CDHA CAAR

September 20, 2017

CAAR – Nature Letter Abstract – September 20, 2017

Filed under: Reports and Articles — Tags: , — admin @ 5:04 pm

A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease,” by Elvira Mass, Christian E. Jacome-Galarza, Thomas Blank, Tomi Lazarov, Benjamin H. Durham, Neval Ozkaya, Alessandro Pastore, Marius Schwabenland, Young Rock Chung, Marc K. Rosenblum, Marco Prinz, Omar Abdel-Wahab & Frederic Geissmann (Vol. 549, No. 7672, September 21, 2017, p. 389-393).Nature Letter Abstract: “A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease,” by Elvira Mass, Christian E. Jacome-Galarza, Thomas Blank, Tomi Lazarov, Benjamin H. Durham, Neval Ozkaya, Alessandro Pastore, Marius Schwabenland, Young Rock Chung, Marc K. Rosenblum, Marco Prinz, Omar Abdel-Wahab & Frederic Geissmann (Vol. 549, No. 7672, September 21, 2017, p. 389-393).

www.nature.com/nature/journal/v549/n7672/abs/nature23672.html

June 28, 2017

CAAR – Nature Letter Abstract – June 28, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:15 pm

T cells from patients with Parkinson’s disease recognize {alpha}-synuclein peptides,” by David Sulzer, Roy N. Alcalay, Francesca Garretti, Lucien Cote, Ellen Kanter, Julian Agin-Liebes, Christopher Liong, Curtis McMurtrey, William H. Hildebrand, Xiaobo Mao, Valina L. Dawson, Ted M. Dawson, Carla Oseroff, John Pham, John Sidney, Myles B. Dillon, Chelsea Carpenter, Daniela Weiskopf, Elizabeth Phillips, Simon Mallal, Bjoern Peters, April Frazier, Cecilia S. Lindestam Arlehamn & Alessandro Sette (Vol. 546, No. 7660, June 29, 2017, p. 656-661).

www.nature.com/nature/journal/v546/n7660/abs/nature22815.html

April 26, 2017

CAAR – Nature Neuroscience Article Abstract – April 26, 2017

Filed under: Reports and Articles — Tags: , , — admin @ 5:18 pm

{alpha}-Synuclein promotes dilation of the exocytotic fusion pore,” by Todd Logan, Jacob Bendor, Chantal Toupin, Kurt Thorn & Robert H. Edwards (Vol. 20, No. 5, May 2017, p. 681-689).

www.nature.com/neuro/journal/v20/n5/abs/nn.4529.html

March 8, 2017

CAAR – Nature Article Abstract – March 8, 2017

Filed under: Reports and Articles — Tags: , — admin @ 5:26 pm

Autophagy maintains the metabolism and function of young and old stem cells,” by Theodore T. Ho, Matthew R. Warr, Emmalee R. Adelman, Olivia M. Lansinger, Johanna Flach, Evgenia V. Verovskaya, Maria E. Figueroa & Emmanuelle Passegue (Vol. 543, No. 7644, March 9, 2017, p. 205-210).

www.nature.com/nature/journal/v543/n7644/abs/nature21388.html

January 26, 2017

CAAR – Nature Article Abstract – January 26, 2017

Filed under: uncategorized — Tags: , — admin @ 5:08 pm

Neurotoxic reactive astrocytes are induced by activated microglia,” by Shane A. Liddelow, Kevin A. Guttenplan, Laura E. Clarke, Frederick C. Bennett, Christopher J. Bohlen, Lucas Schirmer, Mariko L. Bennett, Alexandra E. Münch, Won-Suk Chung, Todd C. Peterson, Daniel K. Wilton, Arnaud Frouin, Brooke A. Napier, Nikhil Panicker, Manoj Kumar, Marion S. Buckwalter, David H. Rowitch, Valina L. Dawson, Ted M. Dawson, Beth Stevens & Ben A. Barres (Vol. 541, No. 7638, January 26, 2017, p. 481-487).

