“Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner,” by Varun K. Gupta, Lisa Scheunemann, Tobias Eisenberg, Sara Mertel, Anuradha Bhukel, Tom S. Koemans, Jamie M. Kramer, Karen S. Y. Liu, Sabrina Schroeder, Hendrik G. Stunnenberg, Frank Sinner, Christoph Magnes, Thomas R. Pieber, Shubham Dipt, Andre Fiala, Annette Schenck, Martin Schwaerzel, Frank Madeo & Stephan J. Sigrist (Vol. 16, No. 10, October 2013, p. 1453-1460).
September 25, 2013
September 20, 2013
CAAR – Public Library of Science (PLoS) Article – September 20, 2013
“Aging-Induced Proteostatic Changes in the Rat Hippocampus Identify ARP3, NEB2 and BRAG2 as a Molecular Circuitry for Cognitive Impairment,” by Philipp Ottis, Bianca Topic, Maarten Loos, Ka Wan Li, Angelica de Souza, Daniela Schulz, August B. Smit, Joseph P. Huston, and Carsten Korth (PLoS ONE 8(9): e75112. doi:10.1371/journal.pone.0075112, XML, HTML, and .pdf format, 17p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0075112
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July 26, 2013
CAAR – British Medical Journal Article – July 26, 2013
“Care in specialist medical and mental health unit compared with standard care for older people with cognitive impairment admitted to general hospital: randomised controlled trial (NIHR TEAM trial),” by Sarah E. Goldberg, Lucy E. Bradshaw, Fiona C. Kearney, Catherine Russell, Kathy H. Whittamore, Pippa E. R. Foster, Jil Mamza, John R. F. Gladman, Rob G. Jones, Sarah A. Lewis, Davina Porock, and Rowan H. Harwood, on behalf of the Medical Crises in Older People Study Group (BMJ 2013;347:f4132, July 20, 2013, .pdf and HTML format).
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July 23, 2013
CAAR – US National Institute on Aging Website of Interest – July 23, 2013
“Instruments to Detect Cognitive Impairment in Older Adults,” (July 2013). Note: This database “contains detailed information about more than 100 published instruments for detecting Alzheimer’s disease and other types of cognitive impairment. It was created by NIA staff in consultation with experts in the field. Many instruments are suitable for outpatient practices and community studies. Each instrument in the database was developed as a cognitive assessment for age-related dementia and has had at least three published studies using the instrument since its debut and at least one publication in the last 10 years.”
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June 14, 2013
CAAR – Public Library of Science (PLoS) Articles – June 14, 2013
A. “Diagnosed Mild Cognitive Impairment Due to Alzheimer’s Disease with PET Biomarkers of Beta Amyloid and Neuronal Dysfunction,” by Shizuo Hatashita and Hidetomo Yamasaki (PLoS ONE 8(6): e66877. doi:10.1371/journal.pone.0066877, XML, HTML, and .pdf format, 6p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0066877
B. “Evaluating Amyloid-{beta} Oligomers in Cerebrospinal Fluid as a Biomarker for Alzheimer’s Disease,” by Mikko Holtta, Oskar Hansson, Ulf Andreasson, Joakim Hertze, Lennart Minthon, Katarina Nagga, Niels Andreasen, Henrik Zetterberg, and Kaj Blennow (PLoS ONE 8(6): e66381. doi:10.1371/journal.pone.0066381, XML, HTML, and .pdf format, 8p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0066381
C. “Risk Factors for Late-Life Cognitive Decline and Variation with Age and Sex in the Sydney Memory and Ageing Study,” by Darren M. Lipnicki, Perminder S. Sachdev, John Crawford, Simone Reppermund, Nicole A. Kochan, Julian N. Trollor, Brian Draper, Melissa J. Slavin, Kristan Kang, Ora Lux, Karen A. Mather, and Henry Brodaty (PLoS ONE 8(6): e65841. doi:10.1371/journal.pone.0065841, XML, HTML, and .pdf format, 9p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0065841
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May 31, 2013
CAAR – Public Library of Science (PLoS) Articles – May 31, 2013
A. “CNF1 Increases Brain Energy Level, Counteracts Neuroinflammatory Markers and Rescues Cognitive Deficits in a Murine Model of Alzheimer’s Disease,” by Stefano Loizzo, Roberto Rimondini, Sara Travaglione, Alessia Fabbri, Marco Guidotti, Alberto Ferri, Gabriele Campana, and Carla Fiorentini (PLoS ONE 8(5): e65898. doi:10.1371/journal.pone.0065898, XML, HTML, and .pdf format, 13p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0065898
