CDHA CAAR

June 20, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 20, 2017

Treatment with diphenyl–pyrazole compound anle138b/c reveals that {alpha}-synuclein protects melanoma cells from autophagic cell death,” by Elisa Turriani, Diana F. Lazaro, Sergey Ryazanov, Andrei Leonov, Armin Giese, Margarete Schon, Michael P. Schon, Christian Griesinger, Tiago F. Outeiro, Donna J. Arndt-Jovin, and Dorothea Becker (Vol. 114, No. 25, June 21, 2017, p. E4971–E4977).

www.pnas.org/content/114/25/E4971.abstract.html?etoc

May 1, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 1, 2017

Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson’s disease,” by Georgia Kouroupi, Era Taoufik, Ioannis S. Vlachos, Konstantinos Tsioras, Nasia Antoniou, Florentia Papastefanaki, Dafni Chroni-Tzartou, Wolfgang Wrasidlo, Delphine Bohl, Dimitris Stellas, Panagiotis K. Politis, Kostas Vekrellis, Dimitra Papadimitriou, Leonidas Stefanis, Piotr Bregestovski, Artemis G. Hatzigeorgiou, Eliezer Masliah, and Rebecca Matsas (Vol. 114, No. 18, May 2, 2017, p. E3679–E3688).

www.pnas.org/content/114/18/E3679.abstract.html?etoc

April 26, 2017

CAAR – Nature Neuroscience Article Abstract – April 26, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:18 pm

{alpha}-Synuclein promotes dilation of the exocytotic fusion pore,” by Todd Logan, Jacob Bendor, Chantal Toupin, Kurt Thorn & Robert H. Edwards (Vol. 20, No. 5, May 2017, p. 681-689).

www.nature.com/neuro/journal/v20/n5/abs/nn.4529.html

April 13, 2017

CAAR – Public Library of Science (PLoS) Article – April 13, 2017

Filed under: Reports and Articles — Tags: — admin @ 4:48 pm

Parkinson’s disease-associated genetic variation is linked to quantitative expression of inflammatory genes,” by Steven Pierce and Gerhard A. Coetzee (PLoS ONE 12(4): e0175882. doi.org/10.1371/journal.pone.0175882, XML, HTML, and .pdf format, 11p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0175882

April 12, 2017

CAAR – Lancet Neurology Article Abstracts – April 12, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:07 pm

A. “Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies,” by Dr. Daryl J. Wile, Pankaj A. Agarwal, Prof. Michael Schulzer, Edwin Mak, Katherine Dinelle, Elham Shahinfard, Nasim Vafai, Kazuko Hasegawa, Prof. Jing Zhang, Jessamyn McKenzie, Nicole Neilson, Audrey Strongosky, Prof. Ryan J. Uitti, Mark Guttman, Cyrus P. Zabetian, Prof. Yu-Shin Ding, Mike Adam, Prof. Jan Aasly, Prof. Zbigniew K. Wszolek, Prof. Matthew Farrer, Prof. Vesna Sossi, and Prof. A. Jon Stoessl (Vol. 16, No. 5, May 2017, p. 351–359).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30056-X/abstract

B. “Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial,” by Sandrine Andrieu, Sophie Guyonnet, Nicola Coley, Christelle Cantet, Marc Bonnefoy, Serge Bordes, Lawrence Bories, Marie-Noelle Cufi, Thierry Dantoine, Jean-François Dartigues, Françoise Desclaux, Audrey Gabelle, Yannick Gasnier, Alain Pesce, Kristel Sudres, Jacques Touchon, Philippe Robert, Olivier Rouaud, Philippe Legrand, Pierre Payoux, Jean-Paul Caubere, Michael Weiner, Isabelle Carrié, Pierre-Jean Ousset, and Bruno Vellas for the MAPT Study Group (Vol. 16, No. 5, May 2017, p. 377–389).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(17)30040-6/abstract

April 11, 2017

CAAR – Public Library of Science (PLoS) Article – April 11, 2017

Filed under: Reports and Articles — Tags: , — admin @ 5:01 pm

Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson’s disease,” by Ismael Huertas, Silvia Jesus, Francisco Javier García-Gomez, Jose Antonio Lojo, Inmaculada Bernal-Bernal, Marta Bonilla-Toribio, Juan Francisco Martín-Rodriguez, David García-Solís, Pilar Gómez-Garre, and Pablo Mir (PLoS ONE 12(4): e0175560. doi.org/10.1371/journal.pone.0175560, XML, HTML, and .pdf format, 11p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0175560

March 14, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – March 14, 2017

Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease,” by Amy R. Dunn, Kristen A. Stout, Minagi Ozawa, Kelly M. Lohr, Carlie A. Hoffman, Alison I. Bernstein, Yingjie Li, Minzheng Wang, Carmelo Sgobio, Namratha Sastry, Huaibin Cai, W. Michael Caudle, and Gary W. Miller (Vol. 114, No. 11, March 14, 2017, p. E2253–E2262).

www.pnas.org/content/114/11/E2253.abstract.html?etoc

March 7, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 7, 2017

A. “Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models,” by S. Pablo Sardi, Catherine Viel, Jennifer Clarke, Christopher M. Treleaven, Amy M. Richards, Hyejung Park, Maureen A. Olszewski, James C. Dodge, John Marshall, Elina Makino, Bing Wang, Richard L. Sidman, Seng H. Cheng, and Lamya S. Shihabuddin (Vol. 114, No. 10, March 7, 2017, p. 2699–2704).

www.pnas.org/content/114/10/2699.abstract.html?etoc

B. “Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson’s disease,” by Holly Green, Xiaoqun Zhang, Katarina Tiklova, Nikolaos Volakakis, Lovisa Brodin, Louise Berg, Paul Greengard, Thomas Perlmann, and Per Svenningsson (Vol. 114, No. 10, March 7, 2017, p. 2735–2740).

