng H. Cheng, and Lamya S. Shihabuddin (Vol. 110, No. 9, February 26, 2013, .pdf and HTML format, p. 3537-3542). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/110/9/3537.abstract.html?etoc

February 15, 2013

CAAR – New England Journal of Medicine Article Abstract – February 15, 2013

Filed under: Reports and Articles — Tags: — admin @ 1:33 pm

Neurostimulation for Parkinson’s Disease with Early Motor Complication,” by W.M.M. Schuepbach, J. Rau, K. Knudsen, J. Volkmann, P. Krack, L. Timmermann, T.D. Halbig, H. Hesekamp, S.M. Navarro, N. Meier, D. Falk, M. Mehdorn, S. Paschen, M. Maarouf, M.T. Barbe, G.R. Fink, A. Kupsch, D. Gruber, G.-H. Schneider, E. Seigneuret, A. Kistner, P. Chaynes, F. Ory-Magne, C. Brefel Courbon, J. Vesper, A. Schnitzler, L. Wojtecki, J.-L. Houeto, B. Bataille, D. Maltete, P. Damier, S. Raoul, F. Sixel-Doering, D. Hellwig, A. Gharabaghi, R. Krüger, M.O. Pinsker, F. Amtage, J.-M. Regis, T. Witjas, S. Thobois, P. Mertens, M. Kloss, A. Hartmann, W.H. Oertel, B. Post, H. Speelman, Y. Agid, C. Schade-Brittinger, and G. Deuschl for the EARLYSTIM Study Group (Vol. 368, No. 7, February 14, 2013, p. 610-622).

www.nejm.org/doi/full/10.1056/NEJMoa1205158?query=TOC#t=abstract

February 14, 2013

CAAR – Public Library of Science (PLoS) Articles – February 14, 2013

Filed under: Reports and Articles — Tags: , , , , — admin @ 4:54 pm

A. “Plasma Adiponectin Levels Correlate Positively with an Increasing Number of Components of Frailty in Male Elders,” by Jaw-Shiun Tsai, Chih-Hsun Wu, Su-Chiu Chen, Kuo-Chin Huang, Chin-Ying Chen, Ching-I Chang, Lee-Ming Chuang, and Ching-Yu Chen (PLoS ONE 8(2): e56250. doi:10.1371/journal.pone.0056250, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056250

B. “The Effects of Aging on Conflict Detection,” by Giuliana Lucci, Marika Berchicci, Donatella Spinelli, Francesco Taddei, and Francesco Di Russo (PLoS ONE 8(2): e56566. doi:10.1371/journal.pone.0056566, XML, HTML, and .pdf format, 14p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056566

C. “Motor Matters: Tackling Heterogeneity of Parkinson’s Disease in Functional MRI Studies,” by Stefan Holiga, Karsten Mueller, Harald E. Moller, Tomas Sieger, Matthias L. Schroeter, Josef Vymazal, Evzen Ruzicka, and Robert Jech (PLoS ONE 8(2): e56133. doi:10.1371/journal.pone.0056133, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056133

D. “Accelerated Cell Aging in Female APOE-{epsilon}4 Carriers: Implications for Hormone Therapy Use,” by Emily G. Jacobs, Candyce Kroenke, Jue Lin, Elissa S. Epel, Heather A. Kenna, Elizabeth H. Blackburn, and Natalie L. Rasgon (PLoS ONE 8(2): e54713. doi:10.1371/journal.pone.0054713, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054713

E. “Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI2/Tau Transgenic Mice,” by Holly J. Garringer, Jill Murrell, Neeraja Sammeta, Anita Gnezda, Bernardino Ghetti, and Ruben Vidal ( PLoS ONE 8(2): e56426. doi:10.1371/journal.pone.0056426, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056426

February 12, 2013

CAAR – Public Library of Science (PLoS) Article – February 12, 2013

Filed under: Reports and Articles — Tags: , , , — admin @ 4:23 pm

A. “Relationship between Plasma Analytes and SPARE-AD Defined Brain Atrophy Patterns in ADNI,” by Jon B. Toledo, Xiao Da, Priyanka Bhatt, David A. Wolk, Steven E. Arnold, Leslie M. Shaw, John Q. Trojanowski, and Christos Davatzikos, Alzheimer’s Disease Neuroimaging Initiative (PLoS ONE 8(2): e55531. doi:10.1371/journal.pone.0055531, XML, HTML, and .pdf format, 10p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055531

B. “Calorie Restriction Hysteretically Primes Aging Saccharomyces cerevisiae toward More Effective Oxidative Metabolism,” by Erich B. Tahara, Fernanda M. Cunha, Thiago O. Basso, Bianca E. Della Bianca, Andreas K. Gombert, and Alicia J. Kowaltowski (PLoS ONE 8(2): e56388. doi:10.1371/journal.pone.0056388, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056388