B. “Altered Functional Connectivity in an Aged Rat Model of Postoperative Cognitive Dysfunction: A Study Using Resting-State Functional MRI,” by Peng Xie, Tian Yu, Xiaoyun Fu, Ye Tu, Yan Zou, Su Lui, Xuna Zhao, Xiaoqi Huang, Graham J. Kemp, and Qiyong Gong (PLoS ONE 8(5): e64820. doi:10.1371/journal.pone.0064820, XML, HTML, and .pdf format, 7p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0064820
C. “Increases in the Risk of Cognitive Impairment and Alterations of Cerebral {beta}-amyloid Metabolism in Mouse Model of Heart Failure,” by Xiaoqi Hong, Liping Bu, Yi Wang, Jing Xu, Jian Wu, Yufang Huang, Jie Liu, Haiyun Suo, Lumeng Yang, Yuncen Shi, Yi Lou, Zhengliang Sun, Guoqi Zhu, Thomas Behnisch, Mei Yu, Jianguo Jia, Wangxi Hai, Hongping Meng, Sheng Liang, Fang Huang, Yunzeng Zou, and Junbo Ge (PLoS ONE 8(5): e63829. doi:10.1371/journal.pone.0063829, XML, HTML, and .pdf format, 13p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0063829
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May 15, 2013
CAAR – Public Library of Science (PLoS) Articles – May 15, 2013
A. “Amyloid Precursor Protein Is an Autonomous Growth Cone Adhesion Molecule Engaged in Contact Guidance,” by Lucas J. Sosa, Jared Bergman, Adriana Estrada-Bernal, Thomas J. Glorioso, John M. Kittelson, and Karl H. Pfenninger (PLoS ONE 8(5): e64521. doi:10.1371/journal.pone.0064521, XML, HTML, and .pdf format, 16p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0064521
B. “An Economic Evaluation of Resistance Training and Aerobic Training versus Balance and Toning Exercises in Older Adults with Mild Cognitive Impairment,” by Jennifer C. Davis, Stirling Bryan, Carlo A. Marra, Devika Sharma, Alison Chan, B. Lynn Beattie, Peter Graf, and Teresa Liu-Ambrose (PLoS ONE 8(5): e63031. doi:10.1371/journal.pone.0063031, XML, HTML, and .pdf format, 9p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0063031
C. “Acetylcholineestarase-Inhibiting Alkaloids from Lycoris radiata Delay Paralysis of Amyloid Beta-Expressing Transgenic C. elegans CL4176,” by Lijuan Xin, Ritupriya Yamujala, Yuehu Wang, Huan Wang, Wen-Hsuan Wu, Michael A. Lawton, Chunlin Long, and Rong Di (PLoS ONE 8(5): e63874. doi:10.1371/journal.pone.0063874, XML, HTML, and .pdf format, 8p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0063874
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May 1, 2013
CAAR – Public Library of Science (PLoS) Articles – May 1, 2013
A. “Mediterranean Diet, Telomere Maintenance and Health Status among Elderly,” by Virginia Boccardi, Antonietta Esposito, Maria Rosaria Rizzo, Raffaele Marfella, Michelangela Barbieri, and Giuseppe Paolisso (PLoS ONE 8(4): e62781. doi:10.1371/journal.pone.0062781, XML, HTML, and .pdf format, 6p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062781
B. “KCNQ Channels Regulate Age-Related Memory Impairment,” by Sonia Cavaliere, Bilal R. Malik, and James J. L. Hodge (PLoS ONE 8(4): e62445. doi:10.1371/journal.pone.0062445, XML, HTML, and .pdf format, 8p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062445
C. “The Association between Pulse Wave Velocity and Cognitive Function: The Sydney Memory and Ageing Study,” by Joel Singer, Julian N. Trollor, John Crawford, Michael F. O’Rourke, Bernhard T. Baune, Henry Brodaty, Katherine Samaras, Nicole A. Kochan, Lesley Campbell, Perminder S. Sachdev, and Evelyn Smith (PLoS ONE 8(4): e61855. doi:10.1371/journal.pone.0061855, XML, HTML, and .pdf format, 6p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061855
D. “Prevalence of Self-Reported Pain, Joint Complaints and Knee or Hip Complaints in Adults Aged => 40 Years: A Cross-Sectional Survey in Herne, Germany,” by Ulrich Thiem, Rainer Lamsfuss, Sven Gunther, Jochen Schumacher, Christian Baker, Heinz G. Endres, Josef Zacher, Gerd R. Burmester, and Ludger Pientka (PLoS ONE 8(4): e60753. doi:10.1371/journal.pone.0060753, XML, HTML, and .pdf format, 10p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0060753
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April 19, 2013
April 11, 2013
CAAR – Public Library of Science (PLoS) Articles – April 11, 2013