www.pnas.org/content/114/10/2735.abstract.html?etoc

February 28, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstract – February 28, 2017

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases {alpha}-synuclein aggregation,” by Sarah Jinn, Robert E. Drolet, Paige E. Cramer, Andus Hon-Kit Wong, Dawn M. Toolan, Cheryl A. Gretzula, Bhavya Voleti, Galya Vassileva, Jyoti Disa, Marija Tadin-Strapps, and David J. Stone (Vol. 114, No. 9, February 28, 2017, .pdf and HTML format, p. 2389-2394). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/9/2389.abstract

February 17, 2017

CAAR – Lancet Article Abstract – February 17, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:00 pm

Living near major roads and the incidence of dementia, Parkinson’s disease, and multiple sclerosis: a population-based cohort study,” by Hong Chen, Jeffrey C Kwong, Ray Copes, Karen Tu, Paul J. Villeneuve, Aaron van Donkelaar, Perry Hystad, Randall V. Martin, Brian J. Murray, Barry Jessiman, Andrew S. Wilton, Alexander Kopp, and Richard T. Burnett (Vol. 389, No. 10070, February 18, 2017, p. 718-726).

www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)32399-6/abstract

February 8, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 8, 2017

A. “Gleevec shifts APP processing from a {beta}-cleavage to a nonamyloidogenic cleavage,” by William J. Netzer, Karima Bettayeb, Subhash C. Sinha, Marc Flajolet, Paul Greengard, and Victor Bustos (Vol. 114, No. 6, February 7, 2017, p. 1389-1394).

www.pnas.org/content/114/6/1389.abstract

B. “A natural product inhibits the initiation of {alpha}-synuclein aggregation and suppresses its toxicity,” by Michele Perni, Céline Galvagnion, Alexander Maltsev, Georg Meisl, Martin B. D. Müller, Pavan K. Challa, Julius B. Kirkegaard, Patrick Flagmeier, Samuel I. A. Cohen, Roberta Cascella, Serene W. Chen, Ryan Limboker, Pietro Sormanni, Gabriella T. Heller, Francesco A. Aprile, Nunilo Cremades, Cristina Cecchi, Fabrizio Chiti, Ellen A. A. Nollen, Tuomas P. J. Knowles, Michele Vendruscolo, Adriaan Bax, Michael Zasloff, and Christopher M. Dobson (Vol. 114, No. 6, February 7, 2017, p. E1009-E1017). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/114/6/E1009.abstract

January 31, 2017

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – January 31, 2017

A. “Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry,” by Palaniappan S. Chetty, Leland Mayne, Sissel Lund-Katz, S. Walter Englander, and Michael C. Phillips (Vol. 114, No. 5, January 31, 2017, p. 968-973).

www.pnas.org/content/114/5/968.abstract.html?etoc

B. “Nrf2 mitigates LRRK2- and {alpha}-synuclein–induced neurodegeneration by modulating proteostasis,” by Gaia Skibinski, Vicky Hwang, Dale Michael Ando, Aaron Daub, Alicia K. Lee, Abinaya Ravisankar, Sara Modan, Mariel M. Finucane, Benjamin A. Shaby, and Steven Finkbeiner (Vol. 114, No. 5, January 31, 2017, p. 1165–1170).

www.pnas.org/content/114/5/1165.abstract.html?etoc

C. “{alpha}-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation,” by Seong Su Kang, Zhentao Zhang, Xia Liu, Fredric P. Manfredsson, Li He, P. Michael Iuvone, Xuebing Cao, Yi E. Sun, Lingjing Jin, and Keqiang Ye (Vol. 114, No. 5, January 31, 2017, p. 1183–1185).

www.pnas.org/content/114/5/1183.abstract.html?etoc

December 8, 2016

CAAR – Lancet Neurology Article Abstract – December 8, 2016

Filed under: Reports and Articles — Tags: , , — admin @ 3:07 pm

Clinical variables and biomarkers in prediction of cognitive impairment in patients with newly diagnosed Parkinson’s disease: a cohort study,” by Anette Schrag, Uzma Faisal Siddiqui, Zacharias Anastasiou, Daniel Weintraub, and Jonathan M. Schott (Vol. 17, No. 1, January 2017, p. 66-75).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(16)30328-3/abstract

November 7, 2016

CAAR – Public Library of Science (PLoS) Article – November 7, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:53 pm

Parkinson Patients’ Initial Trust in Avatars: Theory and Evidence,” by Andrija Javor, Gerhard Ransmayr, Walter Struhal, and Rene Riedl (PLoS ONE 11(11): e0165998. doi:10.1371/journal.pone.0165998, XML, HTML, and .pdf format, 21p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0165998

November 1, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – November 1, 2016

Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson’s disease,” by Istvan Horvath and Pernilla Wittung-Stafshede (Vol. 113, No. 44, November 1, 2016, p. 12473–12477).

www.pnas.org/content/113/44/12473.abstract

September 29, 2016

CAAR – Science Article Abstract – September 29, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:50 pm

Pathological {alpha}-synuclein transmission initiated by binding lymphocyte-activation gene 3,” by Xiaobo Mao, Michael Tianhao Ou, Senthilkumar S. Karuppagounder, Tae-In Kam, Xiling Yin, Yulan Xiong, Preston Ge, George Essien Umanah, Saurav Brahmachari, Joo-Ho Shin, Ho Chul Kang, Jianmin Zhang, Jinchong Xu, Rong Chen, Hyejin Park, Shaida A. Andrabi, Sung Ung Kang, Rafaella Araújo Gonçalves, Yu Liang, Shu Zhang, Chen Qi, Sharon Lam, James A. Keiler, Joel Tyson, Donghoon Kim, Nikhil Panicker, Seung Pil Yun, Creg J. Workman, Dario A. A. Vignali, Valina L. Dawson, Han Seok Ko, and Ted M. Dawson (Vol. 353, No. 6037, September 30, 2016).