C. “The Pathogenic A{beta}43 Is Enriched in Familial and Sporadic Alzheimer Disease,” by Anna Sandebring, Hedvig Welander, Bengt Winblad, Caroline Graff, and Lars O. Tjernberg (PLoS ONE 8(2): e55847. doi:10.1371/journal.pone.0055847, XML, HTML, and .pdf format, 10p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055847

D. “Differentiating Non-Motor Symptoms in Parkinson’s Disease from Controls and Hemifacial Spasm,” by Ming-Hui Yong, John C. Allen, Kumar M. Prakash, and Eng-King Tan (PLoS ONE 8(2): e49596. doi:10.1371/journal.pone.0049596, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0049596

CAAR – Proceedings of the National Academy of Sciences Article – February 12, 2013

Filed under: Reports and Articles — Tags: — admin @ 4:22 pm

Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells,” by Emma R. Andersson, Carmen Salto, J. Carlos Villaescusa, Lukas Cajanek, Shanzheng Yang, Lenka Bryjova, Irina I. Nagy, Seppo J. Vainio, Carmen Ramirez, Vitezslav Bryja, and Ernest Arenas (Vol. 110, No. 7, February 12, 2013, .pdf and HTML format, p. E602-E610).

www.pnas.org/content/110/7/E602.abstract.html?etoc

February 6, 2013

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 6, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:49 pm

A. “CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging,” by Kuti Baruch, Noga Ron-Harel, Hilah Gal, Aleksandra Deczkowska, Eric Shifrut, Wilfred Ndifon, Nataly Mirlas-Neisberg, Michal Cardon, Ilan Vaknin, Liora Cahalon, Tamara Berkutzki, Mark P. Mattson, Fernando Gomez-Pinilla, Nir Friedman, and Michal Schwartz (Vol. 110, No. 6, February 5, 2013, p. 2264-2269).

www.pnas.org/content/110/6/2264.abstract

B. “Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons,” by Banafsheh Kadkhodaei, Alexandra Alvarsson, Nicoletta Schintu, Daniel Ramskold, Nikolaos Volakakis, Eliza Joodmardi, Takashi Yoshitake, Jan Kehr, Mickael Decressac, Anders Bjorklund, Rickard Sandberg, Per Svenningsson, and Thomas Perlmann (Vol. 110, No. 6, February 5, 2013, p. 2360-2365).

www.pnas.org/content/110/6/2360.abstract

February 5, 2013

CAAR – Public Library of Science (PLoS) Articles – February 5, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:48 pm

A. “A Reliable Way to Detect Endogenous Murine {beta}-Amyloid,” by Andrew F. Teich, Mitesh Patel, and Ottavio Arancio (PLoS ONE 8(2): e55647. doi:10.1371/journal.pone.0055647, XML, HTML, and .pdf format, 5p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055647

B. “Striatal Glutamate Release in l-DOPA-Induced Dyskinetic Animals,” by Nina Nevalainen, Martin Lundblad, Greg A. Gerhardt, and Ingrid Stromberg (PLoS ONE 8(2): e55706. doi:10.1371/journal.pone.0055706, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055706

January 25, 2013

CAAR – Public Library of Science (PLoS) Article – January 25, 2013

Filed under: Reports and Articles — Tags: — admin @ 4:50 pm

Obsessive Compulsive Personality Disorder and Parkinson’s Disease,” by Alessandra Nicoletti, Antonina Luca, Loredana Raciti, Donatella Contrafatto, Elisa Bruno, Valeria Dibilio, Giorgia Sciacca, Giovanni Mostile, Antonio Petralia, and Mario Zappia (PLoS ONE 8(1): e54822. doi:10.1371/journal.pone.0054822, XML, HTML, and .pdf format, 5p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054822

January 17, 2013

CAAR – Public Library of Science (PLoS) Articles – January 17, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:08 pm

A. “Hypoxia Promotes Dopaminergic Differentiation of Mesenchymal Stem Cells and Shows Benefits for Transplantation in a Rat Model of Parkinson’s Disease,” by Yue Wang, Jian Yang, Haisheng Li, Xuan Wang, Lingling Zhu, Ming Fan, and Xiaomin Wang (PLoS ONE 8(1): e54296. doi:10.1371/journal.pone.0054296, XML, HTML, and .pdf format, 12p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054296

B. “High Glucose Induced Alteration of SIRTs in Endothelial Cells Causes Rapid Aging in a p300 and FOXO Regulated Pathway,” by Rokhsana Mortuza, Shali Chen, Biao Feng, Subhrojit Sen, and Subrata Chakrabarti ( PLoS ONE 8(1): e54514. doi:10.1371/journal.pone.0054514, XML, HTML, and .pdf format, 13p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054514