A. “Qualitative Evaluation of Advanced Care Planning in Early Dementia (ACP-ED),” by Michaela Poppe, Sarah Burleigh, and Sube Banerjee (PLoS ONE 8(4): e60412. doi:10.1371/journal.pone.0060412, XML, HTML, and .pdf format, 5p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0060412
B. “A Randomized Controlled Trial of Multicomponent Exercise in Older Adults with Mild Cognitive Impairment,” by Takao Suzuki, Hiroyuki Shimada, Hyuma Makizako, Takehiko Doi, Daisuke Yoshida, Kengo Ito, Hiroshi Shimokata, Yukihiko Washimi, Hidetoshi Endo, and Takashi Kato ( PLoS ONE 8(4): e61483. doi:10.1371/journal.pone.0061483, XML, HTML, and .pdf format, 10p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061483
C. “Generation of Amyloid-{beta} Is Reduced by the Interaction of Calreticulin with Amyloid Precursor Protein, Presenilin and Nicastrin,” by Nina Stemmer, Elena Strekalova, Nevena Djogo, Frank Ploger, Gabriele Loers, David Lutz, Friedrich Buck, Marek Michalak, Melitta Schachner, and Ralf Kleene (PLoS ONE 8(4): e61299. doi:10.1371/journal.pone.0061299, XML, HTML, and .pdf format, 15p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061299
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March 28, 2013
CAAR – Public Library of Science (PLoS) Article – March 28, 2013
“Factors Predicting Reversion from Mild Cognitive Impairment to Normal Cognitive Functioning: A Population-Based Study,” by Perminder S. Sachdev, Darren M. Lipnicki, John Crawford, Simone Reppermund, Nicole A. Kochan, Julian N. Trollor, Wei Wen, Brian Draper, Melissa J. Slavin, Kristan Kang, Ora Lux, Karen A. Mather, and Henry Brodaty, the Sydney Memory , Ageing Study Team (PLoS ONE 8(3): e59649. doi:10.1371/journal.pone.0059649, XML, HTML, and .pdf format, 10p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0059649
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February 27, 2013
CAAR – Public Library of Science (PLoS) Article – February 27, 2013
“Childhood Trauma and PTSD Symptoms Increase the Risk of Cognitive Impairment in a Sample of Former Indentured Child Laborers in Old Age,” by Andrea Burri, Andreas Maercker, Sandy Krammer, and Keti Simmen-Janevska (PLoS ONE 8(2): e57826. doi:10.1371/journal.pone.0057826, XML, HTML, and .pdf format, 8p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0057826
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November 5, 2012
CAAR – Public Library of Science (PLoS) Articles – November 5, 2012
A. “A Longitudinal Study of Atrophy in Amnestic Mild Cognitive Impairment and Normal Aging Revealed by Cortical Thickness,” by Zhijun Yao, Bin Hu, Chuanjiang Liang, Lina Zhao, and Mike Jackson, the Alzheimer’s Disease Neuroimaging Initiative (PLoS ONE 7(11): e48973. doi:10.1371/journal.pone.0048973, XML, HTML, and .pdf format, 11p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048973
B. “A Peptide Binding to the {beta}-Site of APP Improves Spatial Memory and Attenuates A{beta} Burden in Alzheimer’s Disease Transgenic Mice,” by Shi-gao Yang, Shao-wei Wang, Min Zhao, Ran Zhang, Wei-wei Zhou, Ya-nan Li, Ya-jing Su, He Zhang, Xiao-lin Yu, and Rui-tian Liu (PLoS ONE 7(11): e48540. doi:10.1371/journal.pone.0048540, XML, HTML, and .pdf format, 12p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048540
C. “Dopaminergic Neuronal Loss and Dopamine-Dependent Locomotor Defects in Fbxo7-Deficient Zebrafish,” by Tianna Zhao, Herma Zondervan-van der Linde, Lies-Anne Severijnen, Ben A. Oostra, Rob Willemsen, and Vincenzo Bonifati (PLoS ONE 7(11): e48911. doi:10.1371/journal.pone.0048911, XML, HTML, and .pdf format, 11p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048911
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October 30, 2012
CAAR – Public Library of Science (PLoS) Articles – October 30, 2012
A. “Loss of RBPj in Postnatal Excitatory Neurons Does Not Cause Neurodegeneration or Memory Impairments in Aged Mice,” by Chihiro Sato, Mustafa Turkoz, Joshua T. Dearborn, David F. Wozniak, Raphael Kopan, and Matthew R. Hass (PLoS ONE 7(10): e48180. doi:10.1371/journal.pone.0048180, HTML, XML, and .pdf format, 10p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048180