www.nature.com/nature/journal/v541/n7638/abs/nature21029.html

December 14, 2016

CAAR – Nature Letter Abstract – December 14, 2016

Filed under: Reports and Articles — Tags: , , — admin @ 5:05 pm

Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals,” by Simon Schwörer, Friedrich Becker, Christian Feller, Ali H. Baig, Ute Kober, Henriette Henze, Johann M. Kraus, Beibei Xin, André Lechel, Daniel B. Lipka, Christy S. Varghese, Manuel Schmidt, Remo Rohs, Ruedi Aebersold, Kay L. Medina, Hans A. Kestler, Francesco Neri, Julia von Maltzahn, Stefan Tumpel & K. Lenhard Rudolph (Vol. 540, No. 7633, December 15, 2016, p. 428-432).

www.nature.com/nature/journal/v540/n7633/abs/nature20603.html

December 8, 2016

CAAR – Nature Article Abstract – December 8, 2016

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Gamma frequency entrainment attenuates amyloid load and modifies microglia,” by Hannah F. Iaccarino, Annabelle C. Singer, Anthony J. Martorell, Andrii Rudenko, Fan Gao, Tyler Z. Gillingham, Hansruedi Mathys, Jinsoo Seo, Oleg Kritskiy, Fatema Abdurrob, Chinnakkaruppan Adaikkan, Rebecca G. Canter, Richard Rueda, Emery N. Brown, Edward S. Boyden & Li-Huei Tsai (Vol. 540, No. 7632, December 8, 2016, p. 230-235).

www.nature.com/nature/journal/v540/n7632/abs/nature20587.html

November 8, 2016

CAAR – Nature Medicine Article Abstract – November 8, 2016

Filed under: Reports and Articles — Tags: , , — admin @ 5:03 pm

Caspase-2 cleavage of tau reversibly impairs memory,” by Xiaohui Zhao, Linda A. Kotilinek, Benjamin Smith, Chris Hlynialuk, Kathleen Zahs, Martin Ramsden, James Cleary & Karen H. Ashe (Vol. 22, No. 11, November 2016, p. 1268–1276).

www.nature.com/nm/journal/v22/n11/abs/nm.4199.html

October 12, 2016

CAAR – Nature Letter Abstracts – October 12, 2016

Filed under: Reports and Articles — Tags: , , , — admin @ 5:15 pm

A. “Evidence for a limit to human lifespan,” by Xiao Dong, Brandon Milholland & Jan Vijg (Vol. 538, No. 7624, October 13, 2016, p. 257-259).

www.nature.com/nature/journal/v538/n7624/abs/nature19793.html

B. “Tissue-specific mutation accumulation in human adult stem cells during life,” by Francis Blokzijl, Joep de Ligt, Myrthe Jager, Valentina Sasselli, Sophie Roerink, Nobuo Sasaki, Meritxell Huch, Sander Boymans, Ewart Kuijk, Pjotr Prins, Isaac J. Nijman, Inigo Martincorena, Michal Mokry, Caroline L. Wiegerinck, Sabine Middendorp, Toshiro Sato, Gerald Schwank, Edward E. S. Nieuwenhuis, Monique M. A. Verstegen, Luc J. W. van der Laan, Jeroen de Jonge, Jan N. M. IJzermans, Robert G. Vries, Marc van de Wetering, Michael R. Stratton, Hans Clevers, Edwin Cuppen & Ruben van Boxtel (Vol. 538, No. 7624, October 13, 2016, p. 260-264).

www.nature.com/nature/journal/v538/n7624/abs/nature19768.html

September 1, 2016

CAAR – Nature Article Abstract – September 1, 2016

Filed under: Reports and Articles — Tags: , , — admin @ 4:39 pm

The antibody aducanumab reduces A{beta} plaques in Alzheimer’s disease,” by Jeff Sevigny, Ping Chiao, Thierry Bussière, Paul H. Weinreb, Leslie Williams, Marcel Maier, Robert Dunstan, Stephen Salloway, Tianle Chen, Yan Ling, John O’Gorman, Fang Qian, Mahin Arastu, Mingwei Li, Sowmya Chollate, Melanie S. Brennan, Omar Quintero-Monzon, Robert H. Scannevin, H. Moore Arnold, Thomas Engber, Kenneth Rhodes, James Ferrero, Yaming Hang, Alvydas Mikulskis, Jan Grimm, Christoph Hock, Roger M. Nitsch & Alfred Sandrock (Vol. 537, No. 7618, September 1, 2016, p. 50-56).