science.sciencemag.org/content/353/6307/aah3374.abstract

September 13, 2016

CAAR – Proceedings of the National Academies of Sciences Article Abstract – September 13, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:44 pm

Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of {alpha}-synuclein aggregation,” by Patrick Flagmeier, Georg Meisl, Michele Vendruscolo, Tuomas P. J. Knowles, Christopher M. Dobson, Alexander K. Buell, and Celine Galvagnion (Vol. 113, No. 37, September 13, 2016, p. 10328–10333).

www.pnas.org/content/113/37/10328.abstract.html?etoc

CAAR – Public Library of Science (PLoS) Article – September 13, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:43 pm

AlphaSynuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant,” by Claire Hoenen, Audrey Gustin, Cindy Birck, Melanie Kirchmeyer, Nicolas Beaume, Paul Felten, Luc Grandbarbe, Paul Heuschling, and Tony Heurtaux (PLoS ONE 11(9): e0162717. doi:10.1371/journal.pone.0162717, XML, HTML, and .pdf format, 24p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162717

September 7, 2016

CAAR – Public Library of Science (PLoS) Articles – September 7, 2016

Filed under: Reports and Articles — Tags: , , , — admin @ 4:34 pm

A. “Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes,” by Jianjia Fan, Shahab Zareyan, Wenchen Zhao, Yoko Shimizu, Tom A. Pfeifer, Jun-Hyung Tak, Murray B. Isman, Bernard Van den Hoven, Mark E. Duggan, Michael W. Wood, Cheryl L. Wellington, and Iva Kulic (PLoS ONE 11(9): e0162384. doi:10.1371/journal.pone.0162384, XML, HTML, and .pdf format, 27p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162384

B. “Quantitative Susceptibility Mapping in Parkinson’s Disease,” by Christian Langkammer, Lukas Pirpamer, Stephan Seiler, Andreas Deistung, Ferdinand Schweser, Sebastian Franthal, Nina Homayoon, Petra Katschnig-Winter, Mariella Koegl-Wallner, Tamara Pendl, Eva Maria Stoegerer, Karoline Wenzel, Franz Fazekas, Stefan Ropele, Jurgen Rainer Reichenbach, Reinhold Schmidt, and Petra Schwingenschuh (PLoS ONE 11(9): e0162460. doi:10.1371/journal.pone.0162460, XML, HTML, and .pdf format, 13p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162460

C. “Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis,” by Yoshihisa Okuchi, Masamichi Imajo, Rei Mizuno, Yuji Kamioka, Hiroyuki Miyoshi, Makoto Mark Taketo, Satoshi Nagayama, Yoshiharu Sakai, and Michiyuki Matsuda ( PLoS ONE 11(9): e0162300. doi:10.1371/journal.pone.0162300, XML, HTML, and .pdf format, 22p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162300

D. “Development of Clinical Vignettes to Describe Alzheimer’s Disease Health States: A Qualitative Study,” by Mark Oremus, Feng Xie, and Kathryn Gaebel (PLoS ONE 11(9): e0162422. doi:10.1371/journal.pone.0162422, XML, HTML, and .pdf format, 15p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162422

August 23, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – August 23, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:51 pm

A. “Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein {alpha}-synuclein,” by Wei Wang, Linh T. T. Nguyen, Christopher Burlak, Fariba Chegini, Feng Guo, Tim Chataway, Shulin Ju, Oriana S. Fisher, David W. Miller, Debajyoti Datta, Fang Wu, Chun-Xiang Wu, Anuradha Landeru, James A. Wells, Mark R. Cookson, Matthew B. Boxer, Craig J. Thomas, Wei Ping Gai, Dagmar Ringe, Gregory A. Petsko, and Quyen Q. Hoang (Vol. 113, No. 34, August 23, 2016, p. 9587–9592).

www.pnas.org/content/113/34/9587.abstract.html?etoc

B. “Human striatal recordings reveal abnormal discharge of projection neurons in Parkinson’s disease,” by Arun Singh, Klaus Mewes, Robert E. Gross, Mahlon R. DeLong, José A. Obeso, and Stella M. Papa (Vol. 113, No. 34, August 23, 2016, p. 9629–9634).

www.pnas.org/content/113/34/9629.abstract.html?etoc

August 17, 2016

CAAR – Public Library of Science (PLoS) Articles – August 17, 2016

Filed under: Reports and Articles — Tags: — admin @ 2:20 pm

A. “Premotor Symptoms as Predictors of Outcome in Parkinsons Disease: A Case-Control Study,” by Yu-Hsuan Wu, Wei-Ju Lee, Yi-Huei Chen, Ming-Hong Chang, and Ching-Heng Lin ( PLoS ONE 11(8): e0161271. doi:10.1371/journal.pone.0161271, XML, HTML, and .pdf format, 10p.)