B. “Ablation of Neurogenesis Attenuates Recovery of Motor Function after Focal Cerebral Ischemia in Middle-Aged Mice,” by Fen Sun, Xiaomei Wang, XiaoOu Mao, Lin Xie, and Kunlin Jin (PLoS ONE 7(10): e46326. doi:10.1371/journal.pone.0046326, XML, HTML, and .pdf format, 8p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046326
C. “Usp14 Deficiency Increases Tau Phosphorylation without Altering Tau Degradation or Causing Tau-Dependent Deficits,” by Youngnam N. Jin, Ping-Chung Chen, Jennifer A. Watson, Brandon J. Walters, Scott E. Phillips, Karen Green, Robert Schmidt, Julie A. Wilson, Gail V. Johnson, Erik D. Roberson, Lynn E. Dobrunz, and Scott M. Wilson (PLoS ONE 7(10): e47884. doi:10.1371/journal.pone.0047884, XML, HTML, and .pdf format, 10p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0047884
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October 4, 2012
CAAR – Public Library of Science (PLoS) Articles – October 4, 2012
A. “Timing Matters in Hip Fracture Surgery: Patients Operated within 48 Hours Have Better Outcomes. A Meta-Analysis and Meta-Regression of over 190,000 Patients,” by Lorenzo Moja, Alessandra Piatti, Valentina Pecoraro, Cristian Ricci, Gianni Virgili, Georgia Salanti, Luca Germagnoli, Alessandro Liberati, and Giuseppe Banfi (PLoS ONE 7(10): e46175. doi:10.1371/journal.pone.0046175, XML, HTML, and .pdf format, 13p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046175
B. “Aging Contributes to Inflammation in Upper Extremity Tendons and Declines in Forelimb Agility in a Rat Model of Upper Extremity Overuse,” by David M. Kietrys, Ann E. Barr-Gillespie, Mamta Amin, Christine K. Wade, Steve N. Popoff, and Mary F. Barbe (PLoS ONE 7(10): e46954. doi:10.1371/journal.pone.0046954, XML, HTML, and .pdf format, 12p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046954
C. “Inappropriate Drugs in Elderly Patients with Severe Cognitive Impairment: Results from the Shelter Study,” by Giuseppe Colloca, Matteo Tosato, Davide L. Vetrano, Eva Topinkova, Daniela Fialova, Jacob Gindin, Henriette G. van der Roest, Francesco Landi, Rosa Liperoti, Roberto Bernabei, and Graziano Onder, SHELTER project (PLoS ONE 7(10): e46669. doi:10.1371/journal.pone.0046669, XML, HTML, and .pdf format, 7p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046669
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October 2, 2012
CSSRR – Public Library of Science (PLoS) Articles – October 2, 2012
A. “The Relationship between Associative Learning, Transfer Generalization, and Homocysteine Levels in Mild Cognitive Impairment,” by Ahmed A. Moustafa, Doaa H. Hewedi, Abeer M. Eissa, Catherine E. Myers, and Hisham A. Sadek (PLoS ONE 7(9): e46496. doi:10.1371/journal.pone.0046496, XML, HTML, and .pdf format, 11p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046496
B. “The Impact of Autonomic Dysfunction on Survival in Patients with Dementia with Lewy Bodies and Parkinson’s Disease with Dementia,” by Kajsa Stubendorff, Dag Aarsland, Lennart Minthon, Elisabet Londos (PLoS ONE 7(10): e45451. doi:10.1371/journal.pone.0045451, XML, HTML, and .pdf format, 6p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0045451
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September 20, 2012
CAAR – Public Library of Science (PLoS) Articles – September 20, 2012
A. “Clinical Disorders in a Post War British Cohort Reaching Retirement: Evidence from the First National Birth Cohort Study,” by Mary B. Pierce, Richard J. Silverwood, Dorothea Nitsch, Judith E. Adams, Alison M. Stephen, Wing Nip, Peter Macfarlane, Andrew Wong, Marcus Richards, Rebecca Hardy, Diana Kuh, on behalf of the NSHD Scientific and Data Collection Teams (PLoS ONE 7(9): e44857. doi:10.1371/journal.pone.0044857, XML, HTML, and .pdf format, 10p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0044857
B. “Structural and Functional Changes in Subcortical Vascular Mild Cognitive Impairment: A Combined Voxel-Based Morphometry and Resting-State fMRI Study,” by Liye Yi, Jinhui Wang, Longfei Jia, Zhilian Zhao, Jie Lu, Kuncheng Li, Jianping Jia, Yong He, Chuanlu Jiang, and Ying Han (PLoS ONE 7(9): e44758. doi:10.1371/journal.pone.0044758, XML, HTML, and .pdf format, 9p.).
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0044758
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