www.nature.com/nature/journal/v537/n7618/abs/nature19323.html

July 27, 2016

CAAR – Nature Letter Abstract – July 27, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:24 pm

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing,” by Ana Latorre-Pellicer, Raquel Moreno-Loshuertos, Ana Victoria Lechuga-Vieco, Fatima Sanchez-Cabo, Carlos Torroja, Rebeca Acín-Perez, Enrique Calvo, Esther Aix, Andres Gonzalez-Guerra, Angela Logan, María Luisa Bernad-Miana, Eduardo Romanos, Raquel Cruz, Sara Cogliati, Beatriz Sobrino, Angel Carracedo, Acisclo Pérez-Martos, Patricio Fernandez-Silva, Jesús Ruíz-Cabello, Michael P. Murphy, Ignacio Flores, Jesus Vazquez & José Antonio Enríquez (Vol. 535, No. 7613, July 28, 2016, p. 561-565).

www.nature.com/nature/journal/v535/n7613/abs/nature18618.html

May 4, 2016

CAAR – Nature Letter Abstract – May 4, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:48 pm

Parkinson-associated risk variant in distal enhancer of {alpha}-synuclein modulates target gene expression,” by Frank Soldner, Yonatan Stelzer, Chikdu S. Shivalila, Brian J. Abraham, Jeanne C. Latourelle, M. Inmaculada Barrasa, Johanna Goldmann, Richard H. Myers, Richard A. Young & Rudolf Jaenisch (Vol. 533, No. 7601, May 5, 2016, p. 95-99).

www.nature.com/nature/journal/v533/n7601/abs/nature17939.html

April 21, 2016

CAAR – Nature Letter Abstract – April 21, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:59 pm

Age-dependent modulation of vascular niches for haematopoietic stem cells,” by Anjali P. Kusumbe, Saravana K. Ramasamy, Tomer Itkin, Maarja Andaloussi Mae, Urs H. Langen, Christer Betsholtz, Tsvee Lapidot & Ralf H. Adams (Vol. 532, No. 7599, April 21, 2016, p. 380-384).

www.nature.com/nature/journal/v532/n7599/abs/nature17638.html

March 23, 2016

CAAR – Nature Letter Abstract – March 23, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:51 pm

Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease,” by Dheeraj S. Roy, Autumn Arons, Teryn I. Mitchell, Michele Pignatelli, Tomas J. Ryan & Susumu Tonegawa (Vol. 531, No. 7595, March 24, 2016, p. 508-512).

www.nature.com/nature/journal/v531/n7595/abs/nature17172.html

January 6, 2016

CAAR – Nature Article Abstract – January 6, 2016

Filed under: Reports and Articles — Tags: , — admin @ 4:30 pm

Autophagy maintains stemness by preventing senescence,” by Laura García-Prat, Marta Martínez-Vicente, Eusebio Perdiguero, Laura Ortet, Javier Rodríguez-Ubreva, Elena Rebollo, Vanessa Ruiz-Bonilla, Susana Gutarra, Esteban Ballestar, Antonio L. Serrano, Marco Sandri & Pura Muñoz-Canoves (Vol. 529, No. 7584, January 5, 2016, p. 37-42).

www.nature.com/nature/journal/v529/n7584/abs/nature16187.html

September 9, 2015

CAAR – Nature Letter Abstract – September 9, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 4:56 pm

Evidence for human transmission of amyloid-{beta} pathology and cerebral amyloid angiopathy,” by Zane Jaunmuktane, Simon Mead, Matthew Ellis, Jonathan D. F. Wadsworth, Andrew J. Nicoll, Joanna Kenny, Francesca Launchbury, Jacqueline Linehan, Angela Richard-Loendt, A. Sarah Walker, Peter Rudge, John Collinge & Sebastian Brandner (Vol. 525, No. 7568, September 9, 2015, p. 247-250).

www.nature.com/nature/journal/v525/n7568/abs/nature15369.html

September 4, 2015

CAAR – Nature Medicine Letter Abstract – September 4, 2015

Filed under: Reports and Articles — Tags: , , — admin @ 4:52 pm

APP intracellular domain–WAVE1 pathway reduces amyloid-{beta} production,” by Ilaria Ceglia, Christiane Reitz, Jodi Gresack, Jung-Hyuck Ahn, Victor Bustos, Marina Bleck, Xiaozhu Zhang, Grant Martin, Sanford M. Simon, Angus C. Nairn, Paul Greengard & Yong Kim (Vol. 21, No. 9, September 2015, p. 1054-1059).

