CDHA CAAR

February 14, 2013

CAAR – Public Library of Science (PLoS) Articles – February 14, 2013

Filed under: Reports and Articles — Tags: , , , , — admin @ 4:54 pm

A. “Plasma Adiponectin Levels Correlate Positively with an Increasing Number of Components of Frailty in Male Elders,” by Jaw-Shiun Tsai, Chih-Hsun Wu, Su-Chiu Chen, Kuo-Chin Huang, Chin-Ying Chen, Ching-I Chang, Lee-Ming Chuang, and Ching-Yu Chen (PLoS ONE 8(2): e56250. doi:10.1371/journal.pone.0056250, XML, HTML, and .pdf format, 8p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056250

B. “The Effects of Aging on Conflict Detection,” by Giuliana Lucci, Marika Berchicci, Donatella Spinelli, Francesco Taddei, and Francesco Di Russo (PLoS ONE 8(2): e56566. doi:10.1371/journal.pone.0056566, XML, HTML, and .pdf format, 14p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056566

C. “Motor Matters: Tackling Heterogeneity of Parkinson’s Disease in Functional MRI Studies,” by Stefan Holiga, Karsten Mueller, Harald E. Moller, Tomas Sieger, Matthias L. Schroeter, Josef Vymazal, Evzen Ruzicka, and Robert Jech (PLoS ONE 8(2): e56133. doi:10.1371/journal.pone.0056133, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056133

D. “Accelerated Cell Aging in Female APOE-{epsilon}4 Carriers: Implications for Hormone Therapy Use,” by Emily G. Jacobs, Candyce Kroenke, Jue Lin, Elissa S. Epel, Heather A. Kenna, Elizabeth H. Blackburn, and Natalie L. Rasgon (PLoS ONE 8(2): e54713. doi:10.1371/journal.pone.0054713, XML, HTML, and .pdf format, 7p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054713

E. “Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI2/Tau Transgenic Mice,” by Holly J. Garringer, Jill Murrell, Neeraja Sammeta, Anita Gnezda, Bernardino Ghetti, and Ruben Vidal ( PLoS ONE 8(2): e56426. doi:10.1371/journal.pone.0056426, XML, HTML, and .pdf format, 11p.).

www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056426

December 12, 2012

CAAR – Institute For Research and Information in Health Economics [IRDES] Working Paper – December 12, 2012

Filed under: Working Papers — Tags: — admin @ 1:27 pm

On the Socio-Economic Determinants of Frailty: Findings from Panel and Retrospective Data from SHARE,” by Nicolas Sirven (Working Paper No. 52, December 2012, .pdf format, 29p.).

Abstract:

Recent studies on the demand for long-term care emphasised the role of frailty as a specific precursor of disability besides chronic diseases. Frailty is defined as vulnerable health status resulting from the reduction of individuals’ reserve capacity. This medical concept is brought here in an economic framework in order to investigate the role social policies may play in preventing disability or maintaining life quality of people in a disablement process.

Using four waves of panel data from the Survey on Health, Ageing, and Retirement in Europe (SHARE), a frailty index is created as a count measure for five physiologic criteria (Fried model) for respondents aged 50+ in 10 European countries, between 2004 and 2011.

The longitudinal dimension is explored in two ways. First, differences in frailty dynamics over a seven-year-time period are analysed through variables that are relevant for social policy (income maintenance, housing adaptation, and prevention of social isolation) in a panel model for count data with fixed effects. Second, the individual fixed effects are decomposed by means of a random effects model with Mundlak specification. SHARE additional retrospective data on life history (SHARELIFE) are then used to investigate differences in frailty levels.

The results reveal the presence of various sources of social inequalities over the life-course. Social Protection Systems thus appear to play a major role in accompanying, preventing or reducing the frailty process. Several policy implications are suggested.

www.irdes.fr/EspaceAnglais/Publications/WorkingPapers/DT52SocioEconomicDeterminantsFrailty.pdf

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