January 15, 2013

CAAR – US National Institutes of Health Press Release – January 15, 2013

Filed under: Reports and Articles — Tags: — admin @ 4:26 pm

NIH launches collaborative effort to find biomarkers for Parkinson’s,” (January 15, 2013).

www.nih.gov/news/health/jan2013/ninds-15.htm

January 9, 2013

CAAR – Proceedings of the National Academy of Sciences Article Abstract – January 9, 2013

Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease,” by Arthur G. Fitzmaurice, Shannon L. Rhodes, Aaron Lulla, Niall P. Murphy, Hoa A. Lam, Kelley C. O’Donnell, Lisa Barnhill, John E. Casida, Myles Cockburn, Alvaro Sagasti, Mark C. Stahl, Nigel T. Maidment, Beate Ritz, and Jeff M. Bronstein (Vol. 110, No. 2, January 9, 2013, p. 636-641).

www.pnas.org/content/110/2/636.abstract.html?etoc

January 2, 2013

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 2, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:48 pm

A. “Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila,” by Michael Reraa, Rebecca I. Clark, and David W. Walker (Vol. 109, No. 52, December 26, 2012, p. 21528-21533).

www.pnas.org/content/109/52/21528.abstract.html?etoc

B. “Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration,” by Xiqun Chen, Thomas C. Burdett, Cody A. Desjardins, Robert Logan, Sara Cipriani, Yuehang Xu, and Michael A. Schwarzschild (Vol. 110, No. 1, January 2, 2013, p. 300-305).

www.pnas.org/content/110/1/300.abstract.html?etoc

December 13, 2012

CAAR – Lancet Neurology Article Abstract – December 13, 2012

Filed under: Reports and Articles — Tags: , — admin @ 3:49 pm

Note: Lancet requires free registration prior to providing access. “Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson’s disease (NSTAPS study): a randomised controlled trial,” by Vincent J.J. Odekerken, Teus van Laar, Michiel J. Staal, Arne Mosch, Carel F.E. Hoffmann, Peter C.G. Nijssen, Guus N. Beute, Jeroen P.P. van Vugt, Mathieu W.P.M. Lenders, M. Fiorella Contarino, Marieke S.J. Mink, Lo J. Bour, Pepijn van den Munckhof, Ben A. Schmand, Rob J. de Haan, P. Richard Schuurman, and Rob M.A. de Bie (Vol. 12, No. 1, January 2013, p. 37-44).

www.thelancet.com/journals/laneur/article/PIIS1474-4422%2812%2970264-8/abstract

December 12, 2012

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – December 12, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 1:30 pm

A. “Direct three-dimensional visualization of membrane disruption by amyloid fibrils,” by Lilia Milanesi, Tania Sheynis, Wei-Feng Xue, Elena V. Orlova, Andrew L. Hellewell, Raz Jelinek, Eric W. Hewitt, Sheena E. Radford, and Helen R. Saibil (Vol. 109, No. 50, December 11, 2012, p. 20455-20460).

www.pnas.org/content/109/50/20455.abstract

B. “CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis,” by Rachel E. Miller, Phuong B. Tran, Rosalina Das, Nayereh Ghoreishi-Haack, Dongjun Ren, Richard J. Miller, and Anne-Marie Malfait (Vol. 109, No. 50, December 11, 2012, p. 20602-20607).

www.pnas.org/content/109/50/20602.abstract

C. “Prefrontal D1 dopamine signaling is required for temporal control,” by Nandakumar S. Narayanan, Benjamin B. Land, John E. Solder, Karl Deisseroth, and Ralph J. DiLeone (Vol. 109, No. 50, December 11, 2012, p. 20726-20731).

www.pnas.org/content/109/50/20726.abstract

December 4, 2012

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – December 4, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 4:28 pm

A. “Evidence for a midlife crisis in great apes consistent with the U-shape in human well-being,” by Alexander Weiss, James E. King, Miho Inoue-Murayama, Tetsuro Matsuzawa, and Andrew J. Oswald (Vol. 109, No. 49, December 4, 2012, .pdf and HTML format, p. 19949-19952). Note: _PNAS_ is providing open access to the full-text of this article.

www.pnas.org/content/109/49/19949.abstract

B. “Rational design of potent domain antibody inhibitors of amyloid fibril assembly,” by Ali Reza A. Ladiwala, Moumita Bhattacharya, Joseph M. Perchiacca, Ping Cao, Daniel P. Raleigh, Andisheh Abedini, Ann Marie Schmidt, Jobin Varkey, Ralf Langen, and Peter M. Tessier (Vol. 109, No. 49, December 4, 2012, p. 19965-19970).