www.nature.com/nm/journal/v21/n9/abs/nm.3924.html

July 23, 2015

CAAR – Nature Article Abstract – July 23, 2015

Filed under: Reports and Articles — Tags: , — admin @ 5:04 pm

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy,” by Asami Kondo, Koorosh Shahpas, Rebekah Mannix, Jianhua Qiu, Juliet Moncaster, Chun-Hau Chen, Yandan Yao, Yu-Min Lin, Jane A. Driver, Yan Sun, Shuo Wei, Man-Li Luo, Onder Albayram, Pengyu Huang, Alexander Rotenberg, Akihide Ryo, Lee E. Goldstein, Alvaro Pascual-Leone, Ann C. McKee, William Meehan, Xiao Zhen Zhou & Kun Ping Lu (Vol. 523, No. 7561, July 23, 2015, p. 431-436).

www.nature.com/nature/journal/v523/n7561/abs/nature14658.html

June 17, 2015

CAAR – Nature Letter Abstract – June 17, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:52 pm

{alpha}-Synuclein strains cause distinct synucleinopathies after local and systemic administration,” by W. Peelaerts, L. Bousset, A. Van der Perren, A. Moskalyuk, R. Pulizzi, M. Giugliano, C. Van den Haute, R. Melki & V. Baekelandt (Vol. 522, No. 7556, June 18, 2015, p. 340-344).

www.nature.com/nature/journal/v522/n7556/abs/nature14547.html

June 5, 2015

CAAR – Nature Letter Abstract – June 5, 2015

Filed under: Reports and Articles — Tags: , — admin @ 5:14 pm

C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits,” by Jeannie Chew, Tania F. Gendron, Mercedes Prudencio, Hiroki Sasaguri, Yong-Jie Zhang, Monica Castanedes-Casey, Chris W. Lee, Karen Jansen-West, Aishe Kurti, Melissa E. Murray, Kevin F. Bieniek, Peter O. Bauer, Ena C. Whitelaw, Linda Rousseau, Jeannette N. Stankowski, Caroline Stetler, Lillian M. Daughrity, Emilie A. Perkerson, Pamela Desaro, Amelia Johnston, Karen Overstreet, Dieter Edbauer, Rosa Rademakers, Kevin B. Boylan, Dennis W. Dickson, John D. Fryer, and Leonard Petrucelli (Vol. 348, No. 6239, June 5, 2015, p. 1150-1154).

www.sciencemag.org/content/348/6239/1151.abstract

May 27, 2015

CAAR – Nature Letter Abstract – May 27, 2015

Filed under: Reports and Articles — Tags: , — admin @ 5:06 pm

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans,” by Konstantinos Palikaras, Eirini Lionaki & Nektarios Tavernarakis (Vol. 521, No. 7553, May 28, 2015, p. 525-528).

www.nature.com/nature/journal/v521/n7553/abs/nature14300.html

February 25, 2015

CAAR – Nature Letter Abstract – February 25, 2015

Filed under: Reports and Articles — Tags: , — admin @ 5:00 pm

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia,” by Terrence N. Wong, Giridharan Ramsingh, Andrew L. Young, Christopher A. Miller, Waseem Touma, John S. Welch, Tamara L. Lamprecht, Dong Shen, Jasreet Hundal, Robert S. Fulton, Sharon Heath, Jack D. Baty, Jeffery M. Klco, Li Ding, Elaine R. Mardis, Peter Westervelt, John F. DiPersio, Matthew J. Walter, Timothy A. Graubert, Timothy J. Ley, Todd E. Druley, Daniel C. Link & Richard K. Wilson (Vol. 518, No. 7540, February 26, 2015, p. 552-555).

www.nature.com/nature/journal/v518/n7540/abs/nature13968.html

February 18, 2015

CAAR – Nature Letter Abstract – February 18, 2015

Filed under: Reports and Articles — Tags: , — admin @ 5:00 pm

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease,” by Elizabeta Gjoneska, Andreas R. Pfenning, Hansruedi Mathys, Gerald Quon, Anshul Kundaje, Li-Huei Tsai & Manolis Kellis (Vol. 518, No. 7539, February 17, 2015, p. 365-369).