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0161271

B. “Striatal Dopamine Depletion Patterns and Early Non-Motor Burden in Parkinsons Disease,” by Su Jin Chung, Jae Jung Lee, Jee Hyun Ham, Byoung Seok Ye, Phil Hyu Lee, and Young H. Sohn (PLoS ONE 11(8): e0161316. doi:10.1371/journal.pone.0161316, XML, HTML, and .pdf format, 10p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0161316

August 9, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – August 9, 2016

A. “Hhip haploinsufficiency sensitizes mice to age-related emphysema,” by Taotao Lao, Zhiqiang Jiang, Jeong Yun, Weiliang Qiu, Feng Guo, Chunfang Huang, John Dominic Mancini, Kushagra Gupta, Maria E. Laucho-Contreras, Zun Zar Chi Naing, Li Zhang, Mark A. Perrella, Caroline A. Owen, Edwin K. Silverman, and Xiaobo Zhou (Vol. 113, No. 32, August 9, 2016, p. E4681-E4687).

www.pnas.org/content/113/32/E4681.abstract

B. “Deubiquitinase Usp8 regulates {alpha}-synuclein clearance and modifies its toxicity in Lewy body disease,” by Zoi Alexopoulou, Johannes Lang, Rebecca M. Perrett, Myriam Elschami, Madeleine E. D. Hurry, Hyoung Tae Kim, Dimitra Mazaraki, Aron Szabo, Benedikt M. Kessler, Alfred Lewis Goldberg, Olaf Ansorge, Tudor A. Fulga, and George K. Tofaris (Vol. 113, No. 32, August 9, 2016, p. E4688-E4697).

www.pnas.org/content/113/32/E4688.abstract

C. “The neural chaperone proSAAS blocks {alpha}-synuclein fibrillation and neurotoxicity,” by Timothy S. Jarvela, Hoa A. Lam, Michael Helwig, Nikolai Lorenzen, Daniel E. Otzen, Pamela J. McLean, Nigel T. Maidment, and Iris Lindberg (Vol. 113, No. 32, August 9, 2016, p. E4708-E4715).

www.pnas.org/content/113/32/E4708.abstract

July 26, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 26, 2016

A. “Equity and length of lifespan are not the same,” by Benjamin Seligman, Gabi Greenberg, and Shripad Tuljapurkar (Vol. 113, No. 30, July 26, 2016, p. 8420-8423).

www.pnas.org/content/113/30/8420.abstract

B. “FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice,” by Henrik Ahlenius, Soham Chanda, Ashley E. Webb, Issa Yousif, Jesse Karmazin, Stanley B. Prusiner, Anne Brunet, Thomas C. Sudhof, and Marius Wernig (Vol. 113, No. 30, July 26, 2016, p. 8514-8519).

www.pnas.org/content/113/30/8514.abstract

C. “Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts,” by Giambattista Guaitoli, Francesco Raimondi, Bernd K. Gilsbach, Yacob Gomez-Llorente, Egon Deyaert, Fabiana Renzi, Xianting Li, Adam Schaffner, Pravin Kumar Ankush Jagtap, Karsten Boldt, Felix von Zweydorf, Katja Gotthardt, Donald D. Lorimer, Zhenyu Yue, Alex Burgin, Nebojsa Janjic, Michael Sattler, Wim Versees, Marius Ueffing, Iban Ubarretxena-Belandia, Arjan Kortholt, and Christian Johannes Gloeckner (Vol. 113, No. 30, July 26, 2016, .pdf and HTML format, p. E4357-E4366). Note: _PNAS_ is providing open access to the full-text of this article.

www.pnas.org/content/113/30/E4357.abstract

June 17, 2016

CAAR – Public Library of Science (PLoS) Articles – June 17, 2016

Filed under: Reports and Articles — Tags: , , — admin @ 4:38 pm

A. “Association between Thigh Muscle Volume and Leg Muscle Power in Older Women,” by Ulrich Lindemann, Christian Mohr, Juergen Machann, Konstantinos Blatzonis, Kilian Rapp, and Clemens Becker (PLoS ONE 11(6): e0157885. doi:10.1371/journal.pone.0157885, .pdf, HTML, and XML format, 10p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0157885

B. “Structural Brain Alterations in Motor Subtypes of Parkinson’s Disease: Evidence from Probabilistic Tractography and Shape,” by Griet Vervoort, Inge Leunissen, Michael Firbank, Elke Heremans, Evelien Nackaerts, Wim Vandenberghe, and Alice Nieuwboer (PLoS ONE 11(6): e0157743. doi:10.1371/journal.pone.0157743, .pdf, HTML, and XML format, 17p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0157743

June 7, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – June 7, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:53 pm

Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain,” by Wen Li, Elisabet Englund, Håkan Widner, Bengt Mattsson, Danielle van Westen, Jimmy Lätt, Stig Rehncrona, Patrik Brundin, Anders Bjorklund, Olle Lindvall, and Jia-Yi Li (Vol. 113, No. 23, June 7, 2016, .pdf and HTML format, p. 6544-6549). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/113/23/6544.abstract

May 4, 2016

CAAR – Nature Letter Abstract – May 4, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:48 pm

Parkinson-associated risk variant in distal enhancer of {alpha}-synuclein modulates target gene expression,” by Frank Soldner, Yonatan Stelzer, Chikdu S. Shivalila, Brian J. Abraham, Jeanne C. Latourelle, M. Inmaculada Barrasa, Johanna Goldmann, Richard H. Myers, Richard A. Young & Rudolf Jaenisch (Vol. 533, No. 7601, May 5, 2016, p. 95-99).

www.nature.com/nature/journal/v533/n7601/abs/nature17939.html

April 5, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstract – April 5, 2016

Nanoscopic insights into seeding mechanisms and toxicity of {alpha}-synuclein species in neurons,” by Dorothea Pinotsi, Claire H. Michel, Alexander K. Buell, Romain F. Laine, Pierre Mahou, Christopher M. Dobson, Clemens F. Kaminski, and Gabriele S. Kaminski Schierle (Vol. 113, No. 14, April 5, 2016, p. 3815-3819).

www.pnas.org/content/113/14/3815.abstract.html?etoc

March 30, 2016

CAAR – Nature Neuroscience Brief Communications Abstract – March 30, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:42 pm

Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders,” by Wen Zhang, Lifeng Zhang, Bo Liang, David Schroeder, Zhong-wei Zhang, Gregory A Cox, Yun Li & Da-Ting Lin (Vol. 19, No. 4, April 2016, p. 557-559).

www.nature.com/neuro/journal/v19/n4/abs/nn.4257.html

March 29, 2016

CAAR – Public Library of Science (PLoS) Article – March 29, 2016

Filed under: Reports and Articles — Tags: — admin @ 5:02 pm

Statin Use and the Risk of Parkinson’s Disease: An Updated Meta-Analysis,” by Shuang Bai, Yi Song, Xin Huang, Lidan Peng, Jie Jia, Yu Liu, and Hong Lu (PLoS ONE 11(3): e0152564. doi:10.1371/journal.pone.0152564, XML, HTML, and .pdf format, 12p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0152564

March 15, 2016

CAAR – Public Library of Science (PLoS) Article – March 15, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:19 pm

Measuring the Burden of Hospitalization in Patients with Parkinson’s Disease in Spain,” by Ruth Gil-Prieto, Raquel Pascual-Garcia, Jesus San-Roman-Montero, Pablo Martinez-Martin, Javier Castrodeza-Sanz, and Angel Gil-de-Miguel (PLoS ONE 11(3): e0151563. doi:10.1371/journal.pone.0151563, XML, HTML, and .pdf format, 11p.).

journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0151563

March 1, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – March 1, 2016

A. “Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading,” by Marija Iljina, Gonzalo A. Garcia, Mathew H. Horrocks, Laura Tosatto, Minee L. Choi, Kristina A. Ganzinger, Andrey Y. Abramov, Sonia Gandhi, Nicholas W. Wood, Nunilo Cremades, Christopher M. Dobson, Tuomas P. J. Knowles, and David Klenerman (Vol. 113, No. 9, March 1, 2016, p. E1206–E1215).

www.pnas.org/content/113/9/E1206.abstract.html?etoc

B. “The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function,” by Samuel E. Marsh, Edsel M. Abud, Anita Lakatos, Alborz Karimzadeh, Stephen T. Yeung, Hayk Davtyan, Gianna M. Fote, Lydia Lau, Jason G. Weinger, Thomas E. Lane, Matthew A. Inlay, Wayne W. Poon, and Mathew Blurton-Jones (Vol. 113, No. 9, March 1, 2016, p. E1316–E1325).

www.pnas.org/content/113/9/E1316.abstract.html?etoc

February 17, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 17, 2017

A. “{alpha}-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models,” by Joseph R. Mazzulli, Friederike Zunke, Ole Isacson, Lorenz Studer, and Dimitri Krainc (Vol. 113, No. 7, February 16, 2016, p. 1931-1936).

www.pnas.org/content/113/7/1931.abstract

B. “Induction of de novo {alpha}-synuclein fibrillization in a neuronal model for Parkinson’s disease,” by Mohamed-Bilal Fares, Bohumil Maco, Abid Oueslati, Edward Rockenstein, Natalia Ninkina, Vladimir L. Buchman, Eliezer Masliah, and Hilal A. Lashuel (Vol. 113, No. 7, February 16, 2016, p. E912-E921).

www.pnas.org/content/113/7/E912.abstract

February 9, 2016

CAAR – Lancet Neurology Article Abstract – February 9, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:46 pm

Rivastigmine for gait stability in patients with Parkinson’s disease (ReSPonD): a randomised, double-blind, placebo-controlled, phase 2 trial,” by Emily J. Henderson, Stephen R. Lord, Matthew A. Brodie, Daisy M. Gaunt, Andrew D. Lawrence, Jacqueline C. T. Close, A. L. Whone, and Y. Ben-Shlomo (Vol. 15, No. 3, March 2016, p. 249-258).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(15)00389-0/abstract

February 3, 2016

CAAR – Nature Article, Letter Abstracts – February 3, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:42 pm

A. “Structural disorder of monomeric {alpha}-synuclein persists in mammalian cells,” by Francois-Xavier Theillet, Andres Binolfi, Beata Bekei, Andrea Martorana, Honor May Rose, Marchel Stuiver, Silvia Verzini, Dorothea Lorenz, Marleen van Rossum, Daniella Goldfarb & Philipp Selenko (Vol. 530, No. 7588, February 4, 2016, p. 45-50).

www.nature.com/nature/journal/v530/n7588/abs/nature16531.html

B. “The temporal scaling of Caenorhabditis elegans ageing,” by Nicholas Stroustrup, Winston E. Anthony, Zachary M. Nash, Vivek Gowda, Adam Gomez, Isaac F. López-Moyado, Javier Apfeld & Walter Fontana (Vol. 530, No. 7588, February 4, 2016, p. 103-107).

www.nature.com/nature/journal/v530/n7588/abs/nature16550.html

February 2, 2016

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – February 2, 2016

A. “Nicastrin functions to sterically hinder {gamma}-secretase–substrate interactions driven by substrate transmembrane domain,” by David M. Bolduc, Daniel R. Montagna, Yongli Gu, Dennis J. Selkoe, and Michael S. Wolfe (Vol. 113, No. 5, February 2, 2016, p. E509-E518).

www.pnas.org/content/113/5/E509.abstract

B. “Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila,” by Sonita Afschar, Janne M. Toivonen, Julia Marianne Hoffmann, Luke Stephen Tain, Daniela Wieser, Andrew John Finlayson, Yasmine Driege, Nazif Alic, Sahar Emran, Julia Stinn, Jenny Froehlich, Matthew D. Piper, and Linda Partridge (Vol. 113, No. 5, February 2, 2016, p. 1321-1326).