www.pnas.org/content/109/49/19965.abstract

C. “p10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicity,” by Lingyan Zhang, Wen Liu, Karen K. Szumlinski, and John Lew (Vol. 109, No. 49, December 4, 2012, p. 20041-20046).

www.pnas.org/content/109/49/20041.abstract

November 30, 2012

CAAR – Public Library of Science (PLoS) Article – November 30, 2012

Filed under: Reports and Articles — Tags: — admin @ 4:46 pm

Allopregnanolone Reinstates Tyrosine Hydroxylase Immunoreactive Neurons and Motor Performance in an MPTP-Lesioned Mouse Model of Parkinson’s Disease,” by Samuel O. Adeosun, Xu Hou, Yun Jiao, Baoying Zheng, Sherry Henry, Rosanne Hill, Zhi He, Amar Pani, Patrick Kyle, Xiaoming Ou, Thomas Mosley, Jerry M. Farley, Craig Stockmeier, Ian Paul, Steven Bigler, Roberta Diaz Brinton, Richard Smeyne, and Jun Ming Wang (PLoS ONE 7(11): e50040. doi:10.1371/journal.pone.0050040, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0050040

November 29, 2012

CAAR – Public Library of Science (PLoS) Articles – November 29, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 4:39 pm

A. “Elevated Homocysteine by Levodopa Is Detrimental to Neurogenesis in Parkinsonian Model,” by Jin Young Shin, Young-Hwan Ahn, Man-Jeong Paik, Hyun Jung Park, Young H. Sohn, and Phil Hyu Lee (PLoS ONE 7(11): e50496. doi:10.1371/journal.pone.0050496, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0050496

B. “The Impact of Influenza Vaccinations on the Adverse Effects and Hospitalization Rate in the Elderly: A National Based Study in an Asian Country,” by Tsung-Yu Ho, Kuang-Yung Huang, Tza-Ta Huang, Yung-Sung Huang, Hsu-Chueh Ho, Pesus Chou, Chun-Hung Lin, Chang-Kao Wei, Wei-Chang Lian, Ting-Chang Chen, Hsien-Bin Huang, and Ching-Chih Lee (PLoS ONE 7(11): e50337. doi:10.1371/journal.pone.0050337, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0050337

C. “No Diagnostic Value of Plasma Clusterin in Alzheimer’s Disease,” by Edina Silajdzic, Lennart Minthon, Maria Bjorkqvist, and Oskar Hansson (PLoS ONE 7(11): e50237. doi:10.1371/journal.pone.0050237, XML, HTML, and .pdf format, 4p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0050237

November 28, 2012

CAAR – Public Library of Science (PLoS) Articles – November 28, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 4:52 pm

A. “Human Anti-A{beta} IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide,” by Alfred T. Welzel, Angela D. Williams, Helen P. McWilliams-Koeppen, Luis Acero, Alfred Weber, Veronika Blinder, Alex Mably, Sebastian Bunk, Corinna Hermann, Michael A. Farrell, Hartmut J. Ehrlich, Hans P. Schwarz, Dominic M. Walsh, Alan Solomon, and Brian O’Nuallain (PLoS ONE 7(11): e50317. doi:10.1371/journal.pone.0050317, XML, HTML, and .pdf format, 12p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0050317

B. “Impaired c-Fos and Polo-Like Kinase 2 Induction in the Limbic System of Fear-conditioned alpha-Synuclein Transgenic,” by Mice Heinrich Schell, Cindy Boden, André Maia Chagas, and Philipp J. Kahle (PLoS ONE 7(11): e50245. doi:10.1371/journal.pone.0050245, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0050245

November 26, 2012

CAAR – Nature Letter Abstract – November 26, 2012

Filed under: Reports and Articles — Tags: , — admin @ 4:08 pm

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2,” by Guang-Hui Liu, Jing Qu, Keiichiro Suzuki, Emmanuel Nivet, Mo Li, Nuria Montserrat, Fei Yi, Xiuling Xu, Sergio Ruiz, Weiqi Zhang, Ulrich Wagner, Audrey Kim, Bing Ren, Ying Li, April Goebl, Jessica Kim, Rupa Devi Soligalla, Ilir Dubova, James Thompson, John Yates III, Concepcion Rodriguez Esteban, Ignacio Sancho-Martinez & Juan Carlos Izpisua Belmonte (Vol. 491, No. 7425, November 22, 2012, p. 603-607).