www.nature.com/nature/journal/v518/n7539/abs/nature14252.html

February 11, 2015

CAAR – Nature Letter Abstract – February 11, 2015

Filed under: Reports and Articles — Tags: , — admin @ 4:46 pm

RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration,” by Diego Peretti, Amandine Bastide, Helois Radford, Nicholas Verity, Colin Molloy, Maria Guerra Martin, Julie A. Moreno, Joern R. Steinert, Tim Smith, David Dinsdale, Anne E. Willis & Giovanna R. Mallucci (Vol. 518, No. 7538, February 12, 2015, p. 236-239).

www.nature.com/nature/journal/v518/n7538/abs/nature14142.html

December 4, 2014

CAAR – Nature Medicine Article, Letter Abstracts – December 4, 2014

Filed under: Reports and Articles — Tags: , , — admin @ 4:29 pm

A. “Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia,” by Eduardo Gascon, Kelleen Lynch, Hongyu Ruan, Sandra Almeida, Jamie M. Verheyden, William W. Seeley, Dennis W. Dickson, Leonard Petrucelli, Danqiong Sun, Jian Jiao, Hongru Zhou, Mira Jakovcevski, Schahram Akbarian, Wei-Dong Yao & Fen-Biao Gao (Vol. 20, No. 12, December 2014, p. 1444-1451).

www.nature.com/nm/journal/v20/n12/abs/nm.3717.html

B. “A rare mutation in UNC5C predisposes to late-onset Alzheimer’s disease and increases neuronal cell death,” by Monica K. Wetzel-Smith, Julie Hunkapiller, Tushar R. Bhangale, Karpagam Srinivasan, Janice A. Maloney, Jasvinder K. Atwal, Susan M. Sa, Murat B. Yaylaoglu, Oded Foreman, Ward Ortmann, Nisha Rathore, David V. Hansen, Marc Tessier-Lavigne, Alzheimer’s Disease Genetics Consortium, Richard Mayeux, Margaret Pericak-Vance, Jonathan Haines, Lindsay A. Farrer, Gerard D. Schellenberg, Alison Goate, Timothy W. Behrens, Carlos Cruchaga, Ryan J. Watts & Robert R. Graham (Vol. 20, No. 12, December 2014, p. 1452-1457).

www.nature.com/nm/journal/v20/n12/abs/nm.3736.html

November 12, 2014

CAAR – Nature Letter Abstract – November 12, 2014

Filed under: Reports and Articles — Tags: , — admin @ 4:27 pm

A three-dimensional human neural cell culture model of Alzheimer’s disease,” by Se Hoon Choi, Young Hye Kim, Matthias Hebisch, Christopher Sliwinski, Seungkyu Lee, Carla D’Avanzo, Hechao Chen, Basavaraj Hooli, Caroline Asselin, Julien Muffat, Justin B. Klee, Can Zhang, Brian J. Wainger, Michael Peitz, Dora M. Kovacs, Clifford J. Woolf, Steven L. Wagner, Rudolph E. Tanzi & Doo Yeon Kim (Vol. 515, No. 7526, November 12, 2014, p. 274-278).

www.nature.com/nature/journal/v515/n7526/abs/nature13800.html

November 6, 2014

CAAR – Nature Medicine Article Abstracts – November 6, 2014

Filed under: Reports and Articles — Tags: , , — admin @ 4:49 pm

A. “Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease,” by Zhentao Zhang, Mingke Song, Xia Liu, Seong Su Kang, Il-Sun Kwon, Duc M. Duong, Nicholas T. Seyfried, William T. Hu, Zhixue Liu, Jian-Zhi Wang, Liming Cheng, Yi E. Sun, Shan Ping Yu, Allan I. Levey & Keqiang Ye (Vol. 20, No. 11, November 2014, p. 1254-1262).

www.nature.com/nm/journal/v20/n11/abs/nm.3700.html

B. “PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis,” by Hui Xie, Zhuang Cui, Long Wang, Zhuying Xia, Yin Hu, Lingling Xian, Changjun Li, Liang Xie, Janet Crane, Mei Wan, Gehua Zhen, Qin Bian, Bin Yu, Weizhong Chang, Tao Qiu, Maureen Pickarski, Le Thi Duong, Jolene J. Windle, Xianghang Luo, Eryuan Liao & Xu Cao (Vol. 20, No. 11, November 2014, p. 1270-1278).