www.pnas.org/content/113/5/1321.abstract.html?etoc

C. “Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice,” by Roberta Marongiu, Margarita Arango-Lievano, Veronica Francardo, Peter Morgenstern, Xiaoqun Zhang, M. Angela Cenci, Per Svenningsson, Paul Greengard, and Michael G. Kaplitt (Vol. 113, No. 5, February 2, 2016, p. 1423-1428).

www.pnas.org/content/113/5/1423.abstract.html?etoc

D. “p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism,” by Nicoletta Schintu, Xiaoqun Zhang, Alexandra Alvarsson, Roberta Marongiu, Michael G. Kaplitt, Paul Greengard, and Per Svenningsson (Vol. 113, No. 5, February 2, 2016, p. 1429-1434).

www.pnas.org/content/113/5/1429.abstract.html?etoc

January 12, 2016

CAAR – Lancet Neurology Article Abstract – January 12, 2016

Filed under: Reports and Articles — Tags: — admin @ 4:52 pm

Opicapone as an adjunct to levodopa in patients with Parkinson’s disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial,” by Joaquim J Ferreira, Andrew Lees, José-Francisco Rocha, Werner Poewe, Olivier Rascol, and Patrício Soares-da-Silva, Bi-Park 1 investigators (Vol. 15, No. 2, February 2016, p. 154-165).

www.thelancet.com/journals/laneur/article/PIIS1474-4422%2815%2900336-1/abstract

January 6, 2016

CAAR – Nature Medicine Article Abstracts – January 16, 2016

Filed under: Reports and Articles — Tags: , , — admin @ 4:19 pm

A. “Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling,” by Natura Myeku, Catherine L. Clelland, Sheina Emrani, Nikolay V. Kukushkin, Wai Haung Yu, Alfred L. Goldberg & Karen E. Duff (Vol. 22, No. 1, January 2016, p. 46-53).

www.nature.com/nm/journal/v22/n1/abs/nm.4011.html

B. “Parkinson’s disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes,” by Wenzhang Wang, Xinglong Wang, Hisashi Fujioka, Charles Hoppel, Alan L Whone, Maeve A. Caldwell, Peter J. Cullen, Jun Liu & Xiongwei Zhu (Vol. 22, No. 1, January 2016, p. 54-63).

www.nature.com/nm/journal/v22/n1/abs/nm.3983.html

December 17, 2015

CAAR – Public Library of Science (PLoS) Articles – December 17, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:57 pm

A. “Omega-3 Fatty Acid Supplementation for 12 Weeks Increases Resting and Exercise Metabolic Rate in Healthy Community-Dwelling Older Females,” by Samantha L. Logan and Lawrence L. Spriet (PLoS ONE 10(12): e0144828. doi:10.1371/journal.pone.0144828, XML, HTML, and .pdf format, 18p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0144828

B. “Freezing of Gait in Parkinson’s Disease: An Overload Problem?” by Eric N. Beck, Kaylena A. Ehgoetz Martens, and Quincy J. Almeida (PLoS ONE 10(12): e0144986. doi:10.1371/journal.pone.0144986, XML, HTML, and .pdf format, 28p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0144986

November 13, 2015

CAAR – Lancet Neurology Article Abstracts – November 13, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:24 pm

A. “Prolonged-release oxycodone–naloxone for treatment of severe pain in patients with Parkinson’s disease (PANDA): a double-blind, randomised, placebo-controlled trial,” by Claudia Trenkwalder, K. Ray Chaudhuri, Pablo Martinez-Martin, Olivier Rascol, Reinhard Ehret, Martin Valis, Maria Sátori, Anna Krygowska-Wajs, Maria J. Marti, Karen Reimer, Alexander Oksche, Mark Lomax, Julia DeCesare, and Michael Hopp, PANDA study group (Vol. 14, No. 12, December 2015, p. 1161-1170).

www.thelancet.com/journals/laneur/article/PIIS1474-4422%2815%2900243-4/abstract

B. “Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer’s Disease (DOMINO-AD) trial: secondary and post-hoc analyses,” by Robert Howard, Rupert McShane, James Lindesay, Craig Ritchie, Ashley Baldwin, Robert Barber, Alistair Burns, Tom Dening, David Findlay, Clive Holmes, Robert Jones, Roy Jones, Ian McKeith, Ajay Macharouthu, John O’Brien, Bart Sheehan, Edmund Juszczak, Cornelius Katona, Robert Hills, Martin Knapp, Clive Ballard, Richard G Brown, Sube Banerjee, Jessica Adams, Tony Johnson, Peter Bentham, and Patrick P. J. Phillips (Vol. 14, No. 12, December 2015, p. 1171-1181).

www.thelancet.com/journals/laneur/article/PIIS1474-4422%2815%2900258-6/abstract

September 22, 2015

CAAR – Proceedings of the National Academies of Science Article Abstracts – September 22, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 4:48 pm

A. “Peptide dimer structure in an A{beta}(1–42) fibril visualized with cryo-EM,” by Matthias Schmidt, Alexis Rohou, Keren Lasker, Jay K. Yadav, Cordelia Schiene-Fischer, Marcus Fändrich, and Nikolaus Grigorieff (Vol. 112, No. 38, September 22, 2015, .pdf and HTML format, p. 11858-11863). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/38/11858.abstract

B. “Evidence for {alpha}-synuclein prions causing multiple system atrophy in humans with parkinsonism,” by Stanley B. Prusiner, Amanda L. Woerman, Daniel A. Mordes, Joel C. Watts, Ryan Rampersaud, David B. Berry, Smita Patel, Abby Oehler, Jennifer K. Lowe, Stephanie N. Kravitz, Daniel H. Geschwind, David V. Glidden, Glenda M. Halliday, Lefkos T. Middleton, Steve M. Gentleman, Lea T. Grinberg, and Kurt Giles (Vol. 112, No. 38, September 22, 2015, p. 11858-11863).