www.nature.com/nature/journal/v491/n7425/abs/nature11557.html

November 16, 2012

CAAR – Science Report Abstract – November 16, 2012

Filed under: Reports and Articles — Tags: — admin @ 4:45 pm

Pathological {alpha}-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice,” by Kelvin C. Luk, Victoria Kehm, Jenna Carroll, Bin Zhang, Patrick O’Brien, John Q. Trojanowski, and Virginia M.-Y. Lee (Vol. 338, No. 6109, November 16, 2012, p. 949-953).

www.sciencemag.org/content/338/6109/949.abstract

November 13, 2012

CAAR – Public Library of Science (PLoS) Articles – November 13, 2012

Filed under: Reports and Articles — Tags: , — admin @ 10:10 am

A. “Automatic Classification of Early Parkinson’s Disease with Multi-Modal MR Imaging,” by Dan Long, Jinwei Wang, Min Xuan, Quanquan Gu, Xiaojun Xu, Dexing Kong, and Minming Zhang (PLOS ONE 7(11): e47714. doi:10.1371/journal.pone.0047714, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0047714

B. “Differential Sialylation of Serpin A1 in the Early Diagnosis of Parkinson’s Disease Dementia,” by Sarah Jesse, Stefan Lehnert, Olaf Jahn, Lucilla Parnetti, Hilkka Soininen, Sanna-Kaisa Herukka, Petra Steinacker, Saskia Tawfik, Hayrettin Tumani, Christine A. F. von Arnim, Manuela Neumann, Hans A. Kretzschmar, Hasan Kulaksiz, Martin Lenter, Jens Wiltfang, Boris Ferger, Bastian Hengerer, and Markus Otto (PLoS ONE 7(11): e48783. doi:10.1371/journal.pone.0048783, XML, HTML, and .pdf format, 10p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048783

November 8, 2012

CAAR – Public Library of Science (PLoS) Articles – November 8, 2012

Filed under: Reports and Articles — Tags: , , , , — admin @ 4:40 pm

A. “Feeding Healthy Beagles Medium-Chain Triglycerides, Fish Oil, and Carnitine Offsets Age-Related Changes in Serum Fatty Acids and Carnitine Metabolites,” by Jean A. Hall and Dennis E. Jewell (PLoS ONE 7(11): e49510. doi:10.1371/journal.pone.0049510, HTML, XML, and .pdf format, 12p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0049510

B. “Mortality Associated with Diabetes and Cardiovascular Disease in Older Women,” by David Nanchen, Nicolas Rodondi, Jacques Cornuz, Teresa Hillier, Kristine E. Ensrud, Jane A. Cauley, and Douglas C. Bauer Study of Osteoporotic Fractures Research Group (PLoS ONE 7(11): e48818. doi:10.1371/journal.pone.0048818, XML, HTML, and .pdf format, 6p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048818

C. “Diffusion Tensor Metrics as Biomarkers in Alzheimer’s Disease,” by Julio Acosta-Cabronero, Stephanie Alley, Guy B. Williams, George Pengas, and Peter J. Nestor (PLoS ONE 7(11): e49072. doi:10.1371/journal.pone.0049072, XML, HTML, and .pdf format, 14p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0049072

D. “The Subthalamic Microlesion Story in Parkinson’s Disease: Electrode Insertion-Related Motor Improvement with Relative Cortico-Subcortical Hypoactivation in fMRI,” Robert Jech, Karsten Mueller, Dusan Urgosik, Stefan Holiga, Filip Ruzicka, Petr Dusek, Petra Havrankova, Josef Vymazal, and Evzen Ruzicka (PLoS ONE 7(11): e49056. doi:10.1371/journal.pone.0049056, XML, HTML, and .pdf format, 13p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0049056

E. “Induced Tauopathy in a Novel 3D-Culture Model Mediates Neurodegenerative Processes: A Real-Time Study on Biochips,” by Diana Seidel, Dana Krinke, Heinz-Georg Jahnke, Anika Hirche, Daniel Kloss, Till G. A. Mack, Frank Striggow, and Andrea Robitzki (PLoS ONE 7(11): e49150. doi:10.1371/journal.pone.0049150, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0049150

November 7, 2012

CAAR – Public Library of Science (PLoS) Articles – November 7, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 4:07 pm

A. “Extreme Levels of Noise Constitute a Key Neuromuscular Deficit in the Elderly,” by Navrag B. Singh, Niklas Konig, Adamantios Arampatzis, Markus O. Heller, and William R. Taylor (PLoS ONE 7(11): e48449. doi:10.1371/journal.pone.0048449, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048449

B. “HLA-DRB1 Alleles Are Associated with the Susceptibility to Sporadic Parkinson’s Disease in Chinese Han Population,” by Congcong Sun, Lei Wei, Feifei Luo, Jiaobiao Li, Feiqi Zhu, Ping Kang, Rensi Xu, LuLu Xiao, Zhuolin Liu, and Pingyi Xu (PLoS ONE 7(11): e48594. doi:10.1371/journal.pone.0048594, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048594