www.nature.com/nm/journal/v20/n11/abs/nm.3668.html

September 25, 2013

CAAR – Nature Article Abstract – September 25, 2013

Filed under: Reports and Articles — Tags: , — admin @ 5:06 pm

The ubiquitin ligase parkin mediates resistance to intracellular pathogens,” by Paolo S. Manzanillo, Janelle S. Ayres, Robert O. Watson, Angela C. Collins, Gianne Souza, Chris S. Rae, David S. Schneider, Ken Nakamura, Michael U. Shiloh & Jeffery S. Cox (Vol. 501, No. 7468, September 25, 2013, p. 512-516).

www.nature.com/nature/journal/v501/n7468/abs/nature12566.html

July 31, 2013

CAAR – Nature Article Abstract – July 31, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:34 pm

Integrative genomics identifies APOE {epsilon}4 effectors in Alzheimer’s disease,” by Herve Rhinn, Ryousuke Fujita, Liang Qiang, Rong Cheng, Joseph H. Lee & Asa Abeliovich (Vol. 500, No. 7460, August 1, 2013, p. 45-50).

www.nature.com/nature/journal/v500/n7460/abs/nature12415.html

January 9, 2013

CAAR – Nature Letter Abstract – January 9, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:24 pm

COUP-TFII inhibits TGF-{beta}-induced growth barrier to promote prostate tumorigenesis,” by Jun Qin, San-Pin Wu, Chad J. Creighton, Fangyan Dai, Xin Xie, Chiang-Min Cheng, Anna Frolov, Gustavo Ayala, Xia Lin, Xin-Hua Feng, Michael M. Ittmann, Shaw-Jenq Tsai, Ming-Jer Tsai & Sophia Y. Tsai (Vol. 493, No. 7431, January 10, 2013, p. 236-240).

www.nature.com/nature/journal/v493/n7431/abs/nature11674.html

January 7, 2013

CAAR – Nature Medicine Article Abstract – January 7, 2013

Filed under: Reports and Articles — Tags: , — admin @ 3:33 pm

[beta]-arrestin 2 regulates A[beta] generation and [gamma]-secretase activity in Alzheimer’s disease,” by Amantha Thathiah, Katrien Horre, An Snellinx, Elke Vandewyer, Yunhong Huang, Marta Ciesielska, Gerdien De Kloe, Sebastian Munck & Bart De Strooper (Vol. 19, No. 1, January 2013, p. 43-49).

www.nature.com/nm/journal/v19/n1/abs/nm.3023.html

January 2, 2013

CAAR – Nature Article Abstract – January 2, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:50 pm

Structure of a presenilin family intramembrane aspartate protease,” by Xiaochun Li, Shangyu Dang, Chuangye Yan, Xinqi Gong, Jiawei Wang & Yigong Shi (Vol. 493, No. 7430, January 2, 2013, p. 56-61).

www.nature.com/nature/journal/v493/n7430/abs/nature11801.html

CAAR – Nature Cell Biology Article Abstract – January 2, 2013

Filed under: Reports and Articles — Tags: , — admin @ 4:49 pm

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan,” by Darren J. Baker, Meelad M. Dawlaty, Tobias Wijshake, Karthik B. Jeganathan, Liviu Malureanu, Janine H. van Ree, Ruben Crespo-Diaz, Santiago Reyes, Lauren Seaburg, Virginia Shapiro, Atta Behfar, Andre Terzic, Bart van de Sluis & Jan M. van Deursen (Vol. 15, No. 1, January 2013, p. 96-102).

www.nature.com/ncb/journal/v15/n1/abs/ncb2643.html

December 13, 2012

CAAR – Nature Letter Abstract – December 13, 2012

Filed under: Reports and Articles — Tags: , — admin @ 3:52 pm

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast,” by Adam L. Hughes and Daniel E. Gottschling (Vol. 492, No. 7428, December 12, 2012, p. 261-265).

www.nature.com/nature/journal/v492/n7428/abs/nature11654.html

October 17, 2012

CAAR – Nature Article Abstract – October 17, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 4:20 pm

