“COUP-TFII inhibits TGF-{beta}-induced growth barrier to promote prostate tumorigenesis,” by Jun Qin, San-Pin Wu, Chad J. Creighton, Fangyan Dai, Xin Xie, Chiang-Min Cheng, Anna Frolov, Gustavo Ayala, Xia Lin, Xin-Hua Feng, Michael M. Ittmann, Shaw-Jenq Tsai, Ming-Jer Tsai & Sophia Y. Tsai (Vol. 493, No. 7431, January 10, 2013, p. 236-240).
www.nature.com/nature/journal/v493/n7431/abs/nature11674.html
“[beta]-arrestin 2 regulates A[beta] generation and [gamma]-secretase activity in Alzheimer’s disease,” by Amantha Thathiah, Katrien Horre, An Snellinx, Elke Vandewyer, Yunhong Huang, Marta Ciesielska, Gerdien De Kloe, Sebastian Munck & Bart De Strooper (Vol. 19, No. 1, January 2013, p. 43-49).
“Structure of a presenilin family intramembrane aspartate protease,” by Xiaochun Li, Shangyu Dang, Chuangye Yan, Xinqi Gong, Jiawei Wang & Yigong Shi (Vol. 493, No. 7430, January 2, 2013, p. 56-61).
www.nature.com/nature/journal/v493/n7430/abs/nature11801.html
“Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan,” by Darren J. Baker, Meelad M. Dawlaty, Tobias Wijshake, Karthik B. Jeganathan, Liviu Malureanu, Janine H. van Ree, Ruben Crespo-Diaz, Santiago Reyes, Lauren Seaburg, Virginia Shapiro, Atta Behfar, Andre Terzic, Bart van de Sluis & Jan M. van Deursen (Vol. 15, No. 1, January 2013, p. 96-102).
“An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast,” by Adam L. Hughes and Daniel E. Gottschling (Vol. 492, No. 7428, December 12, 2012, p. 261-265).
www.nature.com/nature/journal/v492/n7428/abs/nature11654.html
“The aged niche disrupts muscle stem cell quiescence,” by Joe V. Chakkalakal, Kieran M. Jones, M. Albert Basson & Andrew S. Brack (Vol. 490, No. 7420, October 18, 2012, p. 355-360).
www.nature.com/nature/journal/v490/n7420/abs/nature11438.html
“Gut microbiota composition correlates with diet and health in the elderly,” by Marcus J. Claesson, Ian B. Jeffery, Susana Conde, Susan E. Power, Eibhlis M. O’Connor, Siobhan Cusack, Hugh M. B. Harris, Mairead Coakley, Bhuvaneswari Lakshminarayanan, Orla O’Sullivan, Gerald F. Fitzgerald, Jennifer Deane, Michael O’Connor, Norma Harnedy, Kieran O’Connor, Denis O’Mahony, Douwe van Sinderen, Martina Wallace, Lorraine Brennan, Catherine Stanton, Julian R. Marchesi, Anthony P. Fitzgerald, Fergus Shanahan, Colin Hill, R. Paul Ross & Paul W. O’Toole (Vol. 488, No. 7410, August 9, 2012, p. 178-184).
www.nature.com/nature/journal/v488/n7410/abs/nature11319.html
Nature Article, Letter Abstract:
A. “The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche,” by Hila Toledano, Cecilia D’Alterio, Benjamin Czech, Erel Levine & D. Leanne Jones (Vol. 485, No. 7400, May 31, 2012, p. 605-610).
www.nature.com/nature/journal/v485/n7400/abs/nature11061.html
B. “Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-{beta},” by Justin M. Nussbaum, Stephan Schilling, Holger Cynis, Antonia Silva, Eric Swanson, Tanaporn Wangsanut, Kaycie Tayler, Brian Wiltgen, Asa Hatami, Raik Rönicke, Klaus Reymann, Birgit Hutter-Paier, Anca Alexandru, Wolfgang Jagla, Sigrid Graubner, Charles G. Glabe, Hans-Ulrich Demuth & George S. Bloom (Vol. 485, No. 7400, May 31, 2012, p. 651-655).
www.nature.com/nature/journal/v485/n7400/abs/nature11060.html
A. “Apolipoprotein E controls cerebrovascular integrity via cyclophilin A,” by Robert D. Bell, Ethan A. Winkler, Itender Singh, Abhay P. Sagare, Rashid Deane, Zhenhua Wu, David M. Holtzman, Christer Betsholtz, Annika Armulik, Jan Sallstrom, Bradford C. Berk, & Berislav V. Zlokovic (Vol. 485, No. 7399, May 24, 2012, p. 512-516).