C. “The Importance of Group-Wise Registration in Tract Based Spatial Statistics Study of Neurodegeneration: A Simulation Study in Alzheimer’s Disease,” by Shiva Keihaninejad, Natalie S. Ryan, Ian B. Malone, Marc Modat, David Cash, Gerard R. Ridgway, Hui Zhang, Nick C. Fox, and Sebastien Ourselin (PLoS ONE 7(11): e45996. doi:10.1371/journal.pone.0045996, XML, HTML, and .pdf format, 13p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0045996

November 5, 2012

CAAR – Public Library of Science (PLoS) Articles – November 5, 2012

Filed under: Reports and Articles — Tags: , , , — admin @ 2:05 pm

A. “A Longitudinal Study of Atrophy in Amnestic Mild Cognitive Impairment and Normal Aging Revealed by Cortical Thickness,” by Zhijun Yao, Bin Hu, Chuanjiang Liang, Lina Zhao, and Mike Jackson, the Alzheimer’s Disease Neuroimaging Initiative (PLoS ONE 7(11): e48973. doi:10.1371/journal.pone.0048973, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048973

B. “A Peptide Binding to the {beta}-Site of APP Improves Spatial Memory and Attenuates A{beta} Burden in Alzheimer’s Disease Transgenic Mice,” by Shi-gao Yang, Shao-wei Wang, Min Zhao, Ran Zhang, Wei-wei Zhou, Ya-nan Li, Ya-jing Su, He Zhang, Xiao-lin Yu, and Rui-tian Liu (PLoS ONE 7(11): e48540. doi:10.1371/journal.pone.0048540, XML, HTML, and .pdf format, 12p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048540

C. “Dopaminergic Neuronal Loss and Dopamine-Dependent Locomotor Defects in Fbxo7-Deficient Zebrafish,” by Tianna Zhao, Herma Zondervan-van der Linde, Lies-Anne Severijnen, Ben A. Oostra, Rob Willemsen, and Vincenzo Bonifati (PLoS ONE 7(11): e48911. doi:10.1371/journal.pone.0048911, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048911

October 30, 2012

CAAR – Proceedings of the National Academy of Sciences Article Abstract – October 30, 2012

Filed under: Reports and Articles — Tags: — admin @ 4:09 pm

Counteracting chemical chaperone effects on the single-molecule {alpha}-synuclein structural landscape,” by Allan Chris M. Ferreon, Mahdi Muhammad Moosa, Yann Gambin, and Ashok A. Deniz (Vol. 109, No. 44, October 30, 2012, p. 17825-17831).

www.pnas.org/content/109/44/17826.abstract

October 26, 2012

CAAR – Public Library of Science (PLoS) Article – October 26, 2012

Filed under: Reports and Articles — Tags: , — admin @ 3:15 pm

Serum and Cerebrospinal Fluid Levels of Transthyretin in Lewy Body Disorders with and without Dementia,” by Walter Maetzler, Youyong Tian, Stephanie Maria Baur, Tina Gauger, Bartholomaus Odoj, Benjamin Schmid, Claudia Schulte, Christian Deuschle, Susanna Heck, Anja Apel, Arthur Melms, Thomas Gasser, and Daniela Berg (PLoS ONE 7(10): e48042. doi:10.1371/journal.pone.0048042, XML, HTML, and .pdf format, 6p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048042

October 25, 2012

CAAR – Public Library of Science (PLoS) Articles – October 25, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 2:54 pm

A. “Financial Stress and Outcomes after Acute Myocardial Infarction,” by Sachin J. Shah, Harlan M. Krumholz, Kimberly J. Reid, Saif S. Rathore, Aditya Mandawat, John A. Spertus, and Joseph S. Ross (PLoS ONE 7(10): e47420. doi:10.1371/journal.pone.0047420, XML, HTML, and .pdf format, 10p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0047420

B. “ATF6alpha Promotes Astroglial Activation and Neuronal Survival in a Chronic Mouse Model of Parkinson’s Disease,” by Koji Hashida, Yasuko Kitao, Hirofumi Sudo, Yoshitaka Awa, Shinichiro Maeda, Kazutoshi Mori, Ryosuke Takahashi, Munekazu Iinuma, and Osamu Hori (PLoS ONE 7(10): e47950. doi:10.1371/journal.pone.0047950, XML, HTML, and .pdf format, 12p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0047950