The aged niche disrupts muscle stem cell quiescence,” by Joe V. Chakkalakal, Kieran M. Jones, M. Albert Basson & Andrew S. Brack (Vol. 490, No. 7420, October 18, 2012, p. 355-360).

www.nature.com/nature/journal/v490/n7420/abs/nature11438.html

August 8, 2012

CAAR – Nature Article Abstract – August 8, 2012

Filed under: Reports and Articles — Tags: — admin @ 4:18 pm

Gut microbiota composition correlates with diet and health in the elderly,” by Marcus J. Claesson, Ian B. Jeffery, Susana Conde, Susan E. Power, Eibhlis M. O’Connor, Siobhan Cusack, Hugh M. B. Harris, Mairead Coakley, Bhuvaneswari Lakshminarayanan, Orla O’Sullivan, Gerald F. Fitzgerald, Jennifer Deane, Michael O’Connor, Norma Harnedy, Kieran O’Connor, Denis O’Mahony, Douwe van Sinderen, Martina Wallace, Lorraine Brennan, Catherine Stanton, Julian R. Marchesi, Anthony P. Fitzgerald, Fergus Shanahan, Colin Hill, R. Paul Ross & Paul W. O’Toole (Vol. 488, No. 7410, August 9, 2012, p. 178-184).

www.nature.com/nature/journal/v488/n7410/abs/nature11319.html

May 30, 2012

CAAR – Nature Article, Letter Abstract – May 30, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 3:34 pm

Nature Article, Letter Abstract:

A. “The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche,” by Hila Toledano, Cecilia D’Alterio, Benjamin Czech, Erel Levine & D. Leanne Jones (Vol. 485, No. 7400, May 31, 2012, p. 605-610).

www.nature.com/nature/journal/v485/n7400/abs/nature11061.html

B. “Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-{beta},” by Justin M. Nussbaum, Stephan Schilling, Holger Cynis, Antonia Silva, Eric Swanson, Tanaporn Wangsanut, Kaycie Tayler, Brian Wiltgen, Asa Hatami, Raik Rönicke, Klaus Reymann, Birgit Hutter-Paier, Anca Alexandru, Wolfgang Jagla, Sigrid Graubner, Charles G. Glabe, Hans-Ulrich Demuth & George S. Bloom (Vol. 485, No. 7400, May 31, 2012, p. 651-655).

www.nature.com/nature/journal/v485/n7400/abs/nature11060.html

May 23, 2012

CAAR – Nature Letter Abstracts – May 23, 2012

Filed under: Reports and Articles — Tags: , , , — admin @ 3:30 pm

A. “Apolipoprotein E controls cerebrovascular integrity via cyclophilin A,” by Robert D. Bell, Ethan A. Winkler, Itender Singh, Abhay P. Sagare, Rashid Deane, Zhenhua Wu, David M. Holtzman, Christer Betsholtz, Annika Armulik, Jan Sallstrom, Bradford C. Berk, & Berislav V. Zlokovic (Vol. 485, No. 7399, May 24, 2012, p. 512-516).

www.nature.com/nature/journal/v485/n7399/abs/nature11087.html

B. “Sustained translational repression by eIF2a-P mediates prion neurodegeneration,” by Julie A. Moreno, Helois Radford, Diego Peretti, Joern R. Steinert, Nicholas Verity, Maria Guerra Martin, Mark Halliday, Jason Morgan, David Dinsdale, Catherine A. Ortori, David A. Barrett, Pavel Tsaytler, Anne Bertolotti, Anne E. Willis, Martin Bushell, & Giovanna R. Mallucci (Vol. 485, No. 7399, May 24, 2012, p. 507-511).

www.nature.com/nature/journal/v485/n7399/abs/nature11058.html

May 9, 2012

CAAR – Nature Letter Abstract – May 9, 2012

Filed under: Reports and Articles — Tags: , — admin @ 3:12 pm

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure,” by Takafumi Oka, Shungo Hikoso, Osamu Yamaguchi, Manabu Taneike, Toshihiro Takeda, Takahito Tamai, Jota Oyabu, Tomokazu Murakawa, Hiroyuki Nakayama, Kazuhiko Nishida, Shizuo Akira, Akitsugu Yamamoto, Issei Komuro & Kinya Otsu (Vol. 485, No. 7397, May 10, 2012, p. 251-255).