www.pnas.org/content/112/38/E5308.abstract

C. “Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer’s disease pathogenesis,” by Li Zhu, Minghao Zhong, Gregory A. Elder, Mary Sano, David M. Holtzman, Sam Gandy, Christopher Cardozo, Vahram Haroutunian, Nikolaos K. Robakis, and Dongming Cai (Vol. 112, No. 38, September 22, 2015, .pdf and HTML format, p. 11965-11970). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/38/11965.abstract

September 2, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstract – September 2, 2015

Propagation of prions causing synucleinopathies in cultured cells,” by Amanda L. Woerman, Jan Stohr, Atsushi Aoyagi, Ryan Rampersaud, Zuzana Krejciova, Joel C. Watts, Takao Ohyama, Smita Patel, Kartika Widjaja, Abby Oehler, David W. Sanders, Marc I. Diamond, William W. Seeley, Lefkos T. Middleton, Steve M. Gentleman, Daniel A. Mordes, Thomas C. Südhof, Kurt Giles, and Stanley B. Prusiner (Vol. 112, No. 35, September 1, 2015, p. E4949–E4958).

www.pnas.org/content/112/35/E4949.abstract

August 31, 2015

CAAR – Nature Neuroscience Article Abstract – August 31, 2015

Filed under: Reports and Articles — Tags: — admin @ 4:47 pm

Dynamic rewiring of neural circuits in the motor cortex in mouse models of Parkinson’s disease,” by Lili Guo, Huan Xiong, Jae-Ick Kim, Yu-Wei Wu, Rupa R. Lalchandani, Yuting Cui, Yu Shu, Tonghui Xu & Jun B. Ding (Vol. 18, No. 9, September 2015, p. 1299-1309).

www.nature.com/neuro/journal/v18/n9/abs/nn.4082.html

August 13, 2015

CAAR – Public Library of Science (PLoS) Article – August 13, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:52 pm

Influence of Dopaminergic Medication on Conditioned Pain Modulation in Parkinson’s Disease Patients,” by Wiebke Grashorn, Odette Schunke, Carsten Buhmann, Katarina Forkmann, Sabrina Diedrich, Katharina Wesemann, and Ulrike Bingel (PLoS ONE 10(8): e0135287. doi:10.1371/journal.pone.0135287, XML, HTML, and .pdf format, 16p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0135287

July 29, 2015

CAAR – Public Library of Science (PLoS) Articles – July 29, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:59 pm

A. “Did {alpha}-Synuclein and Glucocerebrosidase Coevolve? Implications for Parkinson’s Disease,” by James M. Gruschus (PLoS ONE 10(7): e0133863. doi:10.1371/journal.pone.0133863, XML, HTML, and .pdf format, 21p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0133863

B. “The Clinical Effectiveness and Cost-Effectiveness of Screening for Age-Related Macular Degeneration in Japan: A Markov Modeling Study,” by Hiroshi Tamura, Rei Goto, Yoko Akune, Yoshimune Hiratsuka, Shusuke Hiragi, and Masakazu Yamada (PLoS ONE 10(7): e0133628. doi:10.1371/journal.pone.0133628, XML, HTML, and .pdf format, 20p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0133628

C. “Enrichment of Minor Alleles of Common SNPs and Improved Risk Prediction for Parkinson’s Disease,” by Zuobin Zhu, Dejian Yuan, Denghui Luo, Xitong Lu, and Shi Huang (PLoS ONE 10(7): e0133421. doi:10.1371/journal.pone.0133421, XML, HTML, and .pdf format, 11p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0133421

July 28, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstracts – July 28, 2015

A. “Quantification of biological aging in young adults,” by Daniel W. Belsky, Avshalom Caspi, Renate Houts, Harvey J. Cohen, David L. Corcoran, Andrea Danese, HonaLee Harrington, Salomon Israel, Morgan E. Levine, Jonathan D. Schaefer, Karen Sugden, Ben Williams, Anatoli I. Yashin, Richie Poulton, and
Terrie E. Moffitt (Vol. 112, No. 30, July 28, 2015, p. E4104–E4110).

www.pnas.org/content/112/30/E4104.abstract.html?etoc

B. “Cysteine cathepsins are essential in lysosomal degradation of {alpha}-synuclein,” by Ryan P. McGlinchey and Jennifer C. Lee (Vol. 112, No. 30, July 28, 2015, p. 9322-9327).

www.pnas.org/content/112/30/9322.abstract

C. “Matrix cross-linking–mediated mechanotransduction promotes posttraumatic osteoarthritis,” by Jin-Hong Kim, Gyuseok Lee, Yoonkyung Won, Minju Lee, Ji-Sun Kwak, Churl-Hong Chun, and Jang-Soo Chun (Vol. 112, No. 30, July 28, 2015, .pdf and HTML format, p. 9322-9327). Note: PNAS is providing open access to the full-text of this article.

www.pnas.org/content/112/30/9424.abstract

July 16, 2015

CAAR – Lancet Neurology Article Abstracts – July 16, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:46 pm

Note: Lancet requirers free registration prior to providing content.