C. “Dissociation between Brain Amyloid Deposition and Metabolism in Early Mild Cognitive Impairment,” by Liyong Wu, Jared Rowley, Sara Mohades, Antoine Leuzy, Marina Tedeschi Dauar, Monica Shin, Vladimir Fonov, Jianping Jia, Serge Gauthier, and Pedro Rosa-Neto for the Alzheimer’s Disease Neuroimaging Initiative (PLoS ONE 7(10): e47905. doi:10.1371/journal.pone.0047905, XML, HTML, and .pdf format, p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0047905

October 18, 2012

CAAR – Public Library of Science (PLoS) Articles – October 18, 2012

A. “Treating and Preventing Influenza in Aged Care Facilities: A Cluster Randomised Controlled Trial,” by Robert Booy, Richard I. Lindley, Dominic E. Dwyer, Jiehui K. Yin, Leon G. Heron, Cameron R. M. Moffatt, Clayton K. Chiu, Alexander E. Rosewell, Anna S. Dean, Timothy Dobbins, David J. Philp, Zhanhai Gao, and C. Raina MacIntyre (PLoS ONE 7(10): e46509. doi:10.1371/journal.pone.0046509, XML, HTML, and .pdf format, 16p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046509

B. “Enrichment and Stratification for Predementia Alzheimer Disease Clinical Trials,” by Dominic Holland, Linda K. McEvoy, Rahul S. Desikan, and Anders M. Dale for the Alzheimer’s Disease Neuroimaging Initiative (PLoS ONE 7(10): e47739. doi:10.1371/journal.pone.0047739, XML, HTML, and .pdf format, 12p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0047739

C. “Non-Motor Symptoms in Patients with Parkinson’s Disease – Correlations with Inflammatory Cytokines in Serum,” by Daniel Lindqvist, Eli Kaufman, Lena Brundin, Yulia Surova, and Oskar Hansson (PLoS ONE 7(10): e47387. doi:10.1371/journal.pone.0047387, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0047387

D. “Cross-Sectional and Longitudinal Associations of Different Sedentary Behaviors with Cognitive Performance in Older Adults,” by Emmanuelle Kesse-Guyot, Helene Charreire, Valentina A. Andreeva, Mathilde Touvier, Serge Hercberg, Pilar Galan, and Jean-Michel Oppert (PLoS ONE 7(10): e47831. doi:10.1371/journal.pone.0047831, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0047831

October 16, 2012

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – October 16, 2012

Filed under: Reports and Articles — Tags: , — admin @ 4:31 pm

A. “Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease,” by Hector De Jesus-Cortes, Pin Xu, Jordan Drawbridge, Sandi Jo Estill, Paula Huntington, Stephanie Tran, Jeremiah Britt, Rachel Tesla, Lorraine Morlock, Jacinth Naidoo, Lisa M. Melito, Gelin Wang, Noelle S. Williams, Joseph M. Ready, Steven L. McKnight, and Andrew A. Pieper (Vol. 109, No. 42, October 16, 2012, .pdf and HTML format, p. 17010-17015). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/109/42/17010.abstract.html?etoc

B. “Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model,” by Pascal E. Sanchez, Lei Zhu, Laure Verret, Keith A. Vossel, Anna G. Orr, John R. Cirrito, Nino Devidze, Kaitlyn Ho, Gui-Qiu Yu, Jorge J. Palop, and Lennart Mucke (Vol. 109, No. 42, October 16, 2012, .pdf and HTML format, p. E2895-E2903). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/109/42/E2895.abstract.html?etoc

CAAR – Public Library of Science (PLoS) Articles – October 16, 2012

Filed under: Reports and Articles — Tags: , , , — admin @ 4:30 pm

A. “Reaching a Better Understanding of the Control of Bimanual Movements in Older Adults,” by Rachel O. Coats and John P. Wann (PLoS ONE 7(10): e47222. doi:10.1371/journal.pone.0047222, XML, HTML, and .pdf format, 10p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0047222

B. “Reproducibility and Respiratory Function Correlates of Exhaled Breath Fingerprint in Chronic Obstructive Pulmonary Disease,” by Raffaele Antonelli Incalzi, Giorgio Pennazza, Simone Scarlata, Marco Santonico, Massimo Petriaggi, Domenica Chiurco, Claudio Pedone, and Arnaldo D’Amico (PLoS ONE 7(10): e45396. doi:10.1371/journal.pone.0045396, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0045396

C. “Multivariate Analyses of Amyloid-Beta Oligomer Populations Indicate a Connection between Pore Formation and Cytotoxicity,” by Panchika Prangkio, Erik C. Yusko, David Sept, Jerry Yang, and Michael Mayer (PLoS ONE 7(10): e47261. doi:10.1371/journal.pone.0047261, XML, HTML, and .pdf format, 10p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0047261