www.nature.com/nature/journal/v485/n7399/abs/nature11087.html
B. “Sustained translational repression by eIF2a-P mediates prion neurodegeneration,” by Julie A. Moreno, Helois Radford, Diego Peretti, Joern R. Steinert, Nicholas Verity, Maria Guerra Martin, Mark Halliday, Jason Morgan, David Dinsdale, Catherine A. Ortori, David A. Barrett, Pavel Tsaytler, Anne Bertolotti, Anne E. Willis, Martin Bushell, & Giovanna R. Mallucci (Vol. 485, No. 7399, May 24, 2012, p. 507-511).
www.nature.com/nature/journal/v485/n7399/abs/nature11058.html
“Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure,” by Takafumi Oka, Shungo Hikoso, Osamu Yamaguchi, Manabu Taneike, Toshihiro Takeda, Takahito Tamai, Jota Oyabu, Tomokazu Murakawa, Hiroyuki Nakayama, Kazuhiko Nishida, Shizuo Akira, Akitsugu Yamamoto, Issei Komuro & Kinya Otsu (Vol. 485, No. 7397, May 10, 2012, p. 251-255).
www.nature.com/nature/journal/v485/n7397/abs/nature10992.html
A. “An epigenetic blockade of cognitive functions in the neurodegenerating brain,” by Johannes Gräff, Damien Rei, Ji-Song Guan, Wen-Yuan Wang, Jinsoo Seo, Krista M. Hennig, Thomas J. F. Nieland, Daniel M. Fass, Patricia F. Kao, Martin Kahn, Susan C. Su, Alireza Samiei, Nadine Joseph, Stephen J. Haggarty, Ivana Delalle, and Li-Huei Tsai (Vol. 483, No. 7388, Mar. 8, 2012, doi:10.1038/nature10849).
www.nature.com/nature/journal/vaop/ncurrent/abs/nature10849.html
B. ”The sirtuin SIRT6 regulates lifespan in male mice,” by Yariv Kanfi, Shoshana Naiman, Gail Amir, Victoria Peshti, Guy Zinman, Liat Nahum, Ziv Bar-Joseph & Haim Y. Cohen (Vol. 483, No. 7388, Mar. 8, 2012, p. 218-221).
www.nature.com/nature/journal/v483/n7388/abs/nature10815.html
“The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila,” by Nan Liu, Michael Landreh, Kajia Cao, Masashi Abe, Gert-Jan Hendriks, Jason R. Kennerdell, Yongqing Zhu, Li-San Wang & Nancy M. Bonini (Vol. 482, No. 7386, February 23, 2012, p. 519-523).
www.nature.com/nature/journal/v482/n7386/abs/nature10810.html
A. “Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells,” by Mason A. Israel, Shauna H. Yuan, Cedric Bardy, Sol M. Reyna, Yangling Mu, Cheryl Herrera, Michael P. Hefferan, Sebastiaan Van Gorp, Kristopher L. Nazor, Francesca S. Boscolo, Christian T. Carson, Louise C. Laurent, Martin Marsala, Fred H. Gage, Anne M. Remes, Edward H. Koo and Lawrence S. B. Goldstein (Vol. 482, No. 7384, February 8, 2012, p. 216-220).
www.nature.com/nature/journal/v482/n7384/abs/nature10821.html
B. “Genetic contributions to stability and change in intelligence from childhood to old age,” by Ian J. Deary, Jian Yang, Gail Davies, Sarah E. Harris, Albert Tenesa, David Liewald, Michelle Luciano, Lorna M. Lopez, Alan J. Gow, Janie Corley, Paul Redmond, Helen C. Fox, Suzanne J. Rowe, Paul Haggarty, Geraldine McNeill, Michael E. Goddard, David J. Porteous, Lawrence J. Whalley, John M. Starr & Peter M. Visscher (Vol. 482, No. 7384, February 8, 2012, p. 216-220).
www.nature.com/nature/journal/v482/n7384/abs/nature10781.html
A. “Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells,” by Mason A. Israel, Shauna H. Yuan, Cedric Bardy, Sol M. Reyna, Yangling Mu, Cheryl Herrera, Michael P. Hefferan, Sebastiaan Van Gorp, Kristopher L. Nazor, Francesca S. Boscolo, Christian T. Carson, Louise C. Laurent, Martin Marsala, Fred H. Gage, Anne M. Remes, Edward H. Koo, and Lawrence S.B. Goldstein (doi:10.1038/nature10821, Jan. 25, 2012).
www.nature.com/nature/journal/vaop/ncurrent/abs/nature10821.html
B. “Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001,” by Natasha M. DeVore and Emily E. Scott (doi:10.1038/nature10743, Jan. 22, 2012).
www.nature.com/nature/journal/vaop/ncurrent/abs/nature10743.html
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