www.nature.com/nature/journal/v485/n7397/abs/nature10992.html

March 8, 2012

CAAR – Nature Letter Abstract – March 8, 2012

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A. “An epigenetic blockade of cognitive functions in the neurodegenerating brain,” by Johannes Gräff, Damien Rei, Ji-Song Guan, Wen-Yuan Wang, Jinsoo Seo, Krista M. Hennig, Thomas J. F. Nieland, Daniel M. Fass, Patricia F. Kao, Martin Kahn, Susan C. Su, Alireza Samiei, Nadine Joseph, Stephen J. Haggarty, Ivana Delalle, and Li-Huei Tsai (Vol. 483, No. 7388, Mar. 8, 2012, doi:10.1038/nature10849).

www.nature.com/nature/journal/vaop/ncurrent/abs/nature10849.html

B. “The sirtuin SIRT6 regulates lifespan in male mice,” by Yariv Kanfi, Shoshana Naiman, Gail Amir, Victoria Peshti, Guy Zinman, Liat Nahum, Ziv Bar-Joseph & Haim Y. Cohen (Vol. 483, No. 7388, Mar. 8, 2012, p. 218-221).

www.nature.com/nature/journal/v483/n7388/abs/nature10815.html

February 22, 2012

CAAR – Nature Letter Abstract – February 22, 2012

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The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila,” by Nan Liu, Michael Landreh, Kajia Cao, Masashi Abe, Gert-Jan Hendriks, Jason R. Kennerdell, Yongqing Zhu, Li-San Wang & Nancy M. Bonini (Vol. 482, No. 7386, February 23, 2012, p. 519-523).

www.nature.com/nature/journal/v482/n7386/abs/nature10810.html

February 8, 2012

CAAR – Nature Letter Abstracts – February 8, 2012

Filed under: Reports and Articles — Tags: , , — admin @ 3:51 pm

A. “Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells,” by Mason A. Israel, Shauna H. Yuan, Cedric Bardy, Sol M. Reyna, Yangling Mu, Cheryl Herrera, Michael P. Hefferan, Sebastiaan Van Gorp, Kristopher L. Nazor, Francesca S. Boscolo, Christian T. Carson, Louise C. Laurent, Martin Marsala, Fred H. Gage, Anne M. Remes, Edward H. Koo and Lawrence S. B. Goldstein (Vol. 482, No. 7384, February 8, 2012, p. 216-220).

www.nature.com/nature/journal/v482/n7384/abs/nature10821.html

B. “Genetic contributions to stability and change in intelligence from childhood to old age,” by Ian J. Deary, Jian Yang, Gail Davies, Sarah E. Harris, Albert Tenesa, David Liewald, Michelle Luciano, Lorna M. Lopez, Alan J. Gow, Janie Corley, Paul Redmond, Helen C. Fox, Suzanne J. Rowe, Paul Haggarty, Geraldine McNeill, Michael E. Goddard, David J. Porteous, Lawrence J. Whalley, John M. Starr & Peter M. Visscher (Vol. 482, No. 7384, February 8, 2012, p. 216-220).

www.nature.com/nature/journal/v482/n7384/abs/nature10781.html

January 26, 2012

CAAR – Nature Letter Abstracts – January 26, 2012

Filed under: Reports and Articles — Tags: , , , — admin @ 12:41 pm

A. “Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells,” by Mason A. Israel, Shauna H. Yuan, Cedric Bardy, Sol M. Reyna, Yangling Mu, Cheryl Herrera, Michael P. Hefferan, Sebastiaan Van Gorp, Kristopher L. Nazor, Francesca S. Boscolo, Christian T. Carson, Louise C. Laurent, Martin Marsala, Fred H. Gage, Anne M. Remes, Edward H. Koo, and Lawrence S.B. Goldstein (doi:10.1038/nature10821, Jan. 25, 2012).

www.nature.com/nature/journal/vaop/ncurrent/abs/nature10821.html

B. “Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001,” by Natasha M. DeVore and Emily E. Scott (doi:10.1038/nature10743, Jan. 22, 2012).

www.nature.com/nature/journal/vaop/ncurrent/abs/nature10743.html

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