D. “Radiating Amyloid Fibril Formation on the Surface of Lipid Membranes through Unit-Assembly of Oligomeric Species of alpha-Synuclein,” by Jung-Ho Lee, Chul-Suk Hong, Soonkoo Lee, Jee-Eun Yang, Yong Il Park, Daekyun Lee, Taeghwan Hyeon, Seunho Jung, and Seung R. Paik (PLoS ONE 7(10): e47580. doi:10.1371/journal.pone.0047580, XML, HTML, and .pdf format, 9p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0047580

E. “The Effect of Motivation on Movement: A Study of Bradykinesia in Parkinson’s Disease,” by Tamara Shiner, Ben Seymour, Mkael Symmonds, Peter Dayan, Kailash P. Bhatia, and Raymond J. Dolan (PLoS ONE 7(10): e47138. doi:10.1371/journal.pone.0047138, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0047138

October 10, 2012

CAAR – Public Library of Science (PLoS) Medicine Articles – October 10, 2012

Filed under: Reports and Articles — Tags: — admin @ 4:31 pm

A. “Transplanting Intact Donor Tissue Enhances Dopamine Cell Survival and the Predictability of Motor Improvements in a Rat Model of Parkinson’s Disease,” by Rosemary A. Fricker, Jan Herman Kuiper, and Monte A. Gates (PLoS ONE 7(10): e47169. doi:10.1371/journal.pone.0047169, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0047169

B. “Levodopa Effects on Hand and Speech Movements in Patients with Parkinson’s Disease: A fMRI Study,” by Audrey Maillet, Alexandre Krainik, Bettina Debu, Irène Tropres, Christelle Lagrange, Stephane Thobois, Pierre Pollak, and Serge Pinto (PLoS ONE 7(10): e46541. doi:10.1371/journal.pone.0046541, XML, HTML, and .pdf format, 12p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046541

October 9, 2012

CAAR – Public Library of Science (PLoS) Articles – October 9, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 3:07 pm

A. “Social Participation, Social Environment and Death Ideations in Later Life,” by Thomas Saias, Francois Beck, Julie Bodard, Romain Guignard, and Enguerrand du Roscoat (PLoS ONE 7(10): e46723. doi:10.1371/journal.pone.0046723, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046723

B. “Parkinson Subtypes Progress Differently in Clinical Course and Imaging Pattern,” Carsten Eggers, David J. Pedrosa, Deniz Kahraman, Franziska Maier, Catharine J. Lewis, Gereon R. Fink, Matthias Schmidt, and Lars Timmermann (PLoS ONE 7(10): e46813. doi:10.1371/journal.pone.0046813, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046813

October 3, 2012

CAAR – Journal Tables of Contents – October 3, 2012

Filed under: Journal Table of Contents — Tags: , — admin @ 3:50 pm

Journal of Parkinson’s Disease (Vol. 2, No. 3, 2012).

iospress.metapress.com/content/m4663j2n73h7/

Medical Care (Vol. 50, No. 10, October 2012).

journals.lww.com/lww-medicalcare/pages/currenttoc.aspx

October 2, 2012

CSSRR – Public Library of Science (PLoS) Articles – October 2, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 4:53 pm

A. “The Relationship between Associative Learning, Transfer Generalization, and Homocysteine Levels in Mild Cognitive Impairment,” by Ahmed A. Moustafa, Doaa H. Hewedi, Abeer M. Eissa, Catherine E. Myers, and Hisham A. Sadek (PLoS ONE 7(9): e46496. doi:10.1371/journal.pone.0046496, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046496

B. “The Impact of Autonomic Dysfunction on Survival in Patients with Dementia with Lewy Bodies and Parkinson’s Disease with Dementia,” by Kajsa Stubendorff, Dag Aarsland, Lennart Minthon, Elisabet Londos (PLoS ONE 7(10): e45451. doi:10.1371/journal.pone.0045451, XML, HTML, and .pdf format, 6p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0045451

September 27, 2012

CAAR – Nature Neuroscience Article Abstracts – September 27, 2012

Filed under: Reports and Articles — Tags: , — admin @ 4:39 pm

A. “Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson’s disease,” by Joshua A. Goldberg, Jaime N. Guzman, Chad M. Estep, Ema Ilijic, Jyothisri Kondapalli, Javier Sanchez-Padilla and D. James Surmeier (Vol. 15, No. 10, October 2012, p. 1414-1421).

www.nature.com/neuro/journal/v15/n10/abs/nn.3209.html

B. “Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer’s disease,” by Nikita Rudinskiy, Jonathan M. Hawkes, Rebecca A. Betensky, Megumi Eguchi, Shun Yamaguchi, Tara L Spires-Jones and Bradley T. Hyman (Vol. 15, No. 10, October 2012, p. 1422-1429).

www.nature.com/neuro/journal/v15/n10/abs/nn.3199.html

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