A. “Pioglitazone in early Parkinson’s disease: a phase 2, multicentre, double-blind, randomised trial,” by NINDS Exploratory Trials in Parkinson Disease (NET-PD) FS-ZONE Investigators (Vol. 14, No. 8, August 2015, .pdf format, p. 795-803).

www.thelancet.com/journals/laneur/article/PIIS1474-4422%2815%2900144-1/abstract

B. “Longitudinal assessment of neuroimaging and clinical markers in autosomal dominant Alzheimer’s disease: a prospective cohort study,” by Wai-Ying Wendy Yau, Dana L. Tudorascu, Eric M. McDade, Snezana Ikonomovic, Jeffrey A. James, Davneet Minhas, Wenzhu Mowrey, Lei K. Sheu, Beth E. Snitz, Lisa Weissfeld, Peter J. Gianaros, Howard J. Aizenstein, Julie C Price, Chester A. Mathis, Oscar L. Lopez, and William E. Klunk (Vol. 14, No. 8, August 2015, .pdf format, p. 804-813).

www.thelancet.com/journals/laneur/article/PIIS1474-4422%2815%2900135-0/abstract

C. “Mutations in ABCA7 in a Belgian cohort of Alzheimer’s disease patients: a targeted resequencing study,” by Elise Cuyvers, Arne De Roeck, Tobi Van den Bossche, Caroline Van Cauwenberghe, Karolien Bettens, Steven Vermeulen, Maria Mattheijssens, Karin Peeters, Sebastiaan Engelborghs, Mathieu Vandenbulcke, Rik Vandenberghe, Peter P De Deyn, Christine Van Broeckhoven, and Kristel Sleegers (Vol. 14, No. 8, August 2015, .pdf format, p. 814-822).

www.thelancet.com/journals/laneur/article/PIIS1474-4422%2815%2900133-7/abstract

CAAR – Public Library of Science (PLoS) Articles – July 16, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:45 pm

A. “Can Patients with Parkinson’s Disease Use Dry Powder Inhalers during Off Periods?” by M. Luinstra, A. W. F. Rutgers, H. Dijkstra, F. Grasmeijer, P. Hagedoorn, J. M. J. Vogelzang, H. W. Frijlink, and A. H. de Boer (PLoS ONE 10(7): e0132714. doi:10.1371/journal.pone.0132714, XML, HTML, and .pdf format, 12p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0132714

B. “Sleep Disorders in Parkinsonian and Nonparkinsonian LRRK2 Mutation Carriers,” by Claustre Pont-Sunyer, Alex Iranzo, Carles Gaig, Ana Fernández-Arcos, Dolores Vilas, Francesc Valldeoriola, Yaroslau Compta, Ruben Fernández-Santiago, Manel Fernández, Angels Bayes, Matilde Calopa, Pilar Casquero, Oriol de Fàbregues, Serge Jaumà, Victor Puente, Manel Salamero, Maria José Martí, Joan Santamaría, and Eduard Tolosa (PLoS ONE 10(7): e0132368. doi:10.1371/journal.pone.0132368, XML, HTML, and .pdf format, 20p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0132368

C. “Systemic and Ocular Long Pentraxin 3 in Patients with Age-Related Macular Degeneration,” by Helene Bae Juel, Carsten Faber, Lea Munthe-Fog, Simone Bastrup-Birk, Alexander Lynge Reese-Petersen, Mads Kruger Falk, Amardeep Singh, Torben Lykke Sorensen, Peter Garred, and Mogens Holst Nissen (PLoS ONE 10(7): e0132800. doi:10.1371/journal.pone.0132800, XML, HTML, and .pdf format, p.).

journals.plos.org/plosone/article?id=10.1371/journal.pone.0132800

June 9, 2015

CAAR – Lancet Neurology Article Abstract – June 9, 2015

Filed under: Reports and Articles — Tags: — admin @ 5:08 pm

Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson’s disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study,” by Prof. Lars Timmermann, Roshini Jain, Lilly Chen, Mohamed Maarouf, Michael T. Barbe, Niels Allert, Prof. Thomas Brucke, Iris Kaiser, Sebastian Beirer, Fernando Sejio, Esther Suarez, Beatriz Lozano, Claire Haegelen, Prof. Marc Verin, Mauro Porta, Domenico Servello, Prof. Steven Gill, Alan Whone, Nic Van Dyck, and Prof. Francois Alesch (Vol. 14, No. 7, July 2015, p. 693-701).

www.thelancet.com/journals/laneur/article/PIIS1474-4422(15)00087-3/abstract

May 27, 2015

CAAR – Nature Neuroscience Article, Perspectives Abstracts – May 27, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 5:05 pm

A. “Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson’s disease,” by Ariadna Laguna, Nicoletta Schintu, Andre Nobre, Alexandra Alvarsson, Nikolaos Volakakis, Jesper Kjaer Jacobsen, Marta Gomez-Galan, Elena Sopova, Eliza Joodmardi, Takashi Yoshitake, Qiaolin Deng, Jan Kehr, Johan Ericson, Per Svenningsson, Oleg Shupliakov & Thomas Perlmann (Vol. 18, No. 6, June 2015, p. 825-835).

www.nature.com/neuro/journal/v18/n6/abs/nn.4004.html

B. “The case for rejecting the amyloid cascade hypothesis,” by Karl Herrup (Vol. 18, No. 6, June 2015, p. 794-799).

www.nature.com/neuro/journal/v18/n6/abs/nn.4017.html

C. “Three dimensions of the amyloid hypothesis: time, space and ‘wingmen’,” by Erik S. Musiek & David M. Holtzman (Vol. 18, No. 6, June 2015, p. 800-806).

www.nature.com/neuro/journal/v18/n6/abs/nn.4018.html

May 12, 2015

CAAR – Proceedings of the National Academy of Sciences Article Abstract – May 12, 2015

Targeting {beta}-arrestin2 in the treatment of L-DOPA–induced dyskinesia in Parkinson’s disease,” by Nikhil M. Urs, Simone Bido, Sean M. Peterson, Tanya L. Daigle, Caroline E. Bass, Raul R. Gainetdinov, Erwan Bezard, and Marc G. Caron (Vol. 112, No. 19, May 12, 2015, p. E2517–E2526).

www.pnas.org/content/112/19/E2517.abstract

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